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Dublin Core
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Treatment of Symptoms in Children with Q3 Conditions Scoping Review Results
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<a href="http://doi.org/10.1177/0883073812438100" target="_blank" rel="noreferrer noopener">http://doi.org/10.1177/0883073812438100</a>
Dublin Core
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Title
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Botulinum Toxin Type A for the Treatment of Equinus Deformity in Patients With Mucopolysaccharidosis Type II
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Journal of Child Neurology
Date
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2012
Subject
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children; Pediatrics; Neurosciences & Neurology; management; botulinum toxin type A; cerebral-palsy; disease; equinus deformity; Hunter syndrome; hunter-syndrome; II; mucopolysaccharidosis type; recommendations; skeletal-muscle; tone and motor problems; MPSII; pharmacologic intervention; physical intervention; botulinum toxin type A; serial casting; physical therapy
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Nava E; Weber P; Gautschi M; Nuoffer J M; Grunt S
Description
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Mucopolysaccharidoses are lysosomal storage disorders that are caused by a deficiency in the enzymes that degrade glycosaminoglycans. The accumulation of glycosaminoglycans affects multiple systems, resulting in coarse facial features, short stature, organomegaly, and variable neurological changes from normal intelligence to severe mental retardation and spasticity. Effects on the musculoskeletal system include dysostosis multiplex, joint stiffness, and muscle shortening. This article reports 2 patients with mucopolysaccharidosis type II (Hunter syndrome) who showed progressive equinus deformity of the feet. Both patients were treated with intramuscular botulinum toxin type A injections in the gastrocnemius and the soleus muscles, followed by serial casting. In both patients, passive range of motion, muscle tone, and gait performance were significantly improved. Botulinum toxin type A injections followed by serial casting are a therapeutic option for contractures in patients with mucopolysaccharidosis. However, the long-term effects and the effect of application in other muscles remain unknown.
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<a href="http://doi.org/10.1177/0883073812438100" target="_blank" rel="noreferrer noopener">10.1177/0883073812438100</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
2012
botulinum toxin type A
cerebral-palsy
Children
Disease
equinus deformity
Gautschi M
Grunt S
Hunter syndrome
hunter-syndrome
II
Journal of Child Neurology
Management
MPSII
mucopolysaccharidosis type
Nava E
Neurosciences & Neurology
Nuoffer J M
Pediatrics
pharmacologic intervention
physical intervention
Physical Therapy
Recommendations
serial casting
skeletal-muscle
tone and motor problems
Weber P