1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1002/1097-0142(19931001)72:7%3C2266::aid-cncr2820720734%3E3.0.co" target="_blank" rel="noreferrer">http://doi.org/10.1002/1097-0142(19931001)72:7%3C2266::aid-cncr2820720734%3E3.0.co</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Clinical efficacy of methadone in patients refractory to other mu-opioid receptor agonist analgesics for management of terminal cancer pain. Case presentations and discussion of incomplete cross-tolerance among opioid agonist analgesics Publisher An entity responsible for making the resource available Cancer Date A point or period of time associated with an event in the lifecycle of the resource 1993 Subject The topic of the resource Child; Female; Humans; Male; Palliative Care; Pain; Adult; Middle Aged; adolescent; Neoplasms/physiopathology; Analgesics/pharmacology; Drug Tolerance; Intractable/therapy; Methadone/therapeutic use; mu/drug effects; Opioid; Receptors Creator An entity primarily responsible for making the resource Crews JC; Sweeney NJ; Denson DD Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1002/1097-0142(19931001)72:7%3C2266::aid-cncr2820720734%3E3.0.co" target="_blank" rel="noreferrer">10.1002/1097-0142(19931001)72:7%3C2266::aid-cncr2820720734%3E3.0.co</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article Description An account of the resource BACKGROUND. Development of tolerance to opioid analgesics occurs often in patients with cancer-related pain. Cross-tolerance among opioid analgesics provides the physician with a major management problem. Incomplete cross-tolerance among opioid analgesics has been demonstrated to occur in animals and humans. The current study provides clinical evidence of the incomplete cross-tolerance of methadone with a number of mu-opioid agonist analgesics in patients with advanced cancer-related pain. RESULTS. Patients presented in the current study had cancer-related pain refractory to other mu--opioid receptor agonist analgesics as evidenced by inadequate analgesia despite escalation of opioid dose. All patients were adequately managed by conversion of their opioid dose to methadone. Additionally, the dose of methadone required to establish and maintain analgesia in these patients was modest compared with previous opioid dose requirements. CONCLUSIONS. Methadone is a potent opioid analgesic that demonstrates incomplete cross-tolerance with other mu-opioid receptor agonist analgesics. Conversion of the opioid-tolerant patient with cancer-related pain to methadone may represent an important therapeutic option in the management of patients with this difficult problem. 1993 Adolescent Adult Analgesics/pharmacology Backlog Cancer Child Crews JC Denson DD Drug Tolerance Female Humans Intractable/therapy Journal Article Male Methadone/therapeutic use Middle Aged mu/drug effects Neoplasms/physiopathology Opioid Pain Palliative Care Receptors Sweeney NJ