1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1001/jama.283.6.756" target="_blank" rel="noreferrer">http://doi.org/10.1001/jama.283.6.756</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Outcome at age 4 years in offspring of women with maternal phenylketonuria: the Maternal PKU Collaborative Study Publisher An entity responsible for making the resource available Jama Date A point or period of time associated with an event in the lifecycle of the resource 2000 Subject The topic of the resource Child; Female; Humans; Male; Pregnancy; Logistic Models; Pregnancy Outcome; Longitudinal Studies; Cognition; Developmental Disabilities; Child Behavior; Preschool; AIM; IM; Developmental Disabilities/di [Diagnosis]; Developmental Disabilities/et [Etiology]; Phenylketonurias/dh [Diet Therapy]; Phenylketonurias/pp [Physiopathology]; Pregnancy Complications/dh [Diet Therapy]; Psychological Tests Creator An entity primarily responsible for making the resource Waisbren SE; Hanley W; Levy HL; Shifrin H; Allred E; Azen C; Chang PN; Cipcic-Schmidt S; de la Cruz F; Hall R; Matalon R; Nanson J; Rouse B; Trefz F; Koch R Description An account of the resource CONTEXT: Untreated maternal phenylketonuria (PKU) increases risk for developmental problems in offspring. The extent to which this risk is reduced by maternal dietary therapy at various stages of pregnancy is not known. OBJECTIVE: To determine whether dietary treatment during pregnancy of women with PKU affects developmental outcomes of offspring. DESIGN: The Maternal PKU Collaborative Study, an ongoing, longitudinal prospective study begun in 1984. SETTING: A total of 78 metabolic clinics and obstetrical offices in the United States, Canada, and Germany. PARTICIPANTS: A total of 253 children of women with PKU (n = 149), with untreated mild hyperphenylalaninemia (n = 33), or without known metabolic problems (comparison group; n = 71) were followed up to age 4 years. INTERVENTION: Women with PKU were offered a low-phenylalanine diet prior to or during pregnancy with the aim of maintaining metabolic control (plasma phenylalanine < or =10 mg/dL [< or =605 micromol/L]). Women with mild hyperphenylalaninemia, who had plasma phenylalanine levels of no more than 10 mg/dL (605 micromol/L) on a normal diet, were not treated. MAIN OUTCOME MEASURES: Children's scores on cognitive and behavioral assessments (McCarthy Scales of Children's Abilities, Test of Language Development, Achenbach Child Behavior Checklist, Vineland Adaptive Behavior Scales, and Home Observation for Measurement of the Environment), compared by maternal metabolic status at 0 to 10 weeks', 10 to 20 weeks', and after 20 weeks' gestation. RESULTS: Scores on the McCarthy General Cognitive Index decreased as weeks to metabolic control increased (r = -0.58; P<.001). Offspring of women who had metabolic control prior to pregnancy had a mean (SD) score of 99 (13). Forty-seven percent of offspring whose mothers did not have metabolic control by 20 weeks' gestation had a General Cognitive Index score 2 SDs below the norm. Overall, 30% of children born to mothers with PKU had social and behavioral problems. CONCLUSIONS: Our data suggest that delayed development in offspring of women with PKU is associated with lack of maternal metabolic control prior to or early in pregnancy. Treatment at any time during pregnancy may reduce the severity of delay. 2000 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1001/jama.283.6.756" target="_blank" rel="noreferrer">10.1001/jama.283.6.756</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2000 AIM Allred E Azen C Backlog Chang PN Child Child Behavior Cipcic-Schmidt S Cognition de la Cruz F Developmental Disabilities Developmental Disabilities/di [Diagnosis] Developmental Disabilities/et [Etiology] Female Hall R Hanley W Humans IM JAMA Journal Article Koch R Levy HL Logistic Models Longitudinal Studies Male Matalon R Nanson J Phenylketonurias/dh [Diet Therapy] Phenylketonurias/pp [Physiopathology] Pregnancy Pregnancy Complications/dh [Diet Therapy] Pregnancy Outcome Preschool Psychological Tests Rouse B Shifrin H Trefz F Waisbren SE