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Dublin Core
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Title
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Treatment of Symptoms in Children with Q3 Conditions Scoping Review Results
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URL Address
<a href="http://doi.org/10.1177/0883073817741054" target="_blank" rel="noreferrer noopener">http://doi.org/10.1177/0883073817741054</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Gait, Balance, and Coordination Impairments in Niemann Pick Disease, Type C1
Publisher
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Journal of Child Neurology
Date
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2018
Subject
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adolescent; retrospective study; priority journal; scoring system; school child; outcome assessment; preschool child; intervention study; human; article; child; female; male; adult; clinical article; young adult; comparative study; body equilibrium; stabilography; performance; neurologic examination; balance impairment; coordination disorder; gait disorder; Niemann Pick disease; 2 hydroxypropyl beta cyclodextrin; 94035-02-6 (2 hydroxypropyl beta cyclodextrin); case control study; clinical evaluation; disease severity assessment; human development; molecular stability; motion analysis system; NIH NPC Neurologic Severity Scale; research; spatiotemporal analysis; upper limb; vts 270; tone and motor problems; NPC; trajectory; characteristics
Creator
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Sansare A; Zampieri C; Alter K; Stanley C; Farhat N; Keener L A; Porter F
Description
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This is the first study to objectively measure gait, balance, and upper limb coordination in a group of patients with NPC1 and compare the results to age and gender matched controls. This is also the first study to report effect sizes in these measures. Spatiotemporal gait analysis, static and dynamic posturography, and upper limb reaching motion analysis were performed. The findings showed that the NPC1 subjects had statistically significant deficits on 12 out of the 16 parameters investigated compared to controls, and large effect sizes for all but 1 parameter. When ranking the variables in terms of the effect sizes, the top 5 included at least 1 parameter from each of the 3 motor domains investigated. These results can provide insight to clinical researchers on the selection of outcome measures for longitudinal and interventional studies.
Identifier
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<a href="http://doi.org/10.1177/0883073817741054" target="_blank" rel="noreferrer noopener">10.1177/0883073817741054</a>
Rights
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
2 hydroxypropyl beta cyclodextrin
2018
94035-02-6 (2 hydroxypropyl beta cyclodextrin)
Adolescent
Adult
Alter K
Article
balance impairment
body equilibrium
case control study
characteristics
Child
Clinical Article
clinical evaluation
Comparative Study
coordination disorder
disease severity assessment
Farhat N
Female
gait disorder
Human
Human Development
intervention study
Journal of Child Neurology
Keener L A
Male
molecular stability
motion analysis system
Neurologic Examination
Niemann Pick disease
NIH NPC Neurologic Severity Scale
NPC
outcome assessment
performance
Porter F
Preschool Child
Priority Journal
Research
Retrospective Study
Sansare A
School Child
scoring system
spatiotemporal analysis
stabilography
Stanley C
tone and motor problems
Trajectory
Upper limb
vts 270
Young Adult
Zampieri C