1 40 1 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Treatment of Symptoms in Children with Q3 Conditions Scoping Review Results Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1002/ajmg.1320570223" target="_blank" rel="noreferrer noopener">http://doi.org/​10.1002/ajmg.1320570223</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource CIRCADIAN-RHYTHM STUDIES IN NEURONAL CEROID-LIPOFUSCINOSIS (NCL) Publisher An entity responsible for making the resource available American Journal of Medical Genetics Date A point or period of time associated with an event in the lifecycle of the resource 1995 Subject The topic of the resource children; Genetics & Heredity; sleep; body temperature; circadian rhythms; cortisol; disturbance; melatonin; mental handicap; motor activity; neuronal ceroid lipofuscinosis; radioimmunoassay; retina; sleep disturbance/disorders; NCL3; trajectory; characteristics Creator An entity primarily responsible for making the resource Heikkila E; Hatonen T H; Telakivi T; Laakso M L; Heiskala H; Salmi T; Alila A; Santavuori P Description An account of the resource Sleep disorders are common in NCL patients, The patients have problems such as frequent awakenings, difficulties with sleep onset, nightmares, and night terrors, The aim of the study was to examine whether the sleep disturbance in NCL can be explained on the basis of desynchronised circadian rhythms, Therefore we studied diurnal patterns of melatonin, cortisol, body temperature, and motor activity of 14 patients, The group consisted of 8 JNCL patients, 5 INCL children, and one boy with Jansky-Bielschowsky disease of the variant type, There were healthy age- and sex-matched control subjects, The blood samples for serum melatonin and cortisol were collected every 2 hours during 24-hour periods, Body temperature was recorded continuously for a 24 hour period by a polygraph, Diurnal motor activity was measured by wrist actigraphy for 5 days, In most of our patients sleep was fragmented and the sleep phase was irregular, Disturbances in the daily hormonal rhythms occurred only in the minority of the patients and only at an advanced stage of the disease, Although disturbances in the body temperature rhythm were found in about half of the patients, a general failure in the circadian regulatory system does not explain the frequent disturbances of the sleep-wake cycle of the NCL patients. (C) 1995 Wiley-Liss, Inc. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1002/ajmg.1320570223" target="_blank" rel="noreferrer noopener">10.1002/ajmg.1320570223</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). 1995 Alila A American Journal Of Medical Genetics body temperature characteristics Children circadian rhythms cortisol disturbance Genetics & Heredity Hatonen T H Heikkila E Heiskala H Laakso M L melatonin mental handicap Motor Activity NCL3 neuronal ceroid lipofuscinosis Radioimmunoassay retina Salmi T Santavuori P Sleep sleep disturbance/disorders Telakivi T Trajectory