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Text
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<a href="http://doi.org/10.1038/sj.npp.1301295" target="_blank" rel="noreferrer">http://doi.org/10.1038/sj.npp.1301295</a>
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Title
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A D2 antagonist enhances the rewarding and priming effects of a gambling episode in pathological gamblers.
Publisher
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Neuropsychopharmacology
Date
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2007
Subject
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Female; Humans; Male; Pain Measurement; Adult; Middle Aged; Semantics; Analysis of Variance; Motivation; Double-Blind Method; IM; Psychiatric Status Rating Scales; Neuropsychological Tests; Blood Pressure/de [Drug Effects]; Dopamine Antagonists/ad [Administration & Dosage]; Dopamine Antagonists/ae [Adverse Effects]; Gambling/px [Psychology]; Haloperidol/ad [Administration & Dosage]; Haloperidol/ae [Adverse Effects]; Reaction Time/de [Drug Effects]; Reward
Creator
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Zack M; Poulos CX
Description
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Previous research indicated shared neurochemical substrates for gambling and psychostimulant reward. This suggests that dopamine substrates may directly govern the reinforcement process in pathological gambling. To investigate this issue, the present study assessed the effects of the relatively selective dopamine D2 antagonist, haloperidol (3 mg, oral) on responses to actual gambling (15 min on a slot machine) in 20 non-comorbid pathological gamblers and 18 non-gambler controls in a placebo-controlled, double-blind, counterbalanced design. In gamblers, haloperidol significantly increased self-reported rewarding effects of gambling, post-game priming of desire to gamble, facilitation of reading speed to Gambling words, and gambling-induced elevation in blood pressure. In controls, haloperidol augmented gambling-induced elevation in blood pressure, but had no effect on other indices. The findings provide direct experimental evidence that the D2 substrate modulates gambling reinforcement in pathological gamblers.
2007
Identifier
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<a href="http://doi.org/10.1038/sj.npp.1301295" target="_blank" rel="noreferrer">10.1038/sj.npp.1301295</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
2007
Adult
Analysis of Variance
Backlog
Blood Pressure/de [Drug Effects]
Dopamine Antagonists/ad [Administration & Dosage]
Dopamine Antagonists/ae [Adverse Effects]
Double-Blind Method
Female
Gambling/px [Psychology]
Haloperidol/ad [Administration & Dosage]
Haloperidol/ae [Adverse Effects]
Humans
IM
Journal Article
Male
Middle Aged
Motivation
Neuropsychological Tests
Neuropsychopharmacology
Pain Measurement
Poulos CX
Psychiatric Status Rating Scales
Reaction Time/de [Drug Effects]
Reward
Semantics
Zack M