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Text
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<a href="http://doi.org/10.1007/s00431-004-1541-7" target="_blank" rel="noreferrer">http://doi.org/10.1007/s00431-004-1541-7</a>
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Title
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Effective parenteral clodronate treatment of a child with severe juvenile idiopathic osteoporosis
Publisher
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European Journal Of Pediatrics
Date
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2005
Subject
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Child; Humans; Male; Age Factors; Infusions; Clodronate; Recurrence; Antimetabolites/administration & dosage/therapeutic use; Bone Density/drug effects; Clodronic Acid/administration & dosage/therapeutic use; Osteoporosis/drug therapy; Parenteral; Puberty
Creator
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Melchior R; Zabel B; Spranger J; Schumacher R
Description
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We report on an 8 years and 3 months old boy with severe idiopathic juvenile osteoporosis (IJO). Clinical features included multiple fractures, especially of the vertebrae, and neurological symptoms. Biological studies showed non-parathyroid hormone-mediated excessive bone resorption and massive urinary calcium loss. Although IJO is usually a self-limiting condition after puberty, the severity of our patient's manifestations required therapeutic intervention. Clodronate (dichloromethylene-bisphosphonate) was administered parenterally every 3 months for a period of 2 years. Dramatic clinical and biochemical improvement was noted within 2 weeks. All parameters of bone resorption normalised and no new fractures occurred. After 6 months of treatment, radiological improvement with healing of fractures and rebuilding of the vertebral plates was documented. Bone mineral density increased to normal within 1 year and growth velocity was accelerated. After 2 years, treatment was stopped at the age of 10 years and 3 months. One year later, back pain and increasing pain in the knee region recurred. A tibial fracture was evident and, again, bone mineral density was far below normal. Bisphosphonate medication was reinstituted leading to rapid improvement. No side-effects were observed. CONCLUSION: Parenteral clodronate therapy is effective in managing severe idiopathic juvenile osteoporosis.
2005
Identifier
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<a href="http://doi.org/10.1007/s00431-004-1541-7" target="_blank" rel="noreferrer">10.1007/s00431-004-1541-7</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
2005
Age Factors
Antimetabolites/administration & dosage/therapeutic use
Backlog
Bone Density/drug effects
Child
Clodronate
Clodronic Acid/administration & dosage/therapeutic use
European Journal of Pediatrics
Humans
Infusions
Journal Article
Male
Melchior R
Osteoporosis/drug therapy
Parenteral
Puberty
Recurrence
Schumacher R
Spranger J
Zabel B