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Text
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Citation List Month
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URL Address
<a href="http://doi.org/10.1126/science.197601" target="_blank" rel="noreferrer">http://doi.org/10.1126/science.197601</a>
Dublin Core
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Title
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beta-Endorphin and adrenocorticotropin are selected concomitantly by the pituitary gland
Publisher
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Science
Date
A point or period of time associated with an event in the lifecycle of the resource
1977
Subject
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Male; Time Factors; Animals; Rats; Stress; Biomarkers of Pain; Amino Acid Sequence; Hypophysectomy; Corticotropin-Releasing Hormone/pharmacology; Adrenocorticotropic Hormone/blood/secretion; Endorphins/blood/secretion; Peptides/secretion; Physiological/blood; Pituitary Gland/secretion; Protein Precursors/secretion
Creator
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Guillemin R; Vargo T; Rossier J; Minick S; Ling N; Rivier C; Vale W; Bloom F
Description
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The opiate-like peptide beta-endorphin and adrenocorticotropin are concomitantly secreted in increased amounts by the adenohypophysis in response to acute stress or long-term adrenalectomy as well as in vitro in response to purified corticotropin releasing factor and other secretagogues. Conversely, administration of the synthetic glucocorticoid dexamethasone inhibits the secretion of both adrenocorticotropin and beta-endorphin. Thus, both hormones possess common and identical regulatory mechanisms and there may be a functional role for circulating beta-endorphin.
1977
Identifier
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<a href="http://doi.org/10.1126/science.197601" target="_blank" rel="noreferrer">10.1126/science.197601</a>
Rights
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1977
Adrenocorticotropic Hormone/blood/secretion
Amino Acid Sequence
Animals
Backlog
Biomarkers of Pain
Bloom F
Corticotropin-Releasing Hormone/pharmacology
Endorphins/blood/secretion
Guillemin R
Hypophysectomy
Journal Article
Ling N
Male
Minick S
Peptides/secretion
Physiological/blood
Pituitary Gland/secretion
Protein Precursors/secretion
Rats
Rivier C
Rossier J
Science
Stress
Time Factors
Vale W
Vargo T