2
40
106
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1136/bmj.38740.614954.55" target="_blank" rel="noreferrer">http://doi.org/10.1136/bmj.38740.614954.55</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Factors influencing death at home in terminally ill patients with cancer: systematic review
Publisher
An entity responsible for making the resource available
Bmj (clinical Research Ed.)
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
Subject
The topic of the resource
Humans; Attitude to Death; Health Services Accessibility; Death; Risk Factors; Patient Satisfaction; Time Factors; Residence Characteristics; House Calls; social support; Hospitalization/statistics & numerical data; Terminally Ill/statistics & numerical data; location of death; Neoplasms/psychology/therapy; Home Care Services/standards/statistics & numerical data/utilization; Terminal Care/psychology/statistics & numerical data/utilization
Creator
An entity primarily responsible for making the resource
Gomes B; Higginson IJ
Description
An account of the resource
OBJECTIVES: To determine the relative influence of different factors on place of death in patients with cancer. DATA SOURCES: Four electronic databases-Medline (1966-2004), PsycINFO (1972-2004), CINAHL (1982-2004), and ASSIA (1987-2004); previous contacts with key experts; hand search of six relevant journals. REVIEW METHODS: We generated a conceptual model, against which studies were analysed. Included studies had original data on risk factors for place of death among patients, > 80% of whom had cancer. Strength of evidence was assigned according to the quantity and quality of studies and consistency of findings. Odds ratios for home death were plotted for factors with high strength evidence. RESULTS: 58 studies were included, with over 1.5 million patients from 13 countries. There was high strength evidence for the effect of 17 factors on place of death, of which six were strongly associated with home death: patients' low functional status (odds ratios range 2.29-11.1), their preferences (2.19-8.38), home care (1.37-5.1) and its intensity (1.06-8.65), living with relatives (1.78-7.85), and extended family support (2.28-5.47). The risk factors covered all groups of the model: related to illness, the individual, and the environment (healthcare input and social support), the latter found to be the most important. CONCLUSIONS: The ne of factors that influence where patients with cancer die is complicated. Future policies and clinical practice should focus on ways of empowering families and public education, as well as intensifying home care, risk assessment, and training practitioners in end of life care.
2006
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1136/bmj.38740.614954.55" target="_blank" rel="noreferrer">10.1136/bmj.38740.614954.55</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2006
Attitude To Death
Backlog
Bmj (clinical Research Ed.)
Death
Gomes B
Health Services Accessibility
Higginson IJ
Home Care Services/standards/statistics & numerical data/utilization
Hospitalization/statistics & numerical data
House Calls
Humans
Journal Article
Location Of Death
Neoplasms/psychology/therapy
Patient Satisfaction
Residence Characteristics
Risk Factors
Social Support
Terminal Care/psychology/statistics & numerical data/utilization
Terminally Ill/statistics & numerical data
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1212/01.wnl.0000198776.53007.2c" target="_blank" rel="noreferrer">http://doi.org/10.1212/01.wnl.0000198776.53007.2c</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Course of disability and respiratory function in untreated late-onset Pompe disease
Publisher
An entity responsible for making the resource available
Neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
Subject
The topic of the resource
Child; Female; Humans; Male; Adult; Questionnaires; Follow-Up Studies; Aged; Middle Aged; Disease Progression; Disabled Persons; Time Factors; adolescent; Preschool; 80 and over; Q3 Literature Search; Age of Onset; Respiratory Function Tests; Glycogen Storage Disease Type II/physiopathology
Creator
An entity primarily responsible for making the resource
Hagemans ML; Hop WJ; Van Doorn PA; Reuser AJ; Van der Ploeg AT
Description
An account of the resource
Fifty-two untreated patients with late-onset Pompe disease completed questionnaires about their clinical condition and level of handicap at baseline and at 1-year (n = 41) and 2-year follow-ups (n = 40). During this period, declines in functional activities, respiratory function, handicap, and survival were recorded on a group level. This study illustrates the progressiveness of late-onset Pompe disease and indicates the need for close clinical follow-up of both children and adults with this disorder.
2006
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1212/01.wnl.0000198776.53007.2c" target="_blank" rel="noreferrer">10.1212/01.wnl.0000198776.53007.2c</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2006
80 And Over
Adolescent
Adult
Age of Onset
Aged
Backlog
Child
Disabled Persons
Disease Progression
Female
Follow-up Studies
Glycogen Storage Disease Type II/physiopathology
Hagemans ML
Hop WJ
Humans
Journal Article
Male
Middle Aged
Neurology
Preschool
Q3 Scoping Review Results
Questionnaires
Respiratory Function Tests
Reuser AJ
Time Factors
Van der Ploeg AT
Van Doorn PA
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16182412" target="_blank" rel="noreferrer">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16182412</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Paediatric fever management: continuing education for clinical nurses
Publisher
An entity responsible for making the resource available
Nurse Education Today
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
Subject
The topic of the resource
Child; Cross-Sectional Studies; Female; Humans; Male; Analgesics; Attitude of Health Personnel; Education; Questionnaires; Health Services Needs and Demand; Nurse's Role; Time Factors; Hospitals; Nursing Staff; Practice; Pediatric; Attitudes; PedPal Lit; Health Knowledge; Non-Narcotic/therapeutic use; Nursing; Educational Status; Certification; Urban; Nursing Process; Clinical Competence/standards; Continuing/organization & administration; Evidence-Based Medicine/education; Fever/nursing/prevention & control; Hospital/education/psychology; Negativism; Pediatric Nursing/education
Creator
An entity primarily responsible for making the resource
Walsh AM; Edwards HE; Courtney MD; Wilson JE; Monaghan SJ
Description
An account of the resource
PURPOSE: This study examined the influence of level of practice, additional paediatric education and length of paediatric and current experience on nurses' knowledge of and beliefs about fever and fever management. METHOD: Fifty-one nurses from medical wards in an Australian metropolitan paediatric hospital completed a self-report descriptive survey. RESULTS: Knowledge of fever management was mediocre (Mean 12.4, SD 2.18 on 20 items). Nurses practicing at a higher level and those with between one and four years paediatric or current experience were more knowledgeable than novices or more experienced nurses. Negative beliefs that would impact nursing practice were identified. Interestingly, beliefs about fever, antipyretic use in fever management and febrile seizures were similar; they were not influenced by nurses' knowledge, experience, education or level of practice. CONCLUSIONS: Paediatric nurses are not expert fever managers. Knowledge deficits and negative attitudes influence their practice irrespective of additional paediatric education, paediatric or current experience or level of practice. Continuing education is therefore needed for all paediatric nurses to ensure the latest clear evidence available in the literature for best practice in fever management is applied.
2006
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2006
Analgesics
Attitude Of Health Personnel
Attitudes
Backlog
Certification
Child
Clinical Competence/standards
Continuing/organization & administration
Courtney MD
Cross-sectional Studies
Education
Educational Status
Edwards HE
Evidence-Based Medicine/education
Female
Fever/nursing/prevention & control
Health Knowledge
Health Services Needs And Demand
Hospital/education/psychology
Hospitals
Humans
Journal Article
Male
Monaghan SJ
Negativism
Non-Narcotic/therapeutic use
Nurse Education Today
Nurse's Role
Nursing
Nursing Process
Nursing Staff
Pediatric
Pediatric Nursing/education
PedPal Lit
Practice
Questionnaires
Time Factors
Urban
Walsh AM
Wilson JE
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16384806" target="_blank" rel="noreferrer">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16384806</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Practice patterns in pediatric consultation-liaison psychiatry: a national survey
Publisher
An entity responsible for making the resource available
Psychosomatics
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
Subject
The topic of the resource
Child; Humans; United States; Health Care Surveys; Medical Staff; Questionnaires; Time Factors; PedPal Lit; Child Psychiatry/economics/statistics & numerical data/trends; data/trends; Hospital/statistics & numerical data/trends; Hospitals/statistics & numerical data/trends; Mental Health Services/organization & administration/trends/utilization; Physician's Practice Patterns/economics/statistics & numerical; Referral and Consultation/economics/trends/utilization
Creator
An entity primarily responsible for making the resource
Shaw RJ; Wamboldt M; Bursch B; Stuber M
Description
An account of the resource
The purpose of this survey was to describe the current status of pediatric consultation-liaison (C-L) services in the United States. A total of 144 pediatric C-L programs were surveyed, with a response rate of 33%. Financial and staffing constraints were cited as common problems; 61% of programs reported an increase in consultation requests over the past 5 years, however, 30% of services reported a decrease in funding. Collection rates for professional billings average 30%; 57% of services reported an increase in clinical service demands at the expense of teaching and liaison activities. Discussion includes recommendations based on the results of the survey.
2006
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2006
Backlog
Bursch B
Child
Child Psychiatry/economics/statistics & numerical data/trends
data/trends
Health Care Surveys
Hospital/statistics & numerical data/trends
Hospitals/statistics & numerical data/trends
Humans
Journal Article
Medical Staff
Mental Health Services/organization & administration/trends/utilization
PedPal Lit
Physician's Practice Patterns/economics/statistics & numerical
Psychosomatics
Questionnaires
Referral and Consultation/economics/trends/utilization
Shaw RJ
Stuber M
Time Factors
United States
Wamboldt M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1002/ajmg.a.20664" target="_blank" rel="noreferrer">http://doi.org/10.1002/ajmg.a.20664</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Peroxisome biogenesis disorders with prolonged survival: phenotypic expression in a cohort of 31 patients
Publisher
An entity responsible for making the resource available
American Journal Of Medical Genetics.Part A
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Subject
The topic of the resource
Child; Female; Humans; Male; Survival Rate; Cohort Studies; Adult; Follow-Up Studies; Mutation; Time Factors; Phenotype; adolescent; Preschool; infant; Q3 Literature Search; Developmental Disabilities/pathology; Eye Diseases/pathology; Face/abnormalities; Growth Disorders/pathology; Kidney/pathology; Liver/pathology; Membrane Proteins/genetics; Peroxisomal Disorders/genetics/mortality/pathology; Seizures/pathology; Spleen/pathology
Creator
An entity primarily responsible for making the resource
Poll-The BT; Gootjes J; Duran M; de Klerk JB; Wenniger-Prick LJ; Admiraal RJ; Waterham HR; Wanders RJ; Barth PG
Description
An account of the resource
The peroxisome biogenesis disorders (PBDs) with generalized peroxisomal dysfunction include Zellweger syndrome (ZS), neonatal adrenoleukodystrophy (NALD), and infantile Refsum disease (IRD). There is clinical, biochemical, and genetic overlap among the three phenotypes, also known as Zellweger spectrum disorders. Clinical distinctions between the phenotypes are not sharply defined. Only limited sources are available to serve as a background for prognosis in PBD, especially in case of prolonged survival. We delineated the natural history of 31 PBD patients (age 1.2-24 years) through systematic clinical and biochemical investigations. We excluded classical ZS from our study, and included all patients with a biochemically confirmed generalized peroxisomal disorder over 1 year of age, irrespective of the previously diagnosed phenotype. The initial clinical suspicion, age at diagnosis, growth, development, neurological symptoms, organ involvements, and survival are summarized. Common to all patients were cognitive and motor dysfunction, retinopathy, sensorineural hearing impairment, and hepatic involvement. Many patients showed postnatal growth failure, 10 patients displayed hyperoxaluria of whom 4 had renal stones. Motor skills ranged from sitting with support to normal gait. Speech development ranged from non-verbal expression to grammatical speech and comprehensive reading. The neurodevelopmental course was variable with stable course, rapid decline with leukodystrophy, spinocerebellar syndrome, and slow decline over a wide range of faculties as outcome profiles. At the molecular level, 21 patients had mutations in the PEX1 gene. The two most common PEX1 mutations were the G843D (c.2528G-->A) missense and the c.2097insT frameshift mutation. Patients having the G843D/G843D or the G843D/c.2097insT genotypes were compared. Patients homozygous for G843D generally had a better developmental outcome. However, one patient who was homozygous for the "mild" G843D mutation had an early lethal disease, whereas two other patients had a phenotype overlapping with the G843D/c.2097insT group. This indicates that next to the PEX1 genotype other yet unknown factors determine the ultimate phenotype.
2004
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/ajmg.a.20664" target="_blank" rel="noreferrer">10.1002/ajmg.a.20664</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2004
Admiraal RJ
Adolescent
Adult
American Journal Of Medical Genetics.Part A
Backlog
Barth PG
Child
Cohort Studies
de Klerk JB
Developmental Disabilities/pathology
Duran M
Eye Diseases/pathology
Face/abnormalities
Female
Follow-up Studies
Gootjes J
Growth Disorders/pathology
Humans
Infant
Journal Article
Kidney/pathology
Liver/pathology
Male
Membrane Proteins/genetics
Mutation
Peroxisomal Disorders/genetics/mortality/pathology
Phenotype
Poll-The BT
Preschool
Q3 Scoping Review Results
Seizures/pathology
Spleen/pathology
Survival Rate
Time Factors
Wanders RJ
Waterham HR
Wenniger-Prick LJ
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1007/s00134-003-1853-5" target="_blank" rel="noreferrer">http://doi.org/10.1007/s00134-003-1853-5</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Conflict in the care of patients with prolonged stay in the ICU: types, sources, and predictors
Publisher
An entity responsible for making the resource available
Intensive Care Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Female; Humans; Male; Adult; Prospective Studies; Aged; Middle Aged; Family Relations; Professional-Family Relations; Boston; Communication Barriers; Length of Stay; Dissent and Disputes; Interprofessional Relations; Time Factors; Reproducibility of Results; Case-Control Studies; 80 and over; decision making; ICU Decision Making; Intensive Care Units/statistics & numerical data; Intensive Care/statistics & numerical data
Creator
An entity primarily responsible for making the resource
Studdert DM; Mello MM; Burns JP; Puopolo AL; Galper BZ; Truog RD; Brennan T
Description
An account of the resource
OBJECTIVE: To determine types, sources, and predictors of conflicts among patients with prolonged stay in the ICU. DESIGN AND SETTING: We prospectively identified conflicts by interviewing treating physicians and nurses at two stages during the patients' stays. We then classified conflicts by type and source and used a case-control design to identify predictors of team-family conflicts. DESIGN AND SETTING: Seven medical and surgical ICUs at four teaching hospitals in Boston, USA. PATIENTS: All patients admitted to the participating ICUs over an 11-month period whose stay exceeded the 85th percentile length of stay for their respective unit ( n=656). MEASUREMENTS AND RESULTS: Clinicians identified 248 conflicts involving 209 patients; hence, nearly one-third of patients had conflict associated with their care: 142 conflicts (57%) were team-family disputes, 76 (31%) were intrateam disputes, and 30 (12%) occurred among family members. Disagreements over life-sustaining treatment led to 63 team-family conflicts (44%). Other leading sources were poor communication (44%), the unavailability of family decision makers (15%), and the surrogates' (perceived) inability to make decisions (16%). Nurses detected all types of conflict more frequently than physicians, especially intrateam conflicts. The presence of a spouse reduced the probability of team-family conflict generally (odds ratio 0.64) and team-family disputes over life-sustaining treatment specifically (odds ratio 0.49). CONCLUSIONS: Conflict is common in the care of patients with prolonged stays in the ICU. However, efforts to improve the quality of care for critically ill patients that focus on team-family disagreements over life-sustaining treatment miss significant discord in a variety of other areas.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00134-003-1853-5" target="_blank" rel="noreferrer">10.1007/s00134-003-1853-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
80 And Over
Adult
Aged
Backlog
Boston
Brennan T
Burns JP
Case-Control Studies
Communication Barriers
Decision Making
Dissent And Disputes
Family Relations
Female
Galper BZ
Humans
ICU Decision Making
Intensive Care Medicine
Intensive Care Units/statistics & numerical data
Intensive Care/statistics & numerical data
Interprofessional Relations
Journal Article
Length Of Stay
Male
Mello MM
Middle Aged
Professional-family Relations
Prospective Studies
Puopolo AL
Reproducibility of Results
Studdert DM
Time Factors
Truog RD
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/j.ejpn.2003.12.007" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.ejpn.2003.12.007</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Long-term follow-up, neurological outcome and survival rate in 28 Nordic patients with glutaric aciduria type 1
Publisher
An entity responsible for making the resource available
European Journal Of Paediatric Neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Subject
The topic of the resource
Child; Female; Humans; infant; Male; Survival Rate; Adult; Prognosis; Follow-Up Studies; Time Factors; adolescent; Preschool; infant; Q3 Literature Search; Newborn; Nervous System Diseases/etiology; Glutarates/urine; Glutaryl-CoA Dehydrogenase; Amino Acid Metabolism; Finland/epidemiology; Inborn Errors/complications/diagnosis/mortality; Oxidoreductases Acting on CH-CH Group Donors/deficiency; Scandinavia/epidemiology
Creator
An entity primarily responsible for making the resource
Kyllerman M; Skjeldal O; Christensen E; Hagberg G; Holme E; Lonnquist T; Skov L; Rotwelt T; von Dobeln U
Description
An account of the resource
All 28 patients, 13 females and 15 males, with glutaric aciduria type 1 diagnosed between 1975 and 2001 in Denmark, Finland, Norway and Sweden were identified and studied retrospectively until 2001. Mass screening was not performed. Three were sibling cases. Prenatal enzymatic diagnosis performed in 11 pregnancies led to termination in one. The median follow-up time was 14 years. Six patients had died. At 10 years of age the cumulative survival rate was 89% and at 35 years 44%. The dominating neurological sign was dystonia in 20 and dyskinesia in 4. Three had only slight spastic signs and information was missing in one. The head circumference at birth was significantly larger than normal and increased significantly until 6 months of age. The onset was acute encephalopathic in 24 patients and insidious in 3. From the time of diagnosis, all patients but one were prescribed protein restriction and/or a diet low in lysine and tryptophan. Riboflavine and/or carnitine supplementation were given to 25. Neurological deficits did not improve on the offered treatment. Deterioration may have been averted by intense acute metabolic treatment in a few patients. Dystonia correlated significantly to absence of speech but not to cognitive function. Severe disability, including motor, cognitive and speech functions, correlated significantly with acute onset, dystonia and mortality, and weakly with a deteriorating course, but not with age at onset, diagnosis, or follow-up, nor to head size. Results from future population studies derived from mass screening will have to relate to clinical diagnostic series of the kind presented here.
2004
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.ejpn.2003.12.007" target="_blank" rel="noreferrer">10.1016/j.ejpn.2003.12.007</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2004
Adolescent
Adult
Amino Acid Metabolism
Backlog
Child
Christensen E
European Journal of Paediatric Neurology
Female
Finland/epidemiology
Follow-up Studies
Glutarates/urine
Glutaryl-CoA Dehydrogenase
Hagberg G
Holme E
Humans
Inborn Errors/complications/diagnosis/mortality
Infant
Journal Article
Kyllerman M
Lonnquist T
Male
Nervous System Diseases/etiology
Newborn
Oxidoreductases Acting on CH-CH Group Donors/deficiency
Preschool
Prognosis
Q3 Scoping Review Results
Rotwelt T
Scandinavia/epidemiology
Skjeldal O
Skov L
Survival Rate
Time Factors
von Dobeln U
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/j.healun.2003.09.015" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.healun.2003.09.015</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cardiac transplantation: a temporary solution for Friedreich's ataxia-induced dilated cardiomyopathy
Publisher
An entity responsible for making the resource available
The Journal Of Heart And Lung Transplantation : The Official Publication Of The International Society For Heart Transplantation
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Subject
The topic of the resource
Humans; Male; Adult; Time Factors; Cardiomyopathy; Dilated/etiology/surgery; Friedreich Ataxia/complications; Heart transplantation
Creator
An entity primarily responsible for making the resource
Sedlak TL; Chandavimol M; Straatman L
Description
An account of the resource
Friedreich's ataxia is an autosomal recessive neurodegenerative disease. We report the case of a 34-year-old man with Friedreich's ataxia and dilated cardiomyopathy who underwent successful cardiac transplantation. To our knowledge, this is the first reported case of a heart transplantation for Friedreich's ataxia dilated cardiomyopathy.
2004
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.healun.2003.09.015" target="_blank" rel="noreferrer">10.1016/j.healun.2003.09.015</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2004
Adult
Backlog
Cardiomyopathy
Chandavimol M
Dilated/etiology/surgery
Friedreich Ataxia/complications
Heart transplantation
Humans
Journal Article
Male
Sedlak TL
Straatman L
The Journal Of Heart And Lung Transplantation : The Official Publication Of The International Society For Heart Transplantation
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/j.jpeds.2004.06.066" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.jpeds.2004.06.066</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Short-term safety assessment in the use of intravenous zoledronic acid in children
Publisher
An entity responsible for making the resource available
The Journal Of Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Subject
The topic of the resource
Child; Female; Humans; Male; Follow-Up Studies; Time Factors; adolescent; Preschool; retrospective studies; Infusions; Intravenous; Fever/chemically induced; Nausea/chemically induced; Clodronate; Calcium/blood; Bone Resorption/metabolism/prevention & control; Creatinine/blood; Diphosphonates/administration & dosage/adverse effects; Imidazoles/administration & dosage/adverse effects; Pain/chemically induced; Phosphorus/blood; Urea/blood; Vomiting/chemically induced
Creator
An entity primarily responsible for making the resource
Hogler W; Yap F; Little D; Ambler G; McQuade M; Cowell CT
Description
An account of the resource
The clinical side effects of the potent new bisphosphonate zoledronic acid in children are unknown. In this study of 34 children with various bone disorders, the frequency of postinfusion flu-like illness, hypocalcemia, and hypophosphatemia was 85%, 74%, and 82%, respectively. No renal side effects were detected after up to 3 consecutive infusions.
2004
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jpeds.2004.06.066" target="_blank" rel="noreferrer">10.1016/j.jpeds.2004.06.066</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2004
Adolescent
Ambler G
Backlog
Bone Resorption/metabolism/prevention & control
Calcium/blood
Child
Clodronate
Cowell CT
Creatinine/blood
Diphosphonates/administration & dosage/adverse effects
Female
Fever/chemically induced
Follow-up Studies
Hogler W
Humans
Imidazoles/administration & dosage/adverse effects
Infusions
Intravenous
Journal Article
Little D
Male
McQuade M
Nausea/chemically induced
Pain/chemically induced
Phosphorus/blood
Preschool
Retrospective Studies
The Journal Of Pediatrics
Time Factors
Urea/blood
Vomiting/chemically induced
Yap F
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/j.pain.2004.09.019" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.pain.2004.09.019</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Opioids in chronic non-cancer pain: systematic review of efficacy and safety
Publisher
An entity responsible for making the resource available
Pain
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Subject
The topic of the resource
Humans; Pain Measurement; Analgesics; Treatment Outcome; Methadone; Time Factors; Double-Blind Method; Non-U.S. Gov't; Research Support; Comparative Study; Chronic disease; Pain/drug therapy; Opioid/adverse effects/therapeutic use; Drug Evaluation; Drug Utilization Review; Randomized Controlled Trials/methods
Creator
An entity primarily responsible for making the resource
Kalso E; Edwards JE; Moore RA; McQuay HJ
Description
An account of the resource
Opioids are used increasingly for chronic non-cancer pain. Controversy exists about their effectiveness and safety with long-term use. We analysed available randomised, placebo-controlled trials of WHO step 3 opioids for efficacy and safety in chronic non-cancer pain. The Oxford Pain Relief Database (1950-1994) and Medline, EMBASE and the Cochrane Library were searched until September 2003. Inclusion criteria were randomised comparisons of WHO step 3 opioids with placebo in chronic non-cancer pain. Double-blind studies reporting on pain intensity outcomes using validated pain scales were included. Fifteen randomised placebo-controlled trials were included. Four investigations with 120 patients studied intravenous opioid testing. Eleven studies (1025 patients) compared oral opioids with placebo for four days to eight weeks. Six of the 15 included trials had an open label follow-up of 6-24 months. The mean decrease in pain intensity in most studies was at least 30% with opioids and was comparable in neuropathic and musculoskeletal pain. About 80% of patients experienced at least one adverse event, with constipation (41%), nausea (32%) and somnolence (29%) being most common. Only 44% of 388 patients on open label treatments were still on opioids after therapy for between 7 and 24 months. The short-term efficacy of opioids was good in both neuropathic and musculoskeletal pain conditions. However, only a minority of patients in these studies went on to long-term management with opioids. The small number of selected patients and the short follow-ups do not allow conclusions concerning problems such as tolerance and addiction.
2004
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.pain.2004.09.019" target="_blank" rel="noreferrer">10.1016/j.pain.2004.09.019</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2004
Analgesics
Backlog
Chronic Disease
Comparative Study
Double-Blind Method
Drug Evaluation
Drug Utilization Review
Edwards JE
Humans
Journal Article
Kalso E
McQuay HJ
Methadone
Moore RA
Non-U.S. Gov't
Opioid/adverse effects/therapeutic use
Pain
Pain Measurement
Pain/drug Therapy
Randomized Controlled Trials/methods
Research Support
Time Factors
Treatment Outcome
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0140-6736(03)12387-2" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0140-6736(03)12387-2</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Mortality in parents after death of a child in Denmark: A nationwide follow-up study.
Publisher
An entity responsible for making the resource available
Lancet
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Child; Female; Humans; Male; Adult; Follow-Up Studies; Death; Health Status; Longitudinal Studies; Risk Factors; Life Change Events; Time Factors; Incidence; Proportional Hazards Models; Registries; Population Surveillance; adolescent; Preschool; bereavement; infant; cause of death; Denmark/epidemiology; Parents/psychology; Sex Distribution; mortality; SSHRC CURA
Creator
An entity primarily responsible for making the resource
Li J; Precht DH; Mortensen PB; Olsen J
Description
An account of the resource
BACKGROUND: Little is known about the effect of parental bereavement on physical health. We investigated whether the death of a child increased mortality in parents. METHODS: We undertook a follow-up study based on national registers. From 1980 to 1996, we enrolled 21062 parents in Denmark who had a child who had died (exposed cohort), and 293745 controls--ie, parents whose children were alive, and whose family structure matched that of the exposed cohort. Natural deaths were defined with ICD8 codes 0000-7969 and ICD10 codes A00-R99, and unnatural deaths with codes 8000-9999 and V01-Y98. We used Cox's proportional-hazards regression models to assess the mortality rate of parents up to 18 years after bereavement. FINDINGS: We observed an increased overall mortality rate in mothers whose child had died (hazards ratio 1.43, 95% CI 1.24-1.64; p<0.0001). An excess mortality from natural causes (1.44, 1.15-1.78; p<0.0001) was noted in mothers only during the 10th-18th year of follow-up. Mothers had increased mortality rates from unnatural causes throughout follow-up, with the highest rate recorded during the first 3 years (3.84, 2.48-5.88; p<0.0001). Bereaved fathers had only an early excess mortality from unnatural causes (1.57, 1.06-2.32; p=0.04). Mothers who lost a child due to an unnatural death or an unexpected death had a hazard ratio of 1.72 (1.38-2.15; p=0.0040) and 1.67 (1.37-2.03; p=0.0037), respectively. INTERPRETATION: The death of a child is associated with an overall increased mortality from both natural and unnatural causes in mothers, and an early increased mortality from unnatural causes in fathers.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0140-6736(03)12387-2" target="_blank" rel="noreferrer">10.1016/s0140-6736(03)12387-2</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Adolescent
Adult
Backlog
Bereavement
Cause Of Death
Child
Death
Denmark/epidemiology
Female
Follow-up Studies
Health Status
Humans
Incidence
Infant
Journal Article
Lancet
Li J
Life Change Events
Longitudinal Studies
Male
Mortality
Mortensen PB
Olsen J
Parents/psychology
Population Surveillance
Precht DH
Preschool
Proportional Hazards Models
Registries
Risk Factors
Sex Distribution
SSHRC CURA
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0165-5728(03)00213-3" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0165-5728(03)00213-3</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Different mechanisms of intrinsic pain inhibition in early and late inflammation
Publisher
An entity responsible for making the resource available
Journal Of Neuroimmunology
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Male; Time Factors; Pain Threshold; Animals; Rats; Biomarkers of Pain; Injections; Subcutaneous; Enkephalin; Hindlimb; Wistar; Corticotropin-Releasing Hormone/administration & dosage; Dynorphins/antagonists & inhibitors/biosynthesis/physiology; Edema/immunology/metabolism/physiopathology; Endorphins/antagonists & inhibitors/biosynthesis/physiology; Freund's Adjuvant/administration & dosage; Inflammation/immunology/metabolism/physiopathology; Leukocytes/drug effects/metabolism/physiology; Methionine/antagonists & inhibitors/biosynthesis/physiology; Naloxone/administration & dosage; Pain/immunology/pathology/prevention & control; Stress/immunology/metabolism/physiopathology
Creator
An entity primarily responsible for making the resource
Machelska H; Schopohl JK; Mousa SA; Labuz D; Schafer M; Stein C
Description
An account of the resource
Neuroimmune interactions control pain through activation of opioid receptors on sensory nerves by immune-derived opioid peptides. Here we evaluate mechanisms of intrinsic pain inhibition at different stages of Freund's adjuvant-induced inflammation of the rat paw. We use immunohistochemistry and paw pressure testing. Our data show that in early (6 h) inflammation leukocyte-derived beta-endorphin, met-enkephalin and dynorphin A activate peripheral mu-, delta- and kappa-receptors to inhibit nociception. In addition, central opioid mechanisms seem to contribute significantly to this effect. At later stages (4 days), antinociception is exclusively produced by leukocyte-derived beta-endorphin acting at peripheral mu and delta receptors. Corticotropin-releasing hormone (CRH) is an endogenous trigger of these effects at both stages. These findings indicate that peripheral opioid mechanisms of pain inhibition gain functional relevance with the chronicity of inflammation.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0165-5728(03)00213-3" target="_blank" rel="noreferrer">10.1016/s0165-5728(03)00213-3</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Animals
Backlog
Biomarkers of Pain
Corticotropin-Releasing Hormone/administration & dosage
Dynorphins/antagonists & inhibitors/biosynthesis/physiology
Edema/immunology/metabolism/physiopathology
Endorphins/antagonists & inhibitors/biosynthesis/physiology
Enkephalin
Freund's Adjuvant/administration & dosage
Hindlimb
Inflammation/immunology/metabolism/physiopathology
Injections
Journal Article
Journal Of Neuroimmunology
Labuz D
Leukocytes/drug effects/metabolism/physiology
Machelska H
Male
Methionine/antagonists & inhibitors/biosynthesis/physiology
Mousa SA
Naloxone/administration & dosage
Pain Threshold
Pain/immunology/pathology/prevention & control
Rats
Schafer M
Schopohl JK
Stein C
Stress/immunology/metabolism/physiopathology
Subcutaneous
Time Factors
Wistar
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0885-3924(03)00314-2" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0885-3924(03)00314-2</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Intravenous fentanyl for cancer pain: a "fast titration" protocol for the emergency room
Publisher
An entity responsible for making the resource available
Journal Of Pain And Symptom Management
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Adult; Analgesics; Aged; Middle Aged; Time Factors; Emergency Medical Services; Titrimetry; Pain/drug therapy/etiology; Palliative Care/methods; Injections; Intravenous; Neoplasms/complications; Opioid/administration & dosage; Fentanyl/administration & Humans
Creator
An entity primarily responsible for making the resource
Soares LG; Martins M; Uchoa R
Description
An account of the resource
Patients with cancer sometimes are admitted to the emergency room due to severe pain. Despite the fact that morphine's hydrophilicity can delay its peak effects after intravenous administration up to 30 minutes, it is still the most commonly used opioid during cancer pain emergencies. Fentanyl is a synthetic, lipophilic opioid, more potent than morphine, and achieves peak effects after intravenous administration in 5 minutes. According to our observations, intravenous fentanyl could be safely used in the emergency room to treat patients who need fast titration of an opioid to control their pain. In our study, fentanyl was employed in a four-step protocol to treat patients admitted to our palliative care emergency room due to severe pain, regardless of the previous use of morphine at home. Titration with intravenous fentanyl was successfully employed in 18/18 (100%) of patients, with an average time for pain control at about 11 minutes, and without relevant adverse effects. We conclude that intravenous fentanyl could be safely used for severe cancer pain when rapid titration is being considered.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0885-3924(03)00314-2" target="_blank" rel="noreferrer">10.1016/s0885-3924(03)00314-2</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Adult
Aged
Analgesics
Backlog
Emergency Medical Services
Fentanyl/administration & Humans
Injections
Intravenous
Journal Article
Journal of Pain and Symptom Management
Martins M
Middle Aged
Neoplasms/complications
Opioid/administration & dosage
Pain/drug therapy/etiology
Palliative Care/methods
Soares LG
Time Factors
Titrimetry
Uchoa R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1067/s0022-3476(03)00245-2" target="_blank" rel="noreferrer">http://doi.org/10.1067/s0022-3476(03)00245-2</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Duration and morbidity of newly diagnosed idiopathic thrombocytopenic purpura in children: A prospective Nordic study of an unselected cohort
Publisher
An entity responsible for making the resource available
The Journal Of Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Child; Female; Humans; infant; Male; Cohort Studies; Prospective Studies; Severity of Illness Index; Risk Assessment; Time Factors; adolescent; Preschool; infant; Newborn; Platelet Count; Purpura; Thrombocytopenic; Hemorrhage/diagnosis/etiology/therapy; Idiopathic/complications/diagnosis/therapy; Scandinavia
Creator
An entity primarily responsible for making the resource
Rosthoj S; Hedlund-Treutiger I; Rajantie J; Zeller B; Jonsson OG; Elinder G; Wesenberg F; Henter JI; NOPHOITP Working Group
Description
An account of the resource
OBJECTIVE: To determine the duration of the risk period with platelet counts 1 month and 25 had 30 events. Among 93 patients with chronic ITP, 73 were at risk >1 month and 44 had 111 events. Events occurred with an average frequency of 0.39 per month at risk. Life-threatening hemorrhages did not occur in the first six months after diagnosis. CONCLUSION: Most children with ITP are at risk for serious bleeding for less than one month. Continuing severe thrombocytopenia is associated with little morbidity, bleeding episodes being infrequent and very rarely serious.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1067/s0022-3476(03)00245-2" target="_blank" rel="noreferrer">10.1067/s0022-3476(03)00245-2</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Adolescent
Backlog
Child
Cohort Studies
Elinder G
Female
Hedlund-Treutiger I
Hemorrhage/diagnosis/etiology/therapy
Henter JI
Humans
Idiopathic/complications/diagnosis/therapy
Infant
Jonsson OG
Journal Article
Male
Newborn
NOPHOITP Working Group
Platelet Count
Preschool
Prospective Studies
Purpura
Rajantie J
Risk Assessment
Rosthoj S
Scandinavia
Severity Of Illness Index
The Journal Of Pediatrics
Thrombocytopenic
Time Factors
Wesenberg F
Zeller B
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1097/00005176-200204000-00011" target="_blank" rel="noreferrer">http://doi.org/10.1097/00005176-200204000-00011</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Polyethylene glycol without electrolytes for children with constipation and encopresis
Publisher
An entity responsible for making the resource available
Journal Of Pediatric Gastroenterology And Nutrition
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Child; Female; Humans; Male; Follow-Up Studies; Prospective Studies; Time Factors; adolescent; Preschool; Non-U.S. Gov't; Research Support; Polyethylene Glycols/therapeutic use; Constipation/therapy; Encopresis/therapy; Iowa
Creator
An entity primarily responsible for making the resource
Loening-Baucke V
Description
An account of the resource
BACKGROUND: Children with functional constipation and encopresis benefit from behavior modification and from long-term laxative medication. Polyethylene glycol without electrolytes has become the first option for many pediatric gastroenterologists. METHODS: Twenty-eight children treated with polyethylene glycol without electrolytes were compared with 21 children treated with milk of magnesia to evaluate the efficiency, acceptability, side effects, and treatment dosage of polyethylene glycol in long-term treatment of functional constipation and encopresis. Children were rated as "doing well," "improved," or "not doing well," depending on resolution of constipation and encopresis. RESULTS: At the 1-, 3-, 6-, and 12-month follow-ups, bowel movement frequency increased and soiling frequency decreased significantly in both groups. At the 1-month follow-up, children on polyethylene glycol were soiling more frequently (P < 0.01) and fewer were improved (P < 0.01). At the 3- and 6-month follow-ups, both groups had similarly improved. At the 12-month visit, 61% of children on polyethylene glycol and 67% of children on milk of magnesia were doing well. Children on polyethylene glycol soiled more frequently (P < 0.01). None refused polyethylene glycol, but 33% refused to take milk of magnesia. The mean initial treatment dosage of polyethylene glycol was 0.6 +/- 0.2 g/kg daily. Polyethylene glycol had no taste, and no loss of efficacy occurred. Polyethylene glycol did not cause clinically significant side effects. CONCLUSIONS: Polyethylene glycol without electrolytes is an alternative for long-term management of children with constipation and encopresis.
2002
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/00005176-200204000-00011" target="_blank" rel="noreferrer">10.1097/00005176-200204000-00011</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2002
Adolescent
Backlog
Child
Constipation/therapy
Encopresis/therapy
Female
Follow-up Studies
Humans
Iowa
Journal Article
Journal Of Pediatric Gastroenterology And Nutrition
Loening-Baucke V
Male
Non-U.S. Gov't
Polyethylene Glycols/therapeutic use
Preschool
Prospective Studies
Research Support
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1097/01.pcc.0000123547.28099.44" target="_blank" rel="noreferrer">http://doi.org/10.1097/01.pcc.0000123547.28099.44</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A descriptive study of children dying in the pediatric intensive care unit after withdrawal of life-sustaining treatment
Publisher
An entity responsible for making the resource available
Pediatric Critical Care Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Subject
The topic of the resource
Child; Female; Humans; Male; Intensive Care Units; Palliative Care; Euthanasia; Patient Participation; Time Factors; Pediatric; adolescent; Preschool; infant; retrospective studies; ICU Decision Making; Parents/psychology; Analgesics/administration & dosage; Hypnotics and Sedatives/administration & dosage; Passive; Neuromuscular Blockade
Creator
An entity primarily responsible for making the resource
Zawistowski CA; DeVita MA
Description
An account of the resource
OBJECTIVE: To examine physiologic and therapeutic changes following withdrawal of life-sustaining treatment in children. DESIGN: Retrospective chart review. SETTING: University-affiliated tertiary care pediatric hospital. PATIENTS: All patients who had life-sustaining treatment withdrawn over a 5-yr period. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: A total of 125 charts were examined to obtain 50 in which the terminal event preceding death was withdrawal of life-sustaining treatment. Data are expressed as median (1st, 3rd quartiles). Median hospital stay before death was 20 days (1st and 3rd quartiles, 8 and 30). Median time from decision to withdraw life-sustaining treatment to actual withdrawal was 30 mins (1st and 3rd quartiles, 10 and 180). All interventions were simultaneously discontinued in 80% of patients with mechanical ventilation followed by vasopressors being most common. No patients had stepwise reduction in ventilator rate before discontinuing the mechanical ventilation. Devices were rarely removed from patients including endotracheal tubes. Time from withdrawal of life-sustaining treatment to death was 15 mins (5, 30); only seven patients took >60 mins to die. Multivariable analysis (Kruskal-Wallis test) of various factors revealed simultaneous withdrawal of life-sustaining treatment, female gender, and not having received renal therapy as hastening death. CONCLUSIONS: Forgoing life-sustaining treatment in a small cohort of children at a single institution follows a pattern: Most cases occur after prolonged intensive care unit stays, withdrawal of treatment occurs almost immediately after the decision to withdraw, most treatments are withdrawn simultaneously rather than sequentially, and most patients die within minutes of life-sustaining treatment cessation. This is the first pediatric study to report the time to death after withdrawal of life-sustaining treatment and factors associated with shorter time to death in children.
2004
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/01.pcc.0000123547.28099.44" target="_blank" rel="noreferrer">10.1097/01.pcc.0000123547.28099.44</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2004
Adolescent
Analgesics/administration & dosage
Backlog
Child
DeVita MA
Euthanasia
Female
Humans
Hypnotics and Sedatives/administration & dosage
ICU Decision Making
Infant
Intensive Care Units
Journal Article
Male
Neuromuscular Blockade
Palliative Care
Parents/psychology
Passive
Patient Participation
Pediatric
Pediatric Critical Care Medicine
Preschool
Retrospective Studies
Time Factors
Zawistowski CA
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1111/j.1547-5069.2004.04047.x" target="_blank" rel="noreferrer">http://doi.org/10.1111/j.1547-5069.2004.04047.x</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A survey of IRB process in 68 U.S. hospitals
Publisher
An entity responsible for making the resource available
Journal Of Nursing Scholarship
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Subject
The topic of the resource
Humans; United States; Questionnaires; Guidelines as Topic; Time Factors; Patient Advocacy; Analysis of Variance; Empirical Approach; Ethics Committees; Biomedical and Behavioral Research; Multi-site Ethics; Guideline Adherence/standards; Professional Competence/standards; Research/organization & administration; Human Experimentation; Conflict of Interest; Documentation/methods/standards; Hospital Bed Capacity/statistics & numerical data; Organizational Affiliation; Outcome and Process Assessment (Health Care)/organization & administration
Creator
An entity primarily responsible for making the resource
Larson E; Bratts T; Zwanziger J; Stone P
Description
An account of the resource
PURPOSE: To compare IRB processes in 68 U.S. hospitals for the same multicenter study. DESIGN: Survey of IRB processes in 68 U.S. hospitals during 2001-2002. METHODS: Requirements of IRB submission including type and duration of review and qualifications of principal investigator were compared by hospital bed size, region, and academic affiliation. FINDINGS: The majority of hospitals (63.2%) were on the East coast, and mean bed size was 465 (range: 77-2,112). About one-third (33.8%) required that the principal investigator listed on the application be from within the institution, 26.5% required evidence of human subjects research training, 10.3% required a conflict of interest statement. Mean number of pages for the application was 5.24 (1-31) and up to eight copies were requested. Time from submission of the IRB application to approval averaged 45.4 days (range, 1-303 days), and the majority of reviews were "expedited" (61.8%). Expedited reviews required more time (mean, 54.8 days) than did either exempt (mean, 10.8 days) or full (mean, 47.1 days) reviews. CONCLUSIONS: Current IRB review processes are cumbersome and nonstandardized, and review time varies widely. The absence of efficient and streamlined review might unnecessarily impede national clinical research projects without improving participant safety.
2004
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/j.1547-5069.2004.04047.x" target="_blank" rel="noreferrer">10.1111/j.1547-5069.2004.04047.x</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2004
Analysis of Variance
Backlog
Biomedical and Behavioral Research
Bratts T
Conflict of Interest
Documentation/methods/standards
Empirical Approach
Ethics Committees
Guideline Adherence/standards
Guidelines As Topic
Hospital Bed Capacity/statistics & numerical data
Human Experimentation
Humans
Journal Article
Journal Of Nursing Scholarship
Larson E
Multi-site Ethics
Organizational Affiliation
Outcome and Process Assessment (Health Care)/organization & administration
Patient Advocacy
Professional Competence/standards
Questionnaires
Research/organization & administration
Stone P
Time Factors
United States
Zwanziger J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1111/j.1752-0606.2002.tb00364.x" target="_blank" rel="noreferrer">http://doi.org/10.1111/j.1752-0606.2002.tb00364.x</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Emotionally focused interventions for couples with chronically ill children: a 2-year follow-up
Publisher
An entity responsible for making the resource available
Journal Of Marital And Family Therapy
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Child; Female; Humans; Male; Follow-Up Studies; Treatment Outcome; Ontario; Time Factors; Cost of Illness; Analysis of Variance; Family Characteristics; Stress; Preschool; Adaptation; Psychological; Parents/psychology; Intervention; Interventions; Chronic Disease/psychology; Spouses/psychology; Marriage/psychology; Psychological/etiology; Marital Therapy/methods
Creator
An entity primarily responsible for making the resource
Cloutier PF; Manion IG; Walker JG; Johnson SM
Description
An account of the resource
Couples with chronically ill children are particularly at risk for experiencing marital distress. The study presented here is a 2-year follow-up of a randomized control trial that assessed the efficacy of Emotionally Focused Therapy (EFT) in decreasing marital distress in a sample of couples with a chronically ill child. Thirteen couples with chronically ill children who received treatment were assessed to determine if the significant improvement in relationship distress observed at posttreatment and 5-month follow-up would be maintained at 2-year follow-up. Results demonstrated that improvements in marital functioning were not only maintained but, in some cases, enhanced at the 2-year follow-up. This uncontrolled follow-up study provides initial evidence of the longer-term benefits of EFT.
2002
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/j.1752-0606.2002.tb00364.x" target="_blank" rel="noreferrer">10.1111/j.1752-0606.2002.tb00364.x</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2002
Adaptation
Analysis of Variance
Backlog
Child
Chronic Disease/psychology
Cloutier PF
Cost Of Illness
Family Characteristics
Female
Follow-up Studies
Humans
Intervention
Interventions
Johnson SM
Journal Article
Journal Of Marital And Family Therapy
Male
Manion IG
Marital Therapy/methods
Marriage/psychology
Ontario
Parents/psychology
Preschool
Psychological
Psychological/etiology
Spouses/psychology
Stress
Time Factors
Treatment Outcome
Walker JG
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1177/104990910402100306" target="_blank" rel="noreferrer">http://doi.org/10.1177/104990910402100306</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Hospital charges for a community inpatient palliative care program
Publisher
An entity responsible for making the resource available
The American Journal Of Hospice & Palliative Care
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Subject
The topic of the resource
Female; Humans; Male; Adult; Aged; Middle Aged; Time Factors; Hospitals; Chi-Square Distribution; Tennessee; 80 and over; Comparative Study; referral and consultation; Palliative Care/economics/organization & administration/utilization; Cost Control; Hospital Costs/statistics & numerical data; Community/economics/utilization; Hospital Charges/statistics & numerical data; Length of Stay/economics/statistics & numerical data; Patient Admission/economics; Patient Discharge/economics
Creator
An entity primarily responsible for making the resource
Cowan JD
Description
An account of the resource
Defining financial parameters of palliative care (PC) is important for providing sustainable programming. In our study, we evaluated hospital length of stay (LOS) and charges for the first 164 inpatient PC consultations performed by the Advanced Illness Assistance (AIA) team at Blount Memorial Hospital (BMH). These AIA patients had a median LOS of 11 days (range, 3-114 days), mean total charges per patient of 65,795 dollars, and mean daily charges of 3,809 dollars. Higher mean daily charges (p = 2.74 E-08, chi-square) were associated with patients who received consultation because of nonphysical symptom reasons. Patients were followed in PC consultation (AIA follow-up days) for a median of five days (range, 1-48), and had mean daily charges of 3,117 dollars. These mean daily charges were 414 dollars less than the charges for the five days prior to PC consultation (pre-AIA days) (p = 0.04, t-test). There was a significant decrease in laboratory and imaging charges during AIA follow-up (p = 0.04, t-test). The study included a reference group of patients whose information was obtained retrospectively from the BMH Atlas (MediQual, Marlborough, MA) database. These reference group patients were hospitalized at BMH during the same time, but they were not seen by the AIA team. The reference group was matched by Diagnosis Related Group (DRG), Admission Severity Grade (ASG), and disposition to the AIA patients. The Atlas patients had a shorter median LOS of six days (range, 1-105 days), and significantly greater mean daily charges of 4,105 dollars (p = 0.006, t-test) compared with AIA patients. Mean daily charges decreased for Atlas patients, as their day of discharge approached (p < 0.001). Estimates of potential charge savings were calculated in two ways: 1) by evaluating the effect of decreasing the LOS of Atlas patients with long LOS (more than seven days) to the level of AIA patients with long LOS, and 2) by comparing the actual mean patient charges during AIA follow-up with using the pre-AIA mean daily charges during the AIA follow-up period and correcting for the effect of decreasing charges that occurred as discharge approached. The estimated savings achieved by decreasing long LOS were more than 100,000 dollars per year, and estimated savings achieved using AIA follow-up charges were more than 1,801,930 dollars per year.
2004
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1177/104990910402100306" target="_blank" rel="noreferrer">10.1177/104990910402100306</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2004
80 And Over
Adult
Aged
Backlog
Chi-Square Distribution
Community/economics/utilization
Comparative Study
Cost Control
Cowan JD
Female
Hospital Charges/statistics & numerical data
Hospital Costs/statistics & numerical data
Hospitals
Humans
Journal Article
Length of Stay/economics/statistics & numerical data
Male
Middle Aged
Palliative Care/economics/organization & administration/utilization
Patient Admission/economics
Patient Discharge/economics
Referral And Consultation
Tennessee
The American Journal of Hospice & Palliative Care
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1191/0269216303pm659oa" target="_blank" rel="noreferrer">http://doi.org/10.1191/0269216303pm659oa</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Non-invasive ventilation and palliation: experience in a district general hospital and a review
Publisher
An entity responsible for making the resource available
Palliative Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Female; Humans; Male; Terminally Ill; Aged; Middle Aged; Respiration; Time Factors; Lung Diseases; Carcinoma; Respiratory Insufficiency/therapy; Artificial/ethics/methods; Emphysema/therapy; Lung Neoplasms/complications; Motor Neuron Disease/complications; Multiple Sclerosis/complications; Myeloproliferative Disorders/complications; Obstructive/therapy; Palliative Care/ethics/methods; Small Cell/complications; Syringomyelia/complications
Creator
An entity primarily responsible for making the resource
Shee CD; Green M
Description
An account of the resource
Non-invasive ventilation (NIV) is increasingly being used in hospitals to treat respiratory failure. The use of NIV with palliative intent in a district general hospital is described and ten illustrative cases where NIV was used in an attempt to palliate symptoms or to 'buy time' are presented. The role of NIV in relieving symptoms in various conditions is reviewed and ethical aspects are considered. It is suggested that hospital palliative care teams will increasingly see patients treated by this technique as it becomes more widely used for exacerbations of chronic obstructive airways disease, for relief of breathlessness in the terminally ill and for buying time in patient management. Domiciliary teams will see increasing numbers of people with motor neurone disease and other conditions treated with NIV.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1191/0269216303pm659oa" target="_blank" rel="noreferrer">10.1191/0269216303pm659oa</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Aged
Artificial/ethics/methods
Backlog
Carcinoma
Emphysema/therapy
Female
Green M
Humans
Journal Article
Lung Diseases
Lung Neoplasms/complications
Male
Middle Aged
Motor Neuron Disease/complications
Multiple Sclerosis/complications
Myeloproliferative Disorders/complications
Obstructive/therapy
Palliative Care/ethics/methods
Palliative Medicine
Respiration
Respiratory Insufficiency/therapy
Shee CD
Small Cell/complications
Syringomyelia/complications
Terminally Ill
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/0021-9681(84)90136-x" target="_blank" rel="noreferrer">http://doi.org/10.1016/0021-9681(84)90136-x</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The assessment of values in laryngeal cancer: reliability of measurement methods
Publisher
An entity responsible for making the resource available
Journal Of Chronic Diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
1984
Subject
The topic of the resource
Female; Humans; Male; Adult; Attitude to Health; Aged; Middle Aged; Social Values; Time Factors; Non-U.S. Gov't; Research Support; Psychological; Evaluation Studies; Interview; Laryngeal Neoplasms/psychology/radiotherapy; Voice; Voice Quality
Creator
An entity primarily responsible for making the resource
Llewellyn-Thomas HA; Sutherland HJ; Ciampi A; Etezadi-Amoli J; Boyd NF; Till JE
Description
An account of the resource
Although quantitative estimates of patients' attitudes toward the relative importance of different aspects of health are of great potential usefulness in medical decision making, there is little information about the stability of such values over time, particularly in patients whose clinical state is changing. To examine these questions, we selected a group of patients with laryngeal cancer undergoing treatment with radiotherapy. In this group of patients clinical problems are relatively circumscribed and related to the voice, and a temporary deterioration in voice-related symptoms and abilities is expected during treatment. Thirty patients were interviewed at the start and completion of a month's course of treatment. At each interview patients rated the quality of their own voices using a number of visual analogue scales and also provided both holistic and decomposed quantitative values for the importance of different aspects of voice function and sound. Although the analogue scales demonstrated the anticipated deterioration in the quality of the patients' voices, these changes in clinical state were not accompanied by any changes in the values the patients assigned to each aspect of voice sound and function. These results indicate that at least in the short term the values expressed by patients appear to be stable and uninfluenced by changes in their own clinical state. Longer term studies involving more systemic illnesses should now be carried out.
1984
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0021-9681(84)90136-x" target="_blank" rel="noreferrer">10.1016/0021-9681(84)90136-x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1984
Adult
Aged
Attitude To Health
Backlog
Boyd NF
Ciampi A
Etezadi-Amoli J
Evaluation Studies
Female
Humans
Interview
Journal Article
Journal Of Chronic Diseases
Laryngeal Neoplasms/psychology/radiotherapy
Llewellyn-Thomas HA
Male
Middle Aged
Non-U.S. Gov't
Psychological
Research Support
Social Values
Sutherland HJ
Till JE
Time Factors
Voice
Voice Quality
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0300-595x(76)80028-x" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0300-595x(76)80028-x</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Starvation in man
Publisher
An entity responsible for making the resource available
New England Journal Of Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1970
Subject
The topic of the resource
Time Factors; Adaptation; Body Weight; Human; Homeostasis; Fasting; Gluconeogenesis; Physiological; Fatty Acids; Starvation/me [Metabolism]; Triglycerides/me [Metabolism]; Adrenal Cortex Hormones/ph [Physiology]; Alanine/me [Metabolism]; Brain/me [Metabolism]; Glucagon/me [Metabolism]; Glucose/metabolism; Glucose/pd [Pharmacology]; Insulin/me [Metabolism]; Insulin/ph [Physiology]; Kidney/me [Metabolism]; Liver/me [Metabolism]; Nitrogen/me [Metabolism]; Nonesterified/me [Metabolism]; Proteins/me [Metabolism]
Creator
An entity primarily responsible for making the resource
Cahill GF
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0300-595x(76)80028-x" target="_blank" rel="noreferrer">10.1016/s0300-595x(76)80028-x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
1970
1970
Adaptation
Adrenal Cortex Hormones/ph [Physiology]
Alanine/me [Metabolism]
Backlog
Body Weight
Brain/me [Metabolism]
Cahill GF
Fasting
Fatty Acids
Glucagon/me [Metabolism]
Gluconeogenesis
Glucose/metabolism
Glucose/pd [Pharmacology]
Homeostasis
Human
Insulin/me [Metabolism]
Insulin/ph [Physiology]
Journal Article
Kidney/me [Metabolism]
Liver/me [Metabolism]
New England Journal Of Medicine
Nitrogen/me [Metabolism]
Nonesterified/me [Metabolism]
Physiological
Proteins/me [Metabolism]
Starvation/me [Metabolism]
Time Factors
Triglycerides/me [Metabolism]
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1038/clpt.1988.159" target="_blank" rel="noreferrer">http://doi.org/10.1038/clpt.1988.159</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sublingual absorption of selected opioid analgesics
Publisher
An entity responsible for making the resource available
Clinical Pharmacology And Therapeutics
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
Subject
The topic of the resource
Humans; Adult; Analgesics; Time Factors; Analysis of Variance; Non-U.S. Gov't; P.H.S.; Research Support; U.S. Gov't; Comparative Study; Administration; Biological Availability; Buprenorphine/pharmacokinetics; Fentanyl/pharmacokinetics; Heroin/pharmacokinetics; Hydromorphone/pharmacokinetics; Levorphanol/pharmacokinetics; Methadone/pharmacokinetics; Morphine/blood/pharmacokinetics; Mouth/metabolism; Naloxone/pharmacokinetics; Opioid/administration & dosage/pharmacokinetics; Oxycodone/pharmacokinetics; Sublingual
Creator
An entity primarily responsible for making the resource
Weinberg DS; Inturrisi CE; Reidenberg B; Moulin DE; Nip TJ; Wallenstein S; Houde RW; Foley KM
Description
An account of the resource
Ongoing interest in the improvement of pain management with opioid analgesics had led to the investigation of sublingual opioid absorption. The present report determined the percent absorption of selected opioid analgesics from the oral cavity of normal subjects under conditions of controlled pH and swallowing when a 1.0 ml aliquot of the test drug was placed under the tongue for a 10-minute period. Compared with morphine sulfate at pH 6.5 (18% absorption), buprenorphine (55%), fentanyl (51%), and methadone (34%) were absorbed to a significantly greater extent (p less than 0.05), whereas levorphanol, hydromorphone, oxycodone, heroin, and the opioid antagonist naloxone were not. Overall, lipophilic drugs were better absorbed than were hydrophilic drugs. Plasma morphine concentration-time profiles indicate that the apparent sublingual bioavailability of morphine is only 9.0% +/- 11.9% (SD) of that after intramuscular administration. In the same subjects the estimated sublingual absorption was 22.4% +/- 9.2% (SD), indicating that the sublingual absorption method may overestimate apparent bioavailability. When the oral cavity was buffered to pH 8.5, methadone absorption was increased to 75%. Thus, an alkaline pH microenvironment that favors the unionized fraction of opioids increased sublingual drug absorption. Although absorption was found to be independent of drug concentration, it was contact time dependent for methadone and fentanyl but not for buprenorphine. These results indicate that although the sublingual absorption and apparent sublingual bioavailability of morphine are poor, the sublingual absorption of methadone, fentanyl, and buprenorphine under controlled conditions is relatively high.
1988
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/clpt.1988.159" target="_blank" rel="noreferrer">10.1038/clpt.1988.159</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1988
Administration
Adult
Analgesics
Analysis of Variance
Backlog
Biological Availability
Buprenorphine/pharmacokinetics
Clinical Pharmacology And Therapeutics
Comparative Study
Fentanyl/pharmacokinetics
Foley KM
Heroin/pharmacokinetics
Houde RW
Humans
Hydromorphone/pharmacokinetics
Inturrisi CE
Journal Article
Levorphanol/pharmacokinetics
Methadone/pharmacokinetics
Morphine/blood/pharmacokinetics
Moulin DE
Mouth/metabolism
Naloxone/pharmacokinetics
Nip TJ
Non-U.S. Gov't
Opioid/administration & dosage/pharmacokinetics
Oxycodone/pharmacokinetics
P.H.S.
Reidenberg B
Research Support
Sublingual
Time Factors
U.S. Gov't
Wallenstein S
Weinberg DS
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1111/j.1365-2044.1986.tb12847.x" target="_blank" rel="noreferrer">http://doi.org/10.1111/j.1365-2044.1986.tb12847.x</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Plasma morphine levels produced by continuous infusion in children
Publisher
An entity responsible for making the resource available
Anaesthesia
Date
A point or period of time associated with an event in the lifecycle of the resource
1986
Subject
The topic of the resource
Child; Humans; Pain; Time Factors; adolescent; Preschool; infant; Infusions; Parenteral; Postoperative/drug therapy; Morphine/administration & dosage/blood/therapeutic use
Creator
An entity primarily responsible for making the resource
Bray RJ; Beeton C; Hinton W; Seviour JA
Description
An account of the resource
Blood samples were taken from six children aged between 10 months and 15 years, at intervals over a period of 40 hours while they were receiving continuous morphine infusions. The plasma morphine values obtained showed similar and consistent levels 15-30 minutes after starting the infusions.
1986
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/j.1365-2044.1986.tb12847.x" target="_blank" rel="noreferrer">10.1111/j.1365-2044.1986.tb12847.x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1986
Adolescent
Anaesthesia
Backlog
Beeton C
Bray RJ
Child
Hinton W
Humans
Infant
Infusions
Journal Article
Morphine/administration & dosage/blood/therapeutic use
Pain
Parenteral
Postoperative/drug therapy
Preschool
Seviour JA
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1111/j.1469-8749.1969.tb01419.x" target="_blank" rel="noreferrer">http://doi.org/10.1111/j.1469-8749.1969.tb01419.x</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Permanent gastrostomy in severely brain-damaged children
Publisher
An entity responsible for making the resource available
Developmental Medicine And Child Neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
1969
Subject
The topic of the resource
Child; Humans; Time Factors; Gastrostomy; Preschool; infant; Deglutition Disorders/therapy; Cerebral Palsy/therapy; Child Nutrition; Brain Diseases/therapy; Brain Injuries/therapy; Diffuse Cerebral Sclerosis of Schilder/therapy; Encephalitis/therapy; Infant Nutrition; Lipoidosis/therapy; Postoperative Complications
Creator
An entity primarily responsible for making the resource
Pourfar M; Chafiian J
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/j.1469-8749.1969.tb01419.x" target="_blank" rel="noreferrer">10.1111/j.1469-8749.1969.tb01419.x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
1969
1969
Backlog
Brain Diseases/therapy
Brain Injuries/therapy
Cerebral Palsy/therapy
Chafiian J
Child
Child Nutrition
Deglutition Disorders/therapy
Developmental Medicine and Child Neurology
Diffuse Cerebral Sclerosis of Schilder/therapy
Encephalitis/therapy
Gastrostomy
Humans
Infant
Infant Nutrition
Journal Article
Lipoidosis/therapy
Postoperative Complications
Pourfar M
Preschool
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1126/science.197601" target="_blank" rel="noreferrer">http://doi.org/10.1126/science.197601</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
beta-Endorphin and adrenocorticotropin are selected concomitantly by the pituitary gland
Publisher
An entity responsible for making the resource available
Science
Date
A point or period of time associated with an event in the lifecycle of the resource
1977
Subject
The topic of the resource
Male; Time Factors; Animals; Rats; Stress; Biomarkers of Pain; Amino Acid Sequence; Hypophysectomy; Corticotropin-Releasing Hormone/pharmacology; Adrenocorticotropic Hormone/blood/secretion; Endorphins/blood/secretion; Peptides/secretion; Physiological/blood; Pituitary Gland/secretion; Protein Precursors/secretion
Creator
An entity primarily responsible for making the resource
Guillemin R; Vargo T; Rossier J; Minick S; Ling N; Rivier C; Vale W; Bloom F
Description
An account of the resource
The opiate-like peptide beta-endorphin and adrenocorticotropin are concomitantly secreted in increased amounts by the adenohypophysis in response to acute stress or long-term adrenalectomy as well as in vitro in response to purified corticotropin releasing factor and other secretagogues. Conversely, administration of the synthetic glucocorticoid dexamethasone inhibits the secretion of both adrenocorticotropin and beta-endorphin. Thus, both hormones possess common and identical regulatory mechanisms and there may be a functional role for circulating beta-endorphin.
1977
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1126/science.197601" target="_blank" rel="noreferrer">10.1126/science.197601</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1977
Adrenocorticotropic Hormone/blood/secretion
Amino Acid Sequence
Animals
Backlog
Biomarkers of Pain
Bloom F
Corticotropin-Releasing Hormone/pharmacology
Endorphins/blood/secretion
Guillemin R
Hypophysectomy
Journal Article
Ling N
Male
Minick S
Peptides/secretion
Physiological/blood
Pituitary Gland/secretion
Protein Precursors/secretion
Rats
Rivier C
Rossier J
Science
Stress
Time Factors
Vale W
Vargo T
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1126/science.6254156" target="_blank" rel="noreferrer">http://doi.org/10.1126/science.6254156</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Fasting associated with decrease in hypothalamic beta-endorphin
Publisher
An entity responsible for making the resource available
Science
Date
A point or period of time associated with an event in the lifecycle of the resource
1980
Subject
The topic of the resource
Male; Time Factors; Animals; Rats; Non-U.S. Gov't; Research Support; Fasting; Corticotropin/metabolism; Endorphins/metabolism; Hypothalamus/metabolism; Pituitary Gland/metabolism
Creator
An entity primarily responsible for making the resource
Gambert SR; Garthwaite TL; Pontzer CH; Hagen TC
Description
An account of the resource
In rats that were fasted for 2 to 3 days there was a decline in hypothalamic, but not pituitary, beta-endorphin. There was no change in pituitary or hypothalamic adrenocorticotropin content as a result of fasting. Endogenous opiates may be involved in physiological adaptation to fasting.
1980
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1126/science.6254156" target="_blank" rel="noreferrer">10.1126/science.6254156</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1980
Animals
Backlog
Corticotropin/metabolism
Endorphins/metabolism
Fasting
Gambert SR
Garthwaite TL
Hagen TC
Hypothalamus/metabolism
Journal Article
Male
Non-U.S. Gov't
Pituitary Gland/metabolism
Pontzer CH
Rats
Research Support
Science
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1001/archpedi.153.1.63" target="_blank" rel="noreferrer">http://doi.org/10.1001/archpedi.153.1.63</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Computer-assisted health counselor visits: a low-cost model for comprehensive adolescent preventive services
Publisher
An entity responsible for making the resource available
Archives Of Pediatrics & Adolescent Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
Subject
The topic of the resource
Female; Humans; Male; Pilot Projects; Feasibility Studies; Patient Satisfaction; Medical History Taking; Time Factors; Counseling; adolescent; Adolescent Health Services/economics; Adolescent Transitions; Costs and Cost Analysis; Medical Informatics Applications; Preventive Health Services/economics/methods; Risk-Taking
Creator
An entity primarily responsible for making the resource
Paperny DM; Hedberg VA
Description
An account of the resource
OBJECTIVE: To evaluate a low-cost strategy for providing preventive health services to adolescents using computerized health assessments with individualized educational videos, trained health counselors, and nurses. DESIGN: Feasibility study, cost analysis, and comparative evaluation of health problems identified, guidance delivered, and patient satisfaction. SETTING: Eleven sessions at nontraditional sites including schools, universities, shopping malls, and after-hours clinics on Oahu, Hawaii. PARTICIPANTS AND INTERVENTION: Adolescents (N=258, mean age 17 years) completed confidential computerized health assessments, received individualized feedback, and viewed automatically selected educational videos on a laptop computer. The computer additionally printed a prioritized problems list for the graduate student-level health counselor to review with the adolescent. The counselor subsequently reviewed each encounter with a nurse-educator who performed further counseling and physical examinations when indicated. RESULTS: Visit length averaged 44 minutes. Subjects spent an average of 21 minutes completing the automated health assessment and viewing interactive multimedia and 15 minutes with the health counselor. One third of subjects required further evaluation and counseling by the nurse (average, 8 minutes). A team of 2 counselors and 1 nurse provided comprehensive screening, health counseling, and physical examinations to 1 patient every 10 minutes at a salary cost of $7.46 per visit. This model identified risk behaviors at levels consistent with local behavioral data, and addressed and documented them significantly more often than do physicians in traditional settings. Subjects (71%) preferred the computer-assisted visits to standard office visits, and 92% felt the amount of time spent was acceptable. CONCLUSIONS: Computer-assisted delivery of adolescent preventive services using nonphysician health counselors is a feasible, economical, and acceptable alternative to traditional clinical practice for screening young people for health-compromising behaviors and providing individualized health education and routine physical examinations. This model would likely increase adolescents' access to needed preventive services at a very modest cost.
1999
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1001/archpedi.153.1.63" target="_blank" rel="noreferrer">10.1001/archpedi.153.1.63</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1999
Adolescent
Adolescent Health Services/economics
Adolescent Transitions
Archives Of Pediatrics & Adolescent Medicine
Backlog
Costs And Cost Analysis
Counseling
Feasibility Studies
Female
Hedberg VA
Humans
Journal Article
Male
Medical History Taking
Medical Informatics Applications
Paperny DM
Patient Satisfaction
Pilot Projects
Preventive Health Services/economics/methods
Risk-Taking
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1002/ajmg.1320570205" target="_blank" rel="noreferrer">http://doi.org/10.1002/ajmg.1320570205</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Neuronal ceroid-lipofuscinosis: A clinical and morphological study of 19 patients.
Publisher
An entity responsible for making the resource available
American Journal Of Medical Genetics
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
Subject
The topic of the resource
Child; Female; Humans; Male; Adult; Follow-Up Studies; Longitudinal Studies; Magnetic Resonance Imaging; Time Factors; adolescent; Preschool; infant; Tomography; Age of Onset; Atrophy; Brain/pathology/radiography; Cerebellum/pathology; Neuronal Ceroid-Lipofuscinoses/diagnosis/physiopathology; X-Ray Computed
Creator
An entity primarily responsible for making the resource
Nardocci N; Verga ML; Binelli S; Zorzi G; Angelini L; Bugiani O
Description
An account of the resource
We report on clinical, electrophysiological, neuroradiological, and morphological data from 19 patients with different types (late infantile, juvenile, and adult) of neuronal ceroid-lipofuscinosis (NCL), observed in the last 10 years at the Neurological Institute of Milan. Late Infantile NCL (LINCL) (8 patients, 4m/4f). Age at onset: 2-4 1/2 years. Seizures (6 patients) or decline of mental capacities (2 patients) were the presenting symptoms, followed by myoclonus and ataxia; visual loss and optic atrophy occurred in 6 patients within 3 years. All but 2 children became bedridden within 3 1/2 years. CT and MRI demonstrated different degrees of cerebral and cerebellar atrophy within 3 years from onset of the disease. Ultrastructural studies showed fingerprint profiles (FP) and osmiophilic bodies (OB) in circulating lymphocytes; curvilinear bodies (CB) and FP were detected in eccrine secretory cells. Juvenile NCL (JNCL) (7 patients, 4m/3f). Age at onset: 6-9 years. Visual loss with retinal degeneration was the presenting symptoms, accompanied in all but 2 patients by slight mental impairment. Seizures occurred within 2-4 years. CT and MRI detected cerebral or cerebellar atrophy in those patients (5 patients) with a clinical follow-up longer than 4 years. Electron microscopy showed FP on circulating lymphocytes, and both FP and CB on skin biopsy specimens. Adult NCL (ANCL) (4 patients, 3 m/1f). Age at onset: 12-50 years. Progressive myoclonus epilepsy (1 patient) or dementia with motor disturbances (3 patients) were the clinical phenotypes of the disease. MRI demonstrated cerebral and cerebellar atrophy within 6 years from onset. Electron microscopy disclosed FP in cytoplasmic vacuoles inside eccrine secretory cells.
1995
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/ajmg.1320570205" target="_blank" rel="noreferrer">10.1002/ajmg.1320570205</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1995
Adolescent
Adult
Age of Onset
American Journal Of Medical Genetics
Angelini L
Atrophy
Backlog
Binelli S
Brain/pathology/radiography
Bugiani O
Cerebellum/pathology
Child
Female
Follow-up Studies
Humans
Infant
Journal Article
Longitudinal Studies
Magnetic Resonance Imaging
Male
Nardocci N
Neuronal Ceroid-Lipofuscinoses/diagnosis/physiopathology
Preschool
Time Factors
Tomography
Verga ML
X-Ray Computed
Zorzi G
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1002/tera.1097" target="_blank" rel="noreferrer">http://doi.org/10.1002/tera.1097</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Improving estimates of caregiver time cost and family impact associated with birth defects
Publisher
An entity responsible for making the resource available
Teratology
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
Subject
The topic of the resource
Humans; Parents; Quality-Adjusted Life Years; Time Factors; Cost of Illness; Family Health; Caregivers/psychology; Models; Statistical; ICU Decision Making; social support; Abnormalities/epidemiology/psychology
Creator
An entity primarily responsible for making the resource
Tilford JM; Robbins JM; Hobbs CA
Description
An account of the resource
BACKGROUND: Birth defects impose substantial costs on both families and society because of medical, developmental, and special education needs. Caring for children with birth defects also may influence caregiver time and impact the family. However, the economic cost of caregiver time and other impacts on the family has received far less attention than traditional healthcare costs. METHODS: This study reviews the literature on measuring caregiver time costs and family impact in an economic framework. The economic framework involves translating caregiver time or difficulties into appropriate units such as cost or quality adjusted life years (QALYs). RESULTS: Despite the potential important contribution of caregiver time costs to the total cost estimate of birth defects, few studies estimate caregiver time costs related specifically to birth defects. Only two studies provide estimates of these costs. Recent work has investigated the impact of chronic illness on caregivers in QALY terms, but birth defects have not been studied. Several issues need to be addressed in both the estimation of caregiver time costs and family impact to improve cost estimates. CONCLUSIONS: Improved estimates of caregiver time costs and impact on the family will assist policy makers in allocating resources for the prevention and treatment of birth defects. Future research should investigate the economic costs of caregiver time and family impact associated with caring for children with birth defects.
2001
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/tera.1097" target="_blank" rel="noreferrer">10.1002/tera.1097</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2001
Abnormalities/epidemiology/psychology
Backlog
Caregivers/psychology
Cost Of Illness
Family Health
Hobbs CA
Humans
ICU Decision Making
Journal Article
Models
Parents
Quality-Adjusted Life Years
Robbins JM
Social Support
statistical
Teratology
Tilford JM
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1006/brbi.1994.1023" target="_blank" rel="noreferrer">http://doi.org/10.1006/brbi.1994.1023</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Intermittent but not continuous inescapable footshock stress affects immune responses and immunocyte beta-endorphin concentrations in the rat
Publisher
An entity responsible for making the resource available
Brain, Behavior, And Immunity
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
Subject
The topic of the resource
Male; Time Factors; Animals; Acute Disease; Rats; Comparative Study; Receptors; beta-Endorphin/analysis; Corticosterone/blood; Corticotropin-Releasing Hormone/antagonists & inhibitors; Corticotropin-Releasing Hormone/blood/pharmacology/physiology; Electroshock/adverse effects; Foot; Helplessness; Killer Cells; Learned; Lymphocyte Activation; Lymphoid Tissue/chemistry; Natural/immunology; Neuroimmunomodulation/physiology; Peptide Fragments/pharmacology; Spleen/immunology; Sprague-Dawley; Stress/etiology/immunology
Creator
An entity primarily responsible for making the resource
Sacerdote P; Manfredi B; Bianchi M; Panerai AE
Description
An account of the resource
It is well known that a variety of stressors influence immune responses. The opioid peptide-beta-endorphin (BE) is deeply involved in stress responses, is synthesized in cells of the immune system, and participates in the modulation of immune function. We analyzed the ability of two different stress paradigms to modulate the beta-endorphin concentrations in the immune cells and the immune response in the rat. Two and 24 h after the exposure to inescapable intermittent footshock (1.6 mA, 60 Hz, 1 s, every 5 s for 20 min) the concentrations of beta-endorphin in splenocytes, peripheral blood mononuclear cells and lymph node cells were significantly increased. In contrast, the exposure to a continuous footshock for 3 min did not affect the concentrations of the opioid peptide. Similarly, phytohemoagglutinin-induced proliferation of splenocytes and natural killer activity were significantly impaired only after the exposure to intermittent footshock stress. On the contrary, plasma corticosterone levels were similarly elevated after both paradigms of stress. The pretreatment with the corticotropin-releasing hormone (CRH) receptor antagonist prevented both the stress-induced increase of immunocyte BE and immunosuppression. In conclusion, our data suggest that intermittent and continuous footshock stressors activate different neuroendocrine responses and that CRH plays a central role in mediating the immune effects of the intermittent footshock stress. The possible relationship between the beta-endorphin changes and immunosuppression is discussed.
1994
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1006/brbi.1994.1023" target="_blank" rel="noreferrer">10.1006/brbi.1994.1023</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1994
Acute Disease
Animals
Backlog
beta-Endorphin/analysis
Bianchi M
Brain, Behavior, And Immunity
Comparative Study
Corticosterone/blood
Corticotropin-Releasing Hormone/antagonists & inhibitors
Corticotropin-Releasing Hormone/blood/pharmacology/physiology
Electroshock/adverse effects
Foot
Helplessness
Journal Article
Killer Cells
Learned
Lymphocyte Activation
Lymphoid Tissue/chemistry
Male
Manfredi B
Natural/immunology
Neuroimmunomodulation/physiology
Panerai AE
Peptide Fragments/pharmacology
Rats
Receptors
Sacerdote P
Spleen/immunology
Sprague-Dawley
Stress/etiology/immunology
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/0140-6736(91)93401-t" target="_blank" rel="noreferrer">http://doi.org/10.1016/0140-6736(91)93401-t</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Comparison of continuous subcutaneous and intravenous hydromorphone infusions for management of cancer pain
Publisher
An entity responsible for making the resource available
Lancet
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
Subject
The topic of the resource
Female; Humans; Male; Aged; Middle Aged; Severity of Illness Index; Time Factors; Double-Blind Method; Non-U.S. Gov't; Research Support; Comparative Study; Evaluation Studies; Palliative Care/methods; Infusion Pumps; Infusions; Intravenous; Hydromorphone/administration & dosage/adverse effects/blood/therapeutic use; Implantable; Neoplasms/blood/physiopathology; Pain/blood/drug therapy/etiology; Parenteral/methods
Creator
An entity primarily responsible for making the resource
Moulin DE; Kreeft JH; Murray-Parsons N; Bouquillon AI
Description
An account of the resource
To compare the safety and efficacy of subcutaneous and intravenous infusion of opioid analgesics, a randomised, double-blind, crossover trial was carried out in inpatients. 15 patients with severe cancer pain received two 48 h infusions of hydromorphone--one subcutaneously and one intravenously in randomly allocated order. The study was made double-blind by the use of two infusion pumps throughout; during the active subcutaneous infusion the intravenous pump delivered saline and vice versa. Serial measurements of pain intensity, pain relief, mood, and sedation by means of visual analogue scales showed no clinically or statistically significant difference between the two infusion routes. Side-effects were slight, and the mean number of morphine injections for breakthrough pain did not differ significantly between the routes (4.8 [SD 4.5] for intravenous vs 5.3 [5.6] for subcutaneous). Plasma hydromorphone concentrations measured at 24 h and 48 h of infusion showed stable steady-state pharmacokinetics; the mean bioavailability from subcutaneous infusion was 78% of that with intravenous infusion. Because of the simplicity, technical advantages, and cost-effectiveness of continuous subcutaneous opioid infusion into the chest wall or trunk, intravenous opioid infusion for the management of severe cancer pain should be abandoned.
1991
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0140-6736(91)93401-t" target="_blank" rel="noreferrer">10.1016/0140-6736(91)93401-t</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1991
Aged
Backlog
Bouquillon AI
Comparative Study
Double-Blind Method
Evaluation Studies
Female
Humans
Hydromorphone/administration & dosage/adverse effects/blood/therapeutic use
Implantable
Infusion Pumps
Infusions
Intravenous
Journal Article
Kreeft JH
Lancet
Male
Middle Aged
Moulin DE
Murray-Parsons N
Neoplasms/blood/physiopathology
Non-U.S. Gov't
Pain/blood/drug therapy/etiology
Palliative Care/methods
Parenteral/methods
Research Support
Severity Of Illness Index
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/0361-9230(93)90033-8" target="_blank" rel="noreferrer">http://doi.org/10.1016/0361-9230(93)90033-8</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Pituitary-adrenal function and hypothalamic beta-endorphin release in vitro following food deprivation
Publisher
An entity responsible for making the resource available
Brain Research Bulletin
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
Subject
The topic of the resource
Male; Time Factors; Animals; Rats; Non-U.S. Gov't; Research Support; Body Weight; Blood Glucose/metabolism; Corticosterone/blood; In Vitro; Pituitary-Adrenal System/physiology; Adrenal Glands/physiology; beta-Endorphin/secretion; Corticotropin-Releasing Hormone/pharmacology; Dexamethasone/pharmacology; Food Deprivation; Hypothalamus/drug effects/secretion; Organ Size; Thymus Gland/physiology; Wistar
Creator
An entity primarily responsible for making the resource
Mitev Y; Almeida OF; Patchev V
Description
An account of the resource
Basal and dexamethasone-suppressed adrenal glucocorticoid secretion and hypothalamic beta-endorphin (BE) release in vitro were investigated in rats deprived of food for 24, 48, 72, and 96 h. Fasting for up to 48 h neither caused significant changes in serum corticosterone levels nor in the suppressive effect of dexamethasone. Food deprivation for 72-96 h resulted in increased basal serum corticosterone, diminished suppression by dexamethasone, and a significant involution of the thymus. Basal in vitro BE release from hypothalamic explants was significantly increased after the first day of food deprivation, and in vitro perifusion with corticotropin-releasing hormone (CRH) failed to enhance BE release further. With continuing food deprivation, basal BE release remained significantly greater than that from hypothalami originating from normally fed control rats. The stimulatory effect of CRH on BE release was only partially restored after 2 days of fasting. The results suggest that food deprivation for more than 2 days increases basal glucocorticoid secretion, and signs of impairment in hypothalamic-pituitary-adrenal regulation become apparent. These findings might be implicated in the pathogenetic mechanisms of endocrine dysregulation in diseases related to caloric reduction.
1993
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0361-9230(93)90033-8" target="_blank" rel="noreferrer">10.1016/0361-9230(93)90033-8</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1993
Adrenal Glands/physiology
Almeida OF
Animals
Backlog
beta-Endorphin/secretion
Blood Glucose/metabolism
Body Weight
Brain Research Bulletin
Corticosterone/blood
Corticotropin-Releasing Hormone/pharmacology
Dexamethasone/pharmacology
Food Deprivation
Hypothalamus/drug effects/secretion
In Vitro
Journal Article
Male
Mitev Y
Non-U.S. Gov't
Organ Size
Patchev V
Pituitary-Adrenal System/physiology
Rats
Research Support
Thymus Gland/physiology
Time Factors
Wistar
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0031-3955(05)70226-1" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0031-3955(05)70226-1</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Pediatric acute pain management
Publisher
An entity responsible for making the resource available
Pediatric Clinics Of North America
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
Subject
The topic of the resource
Child; infant; Analgesics; Time Factors; Acute Disease; Nebulizers and Vaporizers; Anesthetics; Preschool; infant; Chronic disease; Newborn; Infusions; Intravenous; Human; Local/therapeutic use; Nerve Block/methods; Non-Narcotic/administration & dosage/therapeutic use; Opioid/administration & dosage/blood/therapeutic use; Pain/drug therapy/physiopathology
Creator
An entity primarily responsible for making the resource
Golianu B; Krane EJ; Galloway KS; Yaster M
Description
An account of the resource
The past decade has brought about an explosion of knowledge about the physiology of nociception and many new techniques for pain relief, new analgesic drugs, and new applications of old analgesic drugs. These techniques include methods of opioid administration by transdermal and transmucosal absorption and the use of neuraxial analgesia for the management of pain in children. Interest in the use of regional anesthesia in children has been rekindled, and analgesic properties and pre-emptive analgesic properties of many agents not typically considered analgesics, such as clonidine and ketamine, have been recognized. Perhaps the greatest advance has been the paradigm shift in the recognition that pain not only exists in infants and children but also is a significant cause of morbidity and even mortality. Given the unprecedented interest in pain management in adults and children, physicians can now look forward to the development of new methods of drug delivery and of receptor-specific drugs that divorce analgesia from the untoward side effects of existing analgesics. Improvement in the quality of life of hospitalized children also will occur.
2000
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0031-3955(05)70226-1" target="_blank" rel="noreferrer">10.1016/s0031-3955(05)70226-1</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2000
Acute Disease
Analgesics
Anesthetics
Backlog
Child
Chronic Disease
Galloway KS
Golianu B
Human
Infant
Infusions
Intravenous
Journal Article
Krane EJ
Local/therapeutic use
Nebulizers and Vaporizers
Nerve Block/methods
Newborn
Non-Narcotic/administration & dosage/therapeutic use
Opioid/administration & dosage/blood/therapeutic use
Pain/drug therapy/physiopathology
Pediatric Clinics of North America
Preschool
Time Factors
Yaster M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0749-0690(05)70016-1" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0749-0690(05)70016-1</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Physician-older patient communication at the end of life.
Publisher
An entity responsible for making the resource available
Clinics In Geriatric Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
Subject
The topic of the resource
Female; Humans; Male; Aged; Communication; Patient Participation; Truth Disclosure; Time Factors; Advance Directive Adherence; advance care planning; DNAR; Attitude to Death; Advance Directives; Physician-Patient Relations; Terminal Care/mt [Methods]; Empirical Research; Palliative Care/mt [Methods]
Creator
An entity primarily responsible for making the resource
Siegler EL; Levin BW
Description
An account of the resource
Communication with dying patients and their families requires special skills to assist them in this extremely stressful period. This article begins with a case that illustrates many of the challenges of communicating with the dying. It then reviews the literature about communication with older patients at the end of life, focusing on physician-patient discussions, decision-making, advance directives, and cultural factors. The article concludes with a practical discussion of problems that physicians may encounter when working with older patients at the end of life and their families and recommendations to improve communication.
2000
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0749-0690(05)70016-1" target="_blank" rel="noreferrer">10.1016/s0749-0690(05)70016-1</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2000
Advance Care Planning
Advance Directive Adherence
Advance Directives
Aged
Attitude To Death
Backlog
Clinics In Geriatric Medicine
Communication
DNAR
Empirical Research
Female
Humans
Journal Article
Levin BW
Male
Palliative Care/mt [methods]
Patient Participation
Physician-patient Relations
Siegler EL
Terminal Care/mt [methods]
Time Factors
Truth Disclosure
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0882-5963(97)80029-2" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0882-5963(97)80029-2</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The multiple meanings of long-term gastrostomy in children with severe disability
Publisher
An entity responsible for making the resource available
Journal Of Pediatric Nursing
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
Subject
The topic of the resource
Child; Humans; United States; Canada; Attitude to Health; Attitude of Health Personnel; Time Factors; Caregivers/psychology; Interviews; Mothers/psychology; Nutritional Failure; Gastrostomy/nursing/psychology; Nurses/psychology
Creator
An entity primarily responsible for making the resource
Thorne SE; Radford MJ; McCormick J
Description
An account of the resource
Although the physiological implications of long-term gastrostomy for children with severe disability are well documented in the nursing literature, little is known about the psychosocial effect of this technological intervention. This study documents and interprets the perspective of expert nurses and parents to reveal conflictual social processes associated with gastrostomy decision-making and the intense moral dilemma that these processes create. The findings suggest that gastrostomy denotes multiple meanings for parents and health care providers, and that an appreciation for these meanings can have a significant positive impact on nursing care for these children and their families.
1997
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0882-5963(97)80029-2" target="_blank" rel="noreferrer">10.1016/s0882-5963(97)80029-2</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1997
Attitude Of Health Personnel
Attitude To Health
Backlog
Canada
Caregivers/psychology
Child
Gastrostomy/nursing/psychology
Humans
Interviews
Journal Article
Journal of Pediatric Nursing
McCormick J
Mothers/psychology
Nurses/psychology
Nutritional Failure
Radford MJ
Thorne SE
Time Factors
United States
-
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
PedPalASCNet Member Publications
Subject
The topic of the resource
A collection of relevant articles published by one or more of PedPalASCNet's members
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1037/h0080386" target="_blank" rel="noreferrer">http://doi.org/10.1037/h0080386</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Perceptions of control and long-term recovery from rape
Publisher
An entity responsible for making the resource available
The American Journal Of Orthopsychiatry
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
Subject
The topic of the resource
Female; Humans; Adult; Middle Aged; Self Efficacy; Ontario; Multivariate Analysis; Time Factors; Internal-External Control; Regression Analysis; adolescent; Non-U.S. Gov't; Research Support; Adaptation; Psychological; retrospective studies; Stress Disorders; Survivors/psychology; Rape/psychology; Disease Susceptibility; Depression/etiology/physiopathology; Post-Traumatic/etiology/physiopathology; Recovery of Function
Creator
An entity primarily responsible for making the resource
Regehr C; Cadell S; Jansen K
Description
An account of the resource
The relationship between perceptions of control and symptoms of both long-term depression and post-traumatic stress was examined. Enduring beliefs of personal competence and control were found to be associated with lower rates of depression and stress and to be stronger predictors of long-term recovery than were rape-specific attributions. Implications for clinical practice are discussed.
1999
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1037/h0080386" target="_blank" rel="noreferrer">10.1037/h0080386</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1999
Adaptation
Adolescent
Adult
Backlog
Cadell S
Depression/etiology/physiopathology
Disease Susceptibility
Female
Humans
Internal-External Control
Jansen K
Journal Article
Middle Aged
Multivariate Analysis
Non-U.S. Gov't
Ontario
Post-Traumatic/etiology/physiopathology
Psychological
Rape/psychology
Recovery of Function
Regehr C
Regression Analysis
Research Support
Retrospective Studies
Self Efficacy
Stress Disorders
Survivors/psychology
The American Journal Of Orthopsychiatry
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1038/jcbfm.1994.17" target="_blank" rel="noreferrer">http://doi.org/10.1038/jcbfm.1994.17</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Brain metabolism during short-term starvation in humans
Publisher
An entity responsible for making the resource available
Journal Of Cerebral Blood Flow And Metabolism
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
Subject
The topic of the resource
Female; Humans; Male; Adult; Time Factors; Tissue Distribution; Non-U.S. Gov't; Research Support; Emission-Computed; Tomography; Brain/metabolism; Starvation/metabolism; Blood Glucose/analysis; Ketone Bodies/metabolism; Arteries; Deoxyglucose/analogs & derivatives/metabolism; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Glucose/metabolism; Osmolar Concentration
Creator
An entity primarily responsible for making the resource
Hasselbalch SG; Knudsen GM; Jakobsen J; Hageman LP; Holm S; Paulson OB
Description
An account of the resource
During prolonged starvation, brain energy requirements are covered in part by the metabolism of ketone bodies. It is unknown whether short-term starvation of a few days' duration may lead to reduced brain glucose metabolism due to the change toward ketone body consumption. In the present study we measured the cerebral metabolism of glucose and ketone bodies in nine healthy volunteers before and after 3.5 days of starvation. Regional glucose metabolism was measured by dynamic positron emission tomography using [18F]2-fluoro-2-deoxy-D-glucose. The mean value of K1* in gray and white matter increased by 12% (p < 0.05), whereas k2* and k3* were unchanged compared with control values. Regional glucose metabolism in cortical gray matter was reduced by 26% from 0.294 +/- 0.054 to 0.217 +/- 0.040 mumol g-1 min-1 (p < 0.001). White matter glucose metabolism decreased by 27% (p < 0.02). The decrease was uniform in gray and white matter with regional decreases ranging from 24 to 30%. A determination using Fick's principle confirmed the reduction in glucose metabolism yielding a decrease of 24% from 0.307 +/- 0.050 to 0.233 +/- 0.073 mumol g-1 min-1 (p < 0.05), whereas CBF did not change (0.57 +/- 0.07 vs. 0.57 +/- 0.06 ml g-1 min-1). The global net uptake of beta-hydroxybutyrate increased 13-fold from 0.012 +/- 0.024 to 0.155 +/- 0.140 mumol g-1 min-1 (p < 0.05). Net uptake of acetoacetate and net efflux of lactate and pyruvate did not change significantly during starvation. The present study shows that the human brain adapts to the changes in energy supply as early as 3 days following initiation of starvation, at which time ketone bodies account for approximately one-fourth of the cerebral energy requirements.
1994
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/jcbfm.1994.17" target="_blank" rel="noreferrer">10.1038/jcbfm.1994.17</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1994
Adult
Arteries
Backlog
Blood Glucose/analysis
Brain/metabolism
Deoxyglucose/analogs & derivatives/metabolism
Emission-Computed
Female
Fluorine Radioisotopes
Fluorodeoxyglucose F18
Glucose/metabolism
Hageman LP
Hasselbalch SG
Holm S
Humans
Jakobsen J
Journal Article
Journal Of Cerebral Blood Flow And Metabolism
Ketone Bodies/metabolism
Knudsen GM
Male
Non-U.S. Gov't
Osmolar Concentration
Paulson OB
Research Support
Starvation/metabolism
Time Factors
Tissue Distribution
Tomography
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1054/clnu.2000.0157" target="_blank" rel="noreferrer">http://doi.org/10.1054/clnu.2000.0157</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Hunger disease
Publisher
An entity responsible for making the resource available
Clinical Nutrition (edinburgh, Scotland)
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
Subject
The topic of the resource
Humans; Nutritional Support; Health Status; Time Factors; Adaptation; Energy Metabolism; Body Composition; Physiological; Starvation/metabolism; Adipose Tissue/metabolism; Appetite/physiology; Eating/physiology; Hunger/physiology; Nutrition Disorders/metabolism; Obesity/metabolism/physiopathology; Weight Loss/physiology
Creator
An entity primarily responsible for making the resource
Elia M
Description
An account of the resource
This paper examines three aspects of hunger disease: the effect of initial fat stores on macronutrient fuel selection during total starvation (no energy) and how it influences survival; the effects of different rates of weight loss on tissue and body function; and the importance of appetite sensations, including hunger, during malnutrition and during enteral and parenteral nutritional support. Long-term starvation studies in humans reveal major differences in fat carbohydrate and protein metabolism between lean and obese subjects, including a 2-4-fold lower contribution of protein oxidation to energy expenditure in obese subjects, which ensures that more of the excess body fat is oxidized. The rate of weight loss, determined by recent dietary intake, can have major effects on tissue and body function, including wound healing, the acute phase protein response, muscle fatigue and psychological/behavioural function in both clinical and non-clinical settings. In depleted states uncomplicated by disease, changes in appetite sensations can result in energy intakes as high as 6000 to 10,000 kcal/day ( 25-42 MJ/day). Long-term enteral tube feeding and parenteral nutrition are associated with frequent disturbances in appetite sensations, and in those able to eat normally they tend to add rather than replace oral intake to an extent that appears to depend on the regimen. It is concluded that 1) differences between lean and obese subjects in macronutrient fuel selection during starvation are adaptive because they optimize survival in both groups of subjects; 2) the rate of weight loss in health and disease has a major effect on certain tissue and body functions, independently of the magnitude of weight loss; and 3) clinically relevant disturbances in appetite sensations are common subjects receiving long-term enteral and parenteral nutrition. The clinical modulation of all these variables would be aided by greater knowledge of the mechanisms involved.
2000
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1054/clnu.2000.0157" target="_blank" rel="noreferrer">10.1054/clnu.2000.0157</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2000
Adaptation
Adipose Tissue/metabolism
Appetite/physiology
Backlog
Body Composition
Clinical Nutrition (edinburgh, Scotland)
Eating/physiology
Elia M
Energy Metabolism
Health Status
Humans
Hunger/physiology
Journal Article
Nutrition Disorders/metabolism
Nutritional Support
Obesity/metabolism/physiopathology
Physiological
Starvation/metabolism
Time Factors
Weight Loss/physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1055/s-2001-12195" target="_blank" rel="noreferrer">http://doi.org/10.1055/s-2001-12195</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Hormonal response to surgical stress in schoolchildren
Publisher
An entity responsible for making the resource available
European Journal Of Pediatric Surgery
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
Subject
The topic of the resource
Child; Humans; Prospective Studies; Time Factors; adolescent; beta-Endorphin/blood; Biomarkers of Pain; Biomarkers Reference List; Adrenocorticotropic Hormone/blood; Hydrocortisone/blood; Stress/blood
Creator
An entity primarily responsible for making the resource
Castejon-Casado J; Moreno-Prieto M; Valladares-Mendias JC; Alaminos-Mingorance M; Lopez-Candel E; Ramirez-Navarro A
Description
An account of the resource
PURPOSE: To determine hormone concentrations (ACTH, cortisol, beta-endorphin) in children before and after surgery, to assess the correlation between any hormonal changes and to study the influence exercised on them by the severity of surgical stress and the elective/emergency nature of the surgery. PATIENTS AND METHODS: Prospective cohort of 78 children (age= 10+/-2.6 years, range 6-13 years) undergoing elective or emergency surgery. Preoperative and postoperative (1 and 24 hours postoperation) plasma concentrations of ACTH, cortisol and beta-endorphin were determined in all children. The severity of surgical stress was evaluated as low ( 6) according to the Oxford scale. Student's t-test was used to analyse hormonal changes and the influence of degree of surgical stress and elective/emergency character of the surgery, and Pearson's coefficient for correlations between hormonal values. p < 0.05 was regarded as significant. RESULTS: We observed a significant increase in hormonal concentrations one hour after surgery. ACTH and cortisol values normalised 24 hours after surgery, but beta-endorphin concentrations remained increased. There was a correlation between ACTH and beta-endorphin values both before surgery and one hour after. Operations with high surgical stress significantly increased cortisol concentrations one hour after surgery and beta-endorphin concentrations 24 hours after surgery. Patients selected for emergency surgery showed significantly higher concentrations of cortisol and ACTH both before and after surgery. CONCLUSIONS: Postoperative hormonal response among children of school age is characterised by increases in ACTH, cortisol and beta-endorphin one hour after surgery, and by high concentrations of beta-endorphin 24 hours after surgery. Cortisol is an index of surgical stress. Emergency surgery is associated with significant increases in ACTH and cortisol.
2001
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1055/s-2001-12195" target="_blank" rel="noreferrer">10.1055/s-2001-12195</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2001
Adolescent
Adrenocorticotropic Hormone/blood
Alaminos-Mingorance M
Backlog
beta-Endorphin/blood
Biomarkers of Pain
Biomarkers Reference List
Castejon-Casado J
Child
European Journal Of Pediatric Surgery
Humans
Hydrocortisone/blood
Journal Article
Lopez-Candel E
Moreno-Prieto M
Prospective Studies
Ramirez-Navarro A
Stress/blood
Time Factors
Valladares-Mendias JC