T-lymphocyte cholecystokinin-8 and beta-endorphin concentrations in eating disorders: I. Anorexia nervosa
Child; Female; Humans; Adult; Treatment Outcome; Combined Modality Therapy; adolescent; Comparative Study; beta-Endorphin/blood; Cognitive Therapy; Anorexia Nervosa/blood/therapy; Antidepressive Agents/administration & dosage; Dibenzocycloheptenes/administration & dosage; Fluoxetine/administration & dosage; Nortriptyline/administration & dosage; Sincalide/blood; T-Lymphocytes/drug effects/metabolism
Baseline concentrations of cholecystokinin-8 (CCK-8) and beta-endorphin (beta-EP) were measured in T-lymphocytes from 33 restricting patients with anorexia nervosa (AN-R), 23 binging/purging patients with anorexia nervosa (AN-BP), and 24 healthy volunteers. CCK-8 basal values were significantly lower and beta-EP values significantly higher in AN-R and AN-BP patients than in normal volunteers. Levels of the peptides were measured three more times during a 4-month combined cognitive-behavioral/psychopharmacological treatment (nortriptyline or fluoxetine in AN-R, fluoxetine or amineptine in AN-BP). CCK-8 values fluctuated (nonsignificantly) during each treatment, while beta-EP values decreased (to a significant degree only in fluoxetine-treated AN-R patients).
1995
Brambilla F; Brunetta M; Peirone A; Perna G; Sacerdote P; Manfredi B; Panerai AE
Psychiatry Research
1995
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1016/0165-1781(95)02664-9" target="_blank" rel="noreferrer">10.1016/0165-1781(95)02664-9</a>
T-lymphocyte concentrations of cholecystokinin-8 and beta-endorphin in eating disorders: II. Bulimia nervosa
Female; Humans; Adult; Middle Aged; Treatment Outcome; Antidepressive Agents; Combined Modality Therapy; adolescent; Comparative Study; beta-Endorphin/blood; Cognitive Therapy; Dibenzocycloheptenes/administration & dosage; Sincalide/blood; T-Lymphocytes/drug effects/metabolism; Bulimia/blood/therapy; Fluvoxamine/administration & dosage; Serotonin Uptake Inhibitors/administration & dosage; Tricyclic/administration & dosage
Concentrations of cholecystokinin-8 (CCK-8) and beta-endorphin (beta-EP) in T-lymphocytes of 26 women with bulimia nervosa (BN) and in 26 age- and sex-matched healthy comparison subjects were measured. Ten patients were then treated with 300 mg/day of fluvoxamine, p.o., and five patients were treated with 300 mg/day of amineptine, p.o., for 4 months. Concentrations of the two peptides were measured again after 1, 2, and 4 months of therapy. Basal CCK-8 values were significantly lower in patients than in healthy subjects. During fluvoxamine therapy, CCK-8 values increased, reaching normal levels by month 4 of treatment. No such increase occurred during amineptine therapy. Baseline beta-EP values were normal in the bulimic patients but had declined by month 4 of fluvoxamine therapy.
1995
Brambilla F; Brunetta M; Draisci A; Peirone A; Perna G; Sacerdote P; Manfredi B; Panerai AE
Psychiatry Research
1995
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1016/0165-1781(95)02674-6" target="_blank" rel="noreferrer">10.1016/0165-1781(95)02674-6</a>