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Text
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<a href="http://doi.org/10.1001/archpedi.157.11.1071" target="_blank" rel="noreferrer">http://doi.org/10.1001/archpedi.157.11.1071</a>
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Title
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Beta-endorphin concentration after administration of sucrose in preterm infants
Publisher
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Archives Of Pediatrics & Adolescent Medicine
Date
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2003
Subject
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Female; Humans; infant; Male; Pain Measurement; Prospective Studies; Intensive Care; Administration; beta-Endorphin/blood; Biomarkers of Pain; Newborn; Oral; Pain/drug therapy/etiology; Premature; Sucrose/administration & dosage
Creator
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Taddio A; Shah V; Shah P; Katz J
Description
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BACKGROUND: Sucrose is an effective analgesic for procedural pain in preterm infants. It has been hypothesized that its analgesic effects are mediated by the release of endogenous opioid neurotransmitters such as beta-endorphin. OBJECTIVE: To determine whether intraoral administration of sucrose was associated with an increase in serum beta-endorphin concentrations in preterm infants with a gestation period less than 29 weeks who were not exposed to a painful stimulus. METHODS: We performed a prospective open-label study in preterm infants admitted to 2 tertiary neonatal intensive care units. Each infant received a single dose of 30% sucrose intraorally during a 1- to 2-minute period. A blood sample was obtained using an indwelling arterial catheter to determine beta-endorphin concentration immediately before and 2 to 5 minutes after the commencement of sucrose administration. RESULTS: We enrolled 11 preterm infants with a mean +/- SD gestational age of 27.2 +/- 0.9 weeks and a mean +/- SD birth weight of 1018 +/- 238 g (1.02 +/- 0.24 kg) at a mean +/- SD postnatal age of 3.0 +/- 2.5 days. The mean +/- SD beta-endorphin concentration before and after sucrose administration was 60.4 +/- 30.5 pg/mL and 57.4 +/- 22.4 pg/mL, respectively (P =.45). No adverse events were observed during the study procedures. CONCLUSION: Intraoral administration of sucrose in preterm infants did not lead to an increase in serum beta-endorphin concentrations at a point in time when the analgesic effects of sucrose were presumed to be present.
2003
Identifier
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<a href="http://doi.org/10.1001/archpedi.157.11.1071" target="_blank" rel="noreferrer">10.1001/archpedi.157.11.1071</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
2003
Administration
Archives Of Pediatrics & Adolescent Medicine
Backlog
beta-Endorphin/blood
Biomarkers of Pain
Female
Humans
Infant
Intensive Care
Journal Article
Katz J
Male
Newborn
Oral
Pain Measurement
Pain/drug therapy/etiology
Premature
Prospective Studies
Shah P
Shah V
Sucrose/administration & dosage
Taddio A