1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.7326/0003-4819-117-11-916" target="_blank" rel="noreferrer">http://doi.org/10.7326/0003-4819-117-11-916</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Measured enthusiasm: does the method of reporting trial results alter perceptions of therapeutic effectiveness? Publisher An entity responsible for making the resource available Annals Of Internal Medicine Date A point or period of time associated with an event in the lifecycle of the resource 1992 Subject The topic of the resource Humans; Male; Adult; Attitude of Health Personnel; Questionnaires; Middle Aged; Treatment Outcome; Ontario; Outcome Assessment (Health Care); Hospitals; Risk; Teaching; Non-U.S. Gov't; Research Support; Statistical; Data Interpretation; Clinical Trials; Gemfibrozil/therapeutic use; Hyperlipidemia/complications/drug therapy/mortality; Myocardial Infarction/etiology/mortality/prevention & control Creator An entity primarily responsible for making the resource Naylor CD; Chen E; Strauss B Description An account of the resource OBJECTIVE: To compare clinicians' ratings of therapeutic effectiveness when different trial end points were presented as percent reductions in relative compared with absolute risk and as numbers of patients treated to avoid one adverse outcome. DESIGN: Survey, with random allocation of two questionnaires. SETTING: Toronto teaching hospitals. RESPONDENTS: Convenience sample of 100 faculty and housestaff in internal medicine and family medicine. INTERVENTION: One questionnaire presented results for three end points of the Helsinki Heart Study as separate drug trials using only absolute differences in events; the other showed the same end points as relative differences. Both questionnaires included a fourth "trial," showing person-years of treatment needed to prevent one myocardial infarction. MAIN OUTCOME MEASURE: The "trials" were each rated on an 11-point scale, from treatment "harmful" to "very effective." RESULTS: Respondents' ratings of effectiveness varied with the end point. Controlling for end point, ratings of effectiveness by the 50 participants receiving absolute event data were lower than those by 50 participants responding to relative risk reductions (P < 0.001); however, no end-point difference was more than 0.6 scale points. For a "trial" reporting that 77 persons were treated for 5 years to prevent one myocardial infarction, mean ratings were 2.3 or 1.8 scale points lower, respectively (both P < 0.001), than when the same data were shown as relative or absolute risk reductions. CONCLUSIONS: Clinicians' views of drug therapies are affected by the common use of relative risk reductions in both trial reports and advertisements, by end-point emphasis, and, above all, by underuse of summary measures that relate treatment burden to therapeutic yields in a clinically relevant manner. 1992 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.7326/0003-4819-117-11-916" target="_blank" rel="noreferrer">10.7326/0003-4819-117-11-916</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 1992 Adult Annals Of Internal Medicine Attitude Of Health Personnel Backlog Chen E Clinical Trials Data Interpretation Gemfibrozil/therapeutic use Hospitals Humans Hyperlipidemia/complications/drug therapy/mortality Journal Article Male Middle Aged Myocardial Infarction/etiology/mortality/prevention & control Naylor CD Non-U.S. Gov't Ontario Outcome Assessment (health Care) Questionnaires Research Support Risk statistical Strauss B Teaching Treatment Outcome