1 40 1 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource 2020 Oncology List Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Oncology 2020 List URL Address <a href="http://doi.org/10.1136/bmjopen-2020-037251" target="_blank" rel="noreferrer noopener">http://doi.org/​10.1136/bmjopen-2020-037251</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Pain Squad+ smartphone app to support real-time pain treatment for adolescents with cancer: protocol for a randomised controlled trial Publisher An entity responsible for making the resource available BMJ Open Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource pediatrics; supportive care; pain; cancer; protocol; randomised controlled trial; smartphone app; symptom treatment Creator An entity primarily responsible for making the resource Jibb L; Nathan P C; Breakey V; Fernandez C; Johnston D; Lewis V; McKillop S; Patel S; Sabapathy C; Strahlendorf C; Victor J C; Moretti M E; Nguyen C; Hundert A; Cassiani C; El-Khechen R G; Insull H; Hamilton R; Fang G; Kuczynski S; Stinson J Description An account of the resource INTRODUCTION: Pain negatively affects the health-related quality of life (HRQL) of adolescents with cancer. The Pain Squad+ smartphone-based application (app), has been developed to provide adolescents with real-time pain self-management support. The app uses a validated pain assessment and personalised pain treatment advice with centralised decision support via a registered nurse to enable real-time pain treatment in all settings. The algorithm informing pain treatment advice is evidence-based and expert-vetted. This trial will longitudinally evaluate the impact of Pain Squad+, with or without the addition of nurse support, on adolescent health and cost outcomes. METHODS AND ANALYSIS: This will be a pragmatic, multicentre, waitlist controlled, 3-arm parallel-group superiority randomised trial with 1:1:1 allocation enrolling 74 adolescents with cancer per arm from nine cancer centres. Participants will be 12 to 18 years, English-speaking and with >/=3/10 pain. Exclusion criteria are significant comorbidities, end-of-life status or enrolment in a concurrent pain study. The primary aim is to determine the effect of Pain Squad+, with and without nurse support, on pain intensity in adolescents with cancer, when compared with a waitlist control group. The secondary aims are to determine the immediate and sustained effect over time of using Pain Squad+, with and without nurse support, as per prospective outcome measurements of pain interference, HRQL, pain self-efficacy and cost. Linear mixed models with baseline scores as a covariate will be used. Qualitative interviews with adolescents from all trial arms will be conducted and analysed. ETHICS AND DISSEMINATION: This trial is approved by the Hospital for Sick Children Research Ethics Board. Results will provide data to guide adolescents with cancer and healthcare teams in treating pain. Dissemination will occur through partnerships with stakeholder groups, scientific meetings, publications, mass media releases and consumer detailing. TRIAL REGISTRATION NUMBER: NCT03632343 (ClinicalTrials.gov). Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1136/bmjopen-2020-037251" target="_blank" rel="noreferrer noopener">10.1136/bmjopen-2020-037251</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). 2020 Bmj Open Breakey V Cancer Cassiani C El-Khechen R G Fang G Fernandez C Hamilton R Hundert A Insull H Jibb L Johnston D Kuczynski S Lewis V McKillop S Moretti M E Nathan P C Nguyen C Oncology 2020 List Pain Patel S Pediatrics protocol randomised controlled trial Sabapathy C smartphone app Stinson J Strahlendorf C Supportive Care symptom treatment Victor J C