1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1093/bja/aeh222" target="_blank" rel="noreferrer">http://doi.org/10.1093/bja/aeh222</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Increased numbers of opioid expressing inflammatory cells do not affect intra-articular morphine analgesia Publisher An entity responsible for making the resource available British Journal Of Anaesthesia Date A point or period of time associated with an event in the lifecycle of the resource 2004 Subject The topic of the resource Female; Humans; Male; Adult; Analgesics; Aged; Middle Aged; Drug Therapy; Double-Blind Method; Biomarkers of Pain; Injections; Dose-Response Relationship; Drug; Opioid/administration & dosage; Receptors; Arthroscopy; Intra-Articular; Morphine/administration & dosage; Pain Measurement/methods; Combination; Knee Joint/metabolism/surgery; Opioid/metabolism; Pirinitramide/administration & dosage; Synovitis/metabolism/pathology Creator An entity primarily responsible for making the resource Likar R; Mousa SA; Philippitsch G; Steinkellner H; Koppert W; Stein C; Schafer M Description An account of the resource BACKGROUND: Both locally expressed beta-endorphin (END) and low doses of morphine relieve pain within inflamed knee joints. Here we examined whether enhanced inflammation and END expression within the synovial tissue of patients undergoing arthroscopic knee surgery might shift the analgesic dose-response curve of intra-articular (i.a.) morphine. METHODS: Following IRB approval and informed consent, patients were randomly assigned to the following i.a. treatments at the end of surgery: group I (n=39), isotonic saline; group II (n=40), 1 mg morphine hydrochloride; group III (n=48), 2 mg morphine hydrochloride; group IV (n=39), 4 mg morphine hydrochloride. Postoperative pain intensity was assessed by the visual analogue scale (VAS), by the time to first analgesic request and by the supplemental piritramide consumption. Synovial specimens from each patient were stained for the presence of inflammatory cells and END and were discriminated into groups with low versus high numbers of these cells. Differences between groups were statistically analyzed by chi(2), anova and mancova where appropiate. RESULTS: Patient characteristics and VAS scores did not differ between groups. Total postoperative piritramide consumption decreased and the time to first analgesic request increased significantly with increasing doses of i.a. morphine (P0.05, mancova). CONCLUSIONS: The dose-response relationship of i.a. morphine analgesia is not shifted by enhanced inflammation and END expression within synovial tissue. Thus, the presence of END within inflamed synovial tissue does not seem to interfere with i.a. morphine analgesia. 2004 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1093/bja/aeh222" target="_blank" rel="noreferrer">10.1093/bja/aeh222</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2004 Adult Aged Analgesics Arthroscopy Backlog Biomarkers of Pain British Journal Of Anaesthesia Combination Dose-Response Relationship Double-Blind Method Drug Drug Therapy Female Humans Injections Intra-Articular Journal Article Knee Joint/metabolism/surgery Koppert W Likar R Male Middle Aged Morphine/administration & dosage Mousa SA Opioid/administration & dosage Opioid/metabolism Pain Measurement/methods Philippitsch G Pirinitramide/administration & dosage Receptors Schafer M Stein C Steinkellner H Synovitis/metabolism/pathology