Browse Items (27 total)
- Tags: Stein C
Attacking pain at its source: new perspectives on opioids
Tags: 2003, Afferent/metabolism, Analgesics, Animals, Backlog, Cell Movement, Drug Tolerance, Humans, Journal Article, Ligands, Machelska H, Nature Medicine, Neurons, Non-U.S. Gov't, Opioid Peptides/metabolism/therapeutic use, Opioid/genetics/metabolism, Opioid/metabolism/therapeutic use, Pain/drug therapy/metabolism/therapy, Receptors, Research Support, Schafer M, Signal Transduction/physiology, Stein C
Beta-endorphin, Met-enkephalin and corresponding opioid receptors within synovium of patients with joint trauma, osteoarthritis and rheumatoid arthritis
Tags: 2007, 80 And Over, Adult, Aged, Annals Of The Rheumatic Diseases, Arthritis, Arthritis/immunology/metabolism, Backlog, beta-Endorphin/analysis, Biological Markers/analysis, Biomarkers of Pain, delta/analysis, Enkephalin, Female, Humans, Immunohistochemistry/methods, Joints/immunology/injuries, Journal Article, Leukocytes/immunology, Male, Methionine/analysis, Middle Aged, Mousa SA, mu/analysis, Opioid, Opioid/analysis, Osteoarthritis/immunology/metabolism, Receptors, Rheumatoid/immunology/metabolism, Schafer M, Stein C, Straub RH, Synovial Membrane/chemistry/immunology
Control of inflammatory pain by chemokine-mediated recruitment of opioid-containing polymorphonuclear cells
Tags: 2004, Analysis of Variance, Animals, Antibodies/pharmacology, Backlog, Brack A, Cell Count/methods, Cell Movement/physiology, Chemokines, Chemokines/immunology/physiology, Comparative Study, Corticotropin-Releasing Hormone/therapeutic use, CXC/immunology/metabolism, Dose-Response Relationship, Drug, Drug Administration Routes, Enzyme-Linked Immunosorbent Assay/methods, Flow Cytometry/methods, Freund's Adjuvant, Gene Expression Regulation/physiology, Immunohistochemistry/methods, Intercellular Signaling Peptides and Proteins/immunology/metabolism, Interleukin-8B/metabolism, Journal Article, Leder K, Machelska H, Male, Mousa SA, Naloxone/pharmacology, Narcotics/metabolism, Neurogenic Inflammation/chemically induced/complications/therapy, Neutrophils/metabolism, Non-U.S. Gov't, Pain, Pain Measurement, Pain Threshold/drug effects, Pain/etiology/therapy, Rats, Receptors, Research Support, Rittner HL, Schafer M, Stein C, Wistar
Different mechanisms of intrinsic pain inhibition in early and late inflammation
Tags: 2003, Animals, Backlog, Biomarkers of Pain, Corticotropin-Releasing Hormone/administration & dosage, Dynorphins/antagonists & inhibitors/biosynthesis/physiology, Edema/immunology/metabolism/physiopathology, Endorphins/antagonists & inhibitors/biosynthesis/physiology, Enkephalin, Freund's Adjuvant/administration & dosage, Hindlimb, Inflammation/immunology/metabolism/physiopathology, Injections, Journal Article, Journal Of Neuroimmunology, Labuz D, Leukocytes/drug effects/metabolism/physiology, Machelska H, Male, Methionine/antagonists & inhibitors/biosynthesis/physiology, Mousa SA, Naloxone/administration & dosage, Pain Threshold, Pain/immunology/pathology/prevention & control, Rats, Schafer M, Schopohl JK, Stein C, Stress/immunology/metabolism/physiopathology, Subcutaneous, Time Factors, Wistar
Gene expression and localization of opioid peptides in immune cells of inflamed tissue: functional role in antinociception
Tags: 1992, Analysis of Variance, Animals, Backlog, beta-Endorphin/genetics/metabolism, Biomarkers of Pain, Biomarkers Reference List, Calcitonin Gene-Related Peptide/analysis/metabolism, Endorphins/analysis/genetics/metabolism, Epplen C, Freund's Adjuvant, Gene Expression/radiation effects, Hassan AH, Herz A, Hindlimb, Inbred Strains, Inflammation/immunology/physiopathology, Journal Article, Lason W, Male, Messenger/genetics/metabolism, Nerve Fibers/physiology/ultrastructure, Neuroscience, Non-U.S. Gov't, Nucleic Acid Hybridization, Oligonucleotide Probes, Pain Measurement, Pain/immunology/physiopathology, Przewlocki R, Rats, Research Support, RNA, Stein C, T-Lymphocytes/immunology/pathology, Whole-Body Irradiation
Immune cell-derived beta-endorphin. Production, release, and control of inflammatory pain in rats
Tags: 1997, Analysis of Variance, Animals, Backlog, beta-Endorphin/biosynthesis, Biomarkers of Pain, Biomarkers Reference List, Cabot PJ, Carter L, Corticotropin-Releasing Hormone/pharmacology, Freund's Adjuvant, Gaiddon C, Genetic, Hindlimb, Humans, Inflammation/physiopathology, Interleukin-1/pharmacology, Journal Article, Loeffler JP, Lymph Nodes/metabolism, Male, Messenger/biosynthesis, Pain/immunology/physiopathology, Pro-Opiomelanocortin/biosynthesis, Rats, Regression Analysis, RNA, Schafer M, Stein C, T-Lymphocytes/drug effects/immunology/metabolism, The Journal Of Clinical Investigation, Time Factors, transcription, Wistar, Zhang Q
Immune mechanisms in pain control
Tags: 2002, Analgesics, Anesthesia & Analgesia, Animals, Backlog, Cellular/physiology, Endorphins/metabolism, Humans, Immune System/physiology, Immunity, Journal Article, Machelska H, Non-U.S. Gov't, Opioid/pharmacology, Opioid/physiology, Pain/drug therapy/immunology/pathology, Receptors, Research Support, Stein C
Immunohistochemical localization of endomorphin-1 and endomorphin-2 in immune cells and spinal cord in a model of inflammatory pain
Tags: 2002, Animals, Backlog, Biomarkers of Pain, Freund's Adjuvant, Hindlimb, Immunohistochemistry, Journal Article, Journal Of Neuroimmunology, Lymph Nodes/cytology, Lymphocytes/chemistry, Machelska H, Macrophages/chemistry, Male, Monocytes/chemistry, Mousa SA, Oligopeptides/analysis, Pain/chemically induced/immunology, Posterior Horn Cells/chemistry, Rats, Schafer M, Skin/chemistry/immunology/innervation, Stein C, Wistar
Increased numbers of opioid expressing inflammatory cells do not affect intra-articular morphine analgesia
Tags: 2004, Adult, Aged, Analgesics, Arthroscopy, Backlog, Biomarkers of Pain, British Journal Of Anaesthesia, Combination, Dose-Response Relationship, Double-Blind Method, Drug, Drug Therapy, Female, Humans, Injections, Intra-Articular, Journal Article, Knee Joint/metabolism/surgery, Koppert W, Likar R, Male, Middle Aged, Morphine/administration & dosage, Mousa SA, Opioid/administration & dosage, Opioid/metabolism, Pain Measurement/methods, Philippitsch G, Pirinitramide/administration & dosage, Receptors, Schafer M, Stein C, Steinkellner H, Synovitis/metabolism/pathology
Influence of pain treatment by epidural fentanyl and bupivacaine on homing of opioid-containing leukocytes to surgical wounds
Tags: 2007, Adjuvants, Aged, Analgesia, Analgesics, Anesthesia, Anesthesia/immunology/pharmacology, Anesthetics, Backlog, beta-Endorphin/drug effects/immunology/metabolism, Biomarkers of Pain, Brain, Behavior, And Immunity, Bupivacaine/immunology/therapeutic use, Cell Movement/drug effects/immunology, Enkephalin, Epidural, Female, Fentanyl/immunology/therapeutic use, Heurich M, Humans, Journal Article, Kopf A, Lenzner M, Leukocytes/drug effects/immunology/metabolism, Local/immunology/therapeutic use, Longitudinal Studies, Male, Methionine/drug effects/immunology/metabolism, Middle Aged, Morciniec P, Mousa SA, Nociceptors/drug effects/immunology, Opioid/immunology/therapeutic use, Pain, Patient-Controlled, Pirinitramide/therapeutic use, Postganglionic/drug effects/immunology, Postoperative/immunology/prevention & control, Stein C, Subcutaneous Tissue/immunology, Sympathetic Fibers, Welte M, Wound Healing/drug effects/immunology
Interleukin 1 beta and corticotropin-releasing factor inhibit pain by releasing opioids from immune cells in inflamed tissue
Tags: 1994, Analysis of Variance, Animals, Antibodies/pharmacology, Backlog, beta-Endorphin/immunology/physiology, Biomarkers of Pain, Carter L, Corticotropin-Releasing Hormone/administration & dosage/pharmacology/therapeutic use, Cyclosporine/pharmacology, Dose-Response Relationship, Drug, Dynorphins/immunology/physiology, Endorphins/immunology/physiology/secretion, Enkephalin, Humans, Inflammation/immunology/physiopathology, Injections, Interleukin-1/administration & dosage/pharmacology/therapeutic use, Journal Article, Leucine/analogs & derivatives/pharmacology, Male, Methionine/immunology/physiology, Naloxone/pharmacology, Pain/immunology/physiopathology/prevention & control, Proceedings Of The National Academy Of Sciences Of The United States Of America, Rats, Recombinant Proteins/pharmacology/therapeutic use, Regression Analysis, Schafer M, Somatostatin/analogs & derivatives/pharmacology, Stein C, Wistar
Involvement of cytokines, chemokines and adhesion molecules in opioid analgesia
Leukocytes in the regulation of pain and analgesia
Tags: 2005, Analgesia, Animals, Backlog, Biomarkers of Pain, Biomarkers Reference List, Humans, Inflammation Mediators/immunology, Journal Article, Journal Of Leukocyte Biology, Leukocytes/immunology/secretion, Machelska H, Nervous System/immunology/physiopathology, Neuropeptides/immunology/pharmacology, Opioid Peptides/immunology/secretion, Opioid/immunology, Pain/immunology/physiopathology, Receptors, Rittner HL, Sensory/immunology/physiopathology, Signal Transduction/immunology, Stein C
Local analgesic effect of endogenous opioid peptides
Tags: 1993, Adult, Aged, Arthroscopy, Backlog, beta-Endorphin/analysis/physiology, Biomarkers of Pain, Double-Blind Method, Dynorphins/analysis/physiology, Endorphins/analysis/physiology, Enkephalin, Giefing J, Hassan AH, Humans, Immunohistochemistry, Injections, Intra-Articular, Intravenous, Journal Article, Knee Joint/surgery, Lancet, Lehrberger K, Methionine/analysis/physiology, Middle Aged, Naloxone/administration & dosage/pharmacology, Opioid/drug effects, Pain, Postoperative/etiology, Receptors, Stein C, Synovial Membrane/chemistry, Synovitis/metabolism, Yassouridis A
Lymphocytes upregulate signal sequence-encoding proopiomelanocortin mRNA and beta-endorphin during painful inflammation in vivo
Tags: 2007, Animals, Backlog, beta-Endorphin/metabolism, Biomarkers of Pain, Busch M, Flow Cytometry/methods, Freund's Adjuvant, Gene Expression Regulation/drug effects/physiology, Gore C, Inflammation/chemically induced/complications/pathology, Journal Article, Journal Of Neuroimmunology, Krause H, Labuz D, Lymphocytes/metabolism, Male, Messenger/metabolism, Mousa SA, Pain/etiology/pathology, Pro-Opiomelanocortin/genetics/metabolism, Protein Sorting Signals, Rats, Reverse Transcriptase Polymerase Chain Reaction/methods, Rittner H, RNA, Schafer M, Sitte N, Stein C, Time Factors, Wistar
Methionine-enkephalin-and Dynorphin A-release from immune cells and control of inflammatory pain
Tags: 2001, Animals, Antibodies/pharmacology, Backlog, Biomarkers of Pain, Biomarkers Reference List, Cabot PJ, Carter L, Corticotropin-Releasing Hormone/antagonists & inhibitors/pharmacology/therapeutic use, Dose-Response Relationship, Drug, Dynorphins/immunology/secretion, Enkephalin, Humans, Inflammation/drug therapy/immunology/metabolism, Interleukin-2/pharmacology, Journal Article, Lymphocytes/drug effects/immunology/secretion, Male, Methionine/immunology/metabolism, Pain, Pain/drug therapy/immunology/metabolism, Rats, Schafer M, Stein C, Wistar
Mobilization of opioid-containing polymorphonuclear cells by hematopoietic growth factors and influence on inflammatory pain
Tags: 2004, Anesthesiology, Animals, Backlog, Beschmann K, Biomarkers of Pain, Brack A, Cell Adhesion Molecules/pharmacology, Cell Separation, Chemokines/biosynthesis, Chemotaxis, DNA Primers, Flow Cytometry, Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology, Hindlimb/physiology, Inflammation/complications, Journal Article, Leukocyte/drug effects, Light, Machelska H, Male, Messenger/biosynthesis, Narcotics/metabolism/pharmacology, Neutrophils/metabolism, Pain Measurement/drug effects, Pain/drug therapy/physiopathology, Radioimmunoassay, Rats, Reverse Transcriptase Polymerase Chain Reaction, Rittner HL, RNA, Schafer M, Sitte N, Stein C, Stem Cell Factor/pharmacology, Wistar
Modulation of peripheral endogenous opioid analgesia by central afferent blockade
Tags: 2003, Afferent/drug effects, Analgesics, Anesthesiology, Animals, Backlog, beta-Endorphin/metabolism, Brack A, Central Nervous System/drug effects, Endorphins/metabolism/physiology, Enkephalin, Flow Cytometry, Foot/pathology, Immunohistochemistry, Inflammation/pathology, Injections, Journal Article, Male, Methionine/metabolism, Morphine/administration & dosage/pharmacology, Mousa SA, Neurons, Opioid/administration & dosage/pharmacology, Pain Threshold/drug effects, Peripheral Nerves/drug effects, Psychomotor Performance/drug effects, Rats, Rittner HL, Schafer M, Schmidt DK, Schmitt TK, Spinal, Stein C, Welte M, Wistar
Opioid peptide-expressing leukocytes: identification, recruitment, and simultaneously increasing inhibition of inflammatory pain
Tags: 2001, Analgesia, Anesthesiology, Animals, Antibodies, Antigens, Backlog, Bauer M, beta-Endorphin/blood, Biomarkers of Pain, Biomarkers Reference List, Brack A, CD45/isolation & purification, Fluorescent Dyes, Hematopoietic Stem Cells/immunology, Immunohistochemistry, Immunomagnetic Separation, Inflammation/chemically induced/metabolism/pathology, Journal Article, Leukocytes/metabolism, Lymphocytes/immunology, Machelska H, Male, Monoclonal/pharmacology, Mousa SA, Opioid Peptides/biosynthesis, Pain Measurement, Pain/physiopathology, Radioimmunoassay, Rats, Rittner HL, Schafer M, Stein C, Wistar
Opioids
Tags: 2007, Amino Acid Sequence, Analgesics, Animals, Backlog, Biomarkers of Pain, Chronic Disease, Drug Tolerance, Handbook Of Experimental Pharmacology, Humans, Journal Article, Ligands, Molecular Sequence Data, Opioid/adverse effects/pharmacology/therapeutic use, Opioid/drug effects, Receptors, Stein C, Zollner C
Pain control by immune-derived opioids
Tags: 2000, Analgesics, Backlog, Biomarkers of Pain, Clinical And Experimental Pharmacology & Physiology, Humans, Journal Article, Machelska H, Neuropeptides/therapeutic use, Opioid/drug effects/immunology, Opioid/therapeutic use, Pain/drug therapy/immunology, Peripheral Nervous System/drug effects, Receptors, Stein C
Peripheral opioid receptors mediating antinociception in inflammation. Activation by endogenous opioids and role of the pituitary-adrenal axis
Tags: 1990, Adrenalectomy, Analysis of Variance, Animals, Backlog, Biomarkers of Pain, Biomarkers Reference List, Cold, Czlonkowski A, Dose-Response Relationship, Drug, Endorphins/physiology, Foot, Herz A, Hypophysectomy, Inbred Strains, Inflammation/physiopathology, Journal Article, Male, Naloxone/pharmacology, Naltrexone/pharmacology, Nociceptors/physiopathology, Opioid/physiology, Pain, Parsons CG, Pituitary-Adrenal System/physiology, Rats, Receptors, Stein C, Stress/physiopathology, Swimming
Subcellular pathways of beta-endorphin synthesis, processing, and release from immunocytes in inflammatory pain
Tags: 2004, Animals, Backlog, beta-Endorphin/biosynthesis, Biomarkers of Pain, Carboxypeptidase H/metabolism, Endocrinology, Extremities, Immunoelectron, Immunohistochemistry, Inflammation/immunology/metabolism, Journal Article, Leukocytes/drug effects/metabolism/ultrastructure, Male, Microscopy, Mousa SA, Norepinephrine/pharmacology, Pain/immunology/metabolism, Pro-Opiomelanocortin/metabolism, Proprotein Convertase 1/metabolism, Proprotein Convertase 2/metabolism, Rats, Schafer M, Secretory Vesicles/metabolism/ultrastructure, Shakibaei M, Sitte N, Stein C, Sympathomimetics/pharmacology, Wistar
Tissue monocytes/macrophages in inflammation: hyperalgesia versus opioid-mediated peripheral antinociception
Tags: 2004, Analgesics, Anesthesiology, Animals, Backlog, Biomarkers of Pain, Brack A, Clodronic Acid/pharmacokinetics/pharmacology, Fentanyl/administration & dosage/pharmacology, Flow Cytometry, Foot/pathology, Freund's Adjuvant, Heat, Hyperalgesia/chemically induced/pathology/psychology, Inflammation/chemically induced/pathology, Injections, Journal Article, Labuz D, Liposomes, Machelska H, Macrophages/pathology, Male, Monocytes/pathology, Non-Narcotic/pharmacokinetics/pharmacology, Opioid/administration & dosage/pharmacology, Pain Measurement/drug effects, Pressure, Rats, Reszka R, Rittner HL, Schafer M, Schiltz A, Stein C, Wistar