1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1200/jco.1998.16.10.3216" target="_blank" rel="noreferrer">http://doi.org/10.1200/jco.1998.16.10.3216</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Switching from morphine to oral methadone in treating cancer pain: what is the equianalgesic dose ratio?
Publisher
An entity responsible for making the resource available
Journal Of Clinical Oncology
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
Subject
The topic of the resource
Cross-Sectional Studies; Female; Humans; Male; Analgesics; Prospective Studies; Aged; Middle Aged; Therapeutic Equivalency; Time Factors; Analgesia; Non-U.S. Gov't; Research Support; Administration; Oral; Pain/drug therapy; Dose-Response Relationship; Drug; Neoplasms/complications; Opioid/administration & dosage; Morphine/administration & dosage; Methadone/administration & dosage
Creator
An entity primarily responsible for making the resource
Ripamonti C; Groff L; Brunelli C; Polastri D; Stavrakis A; De Conno F
Description
An account of the resource
PURPOSE: To define the dose ratio between morphine and methadone in relation to the previous morphine dose and the number of days needed to achieve the same level of analgesia in a group of patients with advanced cancer with pain who switched from morphine to oral methadone. PATIENTS AND METHODS: A cross-sectional prospective study of 38 consecutive cancer patients who switched from morphine to oral methadone was performed. The intensity of pain before, during, and after the switching period was assessed through a four-point verbal Likert scale. The relationship between previous morphine dose and the final equianalgesic methadone dose, dose ratio between morphine and methadone, and the number of days required to achieve equianalgesia have been examined by means of Pearson's correlation coefficient, scatter plots, and Cuzick's test for trend respectively. RESULTS: Before the switch, the median oral equivalent daily dose of morphine was 145 mg/d; after the switch, the median equianalgesic oral methadone dose was 21 mg/d. A median time of 3 days (range, 1 to 7 days) was necessary to achieve the equianalgesia with oral methadone; the lower the preswitching morphine dose, the fewer days necessary to achieve equianalgesia with oral methadone (P < .001). Dose ratios ranged from 2.5:1 to 14.3:1 (median, 7.75:1), which indicated that, in most cases, the dose ratio was much higher than that suggested by the published equianalgesic tables. A strong linear positive relationship between morphine and methadone equianalgesic doses was obtained (Pearson's correlation coefficient, 0.91). The dose ratio increased with the increase of the previous morphine dose with a much higher increase at low morphine doses. CONCLUSION: The results of our study confirm that methadone is a potent opioid, more potent than believed. Caution is recommended when switching from any opioid to methadone, especially in patients who are tolerant to high doses of opioids.
1998
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1200/jco.1998.16.10.3216" target="_blank" rel="noreferrer">10.1200/jco.1998.16.10.3216</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1998
Administration
Aged
Analgesia
Analgesics
Backlog
Brunelli C
Cross-sectional Studies
De Conno F
Dose-Response Relationship
Drug
Female
Groff L
Humans
Journal Article
Journal Of Clinical Oncology
Male
Methadone/administration & Dosage
Middle Aged
Morphine/administration & dosage
Neoplasms/complications
Non-U.S. Gov't
Opioid/administration & dosage
Oral
Pain/drug Therapy
Polastri D
Prospective Studies
Research Support
Ripamonti C
Stavrakis A
Therapeutic Equivalency
Time Factors