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Treatment of Symptoms in Children with Q3 Conditions Scoping Review Results
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<a href="http://doi.org/10.1016/j.ijporl.2010.11.003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ijporl.2010.11.003</a>
Dublin Core
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Title
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Characterization of sleep disturbance in Cornelia de Lange Syndrome
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International Journal of Pediatric Otorhinolaryngology
Date
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2011
Subject
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Cornelia de Lange Syndrome; Sleep disordered breathing; Sleepiness; Snoring; breathing difficulties; sleep disturbance; De Lange syndrome; trajectory; characteristics; sleep disordered breathing
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Stavinoha Rose C; Kline A D; Levy H P; Kimball A; Mettel T L; Ishman S L
Description
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Prior studies have suggested that sleep disturbance is common in Cornelia de Lange Syndrome (CdLS); however, the nature of this sleep disturbance has not been well characterized. In this study, we evaluate the prevalence of sleep disordered breathing (SDB) and sleepiness in children and young adults with CdLS. Caregivers of 22 patients with CdLS completed 3 validated Pediatric Sleep Questionnaires: the Pediatric Sleep Questionnaire (PSQ), Pediatric Daytime Sleepiness Scale (PDSS), and OSA18. Both measures of SDB (OSA18 and PSQ) suggest that 35–36% of these patients may have moderate to severe SDB. This is much higher than the general population estimates of 1–4% for SDB with a relative risk of 5.2 (95% CI: 2.8–9.9). Correlation between the OSA18 and PSQ was significant (R=0.67; 95% CI: 0.33–0.85, p=0.0007). Confirming these results among patients with a high probability of SDB (based upon OSA18 scores ≥60), there was a non-significant trend toward increased sleepiness with a relative risk of 2.0 (95% CI: 0.73–5.7, p=0.31) on the PDSS and 2.9 (95% CI: 0.93–9.1, p=0.08) on the PSQ sleepiness scale. In those patients with low probability of SDB (OSA18<60), sleepiness was still seen in 13–29% of patients. Overall 23–35% of participants were characterized as sleepy. Sleep disordered breathing and sleepiness appear to be common in CdLS although small sample sizes limit further conclusions. Additional studies with larger sample size and confirmation with polysomnography are needed to further explore the nature and extent of sleep disturbance in this population.
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<a href="http://doi.org/10.1016/j.ijporl.2010.11.003" target="_blank" rel="noreferrer noopener">10.1016/j.ijporl.2010.11.003</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
2011
breathing difficulties
characteristics
Cornelia de Lange syndrome
De Lange syndrome
International Journal of Pediatric Otorhinolaryngology
Ishman S L
Kimball A
Kline A D
Levy H P
Mettel T L
Sleep disordered breathing
sleep disturbance
Sleepiness
snoring
Stavinoha Rose C
Trajectory