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Text
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URL Address
<a href="http://doi.org/10.1067/mpd.2000.107838" target="_blank" rel="noreferrer">http://doi.org/10.1067/mpd.2000.107838</a>
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Title
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Osteoporosis pseudoglioma syndrome: treatment of spinal osteoporosis with intravenous bisphosphonates
Publisher
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The Journal Of Pediatrics
Date
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2000
Subject
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Child; Female; Humans; Male; Analgesics; Growth; Non-U.S. Gov't; Research Support; Syndrome; Infusions; Intravenous; Clodronate; Pain/prevention & control; Clodronic Acid/administration & dosage; Non-Narcotic/administration & dosage; Diphosphonates/administration & dosage; Fractures; Bone Density/physiology; Bone/complications/physiopathology; Osteoporosis/complications/drug therapy/physiopathology; Spine/physiopathology; Vision Disorders/complications
Creator
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Zacharin M; Cundy T
Description
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OBJECTIVES: To determine whether intravenous bisphosphonate treatment is helpful for children with osteoporosis pseudoglioma syndrome who have severe osteoporosis. METHODS: Three children (ages 9 to 11 years) with osteoporosis pseudoglioma syndrome who had multiple vertebral collapse were treated over a 2-year period with intermittent intravenous bisphosphonate infusions (pamidronate in 2, clodronate in 1). The responses to therapy were assessed with clinical and radiographic evaluation and bone densitometry of the spine. RESULTS: All 3 subjects reported early reductions in bone pain and improved mobility. Radiographs showed dense new bone in the vertebral end plates and remodeling of the vertebral bodies. Areal bone mineral density at the lumbar spine (age-appropriate SD score) improved from a mean of -4.5 before treatment to -2.8 after 2 years (P <.05). No new fractures occurred, and side effects were minimal. Growth and pubertal development proceeded normally. CONCLUSIONS: Intravenous bisphosphonate therapy appears safe and beneficial in patients with this condition and may prevent progressive vertebral deformity.
2000
Identifier
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<a href="http://doi.org/10.1067/mpd.2000.107838" target="_blank" rel="noreferrer">10.1067/mpd.2000.107838</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
2000
Analgesics
Backlog
Bone Density/physiology
Bone/complications/physiopathology
Child
Clodronate
Clodronic Acid/administration & dosage
Cundy T
Diphosphonates/administration & dosage
Female
Fractures
Growth
Humans
Infusions
Intravenous
Journal Article
Male
Non-Narcotic/administration & dosage
Non-U.S. Gov't
Osteoporosis/complications/drug therapy/physiopathology
Pain/prevention & control
Research Support
Spine/physiopathology
Syndrome
The Journal Of Pediatrics
Vision Disorders/complications
Zacharin M