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Dublin Core
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Title
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Treatment of Symptoms in Children with Q3 Conditions Scoping Review Results
Text
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<a href="http://doi.org/10.1002/mds.25126" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/mds.25126</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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A randomized trial of oral betamethasone to reduce ataxia symptoms in ataxia telangiectasia
Publisher
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Movement Disorders
Date
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2012
Subject
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tone and motor problems; ataxia; ataxia telangectasia; pharmacologic intervention; betamethasone;
Creator
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Zannolli R; Buoni S; Betti G; Salvucci S; Plebani A; Soresina A; Pietrogrande M C; Martino S; Leuzzi V; Finocchi A; Micheli R; Rossi L N; Brusco A; Misiani F; Fois A; Hayek J; Kelly C; Chessa L
Description
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No controlled studies exist regarding the pharmaceutical reduction of ataxia symptoms in ataxia telangiectasia (A-T). In a multicenter, double-blind, randomized, placebo-controlled crossover trial, oral betamethasone (BETA) and placebo were compared in terms of their reduction of ataxia symptoms as assessed with the International Cooperative Ataxia Rating Scale (ICARS). In this study of 13 A-T children, betamethasone reduced the ICARS total score by a median of 13 points in the intent-to-treat population and 16 points in the per-protocol population (ie, median percent decreases of ataxia symptoms of 28% and 31%, respectively). In conclusion, Oral betamethasone could be a promising therapy to relieve ataxia symptoms in A-T patients; however, long-term effectiveness and safety must be established. (Current Controlled Trials, number ISRCTN08774933). © 2012 Movement Disorder Society.
Identifier
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<a href="http://doi.org/10.1002/mds.25126" target="_blank" rel="noreferrer noopener">10.1002/mds.25126</a>
Rights
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
2012
ataxia
ataxia telangectasia
betamethasone
Betti G
Brusco A
Buoni S
Chessa L
Finocchi A
Fois A
Hayek J
Kelly C
Leuzzi V
Martino S
Micheli R
Misiani F
Movement Disorders
pharmacologic intervention
Pietrogrande M C
Plebani A
Rossi L N
Salvucci S
Soresina A
tone and motor problems
Zannolli R