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              <text>&lt;a href="http://doi.org/10.1007/bf02532424" target="_blank" rel="noreferrer"&gt;http://doi.org/10.1007/bf02532424&lt;/a&gt;</text>
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                <text>On the mathematical modelling of pain</text>
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                <text>Humans; Analgesia; Reproducibility of Results; Animals; Models; Pain/physiopathology; Axons/physiology; Nerve Net/physiology; Neurological; Neuronal Plasticity; Neurons/physiology; Theoretical</text>
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                <text>Britton NF; Skevington SM</text>
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                <text>In this review a case is presented for the use of mathematical modelling in the study of pain. The philosophy of mathematical modelling is outlined and a recommendation is made for the use of modern nonlinear techniques and computational neuroscience in the modelling of pain. Classic and more recent examples of modelling in neurobiology in general and pain in particular, at three different levels-molecular, cellular and neural networks-are described and evaluated. Directions for further progress are indicated, particularly in plasticity and in modelling brain mechanisms. Major advantages of mathematical modelling are that it can handle extremely complex theories and it is non-invasive, and so is particularly valuable in the investigation of chronic pain.</text>
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                <text>1996</text>
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              <text>&lt;a href="http://doi.org/10.1023/b:qure.0000018486.91360.00" target="_blank" rel="noreferrer"&gt;http://doi.org/10.1023/b:qure.0000018486.91360.00&lt;/a&gt;</text>
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                <text>The World Health Organization's WHOQOL-BREF quality of life assessment: psychometric properties and results of the international field trial. A report from the WHOQOL group</text>
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                <text>quality of life; Psychological; Adolescent Adult Aged Aged; PedPal Lit; 80 and over Child Comparative Study Cross-Cultural Comparison Cross-Sectional Studies Female Humans Male Middle Aged Psychometrics/; 830). Sick and well respondents were sampled from the general population; and to test its main psychometric properties. The WHOQOL-BREF is a 26-item version of the WHOQOL-100 assessment. Its psychometric properties were analysed using cross-sectional data obtained from a survey of adults carried out in 23 countries (n = 11; as reflected by its four domains: physical; as well as from hospital; clinical settings and clinical trials. Using data from the WHOQOL-BREF field trials; cross-culturally valid assessment of QOL; discriminant validity and construct validity through confirmatory factor analysis; indicate that the WHOQOL-BREF has good to excellent psychometric properties of reliability and performs well in preliminary tests of validity. These results indicate that overall; instrumentation; item-total correlations; rehabilitation and primary care settings; serving patients with physical and mental disorders and with respect to quotas of important socio-demographic variables. The WHOQOL-BREF self-assessment was completed; Sickness Impact Profile World Health Organization%X Quality of life (QOL) assessments that are easily administered and which do not impose a great burden on the respondent are needed for use in large epidemiological surveys; social and environment.; the objectives of this work are to examine the performance of the WHOQOL-BREF as an integrated instrument; the WHOQOL-BREF is a sound; together with socio-demographic and health status questions. Analyses of internal consistency</text>
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