1
40
4
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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URL Address
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2066846" target="_blank" rel="noreferrer">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2066846</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Comparison of morphine and methadone for prevention of postoperative pain in 3- to 7-year-old children
Publisher
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Journal Of Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
Subject
The topic of the resource
Child; Female; Male; Pain; Pain Measurement; Prospective Studies; Analysis of Variance; Double-Blind Method; Preschool; Non-U.S. Gov't; Comparative Study; Drug Evaluation; Human; Support; Postoperative/prevention & control; algorithms; Intraoperative Care; Methadone/adverse effects/pharmacokinetics/therapeutic use; Morphine/adverse effects/therapeutic use
Creator
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Berde CB; Beyer JE; Bournaki MC; Levin CR; Sethna NF
Description
An account of the resource
A randomized, double-blind, prospective study was performed to determine the effects of perioperative administration of morphine or methadone on postoperative analgesic requirements and pain scores in 35 children aged 3 to 7 years undergoing major surgery. After a standardized induction of anesthesia, methadone or morphine, 0.2 mg/kg, was blindly administered, and supplemental doses were titrated to achieve comfort in the recovery room. Pain was assessed during the next 36 hours with a combination of validated behavioral and self-report measures. Patients in the methadone group required fewer supplemental opioid analgesic drugs during the next 36 hours, and reported lower pain scores. No patient had prolonged emergence from anesthesia, and no patient required naloxone or postoperative ventilatory assistance. No major adverse events occurred. We conclude that perioperative intravenous administration of methadone is an effective, inexpensive, and technologically simple means for providing prolonged analgesia for children after surgery.
1991
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1991
algorithms
Analysis of Variance
Backlog
Berde CB
Beyer JE
Bournaki MC
Child
Comparative Study
Double-Blind Method
Drug Evaluation
Female
Human
Intraoperative Care
Journal Article
Journal of Pediatrics
Levin CR
Male
Methadone/adverse effects/pharmacokinetics/therapeutic use
Morphine/adverse effects/therapeutic use
Non-U.S. Gov't
Pain
Pain Measurement
Postoperative/prevention & control
Preschool
Prospective Studies
Sethna NF
Support
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1097/00000542-198709001-00519" target="_blank" rel="noreferrer">http://doi.org/10.1097/00000542-198709001-00519</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Pharmacokinetics of methadone in children and adolescents in the perioperative period
Publisher
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Anesthesiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1987
Subject
The topic of the resource
Child; Analgesics; Methadone; Narcotics; adolescent; Opioid; Antitussive Agents; Biological Transport; Kinetics; Perioperative Care; Pharmacokinetics
Creator
An entity primarily responsible for making the resource
Berde CB; Sethna NF; Holzman RS; Reidy P; Gondek EJ
Description
An account of the resource
Introduction Previous studies by Gourlay and coworkers1-3 have demonstrated that in adults undergoing surgery, methadone has slow elimination and a very long duration of effective analgesia. For children, intramuscular injections are a major source of distress in the peri-operative period. If methadone behaves in children as it does for adults, then use of methadone intravenously should provide a steady analgesic effect. For these reasons, we have undertaken studies of methadone in children and adolescents undergoing major surgery. Methods Fifteen children and adolescents, ages 1-18 years were enrolled with informed parental and patient consent according to procedures approved by the institutional Human Studies committee. Enrollment was restricted to patients requiring prolonged surgery (greater than 3 hours) and placement of arterial cannulae or multiple venous cannulae. Included in the studey were 3 one-year olds, 2 two-year olds and 2 three-year olds. Following tracheal intubation and line placement, methadone (0.2 mg/kg) was administered via rapid intravenous bolus. Heparinized plasma samples for methadone assay were obtained at approzimately 1, 2, 3, 4, 7, 10, and 30 minutes and 1, 3, 6, 12, 18, 24, 48, and 72 hours. Methadone assay (gas-liquid chromatography with mass spectrometry) yielded a lower detection limit of 5 ng/ml; for several patients the final 1-4 points fell below the detection limit and were excluded from analysis. Concentration versus time curves were fitted to a bioexponential equation using nonlinear least-squares. Results Kinetic parameters are summarized in Table 1. It is apparent that in children and adolescents ages 1 to 18 years, methadone has very prolonged elimination and a low clearance rate. For this population, regression analysis showed no dependence of half-lives or normalized volumes and clearances on patient age or weight. Areas under the concentration-versus-time curves from the equation parameters and from the trapezoid rule (model-independent) agreed to within 4%. Discussion Methadone has not been studied previously for post-operative pain in children. Observation of the patients in this study and of 16 additional children suggests that methadone provides prolonged analgesia; many children remained comfortable and required no analgesia for 12-36 hours post-operatively. Studies in progress are directed at testing these impressions via double-blinded administration and formal pain assessment scales. If these studies confirm that methadone's dynamics as well as kinetics are similar in children and adults, then peri-operative administration would be a safe, inexpensive and convenient means for providing prolonged analgesia and decreasing the use of painful intramuscular narcotic injections in children following major surgery. In adults ages 29-69 years, there was a positive correlation between age and beta half life. In the present study, we found no dependence of elimination half-life or normalized clearance on age for patients ages 1-18. The mean value for elimination half-life in the present study, 19.2 hours, is indistinguishable from that of the youngest adults in the previous study. As with adults, there is substantial variability among children in the rates and volumes of methadone distribution and elimination. It therefore seems prudent to follow an approach similar to that used in adults with titration to clinical effect. To date, at least 40 children have received methadone (via blinded or unblinded administration) in this fashion without requiring naloxone or assisted ventilation postoperatively. Further study is required before these conclusions can be extrapolated to newborns and very young infants.
1987
Identifier
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<a href="http://doi.org/10.1097/00000542-198709001-00519" target="_blank" rel="noreferrer">10.1097/00000542-198709001-00519</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1987
Adolescent
Analgesics
Anesthesiology
Antitussive Agents
Backlog
Berde CB
Biological Transport
Child
Gondek EJ
Holzman RS
Journal Article
Kinetics
Methadone
Narcotics
Opioid
Perioperative Care
Pharmacokinetics
Reidy P
Sethna NF
-
Text
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Citation List Month
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URL Address
<a href="http://doi.org/10.1067/mpd.2002.124380" target="_blank" rel="noreferrer">http://doi.org/10.1067/mpd.2002.124380</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Physical therapy and cognitive-behavioral treatment for complex regional pain syndromes
Publisher
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The Journal Of Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Child; Female; Humans; Male; Prospective Studies; adolescent; P.H.S.; Research Support; U.S. Gov't; Nonparametric; Statistics; Cognitive Therapy; Complex Regional Pain Syndromes/psychology/rehabilitation; Physical Therapy Modalities
Creator
An entity primarily responsible for making the resource
Lee BH; Scharff L; Sethna NF; McCarthy CF; Scott-Sutherland J; Shea AM; Sullivan P; Meier P; Zurakowski D; Masek BJ; Berde CB
Description
An account of the resource
Complex regional pain syndromes (CRPS; type 1, reflex sympathetic dystrophy, and type 2, causalgia) involve persistent pain, allodynia, and vasomotor signs. We conducted a prospective, randomized, single-blind trial of physical therapy (PT) and cognitive-behavioral treatment for children and adolescents with CRPS. Children 8 to 17 years of age (n = 28) were randomly assigned to either group A (PT once per week for 6 weeks) or group B (PT 3 times per week for 6 weeks). Both groups received 6 sessions of cognitive-behavioral treatment. Assessments of pain and function were repeated at two follow-up time periods. Outcomes were compared at the three time points through the use of parametric or nonparametric analysis of variance and post hoc tests. All five measures of pain and function improved significantly in both groups after treatment, with sustained benefit evident in the majority of patients at long-term follow-up. Recurrent episodes were reported in 50% of patients, and 10 patients eventually received sympathetic blockade. Most children with CRPS showed reduced pain and improved function with a noninvasive rehabilitative treatment approach. Long-term functional outcomes were also very good.
2002
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1067/mpd.2002.124380" target="_blank" rel="noreferrer">10.1067/mpd.2002.124380</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2002
Adolescent
Backlog
Berde CB
Child
Cognitive Therapy
Complex Regional Pain Syndromes/psychology/rehabilitation
Female
Humans
Journal Article
Lee BH
Male
Masek BJ
McCarthy CF
Meier P
Nonparametric
P.H.S.
Physical Therapy Modalities
Prospective Studies
Research Support
Scharff L
Scott-Sutherland J
Sethna NF
Shea AM
Statistics
Sullivan P
The Journal Of Pediatrics
U.S. Gov't
Zurakowski D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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<a href="http://doi.org/10.1056/NEJMra012626" target="_blank" rel="noreferrer">http://doi.org/10.1056/NEJMra012626</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Analgesics for the treatment of pain in children
Publisher
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The New England Journal Of Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Child; Humans; infant; Analgesics; Analgesia; Anesthetics; Non-U.S. Gov't; P.H.S.; Research Support; U.S. Gov't; infant; Chronic disease; Newborn; Pain/drug therapy/etiology; Anesthesia; Anti-Inflammatory Agents; Neoplasms/complications; Patient-Controlled; Analgesics/administration & dosage/therapeutic use; General; Acetaminophen/therapeutic use; Aspirin/therapeutic use; Local; Non-Steroidal/therapeutic use; Opioid/pharmacokinetics/pharmacology/therapeutic use
Creator
An entity primarily responsible for making the resource
Berde CB; Sethna NF
Identifier
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<a href="http://doi.org/10.1056/NEJMra012626" target="_blank" rel="noreferrer">10.1056/NEJMra012626</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
2002
2002
Acetaminophen/therapeutic use
Analgesia
Analgesics
Analgesics/administration & dosage/therapeutic use
Anesthesia
Anesthetics
Anti-Inflammatory Agents
Aspirin/therapeutic use
Backlog
Berde CB
Child
Chronic Disease
General
Humans
Infant
Journal Article
Local
Neoplasms/complications
Newborn
Non-Steroidal/therapeutic use
Non-U.S. Gov't
Opioid/pharmacokinetics/pharmacology/therapeutic use
P.H.S.
Pain/drug therapy/etiology
Patient-Controlled
Research Support
Sethna NF
The New England Journal Of Medicine
U.S. Gov't