1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1016/s0895-4356(96)00429-5" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0895-4356(96)00429-5</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Combining single patient (N-of-1) trials to estimate population treatment effects and to evaluate individual patient responses to treatment Publisher An entity responsible for making the resource available Journal Of Clinical Epidemiology Date A point or period of time associated with an event in the lifecycle of the resource 1997 Subject The topic of the resource Humans; Outcome Assessment (Health Care); Research Design; Antidepressive Agents; Cross-Over Studies; Models; Statistical; Chronic disease; Amitriptyline/therapeutic use; Bayes Theorem; Fibromyalgia/drug therapy; Randomized Controlled Trials as Topic/statistics & numerical data; Tricyclic Creator An entity primarily responsible for making the resource Zucker DR; Schmid CH; McIntosh MW; D'Agostino RB; Selker HP; Lau J Description An account of the resource When treating individual patients, physicians may face difficulties using the evidence from center-based randomized control trials (RCTs) due to limitations in these studies generalizability. Therefore, they often perform their own "informal" tests of treatment effectiveness. Single patient ("N-of-1") trials provide a structured design for more rigorous assessment of medical treatments of chronic diseases, but are applied only to the index patient. We present a hierarchical Bayesian random effects model to combine N-of-1 studies to obtain an estimate of treatment effectiveness for the population and to use this population information to aid in the evaluation of an individual patient's trial results. The model's treatment effect estimates are adjustments between the population estimate and the individual's observed results. This adjustment is based upon the within-patient and between-patient heterogeneity. We demonstrate this patient-focused method using published data from 23 N-of-1 trial results comparing amitriptyline and placebo for the treatment of fibromyalgia. 1997 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/s0895-4356(96)00429-5" target="_blank" rel="noreferrer">10.1016/s0895-4356(96)00429-5</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 1997 Amitriptyline/therapeutic use Antidepressive Agents Backlog Bayes Theorem Chronic Disease Cross-Over Studies D'Agostino RB Fibromyalgia/drug therapy Humans Journal Article Journal Of Clinical Epidemiology Lau J McIntosh MW Models Outcome Assessment (health Care) Randomized Controlled Trials as Topic/statistics & numerical data Research Design Schmid CH Selker HP statistical Tricyclic Zucker DR