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<a href="http://doi.org/10.1016/j.cell.2010.09.047" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.cell.2010.09.047</a>
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Title
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A Genome-wide Drosophila Screen for Heat Nociception Identifies alpha2delta3 as an Evolutionarily Conserved Pain Gene
Publisher
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Cell
Date
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2010
Subject
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Biomarkers of Pain
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Neely GG; Hess A; Costigan M; Keene AC; Goulas S; Langeslag M; Griffin RS; Belfer I; Dai F; Smith SB; Diatchenko L; Gupta V; Xia CP; Amann S; Kreitz S; Heindl-Erdmann C; Wolz S; Ly CV; Arora S; Sarangi R; Dan D; Novatchkova M; Rosenzweig M; Gibson DG; Truong D; Schramek D; Zoranovic T; Cronin SJ; Angjeli B; Brune K; Dietzl G; Maixner W; Meixner A; Thomas W; Pospisilik JA; Alenius M; Kress M; Subramaniam S; Garrity PA; Bellen HJ; Woolf CJ; Penninger JM
Description
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Worldwide, acute, and chronic pain affects 20% of the adult population and represents an enormous financial and emotional burden. Using genome-wide neuronal-specific RNAi knockdown in Drosophila, we report a global screen for an innate behavior and identify hundreds of genes implicated in heat nociception, including the alpha2delta family calcium channel subunit straightjacket (stj). Mice mutant for the stj ortholog CACNA2D3 (alpha2delta3) also exhibit impaired behavioral heat pain sensitivity. In addition, in humans, alpha2delta3 SNP variants associate with reduced sensitivity to acute noxious heat and chronic back pain. Functional imaging in alpha2delta3 mutant mice revealed impaired transmission of thermal pain-evoked signals from the thalamus to higher-order pain centers. Intriguingly, in alpha2delta3 mutant mice, thermal pain and tactile stimulation triggered strong cross-activation, or synesthesia, of brain regions involved in vision, olfaction, and hearing.
2010
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<a href="http://doi.org/10.1016/j.cell.2010.09.047" target="_blank" rel="noreferrer">10.1016/j.cell.2010.09.047</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
2010
Alenius M
Amann S
Angjeli B
Arora S
Backlog
Belfer I
Bellen HJ
Biomarkers of Pain
Brune K
Cell
Costigan M
Cronin SJ
Dai F
Dan D
Diatchenko L
Dietzl G
Garrity PA
Gibson DG
Goulas S
Griffin RS
Gupta V
Heindl-Erdmann C
Hess A
Journal Article
Keene AC
Kreitz S
Kress M
Langeslag M
Ly CV
Maixner W
Meixner A
Neely GG
Novatchkova M
Penninger JM
Pospisilik JA
Rosenzweig M
Sarangi R
Schramek D
Smith SB
Subramaniam S
Thomas W
Truong D
Wolz S
Woolf CJ
Xia CP
Zoranovic T