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Text
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<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10846153" target="_blank" rel="noreferrer">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10846153</a>
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Title
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Neuronal plasticity: increasing the gain in pain
Publisher
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Science
Date
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2000
Subject
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Models; Human; Signal Transduction; Neurological; Inflammation/physiopathology; Animal; Nociceptors/physiology; Neurons; Pain/physiopathology; Neuronal Plasticity; Afferent/physiology; Peripheral Nerves/injuries; Posterior Horn Cells/physiology; Synaptic Transmission
Creator
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Woolf CJ; Salter MW
Description
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We describe those sensations that are unpleasant, intense, or distressing as painful. Pain is not homogeneous, however, and comprises three categories: physiological, inflammatory, and neuropathic pain. Multiple mechanisms contribute, each of which is subject to or an expression of neural plasticity-the capacity of neurons to change their function, chemical profile, or structure. Here, we develop a conceptual framework for the contribution of plasticity in primary sensory and dorsal horn neurons to the pathogenesis of pain, identifying distinct forms of plasticity, which we term activation, modulation, and modification, that by increasing gain, elicit pain hypersensitivity.
2000
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
2000
Afferent/physiology
Animal
Backlog
Human
Inflammation/physiopathology
Journal Article
Models
Neurological
Neuronal Plasticity
Neurons
Nociceptors/physiology
Pain/physiopathology
Peripheral Nerves/injuries
Posterior Horn Cells/physiology
Salter MW
Science
Signal Transduction
Synaptic Transmission
Woolf CJ