1 40 1 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Treatment of Symptoms in Children with Q3 Conditions Scoping Review Results Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1111/j.1741-4520.2012.00356.x" target="_blank" rel="noreferrer noopener">http://doi.org/​10.1111/j.1741-4520.2012.00356.x</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Age-dependent change in behavioral feature in Rubinstein-Taybi syndrome Publisher An entity responsible for making the resource available Congenital Anomalies Date A point or period of time associated with an event in the lifecycle of the resource 2012 Subject The topic of the resource Adolescent; Adult; Age; Factors; Behavior; Child; Preschool; Female; Humans; Infant; Male; Rubinstein-Taybi Syndrome/di [Diagnosis]; Surveys and Questionnaires; Young Adult; behavioral problems; Rubinstein-Taybi Syndrome; trajectory; characteristics; anxiety; depression; aggression; aggressive behavior Creator An entity primarily responsible for making the resource Yagihashi T; Kosaki K; Okamoto N; Mizuno S; Kurosawa K; Takahashi T; Sato Y; Kosaki R Description An account of the resource Rubinstein-Taybi syndrome (RTS) is characterized by developmental delay, postnatal growth retardation, typical facial appearance, and broad thumbs and big toes. The behavioral phenotype of children with RTS has been described as friendly and having good social contacts; however, a short attention span and hyperactivity are sometimes present. Little attention has been paid to the behavioral aspects of adults with RTS. We conducted an observational study focusing on behavioral problems in adolescents and adults with RTS compared with children with RTS. A total of 63 patients with RTS and their caretakers answered self-administered questionnaires regarding behavioral features including the Child Behavior Checklist (CBCL). High total CBCL scores were observed, and the mean score was beyond the clinical cut-off point. After stratification into two groups according to age, the older group (>14 years) displayed statistically significant higher scores for Anxious/Depression (P = 0.002) and Aggressive Behavior (P = 0.036) than the younger group (<13 years). In analyses of single items, statistically significant differences between the younger group and the older group were found for 'Nervous, high-strung, or tense' (31.3% vs 67.7%, P = 0.004) and 'Too fearful or anxious' (37.5% vs 64.5%, P = 0.032). Here, we showed that the specific behavioral phenotypes of RTS change during adolescence, with anxiety, mood instability, and aggressive behavior emerging as patients age. A clear need exists to follow-up patients with RTS to catch the eventual emergence of psychiatric problems with age. If necessary, pharmacological treatment should be considered.Copyright © 2012 The Authors. Congenital Anomalies © 2012 Japanese Teratology Society. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1111/j.1741-4520.2012.00356.x" target="_blank" rel="noreferrer noopener">10.1111/j.1741-4520.2012.00356.x</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). 2012 Adolescent Adult Age Aggression aggressive behavior anxiety Behavior behavioral problems characteristics Child Congenital Anomalies Depression Factors Female Humans Infant Kosaki K Kosaki R Kurosawa K Male Mizuno S Okamoto N Preschool Rubinstein-Taybi Syndrome Rubinstein-Taybi Syndrome/di [Diagnosis] Sato Y Surveys And Questionnaires Takahashi T Trajectory Yagihashi T Young Adult