1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1016/j.jpainsymman.2006.05.013" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.jpainsymman.2006.05.013</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Nociceptin levels in the cerebrospinal fluid of chronic pain patients with or without intrathecal administration of morphine Publisher An entity responsible for making the resource available Journal Of Pain And Symptom Management Date A point or period of time associated with an event in the lifecycle of the resource 2006 Subject The topic of the resource Female; Humans; Male; Analgesics; Aged; Middle Aged; Chronic disease; Injections; Opioid/administration & dosage; Spinal; Biological Markers/cerebrospinal fluid; Morphine/administration & dosage; Opioid Peptides/cerebrospinal fluid; Pain Measurement/drug effects/methods; Pain/cerebrospinal fluid/diagnosis/drug therapy Creator An entity primarily responsible for making the resource Raffaeli W; Samolsky DBG; Landuzzi D; Caminiti A; Righetti D; Balestri M; Montanari F; Romualdi P; Candeletti S Description An account of the resource The neuropeptide nociceptin/orphanin FQ (N/OFQ) is the endogenous ligand for the opioid-like receptor ORL-1 and is thought to be involved in pain transmission and modulation. Human studies have not yet defined its role in pain patients. The aims of this study were 1) to verify the presence of N/OFQ in the cerebrospinal fluid (CSF) of human controls and patients with chronic noncancer pain, including those treated with intrathecally administered morphine, and 2) to determine whether pain or treatment with long-term intrathecal morphine influences its levels. The CSF of 27 patients (nine controls and 18 with chronic noncancer pain, of whom 12 were treated chronically with intrathecally administered morphine and six were opioid naive) was analyzed, blindly, with radioimmunoassay methods. N/OFQ was detected in all patients. Mean CSF concentrations were lowest in the morphine-treated group and highest in the untreated chronic pain patients (12.06+/-1.19 and 57.41+/-10.06 fmol/ml, respectively), and the difference between the morphine-treated group and controls was statistically significant (44.72+/-13.56 fmol/ml, P<0.05). The presence of N/OFQ peptide in human CSF may correlate with biological activities that are influenced by different pain states and long-term intrathecal-morphine treatment. Further studies should verify whether the determination of this peptide CSF level may provide information on opioid treatment efficacy and on the presence of opioid tolerance. 2006 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/j.jpainsymman.2006.05.013" target="_blank" rel="noreferrer">10.1016/j.jpainsymman.2006.05.013</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2006 Aged Analgesics Backlog Balestri M Biological Markers/cerebrospinal fluid Caminiti A Candeletti S Chronic Disease Female Humans Injections Journal Article Journal of Pain and Symptom Management Landuzzi D Male Middle Aged Montanari F Morphine/administration & dosage Opioid Peptides/cerebrospinal fluid Opioid/administration & dosage Pain Measurement/drug effects/methods Pain/cerebrospinal fluid/diagnosis/drug therapy Raffaeli W Righetti D Romualdi P Samolsky DBG Spinal