1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1016/s0049-0172(98)80014-0" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0049-0172(98)80014-0</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A possible role for saliva as a diagnostic fluid in patients with chronic pain Publisher An entity responsible for making the resource available Seminars In Arthritis And Rheumatism Date A point or period of time associated with an event in the lifecycle of the resource 1998 Subject The topic of the resource Female; Humans; Male; Animals; Arthritis; Chronic disease; Biomarkers of Pain; Fibromyalgia/diagnosis/metabolism; Neuropeptides/diagnostic use/metabolism; Osteoarthritis/diagnosis/metabolism; Pain/diagnosis/metabolism; Rheumatoid/diagnosis/metabolism; Saliva; Salivary Proteins/diagnostic use/metabolism; Serotonin/diagnostic use/metabolism; Specimen Handling/methods/standards Creator An entity primarily responsible for making the resource Fischer HP; Eich W; Russell IJ Description An account of the resource OBJECTIVES: The focus of this review was on proteins and peptides found in saliva. Of greatest interest were those neuropeptides relevant to nociception and to the pathogenesis of chronic pain syndromes. An additional goal was to develop a standardized protocol to collect saliva for laboratory assessment. METHODS: Data were obtained through discussion with experts at the medical schools in San Antonio and Heidelberg and a Medline literature search involving all relevant studies from 1966 to 1997. The literature search was based on the following key terms: saliva, serotonin, neuropeptide, substance P (SP), calcitonin gene-related peptide (CGRP), and nerve growth factor (NGF). RESULTS: The mean concentration of SP in the saliva of healthy normal controls ranged from 9.6 to 220 pg/mL. Generally, the concentration of SP was approximately three times higher in saliva than in plasma. In a number of painful conditions, particularly tension headache, substantial elevations of salivary SP were found. Mean values for salivary CGRP in healthy controls were approximately 22 pmol/L and were significantly elevated in patients with migraine attacks or cluster headache. There were no data to indicate prior quantitative determination of NGF in human saliva. CONCLUSIONS: After sampling and processing techniques have been standardized, measurement of neuropeptides in human saliva could provide a valuable tool for study of patients with chronic painful disorders such as rheumatoid arthritis, osteoarthritis, and even fibromyalgia syndrome. 1998 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/s0049-0172(98)80014-0" target="_blank" rel="noreferrer">10.1016/s0049-0172(98)80014-0</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 1998 Animals Arthritis Backlog Biomarkers of Pain Chronic Disease Eich W Female Fibromyalgia/diagnosis/metabolism Fischer HP Humans Journal Article Male Neuropeptides/diagnostic use/metabolism Osteoarthritis/diagnosis/metabolism Pain/diagnosis/metabolism Rheumatoid/diagnosis/metabolism Russell IJ Saliva Salivary Proteins/diagnostic use/metabolism Seminars In Arthritis And Rheumatism Serotonin/diagnostic use/metabolism Specimen Handling/methods/standards