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Text
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<a href="http://doi.org/10.1016/j.jneumeth.2008.10.013" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jneumeth.2008.10.013</a>
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Title
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Beta-Endorphin Response to an Acute Pain Stimulus
Publisher
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Journal Of Neuroscience Methods
Date
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2009
Subject
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Male; Pain Measurement; Time Factors; Reproducibility of Results; Animals; Mice; Acute Disease; Biomarkers of Pain; Physical Stimulation; Animal; beta-Endorphin/analysis/metabolism/secretion; Biological Markers/analysis/blood; Disease Models; Inbred DBA; Neurochemistry/methods; Pain/blood/physiopathology; Radioimmunoassay/methods; Up-Regulation/physiology
Creator
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Rasmussen NA; Farr LA
Identifier
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<a href="http://doi.org/10.1016/j.jneumeth.2008.10.013" target="_blank" rel="noreferrer noopener">10.1016/j.jneumeth.2008.10.013</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
Description
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The timing of the measurement of biological samples (e.g. biomarkers) is not always standardized. Biomarkers are the focus of many recent studies and treatments. The purpose of this study was to determine the timing of the release of beta-endorphin (BE), a possible biomarker, after exposure to pain and/or handling stress in order to standardize measurements. Mouse plasma was collected for BE analysis following handling i.e. being picked up by the investigator, exposure to a painful (55 degrees C hot-plate), or exposure to a nonpainful stimulus (room temperature hot-plate). The groups exposed to either a painful or nonpainful stimulus released BE in response to the stimulus, but the duration of the response was longer in mice exposed to a painful stimulus than in mice exposed to a nonpainful stimulus. The BE in the mice exposed to a nonpainful stimulus peaked at 1 min and returned to baseline levels by 5 min while the BE response of the mice exposed to a painful stimulus peaked at 10 min and remained elevated for 25 min. The results of this study indicate that BE can be a biomarker for pain and handling stress, however, the timing of the measurement should differ.
2009
Acute Disease
Animal
Animals
Backlog
beta-Endorphin/analysis/metabolism/secretion
Biological Markers/analysis/blood
Biomarkers of Pain
Disease Models
Farr LA
Inbred DBA
Journal Article
Journal Of Neuroscience Methods
Male
Mice
Neurochemistry/methods
Pain Measurement
Pain/blood/physiopathology
Physical Stimulation
Radioimmunoassay/methods
Rasmussen NA
Reproducibility of Results
Time Factors
Up-Regulation/physiology