Childhood idiopathic thrombocytopenic purpura in the Nordic countries: epidemiology and predictors of chronic disease
Child; Female; Humans; infant; Male; Prognosis; Prospective Studies; Risk Factors; Incidence; adolescent; Preschool; infant; Newborn; Nonparametric; Statistics; Purpura; Thrombocytopenic; Chronic Disease/epidemiology; Finland/epidemiology; Scandinavia/epidemiology; Acute Disease/epidemiology; Hemorrhage/epidemiology/etiology; Iceland/epidemiology; Idiopathic/complications/diagnosis/epidemiology
AIM: To describe the epidemiology of idiopathic thrombocytopenic purpura (ITP) in the Nordic countries, to define clinical subgroups and to investigate factors predicting chronic disease. METHODS: A prospective registration was done from 1998 to 2000, including all children with newly diagnosed ITP aged 0-14 y and at least one platelet count <30 x 10(9)/l. RESULTS: 506 children were registered and 423 followed for 6 mo. The incidence was 4.8/10(5) per year. Most children were aged 0-7 y (78%), with a predominance of boys, while patients aged 8-14 y had equal representation of the two sexes. There were seasonal variations determined by variations in postinfectious cases with sudden onset. The platelet count was <10 x 10(9)/l in 58%, but bleeding manifestations were mild or moderate in 97%. The insidious form (symptoms for more than 2 wk) was more frequent in older children and girls, showed little seasonal variation, had milder manifestations and ran a chronic course in more than half the cases. Intracranial haemorrhages did not occur in the first 6 mo after diagnosis. Chronic ITP developed in 25%. The strongest predictor of chronic disease was insidious onset of symptoms (OR 5.97). CONCLUSION: In the Nordic countries, ITP mainly affects children aged 0-7 y, with a winter bulk of postinfectious cases superimposed on a steady occurrence of non-infectious cases. Clinically, it may be useful to distinguish between children with sudden versus insidious onset of symptoms rather than between different age groups.
2005
Zeller B; Rajantie J; Hedlund-Treutiger I; Tedgard U; Wesenberg F; Jonsson OG; Henter JI; NOPHO ITP
Acta Paediatrica
2005
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1111/j.1651-2227.2005.tb01887.x" target="_blank" rel="noreferrer">10.1111/j.1651-2227.2005.tb01887.x</a>
Duration and morbidity of newly diagnosed idiopathic thrombocytopenic purpura in children: A prospective Nordic study of an unselected cohort
Child; Female; Humans; infant; Male; Cohort Studies; Prospective Studies; Severity of Illness Index; Risk Assessment; Time Factors; adolescent; Preschool; infant; Newborn; Platelet Count; Purpura; Thrombocytopenic; Hemorrhage/diagnosis/etiology/therapy; Idiopathic/complications/diagnosis/therapy; Scandinavia
OBJECTIVE: To determine the duration of the risk period with platelet counts 1 month and 25 had 30 events. Among 93 patients with chronic ITP, 73 were at risk >1 month and 44 had 111 events. Events occurred with an average frequency of 0.39 per month at risk. Life-threatening hemorrhages did not occur in the first six months after diagnosis. CONCLUSION: Most children with ITP are at risk for serious bleeding for less than one month. Continuing severe thrombocytopenia is associated with little morbidity, bleeding episodes being infrequent and very rarely serious.
2003
Rosthoj S; Hedlund-Treutiger I; Rajantie J; Zeller B; Jonsson OG; Elinder G; Wesenberg F; Henter JI; NOPHOITP Working Group
The Journal Of Pediatrics
2003
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1067/s0022-3476(03)00245-2" target="_blank" rel="noreferrer">10.1067/s0022-3476(03)00245-2</a>