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Text
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<a href="http://doi.org/10.1016/j.jpainsymman.2006.05.013" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.jpainsymman.2006.05.013</a>
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Title
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Nociceptin levels in the cerebrospinal fluid of chronic pain patients with or without intrathecal administration of morphine
Publisher
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Journal Of Pain And Symptom Management
Date
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2006
Subject
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Female; Humans; Male; Analgesics; Aged; Middle Aged; Chronic disease; Injections; Opioid/administration & dosage; Spinal; Biological Markers/cerebrospinal fluid; Morphine/administration & dosage; Opioid Peptides/cerebrospinal fluid; Pain Measurement/drug effects/methods; Pain/cerebrospinal fluid/diagnosis/drug therapy
Creator
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Raffaeli W; Samolsky DBG; Landuzzi D; Caminiti A; Righetti D; Balestri M; Montanari F; Romualdi P; Candeletti S
Description
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The neuropeptide nociceptin/orphanin FQ (N/OFQ) is the endogenous ligand for the opioid-like receptor ORL-1 and is thought to be involved in pain transmission and modulation. Human studies have not yet defined its role in pain patients. The aims of this study were 1) to verify the presence of N/OFQ in the cerebrospinal fluid (CSF) of human controls and patients with chronic noncancer pain, including those treated with intrathecally administered morphine, and 2) to determine whether pain or treatment with long-term intrathecal morphine influences its levels. The CSF of 27 patients (nine controls and 18 with chronic noncancer pain, of whom 12 were treated chronically with intrathecally administered morphine and six were opioid naive) was analyzed, blindly, with radioimmunoassay methods. N/OFQ was detected in all patients. Mean CSF concentrations were lowest in the morphine-treated group and highest in the untreated chronic pain patients (12.06+/-1.19 and 57.41+/-10.06 fmol/ml, respectively), and the difference between the morphine-treated group and controls was statistically significant (44.72+/-13.56 fmol/ml, P<0.05). The presence of N/OFQ peptide in human CSF may correlate with biological activities that are influenced by different pain states and long-term intrathecal-morphine treatment. Further studies should verify whether the determination of this peptide CSF level may provide information on opioid treatment efficacy and on the presence of opioid tolerance.
2006
Identifier
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<a href="http://doi.org/10.1016/j.jpainsymman.2006.05.013" target="_blank" rel="noreferrer">10.1016/j.jpainsymman.2006.05.013</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
2006
Aged
Analgesics
Backlog
Balestri M
Biological Markers/cerebrospinal fluid
Caminiti A
Candeletti S
Chronic Disease
Female
Humans
Injections
Journal Article
Journal of Pain and Symptom Management
Landuzzi D
Male
Middle Aged
Montanari F
Morphine/administration & dosage
Opioid Peptides/cerebrospinal fluid
Opioid/administration & dosage
Pain Measurement/drug effects/methods
Pain/cerebrospinal fluid/diagnosis/drug therapy
Raffaeli W
Righetti D
Romualdi P
Samolsky DBG
Spinal