Proxy assessment of quality of life in pediatric clinical trials: application of the Health Utilities Index 3
symptoms; U.S. Gov't; PedPal Lit; Extramural Research Support; N.I.H.; Non-U.S. Gov't Research Support; Adolescent ChildClinical Trials Female Health Status Humans Leukemia/drug therapy/physiopathology/psychology MalePediatricsProxy Quality of Life/psychology Research Support; domains specific and sensitive to both disease and treatment; P.H.S.Sickness Impact Profile%X BACKGROUND: With increased cure rates; pediatric oncology protocols increasingly seek to document the impact of treatment on patients' disease; the proxy respondents evaluated the ease of use of the instrument and the data quality. RESULTS: As patients' health status declined
2005
Cox CL; Lensing S; Rai SN; Hinds P; Burghen E; Pui CH
Quality of Life Research
2005
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1007/s11136-004-4714-y" target="_blank" rel="noreferrer">10.1007/s11136-004-4714-y</a>
Quality of life as conveyed by pediatric patients with cancer
adolescent; U.S. Gov't; PedPal Lit; Non-U.S. Gov't Research Support; psychology Questionnaires Research Support; Adolescent Psychology Cancer Care Facilities Child; Child Psychology Female Humans Interviews Male Neoplasms/physiopathology/; methods Quality of Life/; P.H.S. Self Assessment (Psychology); psychology/therapy Pediatrics Pilot Projects Psychometrics/instrumentation/; Sickness Impact Profile Tennessee; the domain most frequently missing was the meaning of being ill domain. Here we present a new definition of the quality of life of pediatric oncology patients that is based on six domains; this definition may ensure the completeness and sensitivity of these important instruments.
2004
Hinds PS; Gattuso JS; Fletcher A; Baker E; Coleman B; Jackson T; Jacobs-Levine A; June D; Rai SN; Lensing S; Pui CH
Quality of Life Research
2004
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1023/b:qure.0000021697.43165.87" target="_blank" rel="noreferrer">10.1023/b:qure.0000021697.43165.87</a>
Challenging issues in pediatric oncology
Improvements in protocol-driven clinical trials and supportive care for children and adolescents with cancer have reduced mortality rates by more than 50% over the past three decades. Overall, the 5-year survival rate for patients with pediatric cancer has increased to approximately 80%. Recognition of the biological heterogeneity within specific subtypes of cancer, the discovery of genetic lesions that drive malignant transformation and cancer progression, and improved understanding of the basis of drug resistance will undoubtedly catalyze further advances in risk-directed treatments and the development of targeted therapies, boosting the cure rates further. Emerging new treatments include novel formulations of existing chemotherapeutic agents, monoclonal antibodies against cancer-associated antigens, and molecular therapies that target genetic lesions and their associated signaling pathways. Recent findings that link pharmacogenomic variations with drug exposure, adverse effects, and efficacy should accelerate efforts to develop personalized therapy for individual patients. Finally, palliative care should be included as an essential part of cancer management to prevent and relieve the suffering and to improve the quality of life of patients and their families.
Pui CH; Gajjar A; Kane JR; Qaddoumi IA; Pappo AS; Medscape
Nature Reviews Clinical Oncology
2011
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1038/nrclinonc.2011.95" target="_blank" rel="noreferrer">10.1038/nrclinonc.2011.95</a>