1
40
3
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1038/nm1208-1313" target="_blank" rel="noreferrer">http://doi.org/10.1038/nm1208-1313</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Breaking the pain connection
Publisher
An entity responsible for making the resource available
Nature Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
Subject
The topic of the resource
Animals; Protein Binding; Receptors; N-Methyl-D-Aspartate/genetics/metabolism; Pain/drug therapy/genetics/metabolism; Peptides/therapeutic use; Signal Transduction/drug effects; src-Family Kinases/genetics/metabolism
Creator
An entity primarily responsible for making the resource
Pallen CJ
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/nm1208-1313" target="_blank" rel="noreferrer">10.1038/nm1208-1313</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
2008
2008
Animals
Backlog
Journal Article
N-Methyl-D-Aspartate/genetics/metabolism
Nature Medicine
Pain/drug therapy/genetics/metabolism
Pallen CJ
Peptides/therapeutic use
Protein Binding
Receptors
Signal Transduction/drug effects
src-Family Kinases/genetics/metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1038/sj.tpj.6500418" target="_blank" rel="noreferrer">http://doi.org/10.1038/sj.tpj.6500418</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
No evidence for binding of clozapine, olanzapine and/or haloperidol to selected receptors involved in body weight regulation.
Publisher
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Pharmacogenomics Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
Subject
The topic of the resource
Humans; Animals; Protein Binding; IM; Receptors; Antipsychotic Agents/me [Metabolism]; Antipsychotic Agents/pd [Pharmacology]; Benzodiazepines/me [Metabolism]; Benzodiazepines/pd [Pharmacology]; Body Weight/de [Drug Effects]; Cell Surface/me [Metabolism]; Clozapine/me [Metabolism]; Clozapine/pd [Pharmacology]; Haloperidol/me [Metabolism]; Haloperidol/pd [Pharmacology]; Radioligand Assay
Creator
An entity primarily responsible for making the resource
Theisen FM; Haberhausen M; Firnges MA; Gregory P; Reinders JH; Remschmidt H; Hebebrand J; Antel J
Description
An account of the resource
The underlying mechanisms of antipsychotic (AP)-induced weight gain are unknown, but both central and peripheral AP target receptors could potentially be involved. This study used radioligand binding assays to compare the binding affinities of clozapine, olanzapine and haloperidol for candidate receptors potentially involved in AP-induced weight gain. Selected candidates derived from known pathways involved in body weight regulation included receptors classified as anorexigenic (bombesin receptor subtype 3, calcitonin gene-related peptide receptor, cholecystokinin receptor, melanocortin-4 receptor, neurotensin receptor 1) or orexigenic (cannabinoid receptor 1, galanin 1 receptor, melanin-concentrating hormone receptor (MCHR), neuropeptide Y1 receptor) as well as receptors involved in physiological actions related to digestion and fluid homeostasis (angiotensin II type 1 receptor, bradykinin B2 receptor, endothelin receptor, neurokinin 1 receptor, vasoactive intestinal polypeptide receptor 1). Clozapine, olanzapine and haloperidol exhibited negligible affinities to all of these receptors except for the MCHR (Ki=501 nM; haloperidol). With respect to other candidates from (neuro)transmitter systems already suggested to be involved in AP-induced weight gain, the binding profile of olanzapine resembled that of clozapine, with high affinity (Ki<10 nM) for serotonin (5-HT) 5-HT2A, 5-HT2C and 5-HT6, muscarinic M1 and histamine H1 receptors. In contrast, the binding profile of haloperidol was substantially different (high affinity only for the dopamine D1 receptor). In conclusion, we have not identified a novel binding site of the two investigated atypical AP that could contribute to the induced weight gain.
2007
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/sj.tpj.6500418" target="_blank" rel="noreferrer">10.1038/sj.tpj.6500418</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2007
Animals
Antel J
Antipsychotic Agents/me [Metabolism]
Antipsychotic Agents/pd [Pharmacology]
Backlog
Benzodiazepines/me [Metabolism]
Benzodiazepines/pd [Pharmacology]
Body Weight/de [Drug Effects]
Cell Surface/me [Metabolism]
Clozapine/me [Metabolism]
Clozapine/pd [Pharmacology]
Firnges MA
Gregory P
Haberhausen M
Haloperidol/me [Metabolism]
Haloperidol/pd [Pharmacology]
Hebebrand J
Humans
IM
Journal Article
Pharmacogenomics Journal
Protein Binding
Radioligand Assay
Receptors
Reinders JH
Remschmidt H
Theisen FM
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/8756-3282(95)00445-9" target="_blank" rel="noreferrer">http://doi.org/10.1016/8756-3282(95)00445-9</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bisphosphonates: a review of their pharmacokinetic properties
Publisher
An entity responsible for making the resource available
Bone
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
Subject
The topic of the resource
Humans; Animals; Protein Binding; Dose-Response Relationship; Drug; Clodronate; Structure-Activity Relationship; Biological Availability; Blood Proteins/metabolism; Diphosphonates/pharmacokinetics/urine; Intestinal Absorption/physiology; Tissue Distribution/physiology
Creator
An entity primarily responsible for making the resource
Lin JH
Description
An account of the resource
Bisphosphonates are a unique class of drugs. As a family, they are characterized pharmacologically by their ability to inhibit bone resorption, whereas, pharmacokinetically, they are classified by their similarity in absorption, distribution, and elimination. Although all bisphosphonates have similar physicochemical properties, their antiresorbing activities differ substantially. Activity is dramatically increased when the amino group is contained in the aliphatic carbon chain. For example, alendronate, an aminobisphosphonate, is approximately 700-fold more potent than etidronate, both in vitro and in vivo. In general, bisphosphonates are poorly absorbed from the gastrointestinal tract as a result of their poor lipophilicity. In vitro and in vivo studies have shown that bisphosphonates are absorbed from the gastrointestinal tract via paracellular transport. Systemically available bisphosphonates disappear very rapidly from plasma, and are partly taken up by the bone and partly excreted by the kidney. The relative contribution of these two processes to overall plasma elimination differs significantly among bisphosphonates. To date, all bisphosphonates studied show no evidence of metabolism. Renal excretion is the only route of elimination. Studies with alendronate in rats indicate that the drug is actively secreted by an uncharacterized renal transport system, and not by the anionic or cationic renal transport systems. Bisphosphonates bind preferentially to bones which have high turnover rates, and their distribution in bone is not homogeneous. After bone uptake, the bisphosphonates are liberated again only when the bone in which they are deposited is resorbed. Thus, the half-life of bisphosphonates in bone is very long, ranging among different species from 1 to 10 years, depending largely on the rate of bone turnover.
1996
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/8756-3282(95)00445-9" target="_blank" rel="noreferrer">10.1016/8756-3282(95)00445-9</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1996
Animals
Backlog
Biological Availability
Blood Proteins/metabolism
Bone
Clodronate
Diphosphonates/pharmacokinetics/urine
Dose-Response Relationship
Drug
Humans
Intestinal Absorption/physiology
Journal Article
Lin JH
Protein Binding
Structure-Activity Relationship
Tissue Distribution/physiology