1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1001/jama.283.6.756" target="_blank" rel="noreferrer">http://doi.org/10.1001/jama.283.6.756</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Outcome at age 4 years in offspring of women with maternal phenylketonuria: the Maternal PKU Collaborative Study
Publisher
An entity responsible for making the resource available
Jama
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
Subject
The topic of the resource
Child; Female; Humans; Male; Pregnancy; Logistic Models; Pregnancy Outcome; Longitudinal Studies; Cognition; Developmental Disabilities; Child Behavior; Preschool; AIM; IM; Developmental Disabilities/di [Diagnosis]; Developmental Disabilities/et [Etiology]; Phenylketonurias/dh [Diet Therapy]; Phenylketonurias/pp [Physiopathology]; Pregnancy Complications/dh [Diet Therapy]; Psychological Tests
Creator
An entity primarily responsible for making the resource
Waisbren SE; Hanley W; Levy HL; Shifrin H; Allred E; Azen C; Chang PN; Cipcic-Schmidt S; de la Cruz F; Hall R; Matalon R; Nanson J; Rouse B; Trefz F; Koch R
Description
An account of the resource
CONTEXT: Untreated maternal phenylketonuria (PKU) increases risk for developmental problems in offspring. The extent to which this risk is reduced by maternal dietary therapy at various stages of pregnancy is not known. OBJECTIVE: To determine whether dietary treatment during pregnancy of women with PKU affects developmental outcomes of offspring. DESIGN: The Maternal PKU Collaborative Study, an ongoing, longitudinal prospective study begun in 1984. SETTING: A total of 78 metabolic clinics and obstetrical offices in the United States, Canada, and Germany. PARTICIPANTS: A total of 253 children of women with PKU (n = 149), with untreated mild hyperphenylalaninemia (n = 33), or without known metabolic problems (comparison group; n = 71) were followed up to age 4 years. INTERVENTION: Women with PKU were offered a low-phenylalanine diet prior to or during pregnancy with the aim of maintaining metabolic control (plasma phenylalanine < or =10 mg/dL [< or =605 micromol/L]). Women with mild hyperphenylalaninemia, who had plasma phenylalanine levels of no more than 10 mg/dL (605 micromol/L) on a normal diet, were not treated. MAIN OUTCOME MEASURES: Children's scores on cognitive and behavioral assessments (McCarthy Scales of Children's Abilities, Test of Language Development, Achenbach Child Behavior Checklist, Vineland Adaptive Behavior Scales, and Home Observation for Measurement of the Environment), compared by maternal metabolic status at 0 to 10 weeks', 10 to 20 weeks', and after 20 weeks' gestation. RESULTS: Scores on the McCarthy General Cognitive Index decreased as weeks to metabolic control increased (r = -0.58; P<.001). Offspring of women who had metabolic control prior to pregnancy had a mean (SD) score of 99 (13). Forty-seven percent of offspring whose mothers did not have metabolic control by 20 weeks' gestation had a General Cognitive Index score 2 SDs below the norm. Overall, 30% of children born to mothers with PKU had social and behavioral problems. CONCLUSIONS: Our data suggest that delayed development in offspring of women with PKU is associated with lack of maternal metabolic control prior to or early in pregnancy. Treatment at any time during pregnancy may reduce the severity of delay.
2000
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1001/jama.283.6.756" target="_blank" rel="noreferrer">10.1001/jama.283.6.756</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2000
AIM
Allred E
Azen C
Backlog
Chang PN
Child
Child Behavior
Cipcic-Schmidt S
Cognition
de la Cruz F
Developmental Disabilities
Developmental Disabilities/di [Diagnosis]
Developmental Disabilities/et [Etiology]
Female
Hall R
Hanley W
Humans
IM
JAMA
Journal Article
Koch R
Levy HL
Logistic Models
Longitudinal Studies
Male
Matalon R
Nanson J
Phenylketonurias/dh [Diet Therapy]
Phenylketonurias/pp [Physiopathology]
Pregnancy
Pregnancy Complications/dh [Diet Therapy]
Pregnancy Outcome
Preschool
Psychological Tests
Rouse B
Shifrin H
Trefz F
Waisbren SE
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
March 2017 List
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Antenatal Palliative Care Consultation: Implications For Decision-making And Perinatal Outcomes In A Single-centre Experience
Publisher
An entity responsible for making the resource available
Archives Of Disease In Childhood. Fetal And Neonatal Edition
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
Subject
The topic of the resource
Decision Making; Adult; Female; Follow-up Studies; Humans; Infant Newborn; Male; Palliative Care/methods; Pregnancy; Pregnancy Outcome; Prenatal Care/methods; Referral And Consultation/organization & Administration; Retrospective Studies; Young Adult
Creator
An entity primarily responsible for making the resource
Kukora S; Gollehon N; Laventhal N
Description
An account of the resource
BACKGROUND: Some pregnant patients with complex fetal anomalies meet with paediatric palliative care subspecialists prior to delivery, but referral to antenatal palliative care consultation (APCC) is not standard. Little is known about its role in perinatal decision-making. METHODS: A single-centre retrospective cohort study was undertaken for patients referred for outpatient antenatal counselling by a neonatologist over a two-and-half-year period. Patients also receiving APCC were compared with infants with similar prognoses who did not. Outcomes assessed included antenatal decision-making, obstetric and neonatal outcomes. RESULTS: 24 (17%) of the 144 referred fetuses received APCC; nearly all had been given the prognoses of 'non-survivable' or 'uncertain, likely poor'. Fetal or neonatal outcome included: fetal demise 5 (21%), in-hospital death 16 (67%) and survival to discharge (DC) 3(12%). 24 fetuses with similarly poor prognoses were not referred, but had similar outcomes: fetal demise 5 (21%), in-hospital death 16 (67%) and survival to DC 3 (12%). Those with APCC were more likely to choose comfort care than those without (67% vs 17%, p<0.01) and those who died in hospital had a shorter time to death than those who did not receive APCC. Less racial diversity was noted in the group receiving APCC. Infants with identified/suspected genetic syndromes were more likely to receive consultation despite similar mortality to the remaining cohort. CONCLUSIONS: Long-term outcomes with and without APCC were similar for infants with poor prognoses, though non-survivors with APCC were more likely to have a comfort care plan and shorter time to in-hospital death.
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Adult
Archives of Disease in Childhood. Fetal and Neonatal Edition
Decision Making
Female
Follow-up Studies
Gollehon N
Humans
Infant Newborn
Kukora S
Laventhal N
Male
March 2017 List
Palliative Care/methods
Pregnancy
Pregnancy Outcome
Prenatal Care/methods
Referral And Consultation/organization & Administration
Retrospective Studies
Young Adult