Canadian surveillance study of complex regional pain syndrome in children
Complex Regional Pain Syndrome; Incidence; Pain Management; Pediatrics; Population Surveillance
This study describes the minimum incidence of pediatric complex regional pain syndrome (CRPS), clinical features, and treatments recommended by pediatricians and pain clinics in Canada. Participants in the Canadian Paediatric Surveillance Program (CPSP) reported new cases of CRPS aged 2-18 years monthly and completed a detailed case reporting questionnaire from September 2017 to August 2019. Descriptive analysis was completed and the annual incidence of CRPS by sex and age groupings was estimated. A total of 198 cases were reported to CPSP, 168 (84.8%) met the case definition. The minimum Canadian incidence of CRPS is estimated at 1.14/100 000 (95% CI 0.93 to 1.35/100 000) children per year. Incidence was highest among females 12 years and older (3.10, 95% CI 2.76 to 3.44/100 000). Mean age of CRPS diagnosis was 12.2 years (SD=2.4) with mean time from symptom onset to diagnosis of 5.6 months (SD=9.9) and no known inciting event for 19.6% of cases. The majority of cases had lower limb involvement (79.8%). Nonsteroidal anti-inflammatory drugs (82.7%) and acetaminophen (66.0%) were prescribed more commonly than antiepileptic drugs (52.3%) and antidepressants (32.0%). Referrals most commonly included physical therapy (83.3%) and multidisciplinary pain clinics (72.6%); a small number of patients withdrew from treatment due to pain exacerbation (5.3%). Pain education was recommended for only 65.6% of cases. Treatment variability highlights the need for empiric data to support treatment of pediatric CRPS and development of treatment consensus guidelines.
Baerg KL; Tupper SM; Chu LM; Cooke N; Dick BD; Doré-Bergeron MJ; Findlay S; Ingelmo PM; Lamontagne C; Mesaroli G; Oberlander T; Poolacherla R; Spencer AO; Stinson J; Finley GA
PAIN
2021
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1097/j.pain.0000000000002482" target="_blank" rel="noreferrer noopener">10.1097/j.pain.0000000000002482</a>
Early mortality in children with acute lymphoblastic leukemia in a developing country: the role of malnutrition at diagnosis. A multicenter cohort MIGICCL study
Age Factors; Male; Infant Newborn; Comorbidity; Proportional Hazards Models; children; Child; Humans; Adolescent; Prevalence; Socioeconomic Factors; Female; Child Preschool; Infant; mortality; Developing Countries; Population Surveillance; Remission Induction; prognosis; Leukemia; Body Weights and Measures; malnutrition; Malnutrition/diagnosis/epidemiology; Mexico/epidemiology; Precursor Cell Lymphoblastic Leukemia-Lymphoma/epidemiology/ mortality/therapy
Martin-Trejo JA; Nunez-Enriquez JC; Fajardo-Gutierrez A; Medina-Sanson A; Flores-Lujano J; Jimenez-Hernandez E; Amador-Sanchez R; Penaloza-Gonzalez JG; Alvarez-Rodriguez FJ; Bolea-Murga V; Espinosa-Elizondo RM; de Diego Flores-Chapa J; Perez-Saldivar ML; Rodriguez-Zepeda MD; Dorantes-Acosta EM; Nunez-Villegas NN; Velazquez-Avina MM; Torres-Nava JR; Reyes-Zepeda NC; Gonzalez-Bonilla CR; Flores-Villegas LV; Rangel-Lopez A; Rivera-Luna R; Paredes-Aguilera R; Cardenas-Cardos R; Martinez-Avalos A; Gil-Hernandez AE; Duarte-Rodriguez DA; Mejia-Arangure JM
Leukemia & Lymphoma
2017
<a href="http://doi.org/10.1080/10428194.2016.1219904" target="_blank" rel="noreferrer noopener">10.1080/10428194.2016.1219904</a>
Canadian cancer statistics at a glance: cancer in children
Child; Humans; infant; Survival Rate; Incidence; Population Surveillance; adolescent; Preschool; infant; Newborn; Canada/epidemiology; Neoplasms/diagnosis/epidemiology/mortality
2009
Ellison LF; De P; Mery LS; Grundy PE; Canadian Cancer Society's Steering Committee for Canadian Cancer Statistics
Canadian Medical Association Journal
2009
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1503/cmaj.081155" target="_blank" rel="noreferrer">10.1503/cmaj.081155</a>
Mortality in parents after death of a child in Denmark: A nationwide follow-up study.
Child; Female; Humans; Male; Adult; Follow-Up Studies; Death; Health Status; Longitudinal Studies; Risk Factors; Life Change Events; Time Factors; Incidence; Proportional Hazards Models; Registries; Population Surveillance; adolescent; Preschool; bereavement; infant; cause of death; Denmark/epidemiology; Parents/psychology; Sex Distribution; mortality; SSHRC CURA
BACKGROUND: Little is known about the effect of parental bereavement on physical health. We investigated whether the death of a child increased mortality in parents. METHODS: We undertook a follow-up study based on national registers. From 1980 to 1996, we enrolled 21062 parents in Denmark who had a child who had died (exposed cohort), and 293745 controls--ie, parents whose children were alive, and whose family structure matched that of the exposed cohort. Natural deaths were defined with ICD8 codes 0000-7969 and ICD10 codes A00-R99, and unnatural deaths with codes 8000-9999 and V01-Y98. We used Cox's proportional-hazards regression models to assess the mortality rate of parents up to 18 years after bereavement. FINDINGS: We observed an increased overall mortality rate in mothers whose child had died (hazards ratio 1.43, 95% CI 1.24-1.64; p<0.0001). An excess mortality from natural causes (1.44, 1.15-1.78; p<0.0001) was noted in mothers only during the 10th-18th year of follow-up. Mothers had increased mortality rates from unnatural causes throughout follow-up, with the highest rate recorded during the first 3 years (3.84, 2.48-5.88; p<0.0001). Bereaved fathers had only an early excess mortality from unnatural causes (1.57, 1.06-2.32; p=0.04). Mothers who lost a child due to an unnatural death or an unexpected death had a hazard ratio of 1.72 (1.38-2.15; p=0.0040) and 1.67 (1.37-2.03; p=0.0037), respectively. INTERPRETATION: The death of a child is associated with an overall increased mortality from both natural and unnatural causes in mothers, and an early increased mortality from unnatural causes in fathers.
2003
Li J; Precht DH; Mortensen PB; Olsen J
Lancet
2003
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1016/s0140-6736(03)12387-2" target="_blank" rel="noreferrer">10.1016/s0140-6736(03)12387-2</a>
Retrospective cross-sectional review of survival rates in critically ill children admitted to a combined paediatric/neonatal intensive care unit in Johannesburg, South Africa, 2013-2015
Intensive Care Units Neonatal; Birth Weight; cause of death; Child; Critical Illness/ mortality; Cross-Sectional Studies; Female; Health services administration & management; Hospitalization/ statistics & numerical data; Humans; infant; Infant Newborn; Infant Newborn Diseases/ mortality; Infant Very Low Birth Weight; Male; Neonatology; Patient Discharge/ statistics & numerical data; Population Surveillance; retrospective studies; Risk Factors; South Africa/epidemiology; Survival Rate/ trends
OBJECTIVE: Report on survival to discharge of children in a combined paediatric/neonatal intensive care unit (PNICU). DESIGN AND SETTING: Retrospective cross-sectional record review. PARTICIPANTS: All children (medical and surgical patients) admitted to PNICU between 1 January 2013 and 30 June 2015. OUTCOME MEASURES: Primary outcome-survival to discharge. Secondary outcomes-disease profiles and predictors of mortality in different age categories. RESULTS: There were 1454 admissions, 182 missing records, leaving 1272 admissions for review. Overall mortality rate was 25.7% (327/1272). Mortality rate was 41.4% (121/292) (95% CI 35.8% to 47.1%) for very low birthweight (VLBW) babies, 26.6% (120/451) (95% CI 22.5% to 30.5%) for bigger babies and 16.2% (86/529) (95% CI 13.1% to 19.3%) for paediatric patients. Risk factors for a reduced chance of survival to discharge in paediatric patients included postcardiac arrest (OR 0.21, 95% CI 0.09 to 0.49), inotropic support (OR 0.085, 95% CI 0.04 to 0.17), hypernatraemia (OR 0.16, 95% CI 0.04 to 0.6), bacterial sepsis (OR 0.32, 95% CI 0.16 to 0.65) and lower respiratory tract infection (OR 0.54, 95% CI 0.30 to 0.97). Major birth defects (OR 0.44, 95% CI 0.26 to 0.74), persistent pulmonary hypertension of the new born (OR 0.44, 95% CI 0.21 to 0.91), metabolic acidosis (OR 0.23, 95% CI 0.12 to 0.74), inotropic support (OR 0.23, 95% CI 0.12 to 0.45) and congenital heart defects (OR 0.29, 95% CI 0.13 to 0.62) predicted decreased survival in bigger babies. Birth weight (OR 0.997, 95% CI 0.995 to 0.999), birth outside the hospital (OR 0.21, 95% CI 0.05 to 0.84), HIV exposure (OR 0.54, 95% CI 0.30 to 0.99), resuscitation at birth (OR 0.49, 95% CI 0.25 to 0.94), metabolic acidosis (OR 0.25, 95% CI 0.10 to 0.60) and necrotising enterocolitis (OR 0.23, 95% CI 0.12 to 0.46) predicted poor survival in VLBW babies. CONCLUSIONS: Ongoing mortality review is essential to improve provision of paediatric critical care.
Ballot DE; Davies VA; Cooper PA; Chirwa T; Argent A; Mer M
Bmj Open
2016
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1136/bmjopen-2015-010850" target="_blank" rel="noreferrer">10.1136/bmjopen-2015-010850</a>