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Text
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<a href="http://doi.org/10.1055/s-2007-989274" target="_blank" rel="noreferrer">http://doi.org/10.1055/s-2007-989274</a>
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Title
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Increase of plasmatic beta-endorphin immunoreactive material in children in the perioperative period: the influence of the site of surgery
Publisher
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European Journal Of Pediatric Surgery
Date
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2008
Subject
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Child; Female; Humans; Male; Time Factors; Linear Models; Analysis of Variance; adolescent; Preschool; Adaptation; Stress/immunology; Ambulatory Surgical Procedures/adverse effects/statistics & numerical data; beta-Endorphin/blood/immunology; Perioperative Care/statistics & numerical data; Physiological/immunology
Creator
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Bachiocco V; Mastrolia A; Gentili A; Pipitone E; Lima M
Description
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BACKGROUND: The primary aim of the study was to confirm the increase of plasmatic IR beta-endorphin material during the perioperative period in children. The second was to search for the factors responsible for this increment. METHODS: Seventy-two consecutive children undergoing a surgical procedure were recruited. Pre-anaesthesia and anaesthesia were standardised. Plasmatic IR beta-endorphin material was measured at three timepoints: at baseline (t (0)), before induction (t (1)), and at the end of anaesthesia (t (2)). Two general linear models were set up to analyse the influence of demographics and clinics on the IR beta-endorphin variation between t (0) and t (1). A third model was established to process the possible surgical factors contributing to the IR beta-endorphin variation between t (1) and t (2). RESULTS: ANOVA showed that IR beta-endorphin concentrations increased significantly across the three timepoints (p < 0.0001). Wilcoxon test proved that the difference was significant both for t (0) vs. t (1) and for t (1) vs. t (2). None of the factors taken into account in the pre-operative period influenced the increase in IR beta-endorphin between t (0) and t (1). Of the factors taken into account in the surgical period, only the type of procedure was significant (p = 0.005). The t-test showed that IR beta-endorphin significantly increased during spermatic and epigastric anastomosis (p = 0.000), orchidopexy (p = 0.02), Van der Meulen urethroplasty (p = 0.004), and Duckett urethroplasty (p = 0.003). CONCLUSION: Plasmatic beta-endorphin increases during the perioperative period in children. The site of surgery is responsible for this increment during intervention.
2008
Identifier
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<a href="http://doi.org/10.1055/s-2007-989274" target="_blank" rel="noreferrer">10.1055/s-2007-989274</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
2008
Adaptation
Adolescent
Ambulatory Surgical Procedures/adverse effects/statistics & numerical data
Analysis of Variance
Bachiocco V
Backlog
beta-Endorphin/blood/immunology
Child
European Journal Of Pediatric Surgery
Female
Gentili A
Humans
Journal Article
Lima M
Linear Models
Male
Mastrolia A
Perioperative Care/statistics & numerical data
Physiological/immunology
Pipitone E
Preschool
Stress/immunology
Time Factors