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Text
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<a href="http://doi.org/10.1016/j.jpainsymman.2004.02.021" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.jpainsymman.2004.02.021</a>
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Title
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Opioids in renal failure and dialysis patients
Publisher
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Journal Of Pain And Symptom Management
Date
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2004
Subject
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Humans; Analgesics; Pain/drug therapy; Opioid/therapeutic use; Chronic/complications/therapy; Kidney Failure; Peritoneal Dialysis
Creator
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Dean M
Description
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This article reviews the literature pertaining to the metabolism of several of the commonly used opioids, and the known activity of their metabolites. The effect of renal failure on the pharmacokinetics of these drugs and metabolites is then reviewed. Finally, the effect of renal dialysis on opioid drugs and metabolites is reviewed. Based on the review, it is recommended that morphine and codeine are avoided in renal failure/dialysis patients; hydromorphone or oxycodone are used with caution and close monitoring; and that methadone and fentanyl/sufentanil appear to be safe to use. Note is made that the "safe" drugs in renal failure are also the least dialyzable.
2004
Identifier
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<a href="http://doi.org/10.1016/j.jpainsymman.2004.02.021" target="_blank" rel="noreferrer">10.1016/j.jpainsymman.2004.02.021</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
2004
Analgesics
Backlog
Chronic/complications/therapy
Dean M
Humans
Journal Article
Journal of Pain and Symptom Management
Kidney Failure
Opioid/therapeutic use
Pain/drug Therapy
Peritoneal Dialysis