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Text
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<a href="http://doi.org/10.1016/0361-9230(93)90033-8" target="_blank" rel="noreferrer">http://doi.org/10.1016/0361-9230(93)90033-8</a>
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Title
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Pituitary-adrenal function and hypothalamic beta-endorphin release in vitro following food deprivation
Publisher
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Brain Research Bulletin
Date
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1993
Subject
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Male; Time Factors; Animals; Rats; Non-U.S. Gov't; Research Support; Body Weight; Blood Glucose/metabolism; Corticosterone/blood; In Vitro; Pituitary-Adrenal System/physiology; Adrenal Glands/physiology; beta-Endorphin/secretion; Corticotropin-Releasing Hormone/pharmacology; Dexamethasone/pharmacology; Food Deprivation; Hypothalamus/drug effects/secretion; Organ Size; Thymus Gland/physiology; Wistar
Creator
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Mitev Y; Almeida OF; Patchev V
Description
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Basal and dexamethasone-suppressed adrenal glucocorticoid secretion and hypothalamic beta-endorphin (BE) release in vitro were investigated in rats deprived of food for 24, 48, 72, and 96 h. Fasting for up to 48 h neither caused significant changes in serum corticosterone levels nor in the suppressive effect of dexamethasone. Food deprivation for 72-96 h resulted in increased basal serum corticosterone, diminished suppression by dexamethasone, and a significant involution of the thymus. Basal in vitro BE release from hypothalamic explants was significantly increased after the first day of food deprivation, and in vitro perifusion with corticotropin-releasing hormone (CRH) failed to enhance BE release further. With continuing food deprivation, basal BE release remained significantly greater than that from hypothalami originating from normally fed control rats. The stimulatory effect of CRH on BE release was only partially restored after 2 days of fasting. The results suggest that food deprivation for more than 2 days increases basal glucocorticoid secretion, and signs of impairment in hypothalamic-pituitary-adrenal regulation become apparent. These findings might be implicated in the pathogenetic mechanisms of endocrine dysregulation in diseases related to caloric reduction.
1993
Identifier
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<a href="http://doi.org/10.1016/0361-9230(93)90033-8" target="_blank" rel="noreferrer">10.1016/0361-9230(93)90033-8</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
1993
Adrenal Glands/physiology
Almeida OF
Animals
Backlog
beta-Endorphin/secretion
Blood Glucose/metabolism
Body Weight
Brain Research Bulletin
Corticosterone/blood
Corticotropin-Releasing Hormone/pharmacology
Dexamethasone/pharmacology
Food Deprivation
Hypothalamus/drug effects/secretion
In Vitro
Journal Article
Male
Mitev Y
Non-U.S. Gov't
Organ Size
Patchev V
Pituitary-Adrenal System/physiology
Rats
Research Support
Thymus Gland/physiology
Time Factors
Wistar