1 40 78 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource June 2024 List Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month June List 2024 URL Address <a href="http://doi.org/10.3390/children11040485" target="_blank" rel="noreferrer noopener"> http://doi.org/10.3390/children11040485</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Definition and Assessment of Paediatric Breakthrough Pain: A Qualitative Interview Study Publisher An entity responsible for making the resource available Children Date A point or period of time associated with an event in the lifecycle of the resource 2024 Subject The topic of the resource palliative care; pediatrics; interview; pain measurement; breakthrough pain; delivery of healthcare Creator An entity primarily responsible for making the resource Dawson E; Greenfield K; Carter B; Bailey S; Anderson AK; Rajapakse D; Renton K; Mott C; Hain R; Harrop E; Johnson M; Liossi C Description An account of the resource Infants, children and young people with life-limiting or life-threatening conditions often experience acute, transient pain episodes known as breakthrough pain. There is currently no established way to assess breakthrough pain in paediatric palliative care. Anecdotal evidence suggests that it is frequently underdiagnosed and undertreated, resulting in reduced quality of life. The development of a standardised paediatric breakthrough pain assessment, based on healthcare professionals' insights, could improve patient outcomes. This study aimed to explore how healthcare professionals define and assess breakthrough pain in paediatric palliative care and their attitudes towards a validated paediatric breakthrough pain assessment. This was a descriptive qualitative interview study. Semi-structured interviews were conducted with 29 healthcare professionals working in paediatric palliative care across the UK. An inductive thematic analysis was conducted on the data. Five themes were generated: 'the elusive nature of breakthrough pain', 'breakthrough pain assessment', 'positive attitudes towards', 'reservations towards' and 'features to include in' a paediatric breakthrough pain assessment. The definition and assessment of breakthrough pain is inconsistent in paediatric palliative care. There is a clear need for a validated assessment questionnaire to improve assessment, diagnosis and management of breakthrough pain followed by increased healthcare professional education on the concept. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.3390/children11040485" target="_blank" rel="noreferrer noopener">10.3390/children11040485</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). 2024 Anderson AK Bailey S Breakthrough Pain Carter B Children Dawson E Delivery Of Healthcare Greenfield K Hain R Harrop E Interview Johnson M June List 2024 Liossi C Mott C Pain Measurement Palliative Care Pediatrics Rajapakse D Renton K Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource February 2022 List Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month February 2022 List URL Address <a href="http://doi.org/10.1177/02692163211049309" target="_blank" rel="noreferrer noopener">http://doi.org/​10.1177/02692163211049309</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Pain assessment tools in paediatric palliative care: A systematic review of psychometric properties and recommendations for clinical practice Publisher An entity responsible for making the resource available Palliative Medicine Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource paediatrics; pain assessment; Pain measurement; palliative care; systematic review Creator An entity primarily responsible for making the resource Chan AY; Ge M; Harrop E; Johnson M; Oulton K; Skene SS; Wong IC; Jamieson L; Howard RF; Liossi C Description An account of the resource BACKGROUND: Assessing pain in infants, children and young people with life-limiting conditions remains a challenge due to diverse patient conditions, types of pain and often a reduced ability or inability of patients to communicate verbally. AIM: To systematically identify pain assessment tools that are currently used in paediatric palliative care and examine their psychometric properties and feasibility and make recommendations for clinical practice. DESIGN: A systematic literature review and evaluation of psychometric properties of pain assessment tools of original peer-reviewed research published from inception of data sources to April 2021. DATA SOURCES: PsycINFO via ProQuest, Web of Science Core, Medline via Ovid, EMBASE, BIOSIS and CINAHL were searched from inception to April 2021. Hand searches of reference lists of included studies and relevant reviews were performed. RESULTS: From 1168 articles identified, 201 papers were selected for full-text assessment. Thirty-four articles met the eligibility criteria and we examined the psychometric properties of 22 pain assessment tools. Overall, the Faces Pain Scale-Revised (FPS-R) had high cross-cultural validity, construct validity (hypothesis testing) and responsiveness; while the Faces, Legs, Activity, Cry and Consolability (FLACC) scale and Paediatric Pain Profile (PPP) had high internal consistency, criterion validity, reliability and responsiveness. The number of studies per psychometric property of each pain assessment tool was limited and the methodological quality of included studies was low. CONCLUSION: Balancing aspects of feasibility and psychometric properties, the FPS-R is recommended for self-assessment, and the FLACC scale/FLACC Revised and PPP are the recommended observational tools in their respective age groups. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1177/02692163211049309" target="_blank" rel="noreferrer noopener">10.1177/02692163211049309</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). 2021 Chan AY February 2022 List Ge M Harrop E Howard RF Jamieson L Johnson M Liossi C Oulton K Paediatrics Pain Assessment Pain Measurement Palliative Care Palliative Medicine Skene SS Systematic Review Wong IC Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource April 2021 List Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month April 2021 List URL Address <a href="http://doi.org/10.1093/jpepsy/jsz098" target="_blank" rel="noreferrer noopener">http://doi.org/​10.1093/jpepsy/jsz098</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Caregiver-Child Discrepancies in Reports of Child Emotional Symptoms in Pediatric Chronic Pain Publisher An entity responsible for making the resource available Journal of Pediatric Psychology Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource children; Child; Female; Humans; Male; Emotions; Quality of Life; depression; Caregivers; Pain Measurement; Chronic Pain; Depression; anxiety; Anxiety/epidemiology; parents; chronic and recurrent pain; informant discrepancies Creator An entity primarily responsible for making the resource Martin SR; Zeltzer LK; Seidman LC; Allyn KE; Payne LA Description An account of the resource OBJECTIVE: Pediatric chronic pain evaluation includes self-reports and/or caregiver proxy-reports across biopsychosocial domains. Limited data exist on the effects of caregiver-child discrepancies in pediatric pain assessment. In children with chronic pain, we examined associations among discrepancies in caregiver-child reports of child anxiety and depressive symptoms and child functional impairment. METHODS: Participants were 202 children (Mage=14.49 ± 2.38 years; 68.8% female) with chronic pain and their caregivers (95.5% female). Children and caregivers completed the Revised Child Anxiety and Depression Scale (RCADS) and RCADS-Parent, respectively. Children also completed the Functional Disability Inventory. Mean difference tests examined caregiver-child discrepancies. Moderation analyses examined whether associations between child self-reported anxiety and depressive symptoms and functional impairment varied as a function of caregiver proxy-report. RESULTS: Children reported more anxiety and depressive symptoms compared with their caregivers' proxy-reports (Z = -4.83, p < .001). Both informants' reports of child anxiety and depressive symptoms were associated with child functional impairment (rs = .44, rs = .30, p < .001). Caregiver proxy-report moderated associations between child-reported anxiety and depressive symptoms and functional impairment (B = -0.007, p = .003). When caregiver proxy-report was low, child self-reported anxiety and depressive symptoms were positively related to functional impairment (B = 0.28, SE = 0.07, 95% CI [0.15, 0.41], p < .001). CONCLUSIONS: Discrepant caregiver-child perceptions of child anxiety and depressive symptoms may be associated with functioning in children with chronic pain, especially when caregivers report less child internalizing symptoms. These findings highlight the need for further examination of the effects of caregiver-child discrepancies on pediatric chronic pain outcomes and may indicate targets for intervention. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1093/jpepsy/jsz098" target="_blank" rel="noreferrer noopener">10.1093/jpepsy/jsz098</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). 2020 Allyn KE anxiety Anxiety/epidemiology April 2021 List Caregivers Child Children chronic and recurrent pain Chronic Pain Depression Emotions Female Humans informant discrepancies Journal of Pediatric Psychology Male Martin SR Pain Measurement Parents Payne LA Quality Of Life Seidman LC Zeltzer LK Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource April 2021 List Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month April 2021 List URL Address <a href="http://doi.org/10.1002/ejp.1623" target="_blank" rel="noreferrer noopener">http://doi.org/​10.1002/ejp.1623</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Crying out in pain-A systematic review into the validity of vocalization as an indicator for pain Publisher An entity responsible for making the resource available European Journal of Pain Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Child; Humans; Aged; Aged 80 and over; Pain Measurement; Crying; Pain/diagnosis Creator An entity primarily responsible for making the resource Helmer LML; Weijenberg RAF; de Vries R; Achterberg WP; Lautenbacher S; Sampson EL; Lobbezoo F Description An account of the resource BACKGROUND: Vocalization is often used to assess pain, sometimes combined with other behaviours such as facial expressions. Contrary to facial expressions, however, for vocalization, there is little evidence available on the association with pain. The aim of this systematic review was to critically analyse the association between vocalization and pain, to explore if vocalizations can be used as a "stand-alone" indicator for pain. METHODS: The search was performed according to the Prisma Guidelines for systematic reviews and meta-analysis. The following terms were used: "Pain Measurement," "Vocalization" and "Verbalization." The study population included verbal and non-verbal individuals, including older people and children. The search was performed in three different databases: PubMed, Embase and CINAHL. A total of 35 studies were selected for detailed investigation. Quality assessments were made using two grading systems: Grading of Recommendations Assessment Development and Evaluation system and the Newcastle-Ottawa scale. RESULTS: An association between vocalization and pain was found in most studies, particularly when different types of vocalizations were included in the investigation. Different types of vocalization, but also different types of pain, shape this association. The association is observed within all groups of individuals, although age, amongst others, may have an influence on preferred type of vocalization. CONCLUSIONS: There is an association between vocalization and pain. However, vocalization as a "stand-alone" indicator for pain indicates only a limited aspect of this multifactorial phenomenon. Using vocalization as an indicator for pain may be more reliable if other pain indicators are also taken into account. SIGNIFICANCE: Vocalizations are frequently used in pain scales, although not yet thoroughly investigated as a "single indicator" for pain, like, e.g. facial expression. This review confirms the role of vocalizations in pain scales, and stresses that vocalizations might be more reliable if used in combination with other pain indicators. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1002/ejp.1623" target="_blank" rel="noreferrer noopener">10.1002/ejp.1623</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). 2020 Achterberg WP Aged Aged 80 and over April 2021 List Child Crying de Vries R European Journal Of Pain Helmer LML Humans Lautenbacher S Lobbezoo F Pain Measurement Pain/diagnosis Sampson EL Weijenberg RAF Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource 2020 Oncology List Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Oncology 2020 List URL Address <a href="http://doi.org/10.1016/j.ctim.2019.102263" target="_blank" rel="noreferrer noopener">http://doi.org/​10.1016/j.ctim.2019.102263</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Massage therapy for symptom reduction and improved quality of life in children with cancer in palliative care: A pilot study Publisher An entity responsible for making the resource available Complementary Therapies in Medicine Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource child; human; palliative therapy; controlled study; female; male; article; Quality of Life; adolescent; clinical article; pain; Massage; follow up; quantitative study; pilot study; expectation; leukemia; lymphoma; sarcoma; carcinoma; pain measurement; patient worry Creator An entity primarily responsible for making the resource Genik L M; McMurtry C M; Marshall S; Rapoport A; Stinson J Description An account of the resource Background: For children with cancer in palliative care, pain and worry are common and frequently under-managed, which negatively impacts quality of life (QOL). Massage therapy (MT) can lead to reduced pain in children with chronic illnesses. Children with cancer have experienced lower anxiety after MT. No studies have examined the effects of MT in pediatric oncology patients receiving palliative care. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/j.ctim.2019.102263" target="_blank" rel="noreferrer noopener">10.1016/j.ctim.2019.102263</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). 2020 Adolescent Article Carcinoma Child Clinical Article Complementary Therapies in Medicine Controlled Study Expectation Female Follow Up Genik L M Human Leukemia Lymphoma Male Marshall S Massage McMurtry C M Oncology 2020 List Pain Pain Measurement Palliative Therapy patient worry Pilot Study Quality Of Life Quantitative Study Rapoport A Sarcoma Stinson J Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1007/s00520-014-2178-3" target="_blank" rel="noreferrer">http://doi.org/10.1007/s00520-014-2178-3</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A cross-sectional study on prevalence of pain and breakthrough pain among an unselected group of outpatients in a tertiary cancer clinic Publisher An entity responsible for making the resource available Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer Date A point or period of time associated with an event in the lifecycle of the resource 2014 Subject The topic of the resource adolescent; Cross-Sectional Studies; Female; Humans; Male; Young Adult; Neoplasms; Pain Measurement; Cohort Studies; Adult; Prevalence; Aged; Middle Aged; Comorbidity; Ambulatory Care Facilities; Breakthrough Pain; Norway; Outpatients Creator An entity primarily responsible for making the resource Raj Sunil X; Thronaes M; Brunelli C; Hjermstad MJ; Klepstad P; Kaasa S Description An account of the resource PURPOSE: Systematic knowledge about the prevalence and the treatment effects of cancer pain in patients attending a general oncology outpatient department is limited. The purpose of this study was to investigate the prevalence of pain in a large representative cohort of patients attending a general oncology outpatient department in order to guide further screening, classification, and treatment of pain. MATERIAL AND METHODS: A cross-sectional study among patients visiting the outpatient clinic with histologically verified cancer, age≥18 years, adequate cognitive function, and no surgical procedures last 24 h were included. Pain was assessed by the Brief Pain Inventory and the Alberta Breakthrough Pain Assessment Tool. RESULTS: Three hundred five patients were included. The mean age was 60 years, 94% had a WHO performance status of 0-1 and 59% received oncological treatment with a curative intent. The mean score for average pain last 24 h (numerical rating scale, 0-10) and current pain was 1.84 and 1.08, respectively. Twenty-two percent reported pain score of ≥4 as their average pain in the previous 24 h. Twenty-one percent reported breakthrough pain (BTP). In multivariate analyses, sleep, BTP, age, treatment intent, and comorbidity was significantly associated with mean average pain in the previous 24 h and explained 29% of the variability of average pain in the previous 24 h. CONCLUSION: Of the patients at an oncology outpatient clinic, 22% reported clinically significant pain. These findings indicate that all patients are candidates to be screened for pain and, if present, a more detailed pain diagnosis should be established before any interventions can be recommended. 2014-07 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1007/s00520-014-2178-3" target="_blank" rel="noreferrer">10.1007/s00520-014-2178-3</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2014 Adolescent Adult Aged Ambulatory Care Facilities Backlog Breakthrough Pain Brunelli C Cohort Studies Comorbidity Cross-sectional Studies Female Hjermstad MJ Humans Journal Article Kaasa S Klepstad P Male Middle Aged Neoplasms Norway Outpatients Pain Measurement Prevalence Raj Sunil X Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer Thronaes M Young Adult Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1007/s10147-013-0521-1" target="_blank" rel="noreferrer">http://doi.org/10.1007/s10147-013-0521-1</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Safe lumbar puncture under analgo-sedation in children with acute lymphoblastic leukemia Publisher An entity responsible for making the resource available International Journal Of Clinical Oncology Date A point or period of time associated with an event in the lifecycle of the resource 2014 Subject The topic of the resource adolescent; Child; Female; Humans; infant; Male; Pain; Pain Measurement; Deep Sedation; Propofol; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Central Nervous System; Preschool; Injections; Spinal; Spinal Puncture Creator An entity primarily responsible for making the resource Maurizi P; Russo I; Rizzo D; Chiaretti A; Coccia P; Attinà G; Ruggiero A; Riccardi R Description An account of the resource BACKGROUND: Children with acute lymphoblastic leukemia (ALL) undergo multiple lumbar punctures (LPs) during their course of treatment for diagnostic and therapeutic purposes. LP is a stressful and painful procedure, affecting the quality of life of these children. Procedural analgo-sedation might improve the child's comfort and prevent the child's movements, reducing the risk of traumatic lumbar puncture with blasts (TLP+), mainly at diagnosis, when higher numbers of blast cells are circulating in the peripheral blood. The aim of this study was to evaluate the safety and efficacy of procedural analgo-sedation in children with ALL. METHODS: From September 2006 to November 2008, we performed a total of 252 lumbar punctures under deep sedation with propofol and ketamine in 25 children with ALL treated at our division. During the procedures, vital parameters were monitored and side effects were recorded. The efficacy of deep sedation was evaluated using Ramsay and Children's Hospital Eastern Ontario Pain scales. Cerebrospinal fluid was collected for chemical and cytological examinations. RESULTS: In all patients a satisfactory sedation and analgesia were achieved. The evaluation of vital parameters did not show any significant variation compared to baseline values. No side effects were recorded. Only 3 (1.2 %) of 252 lumbar punctures resulted in traumatic effects. CONCLUSION: To strongly improve comfort and quality of life of children with ALL and reduce the risk of TLP+ mainly at diagnosis, we recommend performing the lumbar punctures under analgo-sedation because it is a safe and effective procedure. 2014-02 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1007/s10147-013-0521-1" target="_blank" rel="noreferrer">10.1007/s10147-013-0521-1</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2014 Adolescent Attinà G Backlog Central Nervous System Chiaretti A Child Coccia P Deep Sedation Female Humans Infant Injections International Journal Of Clinical Oncology Journal Article Male Maurizi P Pain Pain Measurement Precursor Cell Lymphoblastic Leukemia-Lymphoma Preschool Propofol Riccardi R Rizzo D Ruggiero A Russo I Spinal Spinal Puncture Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1016/j.pain.2013.09.015" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.pain.2013.09.015</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Inpatient-based intensive interdisciplinary pain treatment for highly impaired children with severe chronic pain: randomized controlled trial of efficacy and economic effects Publisher An entity responsible for making the resource available Pain Date A point or period of time associated with an event in the lifecycle of the resource 2014 Subject The topic of the resource adolescent; Child; Female; Humans; Male; Pain Management; Pain Measurement; Follow-Up Studies; Treatment Outcome; Chronic Pain; Inpatients; Depression; Catastrophization; Anxiety; Disability Evaluation Creator An entity primarily responsible for making the resource Hechler T; Ruhe A-K; Schmidt P; Hirsch J; Wager J; Dobe M; Krummenauer F; Zernikow B Description An account of the resource Pediatric chronic pain, which can result in deleterious effects for the child, bears the risk of aggravation into adulthood. Intensive interdisciplinary pain treatment (IIPT) might be an effective treatment, given the advantage of consulting with multiple professionals on a daily basis. Evidence for the effectiveness of IIPT is scarce. We investigated the efficacy of an IIPT within a randomized controlled trial by comparing an intervention group (IG) (n=52) to a waiting-list control group (WCG) (n=52). We made assessments before treatment (PRE), immediately after treatment (POST), as well as at short-term (POST6MONTHS) and long-term (POST12MONTHS) follow-up. We determined a combined endpoint, improvement (pain intensity, disability, school absence), and investigated 3 additional outcome domains (anxiety, depression, catastrophizing). We also investigated changes in economic parameters (health care use, parental work absenteeism, subjective financial burden) and their relationship to the child's improvement. Results at POST showed that significantly more children in the IG than in the WCG were assigned to improvement (55% compared to 14%; Fisher P<.001; 95% confidence interval for incidence difference: 0.21% to 0.60%). Although immediate effects were achieved for disability, school absence, depression, and catastrophizing, pain intensity and anxiety did not change until short-term follow-up. More than 60% of the children in both groups were improved long-term. The parents reported significant reductions in all economic parameters. The results from the present study support the efficacy of the IIPT. Future research is warranted to investigate differences in treatment response and to understand the changes in economic parameters in nonimproved children. 2014-01 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/j.pain.2013.09.015" target="_blank" rel="noreferrer">10.1016/j.pain.2013.09.015</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2014 Adolescent anxiety Backlog Catastrophization Child Chronic Pain Depression Disability Evaluation Dobe M Female Follow-up Studies Hechler T Hirsch J Humans Inpatients Journal Article Krummenauer F Male Pain Pain Management Pain Measurement Ruhe A-K Schmidt P Treatment Outcome Wager J Zernikow B Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1097/MPH.0b013e31828e5dca" target="_blank" rel="noreferrer">http://doi.org/10.1097/MPH.0b013e31828e5dca</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The use of an intrathecal pump to manage intractable cancer pain in a pediatric patient: a case report Publisher An entity responsible for making the resource available Journal Of Pediatric Hematology/oncology Date A point or period of time associated with an event in the lifecycle of the resource 2014 Subject The topic of the resource adolescent; Female; Humans; Pain; Pain Measurement; Analgesics; Prognosis; Fatal Outcome; Infusion Pumps; Injections; Spinal; Implantable; Carcinoma; Intractable; Anus Neoplasms; Condylomata Acuminata; Immunologic Deficiency Syndromes; Neutropenia; Squamous Cell; Vulvar Diseases Creator An entity primarily responsible for making the resource Bengali R; Huang MS; Gulur P Description An account of the resource A 15-year-old girl with combined immune deficiency syndrome, diagnosed with metastatic squamous cell cancer of the anus, had significant pain secondary to vulvar-perianal condyloma. Conventional treatment with oral and intravenous analgesics was limited by significant side effects of mental status changes and urinary retention leading to clinical deterioration that precluded attempts at chemotherapy. An intrathecal pump was implanted in the challenging setting of neutropenia. There was a drastic improvement in her quality of life and the ability to tolerate further chemotherapy. The option of an intrathecal pump for pain control extended our patient's ability to enjoy important quality time with family by several months. 2014-04 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1097/MPH.0b013e31828e5dca" target="_blank" rel="noreferrer">10.1097/MPH.0b013e31828e5dca</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2014 Adolescent Analgesics Anus Neoplasms Backlog Bengali R Carcinoma Condylomata Acuminata Fatal Outcome Female Gulur P Huang MS Humans Immunologic Deficiency Syndromes Implantable Infusion Pumps Injections Intractable Journal Article Journal Of Pediatric Hematology/oncology Neutropenia Pain Pain Measurement Prognosis Spinal Squamous Cell Vulvar Diseases Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1111/pme.12274" target="_blank" rel="noreferrer">http://doi.org/10.1111/pme.12274</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Ganglion impar phenol injection in a pediatric patient with refractory cancer pain Publisher An entity responsible for making the resource available Pain Medicine (malden, Mass.) Date A point or period of time associated with an event in the lifecycle of the resource 2014 Subject The topic of the resource Child; Humans; Male; Pain; Pain Measurement; Rhabdomyosarcoma; Nerve Block; Preschool; Intractable; Ganglia; Embryonal; Phenol; Prostatic Neoplasms; Sympathetic; Urinary Bladder Neoplasms Creator An entity primarily responsible for making the resource Restrepo-Garces CE; Saldarriaga NE; Jaramillo S; Gomez CM; Vargas JF; Ramirez LJ Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1111/pme.12274" target="_blank" rel="noreferrer">10.1111/pme.12274</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article Description An account of the resource 2014-02 2014 Backlog Child Embryonal Ganglia Gomez CM Humans Intractable Jaramillo S Journal Article Male Nerve Block Pain Pain Measurement Pain Medicine (malden, Mass.) Phenol Preschool Prostatic Neoplasms Ramirez LJ Restrepo-Garces CE Rhabdomyosarcoma Saldarriaga NE Sympathetic Urinary Bladder Neoplasms Vargas JF Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1007/s00431-012-1720-x" target="_blank" rel="noreferrer">http://doi.org/10.1007/s00431-012-1720-x</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Pain in cognitively impaired children: a focus for general pediatricians. Publisher An entity responsible for making the resource available European Journal Of Pediatrics Date A point or period of time associated with an event in the lifecycle of the resource 2013 Subject The topic of the resource Child; Humans; Pain Measurement; quality of life; Analgesics/tu [Therapeutic Use]; Cerebral Palsy/co [Complications]; Cognition Disorders/co [Complications]; Pain/et [Etiology]; Pain/di [Diagnosis]; Pain/dt [Drug Therapy] Creator An entity primarily responsible for making the resource Pastore S; Ventura A; Barbi E Description An account of the resource UNLABELLED: Pain in children with cognitive impairment and cerebral palsy is a particularly relevant issue due to its high prevalence and impact on quality of life. We review available evidence about prevalence of pain, causes and specific treatment, recognition and use of specific pain scales, physiology, and consequences of pain in this subset of patients., CONCLUSIONS: Pain is very common and is a critical determinant of quality of life in children with cognitive impairment and cerebral palsy. The diseases and associated complications that frequently expose these patients to pain can be treated and pain prevented. For patients with communication difficulties, appropriate, effective, validated tools are available and should be used to diagnose pain in itself, to >choose analgesic treatment and to determine effectiveness of these therapies. The level of awareness of pediatricians towards this issue seems to be quite low. 2013 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1007/s00431-012-1720-x" target="_blank" rel="noreferrer">10.1007/s00431-012-1720-x</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2013 Analgesics/tu [Therapeutic Use] Backlog Barbi E Cerebral Palsy/co [Complications] Child Cognition Disorders/co [Complications] European Journal of Pediatrics Humans Journal Article Pain Measurement Pain/di [diagnosis] Pain/dt [drug Therapy] Pain/et [Etiology] Pastore S Quality Of Life Ventura A Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1007/s11916-012-0317-4" target="_blank" rel="noreferrer">http://doi.org/10.1007/s11916-012-0317-4</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Psychological resilience, pain catastrophizing, and positive emotions: perspectives on comprehensive modeling of individual pain adaptation Publisher An entity responsible for making the resource available Current Pain And Headache Reports Date A point or period of time associated with an event in the lifecycle of the resource 2013 Subject The topic of the resource Female; Humans; Male; Pain; Pain Measurement; Emotions; Cognition; Catastrophization; Motivation; Adaptation; Psychological; Models; Resilience Creator An entity primarily responsible for making the resource Sturgeon JA; Zautra AJ Description An account of the resource Pain is a complex construct that contributes to profound physical and psychological dysfunction, particularly in individuals coping with chronic pain. The current paper builds upon previous research, describes a balanced conceptual model that integrates aspects of both psychological vulnerability and resilience to pain, and reviews protective and exacerbating psychosocial factors to the process of adaptation to chronic pain, including pain catastrophizing, pain acceptance, and positive psychological resources predictive of enhanced pain coping. The current paper identifies future directions for research that will further enrich the understanding of pain adaptation and espouses an approach that will enhance the ecological validity of psychological pain coping models, including introduction of advanced statistical and conceptual models that integrate behavioral, cognitive, information processing, motivational and affective theories of pain. 2013-03 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1007/s11916-012-0317-4" target="_blank" rel="noreferrer">10.1007/s11916-012-0317-4</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2013 Adaptation Backlog Catastrophization Cognition Current Pain and Headache Reports Emotions Female Humans Journal Article Male Models Motivation Pain Pain Measurement Psychological Resilience Sturgeon JA Zautra AJ Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1177/0269216312464408" target="_blank" rel="noreferrer">http://doi.org/10.1177/0269216312464408</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Neuropathic cancer pain: prevalence, severity, analgesics and impact from the European Palliative Care Research Collaborative-Computerised Symptom Assessment study Publisher An entity responsible for making the resource available Palliative Medicine Date A point or period of time associated with an event in the lifecycle of the resource 2013 Subject The topic of the resource adolescent; Cross-Sectional Studies; Female; Humans; Male; Young Adult; Neoplasms; Pain Measurement; Adult; Prevalence; Analgesics; Aged; Middle Aged; Neuralgia; Symptom Assessment; quality of life; 80 and over; Life Expectancy; Neoplasm Metastasis Creator An entity primarily responsible for making the resource Rayment C; Hjermstad MJ; Aass N; Kaasa S; Caraceni A; Strasser F; Heitzer E; Fainsinger R; Bennett MI; (EPCRC) European Palliative Care Research Collaborative Description An account of the resource BACKGROUND: Neuropathic pain causes greater pain intensity and worse quality of life than nociceptive pain. There are no published data that confirm this in the cancer population. AIM: We hypothesised that patients with neuropathic cancer pain had more intense pain, experienced greater suffering and were treated with more analgesics than those with nociceptive cancer pain, and a neuropathic pain screening tool, painDETECT, would perform as well in those with cancer pain as is reported in those with non-cancer pain. DESIGN: The data were obtained from an international cross-sectional observational study. SETTING/PARTICIPANTS: A total of 1051 patients from inpatients and outpatients, with incurable cancer completed a computerised assessment on symptoms, function and quality of life. In all, 17 centres within eight countries participated. Medical data were recorded by physicians. Pain type was a clinical diagnosis recorded on the Edmonton Classification System for Cancer Pain. RESULTS: Of the patients, 670 had pain: 534 with nociceptive pain, 113 with neuropathic pain and 23 were unclassified. Patients with neuropathic cancer pain were significantly more likely to be receiving oncological treatment, strong opioids and adjuvant analgesia and have a reduced performance status. They reported worse physical, cognitive and social function. Sensitivity and specificity of painDETECT for identifying neuropathic cancer pain was less accurate than when used in non-cancer populations. CONCLUSIONS: Neuropathic cancer pain is associated with a negative impact on daily living and greater analgesic requirements than nociceptive cancer pain. Validated assessment methods are needed to enable early identification of neuropathic cancer pain, leading to more appropriate treatment and reduced burden on patients. 2013-09 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1177/0269216312464408" target="_blank" rel="noreferrer">10.1177/0269216312464408</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article (EPCRC) European Palliative Care Research Collaborative 2013 80 And Over Aass N Adolescent Adult Aged Analgesics Backlog Bennett MI Caraceni A Cross-sectional Studies Fainsinger R Female Heitzer E Hjermstad MJ Humans Journal Article Kaasa S Life Expectancy Male Middle Aged Neoplasm Metastasis Neoplasms Neuralgia Pain Measurement Palliative Medicine Prevalence Quality Of Life Rayment C Strasser F Symptom Assessment Young Adult Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1016/j.jneumeth.2008.10.013" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jneumeth.2008.10.013</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Beta-Endorphin Response to an Acute Pain Stimulus Publisher An entity responsible for making the resource available Journal Of Neuroscience Methods Date A point or period of time associated with an event in the lifecycle of the resource 2009 Subject The topic of the resource Male; Pain Measurement; Time Factors; Reproducibility of Results; Animals; Mice; Acute Disease; Biomarkers of Pain; Physical Stimulation; Animal; beta-Endorphin/analysis/metabolism/secretion; Biological Markers/analysis/blood; Disease Models; Inbred DBA; Neurochemistry/methods; Pain/blood/physiopathology; Radioimmunoassay/methods; Up-Regulation/physiology Creator An entity primarily responsible for making the resource Rasmussen NA; Farr LA Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/j.jneumeth.2008.10.013" target="_blank" rel="noreferrer noopener">10.1016/j.jneumeth.2008.10.013</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article Description An account of the resource The timing of the measurement of biological samples (e.g. biomarkers) is not always standardized. Biomarkers are the focus of many recent studies and treatments. The purpose of this study was to determine the timing of the release of beta-endorphin (BE), a possible biomarker, after exposure to pain and/or handling stress in order to standardize measurements. Mouse plasma was collected for BE analysis following handling i.e. being picked up by the investigator, exposure to a painful (55 degrees C hot-plate), or exposure to a nonpainful stimulus (room temperature hot-plate). The groups exposed to either a painful or nonpainful stimulus released BE in response to the stimulus, but the duration of the response was longer in mice exposed to a painful stimulus than in mice exposed to a nonpainful stimulus. The BE in the mice exposed to a nonpainful stimulus peaked at 1 min and returned to baseline levels by 5 min while the BE response of the mice exposed to a painful stimulus peaked at 10 min and remained elevated for 25 min. The results of this study indicate that BE can be a biomarker for pain and handling stress, however, the timing of the measurement should differ. 2009 Acute Disease Animal Animals Backlog beta-Endorphin/analysis/metabolism/secretion Biological Markers/analysis/blood Biomarkers of Pain Disease Models Farr LA Inbred DBA Journal Article Journal Of Neuroscience Methods Male Mice Neurochemistry/methods Pain Measurement Pain/blood/physiopathology Physical Stimulation Radioimmunoassay/methods Rasmussen NA Reproducibility of Results Time Factors Up-Regulation/physiology Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1016/j.pcl.2007.07.007" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.pcl.2007.07.007</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The management of pain in children with life-limiting illnesses Publisher An entity responsible for making the resource available Pediatric Clinics Of North America Date A point or period of time associated with an event in the lifecycle of the resource 2007 Subject The topic of the resource Child; Humans; Pain Measurement; Analgesics; Severity of Illness Index; Chronic disease; Methadone/therapeutic use; Hydromorphone/therapeutic use; Opioid/therapeutic use; Fentanyl/therapeutic use; Morphine/therapeutic use; Nociceptors/physiology; Codeine/therapeutic use; Ketamine/therapeutic use; Oxycodone/therapeutic use; Pain/diagnosis/drug therapy/physiopathology Creator An entity primarily responsible for making the resource Friedrichsdorf SJ; Kang T Description An account of the resource The management of pain in children with life-limiting illnesses is complex and unfortunately not often done effectively. Pain is a multidimensional symptom that can overshadow all other experiences of both the child and family. This article focuses on topics common to practitioners caring for children with lifelimiting illnesses, including a review of myths and obstacles to achieving adequate pain control, a review of the pathophysiology of pain, an overview of the use of opioids in children, an approach to the management of neuropathic pain, and a brief discussion of nonpharmacologic pain management strategies. 2007 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/j.pcl.2007.07.007" target="_blank" rel="noreferrer">10.1016/j.pcl.2007.07.007</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2007 Analgesics Backlog Child Chronic Disease Codeine/therapeutic use Fentanyl/therapeutic use Friedrichsdorf SJ Humans Hydromorphone/therapeutic use Journal Article Kang T Ketamine/therapeutic use Methadone/therapeutic use Morphine/therapeutic Use Nociceptors/physiology Opioid/therapeutic use Oxycodone/therapeutic use Pain Measurement Pain/diagnosis/drug therapy/physiopathology Pediatric Clinics of North America Severity Of Illness Index Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1038/sj.npp.1301295" target="_blank" rel="noreferrer">http://doi.org/10.1038/sj.npp.1301295</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A D2 antagonist enhances the rewarding and priming effects of a gambling episode in pathological gamblers. Publisher An entity responsible for making the resource available Neuropsychopharmacology Date A point or period of time associated with an event in the lifecycle of the resource 2007 Subject The topic of the resource Female; Humans; Male; Pain Measurement; Adult; Middle Aged; Semantics; Analysis of Variance; Motivation; Double-Blind Method; IM; Psychiatric Status Rating Scales; Neuropsychological Tests; Blood Pressure/de [Drug Effects]; Dopamine Antagonists/ad [Administration & Dosage]; Dopamine Antagonists/ae [Adverse Effects]; Gambling/px [Psychology]; Haloperidol/ad [Administration & Dosage]; Haloperidol/ae [Adverse Effects]; Reaction Time/de [Drug Effects]; Reward Creator An entity primarily responsible for making the resource Zack M; Poulos CX Description An account of the resource Previous research indicated shared neurochemical substrates for gambling and psychostimulant reward. This suggests that dopamine substrates may directly govern the reinforcement process in pathological gambling. To investigate this issue, the present study assessed the effects of the relatively selective dopamine D2 antagonist, haloperidol (3 mg, oral) on responses to actual gambling (15 min on a slot machine) in 20 non-comorbid pathological gamblers and 18 non-gambler controls in a placebo-controlled, double-blind, counterbalanced design. In gamblers, haloperidol significantly increased self-reported rewarding effects of gambling, post-game priming of desire to gamble, facilitation of reading speed to Gambling words, and gambling-induced elevation in blood pressure. In controls, haloperidol augmented gambling-induced elevation in blood pressure, but had no effect on other indices. The findings provide direct experimental evidence that the D2 substrate modulates gambling reinforcement in pathological gamblers. 2007 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1038/sj.npp.1301295" target="_blank" rel="noreferrer">10.1038/sj.npp.1301295</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2007 Adult Analysis of Variance Backlog Blood Pressure/de [Drug Effects] Dopamine Antagonists/ad [Administration & Dosage] Dopamine Antagonists/ae [Adverse Effects] Double-Blind Method Female Gambling/px [Psychology] Haloperidol/ad [Administration & Dosage] Haloperidol/ae [Adverse Effects] Humans IM Journal Article Male Middle Aged Motivation Neuropsychological Tests Neuropsychopharmacology Pain Measurement Poulos CX Psychiatric Status Rating Scales Reaction Time/de [Drug Effects] Reward Semantics Zack M Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1038/sj.npp.1301393" target="_blank" rel="noreferrer">http://doi.org/10.1038/sj.npp.1301393</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Inhibition of inflammatory pain by CRF at peripheral, spinal and supraspinal sites: involvement of areas coexpressing CRF receptors and opioid peptides Publisher An entity responsible for making the resource available Neuropsychopharmacology Date A point or period of time associated with an event in the lifecycle of the resource 2007 Subject The topic of the resource Male; Pain Measurement; Animals; Rats; Biomarkers of Pain; Dose-Response Relationship; Drug; Receptors; Freund's Adjuvant; Wistar; Animal; Disease Models; Analgesics/administration & dosage; Drug Administration Routes; Pain Threshold/drug effects; Brain/drug effects/metabolism; Spinal Cord/drug effects/metabolism; Corticotropin-Releasing Hormone/administration & dosage; Opioid Peptides/metabolism; Corticotropin-Releasing Hormone/metabolism; Ganglia; Hormone Antagonists/administration & dosage; Inflammation/chemically induced/complications; Pain/drug therapy/etiology/pathology; Sciatic Nerve/pathology; Spinal/drug effects/metabolism Creator An entity primarily responsible for making the resource Mousa SA; Bopaiah CP; Richter JF; Yamdeu RS; Schafer M Description An account of the resource There is conflicting evidence on the antinociceptive effects of corticotropin-releasing factor (CRF) along the neuraxis of pain transmission and the responsible anatomical sites of CRF's action at the level of the brain, spinal cord and periphery. In an animal model of tonic pain, that is, Freunds complete adjuvant (FCA) hindpaw inflammation, we systematically investigated CRF's ability to modulate inflammatory pain at those three levels of pain transmission by algesiometry following the intracerebroventricular, intrathecal, and intraplantar application of low, systemically inactive doses of CRF. At each level, CRF elicits potent antinociceptive effects, which are dose dependent and antagonized by local, but not systemic CRF receptor antagonist alpha-helical CRF indicating CRF receptor specificity. Consistently, we have identified by immunohistochemistry multiple brain areas, inhibitory interneurons within the dorsal horn of the spinal cord as well as immune cells within subcutaneous tissue--but not peripheral sensory neurons--that coexpress both CRF receptors and opioid peptides. In line with these anatomical findings, local administration of CRF together with the opioid receptor antagonist naloxone dose-dependently reversed CRF's antinociceptive effects at each of these three levels of pain transmission. Therefore, local application of low, systemically inactive doses of CRF at the level of the brain, spinal cord and periphery inhibits tonic inflammatory pain most likely through an activation of CRF receptors on cells that coexpress opioid peptides which results in opioid-mediated pain inhibition. Future studies have to delineate whether endogenous CRF at these three levels contributes to the body's response to cope with the stressful stimulus pain in an opioid-mediated manner. 2007 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1038/sj.npp.1301393" target="_blank" rel="noreferrer">10.1038/sj.npp.1301393</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2007 Analgesics/administration & dosage Animal Animals Backlog Biomarkers of Pain Bopaiah CP Brain/drug effects/metabolism Corticotropin-Releasing Hormone/administration & dosage Corticotropin-Releasing Hormone/metabolism Disease Models Dose-Response Relationship Drug Drug Administration Routes Freund's Adjuvant Ganglia Hormone Antagonists/administration & dosage Inflammation/chemically induced/complications Journal Article Male Mousa SA Neuropsychopharmacology Opioid Peptides/metabolism Pain Measurement Pain Threshold/drug effects Pain/drug therapy/etiology/pathology Rats Receptors Richter JF Schafer M Sciatic Nerve/pathology Spinal Cord/drug effects/metabolism Spinal/drug effects/metabolism Wistar Yamdeu RS Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1056/NEJMc071927" target="_blank" rel="noreferrer">http://doi.org/10.1056/NEJMc071927</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Mirror therapy for phantom limb pain Publisher An entity responsible for making the resource available The New England Journal Of Medicine Date A point or period of time associated with an event in the lifecycle of the resource 2007 Subject The topic of the resource Humans; Pain Measurement; Movement; Cross-Over Studies; Amputation Stumps; Amputation/adverse effects; Audiovisual Aids; Biofeedback (Psychology); Imagery (Psychotherapy); Phantom Limb/therapy Creator An entity primarily responsible for making the resource Chan BL; Witt R; Charrow AP; Magee A; Howard R; Pasquina PF; Heilman KM; Tsao JW Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1056/NEJMc071927" target="_blank" rel="noreferrer">10.1056/NEJMc071927</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article Description An account of the resource 2007 2007 Amputation Stumps Amputation/adverse effects Audiovisual Aids Backlog Biofeedback (Psychology) Chan BL Charrow AP Cross-Over Studies Heilman KM Howard R Humans Imagery (Psychotherapy) Journal Article Magee A Movement Pain Measurement Pasquina PF Phantom Limb/therapy The New England Journal Of Medicine Tsao JW Witt R Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1089/jpm.2007.0105" target="_blank" rel="noreferrer">http://doi.org/10.1089/jpm.2007.0105</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Determinants of do-not-resuscitate orders in palliative home care. Publisher An entity responsible for making the resource available Journal Of Palliative Medicine Date A point or period of time associated with an event in the lifecycle of the resource 2008 Subject The topic of the resource Female; Humans; Male; Pain Measurement; Adult; Canada; Aged; Middle Aged; Activities of Daily Living; Demography; Case Management; adolescent; 80 and over; retrospective studies; DNAR; Resuscitation Orders; Neuropsychological Tests; Pain/di [Diagnosis]; Advance Directives/sn [Statistics & Numerical Data]; Critical Illness/mo [Mortality]; Critical Illness/th [Therapy]; Palliative Care/sn [Statistics & Numerical Data]; Cognition Disorders/di [Diagnosis]; Cognition Disorders/ep [Epidemiology]; Palliative Care/lj [Legislation & Jurisprudence] Creator An entity primarily responsible for making the resource Brink P; Smith TF; Kitson M Description An account of the resource OVERVIEW: Do-not-resuscitate (DNR) orders allow home care clients to communicate their own wishes over medical treatment decisions, helping to preserve their dignity and autonomy. To date, little is known about DNR orders in palliative home care. Basic research to identify rates of completion and determinants of DNR orders has yet to be examined in palliative home care., PURPOSE: The purpose of this exploratory study was to determine who in palliative home care has a DNR order as part of their advance directive., METHODS: Information on health was collected using the interRAI instrument for palliative care (interRAI PC). The sample included 470 home care clients from one community care access centre in Ontario., RESULTS: This study indicated that a preference to die at home (odds ratio [OR]: 8.29, confidence interval [CI]: 4.55-15.11); close proximity to death (OR: 0.99, CI: 0.99-1.00); daily incontinence (OR: 2.74, CI: 1.05-7.16); and sleep problems (OR: 1.85, CI: 1.02-3.37) are associated with DNR orders. In addition, clients who are more accepting of their situation are 5.67 times (CI: 1.67-19.27) more likely to have a DNR in place., CONCLUSION: This study represents an important first step to identifying issues related to DNR orders. In addition to proximity to death, incontinence, and sleep problems, acceptance of one's own situation and a preference to die at home are important determinants of DNR completion. The results imply that these discussions might often depend not only on the health of the clients but also on the clients' acceptance of their current situation and where they wish to die. 2008 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1089/jpm.2007.0105" target="_blank" rel="noreferrer">10.1089/jpm.2007.0105</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2008 80 And Over Activities of Daily Living Adolescent Adult Advance Directives/sn [Statistics & Numerical Data] Aged Backlog Brink P Canada Case Management Cognition Disorders/di [Diagnosis] Cognition Disorders/ep [Epidemiology] Critical Illness/mo [Mortality] Critical Illness/th [therapy] Demography DNAR Female Humans Journal Article Journal of Palliative Medicine Kitson M Male Middle Aged Neuropsychological Tests Pain Measurement Pain/di [diagnosis] Palliative Care/lj [Legislation & Jurisprudence] Palliative Care/sn [Statistics & Numerical Data] Resuscitation Orders Retrospective Studies Smith TF Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1097/BPO.0b013e3181558bc1" target="_blank" rel="noreferrer">http://doi.org/10.1097/BPO.0b013e3181558bc1</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Diagnostic evaluation using whole-body technetium bone scan in children with cerebral palsy and pain. Publisher An entity responsible for making the resource available Journal Of Pediatric Orthopedics Date A point or period of time associated with an event in the lifecycle of the resource 2008 Subject The topic of the resource Child; Female; Humans; Male; Pain Measurement; Adult; Severity of Illness Index; Reproducibility of Results; adolescent; Preschool; retrospective studies; Emission-Computed; Tomography; Diagnosis; Differential; Bone and Bones/radionuclide imaging; Cerebral Palsy/complications/radionuclide imaging; Pain/etiology/radionuclide imaging; Single-Photon/methods; Technetium/diagnostic use; Whole Body Imaging/methods Creator An entity primarily responsible for making the resource Bajelidze G; Belthur MV; Littleton AG; Dabney Kirk W; Miller F Description An account of the resource BACKGROUND: Pain in noncommunicative children can be difficult to localize and diagnose. The purpose of this study is to report our experience using a 3-phase whole-body technetium bone scan as a screening tool in identifying the source of persistent pain in children with profound disabilities who cannot communicate. METHODS: We reviewed the medical and imaging records of 45 patients who met the inclusion criteria of the study, which included a diagnosis of spastic quadriplegic cerebral palsy with severe motor and cognitive impairment, persistent pain of more than 1 week in duration with no recognizable source, and a 3-phase whole-body bone scan as part of the pain workup. RESULTS: The study group included 26 females and 19 males with an average age at presentation of 13.5 years (range, 3-20 years). A positive bone scan was seen in 24 patients (53%). The diagnosis and the source of pain were identified in all 24 patients with a positive bone scan, with the bone scan being instrumental in establishing a diagnosis or localization in 22 patients. An orthopaedic diagnosis was not established in the 21 other patients with a negative bone scan. Based on the bone scan results, additional imaging was obtained at the anatomical location indicated. The bone scan was used to establish a diagnosis of fracture in 10 of 24 patients. Other diagnoses included 3 patients with painful internal hardware, 2 with sinusitis, 2 with infections, and 1 with an obstructed kidney. CONCLUSIONS: Whole-body bone scan is a viable imaging option to identify the source of persistent pain in children who are noncommunicative. The bone scan can assist in localizing the source of pain and direct the location for further imaging as needed. 2008-02 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1097/BPO.0b013e3181558bc1" target="_blank" rel="noreferrer">10.1097/BPO.0b013e3181558bc1</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2008 Adolescent Adult Backlog Bajelidze G Belthur MV Bone and Bones/radionuclide imaging Cerebral Palsy/complications/radionuclide imaging Child Dabney Kirk W Diagnosis Differential Emission-Computed Female Humans Journal Article Journal Of Pediatric Orthopedics Littleton AG Male Miller F Pain Measurement Pain/etiology/radionuclide imaging Preschool Reproducibility of Results Retrospective Studies Severity Of Illness Index Single-Photon/methods Technetium/diagnostic use Tomography Whole Body Imaging/methods Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1186/1471-2474-10-107" target="_blank" rel="noreferrer">http://doi.org/10.1186/1471-2474-10-107</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Emotion regulation in patients with rheumatic diseases: validity and responsiveness of the Emotional Approach Coping Scale (EAC) Publisher An entity responsible for making the resource available Bmc Musculoskeletal Disorders Date A point or period of time associated with an event in the lifecycle of the resource 2009 Subject The topic of the resource adolescent; Cross-Sectional Studies; Female; Humans; Male; Young Adult; Pain Measurement; Adult; Emotions; Aged; Middle Aged; Activities of Daily Living; Stress; 80 and over; Adaptation; Psychological; Rheumatic Diseases Creator An entity primarily responsible for making the resource Zangi HA; Garratt A; Hagen KB; Stanton AL; Mowinckel P; Finset A Description An account of the resource BACKGROUND: Chronic rheumatic diseases are painful conditions which are not entirely controllable and can place high emotional demands on individuals. Increasing evidence has shown that emotion regulation in terms of actively processing and expressing disease-related emotions are likely to promote positive adjustment in patients with chronic diseases. The Emotional Approach Coping Scale (EAC) measures active attempts to acknowledge, understand, and express emotions. Although tested in other clinical samples, the EAC has not been validated for patients with rheumatic diseases. This study evaluated the data quality, internal consistency reliability, validity and responsiveness of the Norwegian version of the EAC for this group of patients. METHODS: 220 patients with different rheumatic diseases were included in a cross-sectional study in which data quality and internal consistency were assessed. Construct validity was assessed through comparisons with the Brief Approach/Avoidance Coping Questionnaire (BACQ) and the General Health Questionnaire (GHQ-20). Responsiveness was tested in a longitudinal pretest-posttest study of two different coping interventions, the Vitality Training Program (VTP) and a Self-Management Program (SMP). RESULTS: The EAC had low levels of missing data. Results from principal component analysis supported two subscales, Emotional Expression and Emotional Processing, which had high Cronbach's alphas of 0.90 and 0.92, respectively. The EAC had correlations with approach-oriented items in the BACQ in the range 0.17-0.50. The EAC Expression scale had a significant negative correlation with the GHQ-20 of -0.13. As hypothesized, participation in the VTP significantly improved EAC scores, indicating responsiveness to change. CONCLUSION: The EAC is an acceptable and valid instrument for measuring emotional processing and expression in patients with rheumatic diseases. The EAC scales were responsive to change in an intervention designed to promote emotion regulation. The instrument has not yet been tested for test-retest reliability, which is recommended in future studies. 2009 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1186/1471-2474-10-107" target="_blank" rel="noreferrer">10.1186/1471-2474-10-107</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2009 80 And Over Activities of Daily Living Adaptation Adolescent Adult Aged Backlog Bmc Musculoskeletal Disorders Cross-sectional Studies Emotions Female Finset A Garratt A Hagen KB Humans Journal Article Male Middle Aged Mowinckel P Pain Measurement Psychological Rheumatic Diseases Stanton AL Stress Young Adult Zangi HA Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1503/cmaj.091414" target="_blank" rel="noreferrer">http://doi.org/10.1503/cmaj.091414</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Smoked cannabis for chronic neuropathic pain: a randomized controlled trial Publisher An entity responsible for making the resource available Canadian Medical Association Journal Date A point or period of time associated with an event in the lifecycle of the resource 2010 Subject The topic of the resource Female; Humans; Male; Pain Measurement; Adult; Aged; Middle Aged; Treatment Outcome; Linear Models; Double-Blind Method; Cross-Over Studies; quality of life; Chronic disease; Sleep/drug effects; Placebos; Neuralgia/drug therapy; Marijuana Smoking; Tetrahydrocannabinol/administration & dosage/adverse effects/therapeutic use Creator An entity primarily responsible for making the resource Ware M; Wang T; Shapiro S; Robinson A; Ducruet T; Huynh T; Gamsa A; Bennett GJ; Collet JP Description An account of the resource BACKGROUND: Chronic neuropathic pain affects 1%-2% of the adult population and is often refractory to standard pharmacologic treatment. Patients with chronic pain have reported using smoked cannabis to relieve pain, improve sleep and improve mood. METHODS: Adults with post-traumatic or postsurgical neuropathic pain were randomly assigned to receive cannabis at four potencies (0%, 2.5%, 6% and 9.4% tetrahydrocannabinol) over four 14-day periods in a crossover trial. Participants inhaled a single 25-mg dose through a pipe three times daily for the first five days in each cycle, followed by a nine-day washout period. Daily average pain intensity was measured using an 11-point numeric rating scale. We recorded effects on mood, sleep and quality of life, as well as adverse events. RESULTS: We recruited 23 participants (mean age 45.4 [standard deviation 12.3] years, 12 women [52%]), of whom 21 completed the trial. The average daily pain intensity, measured on the 11-point numeric rating scale, was lower on the prespecified primary contrast of 9.4% v. 0% tetrahydrocannabinol (5.4 v. 6.1, respectively; difference = 0.7, 95% confidence interval [CI] 0.02-1.4). Preparations with intermediate potency yielded intermediate but nonsignificant degrees of relief. Participants receiving 9.4% tetrahydrocannabinol reported improved ability to fall asleep (easier, p = 0.001; faster, p < 0.001; more drowsy, p = 0.003) and improved quality of sleep (less wakefulness, p = 0.01) relative to 0% tetrahydrocannabinol. We found no differences in mood or quality of life. The most common drug-related adverse events during the period when participants received 9.4% tetrahydrocannabinol were headache, dry eyes, burning sensation in areas of neuropathic pain, dizziness, numbness and cough. CONCLUSION: A single inhalation of 25 mg of 9.4% tetrahydrocannabinol herbal cannabis three times daily for five days reduced the intensity of pain, improved sleep and was well tolerated. Further long-term safety and efficacy studies are indicated. (International Standard Randomised Controlled Trial Register no. ISRCTN68314063). 2010 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1503/cmaj.091414" target="_blank" rel="noreferrer">10.1503/cmaj.091414</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2010 Adult Aged Backlog Bennett GJ Canadian Medical Association Journal Chronic Disease Collet JP Cross-Over Studies Double-Blind Method Ducruet T Female Gamsa A Humans Huynh T Journal Article Linear Models Male Marijuana Smoking Middle Aged Neuralgia/drug therapy Pain Measurement Placebos Quality Of Life Robinson A Shapiro S Sleep/drug effects Tetrahydrocannabinol/administration & dosage/adverse effects/therapeutic use Treatment Outcome Wang T Ware M Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1542/peds.2006-1347" target="_blank" rel="noreferrer">http://doi.org/10.1542/peds.2006-1347</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma Publisher An entity responsible for making the resource available Pediatrics Date A point or period of time associated with an event in the lifecycle of the resource 2007 Subject The topic of the resource Child; Female; Humans; Male; Pain Measurement; Analgesics; Treatment Outcome; Patient Satisfaction; Acute Disease; adolescent; Administration; Oral; Non-Narcotic/therapeutic use; Dose-Response Relationship; Drug; Opioid/therapeutic use; Pain/diagnosis/drug therapy/etiology; Codeine/therapeutic use; Acetaminophen/therapeutic use; Ibuprofen/therapeutic use; Wounds and Injuries/complications Creator An entity primarily responsible for making the resource Clark E; Plint AC; Correll R; Gaboury I; Passi B Description An account of the resource OBJECTIVE: Our goal was to determine which of 3 analgesics, acetaminophen, ibuprofen, or codeine, given as a single dose, provides the most efficacious analgesia for children presenting to the emergency department with pain from acute musculoskeletal injuries. PATIENTS AND METHODS: Children 6 to 17 years old with pain from a musculoskeletal injury (to extremities, neck, and back) that occurred in the preceding 48 hours before presentation in the emergency department were randomly assigned to receive orally 15 mg/kg acetaminophen, 10 mg/kg ibuprofen, or 1 mg/kg codeine. Children, parents, and the research assistants were blinded to group assignment. The primary outcome was change in pain from baseline to 60 minutes after treatment with study medication as measured by using a visual analog scale. RESULTS: A total of 336 patients were randomly assigned, and 300 were included in the analysis of the primary outcome (100 in the acetaminophen group, 100 in the ibuprofen group, and 100 in the codeine group). Study groups were similar in age, gender, final diagnosis, previous analgesic given, and baseline pain score. Patients in the ibuprofen group had a significantly greater improvement in pain score (mean decrease: 24 mm) than those in the codeine (mean decrease: 11 mm) and acetaminophen (mean decrease: 12 mm) groups at 60 minutes. In addition, at 60 minutes more patients in the ibuprofen group achieved adequate analgesia (as defined by a visual analog scale <30 mm) than the other 2 groups. There was no significant difference between patients in the codeine and acetaminophen groups in the change in pain score at any time period or in the number of patients achieving adequate analgesia. CONCLUSIONS: For the treatment of acute traumatic musculoskeletal injuries, ibuprofen provides the best analgesia among the 3 study medications. 2007 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1542/peds.2006-1347" target="_blank" rel="noreferrer">10.1542/peds.2006-1347</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2007 Acetaminophen/therapeutic use Acute Disease Administration Adolescent Analgesics Backlog Child Clark E Codeine/therapeutic use Correll R Dose-Response Relationship Drug Female Gaboury I Humans Ibuprofen/therapeutic use Journal Article Male Non-Narcotic/therapeutic use Opioid/therapeutic use Oral Pain Measurement Pain/diagnosis/drug therapy/etiology Passi B Patient Satisfaction Pediatrics Plint AC Treatment Outcome Wounds and Injuries/complications Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1002/cncr.21497" target="_blank" rel="noreferrer">http://doi.org/10.1002/cncr.21497</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Transdermal fentanyl in the management of children with chronic severe pain: results from an international study Publisher An entity responsible for making the resource available Cancer Date A point or period of time associated with an event in the lifecycle of the resource 2005 Subject The topic of the resource Child; Female; Humans; Male; Pain; Pain Measurement; Analgesics; Follow-Up Studies; Severity of Illness Index; Risk Assessment; Single-Blind Method; International Cooperation; adolescent; Preschool; Chronic disease; Administration; Dose-Response Relationship; Drug; Opioid/administration & dosage; Cutaneous; Fentanyl/administration & dosage; Intractable/diagnosis/drug therapy; Skin Absorption/drug effects Creator An entity primarily responsible for making the resource Finkel JC; Finley A; Greco C; Weisman SJ; Zeltzer L Description An account of the resource BACKGROUND: The current study was conducted to assess the safety and tolerability of a transdermal fentanyl delivery system for the relief of chronic pain in a pediatric population, and also to validate titration recommendations and conversion to transdermal fentanyl from oral opioid therapy. METHODS: This 15-day (with 3-month extension), single-arm, open-label trial was conducted at 66 sites in 10 countries. A total of 199 pediatric patients (ages 2-16 years) with both malignant and nonmalignant conditions who were receiving oral or parenteral opioids for moderate to severe chronic pain were enrolled. Transdermal fentanyl doses were titrated upward according to the rescue medication consumed during the previous application period. Degree of pain was assessed by patients and parents/guardians using visual and numeric scales. Level of play and quality of life were assessed using the Play Performance Scale (PPS) and the Child Health Questionnaire (CHQ). Adverse events were monitored on Days 1-15. Hypoventilation and sedation were monitored every 4 hours during the first 72 hours of the study. RESULTS: A total of 173 patients completed the primary treatment period and 130 entered the extension phase. The average daily pain intensity scores were reported to have decreased by Day 16 and improvements in the mean PPS scores were observed to the end of the extension period. The CHQ scores demonstrated improvements in 11 of 12 domains after Month 1 of the extension period. CONCLUSIONS: Transdermal fentanyl was found to be a safe and well tolerated alternative to oral opioid treatment for children ages 2-16 years who were previously exposed to opioid therapy. 2005 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1002/cncr.21497" target="_blank" rel="noreferrer">10.1002/cncr.21497</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2005 Administration Adolescent Analgesics Backlog Cancer Child Chronic Disease Cutaneous Dose-Response Relationship Drug Female Fentanyl/administration & dosage Finkel JC Finley A Follow-up Studies Greco C Humans International Cooperation Intractable/diagnosis/drug therapy Journal Article Male Opioid/administration & dosage Pain Pain Measurement Preschool Risk Assessment Severity Of Illness Index Single-Blind Method Skin Absorption/drug effects Weisman SJ Zeltzer L Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1016/j.ejpain.2005.11.005" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.ejpain.2005.11.005</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The course of high-sensitive C-reactive protein in correlation with pain and clinical function in patients with acute lumbosciatic pain and chronic low back pain - a 6 months prospective longitudinal study Publisher An entity responsible for making the resource available European Journal Of Pain Date A point or period of time associated with an event in the lifecycle of the resource 2006 Subject The topic of the resource Female; Humans; Male; Pain Measurement; Cohort Studies; Adult; Middle Aged; Time Factors; Acute Disease; Chronic disease; C-Reactive Protein/metabolism; Low Back Pain/blood/physiopathology/therapy; Recovery of Function/physiology; Sciatica/blood/physiopathology/therapy Creator An entity primarily responsible for making the resource Gebhardt K; Brenner H; Sturmer T; Raum E; Richter W; Schiltenwolf M; Buchner M Description An account of the resource In this prospective longitudinal study with a follow-up of 6 months, the course of serum concentration of C-reactive protein was measured by an ultrasensitive immunoassay in 31 patients with acute lumbosciatic pain and 41 patients with chronic low back pain. High-sensitive CRP (hsCRP), pain and clinical function were assessed at ten fixed time-points during follow-up. The course of hsCRP values was assessed in relation to the course of pain and clinical function adjusting for possible confounding factors. At the beginning of the study, there were no statistically significant differences in mean hsCRP levels in patients with acute lumbosciatic pain (1.49mg/l) compared to the levels obtained in patients with chronic low back pain (1.30mg/l) and those in a control group from the general population (1.26mg/l). In patients with acute lumbosciatic pain, hsCRP declined significantly in the initial period of 3 weeks with a corresponding decrease in pain and improvement in function and clinical evaluation as assessed with the straight leg raising test (SLR), whereas after this period, the course of the hsCRP did not correspond with the clinical parameters. In patients with chronic low back pain, hsCRP remained approximately constant throughout the whole period with no correlation with pain or function. As a conclusion, according to this study levels of hsCRP do not have a major clinical relevance when evaluating the long-term course of patients with acute lumbosciatic pain and chronic low back pain and therefore should not be taken into primary consideration when decisions on therapy are made. 2006 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/j.ejpain.2005.11.005" target="_blank" rel="noreferrer">10.1016/j.ejpain.2005.11.005</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2006 Acute Disease Adult Backlog Brenner H Buchner M C-Reactive Protein/metabolism Chronic Disease Cohort Studies European Journal Of Pain Female Gebhardt K Humans Journal Article Low Back Pain/blood/physiopathology/therapy Male Middle Aged Pain Measurement Raum E Recovery of Function/physiology Richter W Schiltenwolf M Sciatica/blood/physiopathology/therapy Sturmer T Time Factors Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1097/01.ajp.0000146165.15529.50" target="_blank" rel="noreferrer">http://doi.org/10.1097/01.ajp.0000146165.15529.50</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Oral methadone for chronic noncancer pain: a systematic literature review of reasons for administration, prescription patterns, effectiveness, and side effects Publisher An entity responsible for making the resource available The Clinical Journal Of Pain Date A point or period of time associated with an event in the lifecycle of the resource 2005 Subject The topic of the resource Female; Humans; Male; Pain Measurement; Methadone; Drug Administration Schedule; Non-U.S. Gov't; Research Support; Comparative Study; Chronic disease; Administration; Oral; Dose-Response Relationship; Drug; Methadone/administration & dosage/adverse effects; Narcotics/administration & dosage/adverse effects; Pain/classification/drug therapy; Literature review Creator An entity primarily responsible for making the resource Sandoval JA; Furlan AD; Mailis-Gagnon A Description An account of the resource OBJECTIVE: To assess the indications, prescription patterns, effectiveness, and side effects of oral methadone for the treatment of chronic noncancer pain. METHODS: We conducted searches of several electronic databases, textbooks and reference lists for controlled or uncontrolled studies in humans. Effectiveness was assessed using a dichotomous classification of "meaningful" versus "nonmeaningful" outcomes. RESULTS: Twenty-one papers (1 small randomized trial, 13 case reports, and 7 case series) involving 545 patients with multiple noncancer pain conditions were included. In half of the patients, no specific diagnosis was reported. Methadone was administered primarily when previous opioid treatment was ineffective or produced intolerable side effects. Starting dose ranged from 0.2 to 80 mg/day and maximum dose ranged from 20 to 930 mg/day. Pain outcomes were meaningful in 59% of the patients in the uncontrolled studies. The randomized trial demonstrated a statistically significant improvement in pain for methadone (20 mg/day) compared to placebo. Side effects were considered minor. DISCUSSION: Oral methadone is used for various noncancer pain syndromes, at different settings and with no prescription pattern that could be identifiable. Starting, maintenance, and maximum doses showed great variability. The figure of 59% effectiveness of methadone should be interpreted very cautiously, as it seems overrated due to the poor quality of the uncontrolled studies and their tendency to report positive results. The utilization of oral methadone for noncancer pain is based on primarily uncontrolled literature. Well-designed controlled trials may provide more accurate information on the drug's efficiency in pain syndromes and in particular neuropathic pain. 2005 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1097/01.ajp.0000146165.15529.50" target="_blank" rel="noreferrer">10.1097/01.ajp.0000146165.15529.50</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2005 Administration Backlog Chronic Disease Comparative Study Dose-Response Relationship Drug Drug Administration Schedule Female Furlan AD Humans Journal Article Literature review Mailis-Gagnon A Male Methadone Methadone/administration & dosage/adverse effects Narcotics/administration & dosage/adverse effects Non-U.S. Gov't Oral Pain Measurement Pain/classification/drug therapy Research Support Sandoval JA The Clinical Journal Of Pain Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1136/qshc.2005.017707" target="_blank" rel="noreferrer">http://doi.org/10.1136/qshc.2005.017707</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Improving comfort and communication in the ICU: a practical new tool for palliative care performance measurement and feedback Publisher An entity responsible for making the resource available Quality & Safety in Health Care Date A point or period of time associated with an event in the lifecycle of the resource 2006 Subject The topic of the resource Humans; United States; Pain Measurement; Professional-Family Relations; Cooperative Behavior; Communication; Pilot Projects; Program Development; Patient Satisfaction; Spirituality; Hospitals; Proxy; Feedback; decision making; Health Care; Quality Assurance; Health Care/organization & administration; Quality Indicators; Palliative Care/psychology/standards; Intensive Care Units/standards; Critical Care/psychology/standards; Voluntary/organization & administration/standards Creator An entity primarily responsible for making the resource Nelson JE; Mulkerin CM; Adams LL; Pronovost PJ Description An account of the resource OBJECTIVE: To develop a practical set of measures for routine monitoring, performance feedback, and improvement in the quality of palliative care in the intensive care unit (ICU). DESIGN: Use of an interdisciplinary iterative process to create a prototype "bundle" of indicators within previously established domains of ICU palliative care quality; operationalization of indicators as specified measures; and pilot implementation to evaluate feasibility and baseline ICU performance. SETTING: The national Transformation of the Intensive Care Unit program developed in the United States by VHA Inc. PATIENTS: Critically ill patients in ICUs for 1, > 3, and > 5 days. MEASUREMENTS AND MAIN RESULTS: Palliative care processes including identification of patient preferences and decision making surrogates, communication between clinicians and patients/families, social and spiritual support, and pain assessment and management, as documented in medical records. Application is triggered by specified lengths of ICU stay. Pilot testing in 19 ICUs (review of > 100 patients' records) documented feasibility, while revealing opportunities for quality improvement in clinician-patient/family communication and other key components of ICU palliative care. CONCLUSIONS: The new bundle of measures is a prototype for routine measurement of the quality of palliative care in the ICU. Further investigation is needed to confirm associations between measured processes and outcomes of importance to patients and families, as well as other aspects of validity. 2006 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1136/qshc.2005.017707" target="_blank" rel="noreferrer">10.1136/qshc.2005.017707</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2006 Adams LL Backlog Communication Cooperative Behavior Critical Care/psychology/standards Decision Making Feedback Health Care Health Care/organization & administration Hospitals Humans Intensive Care Units/standards Journal Article Mulkerin CM Nelson JE Pain Measurement Palliative Care/psychology/standards Patient Satisfaction Pilot Projects Professional-family Relations Program Development Pronovost PJ Proxy Quality & Safety in Health Care Quality Assurance Quality Indicators Spirituality United States Voluntary/organization & administration/standards Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.12968/ijpn.2006.12.6.21450" target="_blank" rel="noreferrer">http://doi.org/10.12968/ijpn.2006.12.6.21450</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Symptoms suffered by life-limited children that cause anxiety to UK children's hospice staff Publisher An entity responsible for making the resource available International Journal Of Palliative Nursing Date A point or period of time associated with an event in the lifecycle of the resource 2006 Subject The topic of the resource Child; Humans; Pain Measurement; Great Britain; Attitude to Health; Attitude of Health Personnel; Questionnaires; Pediatric Nursing; Child Psychology; Fear; Nursing Methodology Research; Nonverbal Communication; Crying; Child Behavior; Stress; Adaptation; Psychological; Charting the Territory; Causality; Vomiting/etiology/prevention & control; Hospice Care/psychology; Anxiety/etiology; Medical Staff/psychology; Nursing Staff/psychology; Occupational Diseases/etiology; Psychological/diagnosis/etiology/prevention & control; Seizures/etiology/prevention & control; Spasm/etiology/prevention & control Creator An entity primarily responsible for making the resource McCluggage HL Description An account of the resource BACKGROUND: Very little is published about the symptom profile of children with life-limiting illnesses other than cancer. METHOD: A postal questionnaire was sent to children's hospice staff who were asked to identify symptoms experienced by life-limited children which caused them anxiety. RESULTS: Staff in 23 hospices were sent questionnaires. Twenty-eight questionnaires were returned from 10 doctors and 18 nurses. Just under half of the hospices contacted were represented. The staff were very experienced but had significant anxieties about treating some of their patients. AIMS: This study aimed to identify the symptoms which cause anxiety to staff working in children's hospices. More than 70% of all staff groups felt that identifying the symptom correctly caused more anxiety than treating identified symptoms. For doctors the top five symptom problems were, seizure control, spasms, pain assessment, unidentified distress and vomiting. For nurses the main concerns were the non-verbal child in distress, psychiatric or psychological problems, assessing pain, seizures, pain management, vomiting. CONCLUSIONS: Doctors and nurses perceive seizures, pain management, and vomiting as the most troublesome symptoms for children with life-limiting conditions. Further research is needed into symptom management in this area. 2006 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.12968/ijpn.2006.12.6.21450" target="_blank" rel="noreferrer">10.12968/ijpn.2006.12.6.21450</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2006 Adaptation Anxiety/etiology Attitude Of Health Personnel Attitude To Health Backlog Causality Child Child Behavior Child Psychology Crying Fear Great Britain Hospice Care/psychology Humans International Journal of Palliative Nursing Journal Article McCluggage HL Medical Staff/psychology Nonverbal Communication Nursing Methodology Research Nursing Staff/psychology Occupational Diseases/etiology Pain Measurement Pediatric Nursing Psychological Psychological/diagnosis/etiology/prevention & control Questionnaires Seizures/etiology/prevention & control Spasm/etiology/prevention & control Stress Vomiting/etiology/prevention & control Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1542/peds.2005-0620C" target="_blank" rel="noreferrer">http://doi.org/10.1542/peds.2005-0620C</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Summary proceedings from the neonatal pain-control group Publisher An entity responsible for making the resource available Pediatrics Date A point or period of time associated with an event in the lifecycle of the resource 2006 Subject The topic of the resource Humans; infant; United States; Pain; Pain Measurement; Respiration; Analgesia; Research Support; U.S. Gov't; Newborn; Pain/drug therapy/etiology; Government Regulation; Anesthesia; N.I.H.; Postoperative/drug therapy; Non-P.H.S.; Extramural; General; Outcome Assessment (Health Care)/methods; Artificial/adverse effects; Clinical Trials/ethics/legislation & jurisprudence Creator An entity primarily responsible for making the resource Anand KJ; Aranda JV; Berde CB; Buckman S; Capparelli EV; Carlo W; Hummel P; Johnston CC; Lantos J; Tutag-Lehr V; Lynn AM; Maxwell LG; Oberlander T; Raju TN; Soriano SG; Taddio A; Walco GA Description An account of the resource Recent advances in neurobiology and clinical medicine have established that the fetus and newborn may experience acute, established, and chronic pain. They respond to such noxious stimuli by a series of complex biochemical, physiologic, and behavioral alterations. Studies have concluded that controlling pain experience is beneficial with respect to short-term and perhaps long-term outcomes. Yet, pain-control measures are adopted infrequently because of unresolved scientific issues and lack of appreciation for the need for control of pain and its long-term sequelae during the critical phases of neurologic maturation in the preterm and term newborn. The neonatal pain-control group, as part of the Newborn Drug Development Initiative (NDDI) Workshop I, addressed these concerns. The specific issues addressed were (1) management of pain associated with invasive procedures, (2) provision of sedation and analgesia during mechanical ventilation, and (3) mitigation of pain and stress responses during and after surgery in the newborn infant. The cross-cutting themes addressed within each category included (1) clinical-trial designs, (2) drug prioritization, (3) ethical constraints, (4) gaps in our knowledge, and (5) future research needs. This article provides a summary of the discussions and deliberations. Full-length articles on procedural pain, sedation and analgesia for ventilated infants, perioperative pain, and study designs for neonatal pain research were published in Clinical Therapeutics (June 2005). 2006 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1542/peds.2005-0620C" target="_blank" rel="noreferrer">10.1542/peds.2005-0620C</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2006 Analgesia Anand KJ Anesthesia Aranda JV Artificial/adverse effects Backlog Berde CB Buckman S Capparelli EV Carlo W Clinical Trials/ethics/legislation & jurisprudence Extramural General Government Regulation Humans Hummel P Infant Johnston CC Journal Article Lantos J Lynn AM Maxwell LG N.I.H. Newborn Non-P.H.S. Oberlander T Outcome Assessment (Health Care)/methods Pain Pain Measurement Pain/drug therapy/etiology Pediatrics Postoperative/drug therapy Raju TN Research Support Respiration Soriano SG Taddio A Tutag-Lehr V U.S. Gov't United States Walco GA Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=16439902" target="_blank" rel="noreferrer">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=16439902</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The use of conscious sedation for pain control during forearm fracture reduction in children: does race matter? Publisher An entity responsible for making the resource available Journal of Pediatric Orthopaedics Date A point or period of time associated with an event in the lifecycle of the resource 2006 Subject The topic of the resource Child; Female; Humans; Male; Pain Measurement; Cohort Studies; Logistic Models; Follow-Up Studies; Risk Assessment; Multivariate Analysis; Probability; Chi-Square Distribution; Emergency Service; adolescent; Preschool; Non-U.S. Gov't; Research Support; PedPal Lit; Comparative Study; retrospective studies; Analgesia/methods; Hospital; Fractures; Attitude to Health/ethnology; African Americans/statistics & numerical data; Bone/ethnology/radiography/surgery; Conscious Sedation/methods; European Continental Ancestry Group/statistics & numerical data; Forearm Injuries/ethnology/radiography/surgery; Fracture Fixation/methods; Injury Severity Score Creator An entity primarily responsible for making the resource VanderBeek BL; Mehlman CT; Foad SL; Wall EJ; Crawford AH Description An account of the resource Recent reports in the medical literature indicate that certain racial disparities have been identified in healthcare. The authors sought to identify the potential relationship between the use of pain medications in African-American and Caucasian children undergoing forearm fracture reduction. This retrospective cohort study was performed at a university-affiliated tertiary care children's hospital emergency department. All Caucasian and African-American patients who underwent a closed reduction of a fractured ulna or radius over the 2-year observational period were enrolled. Patients were excluded from the study if they were admitted to the hospital for an open reduction or had multiple injuries. The relationship between race, gender, insurance status, time of admission, length of stay in the emergency department, fracture characteristics, and the use of conscious sedation was analyzed. t tests, chi-square tests, and stepwise logistic regression were used for data analysis. A total of 503 patients were included, 83% Caucasian and 17% African-American. Four hundred four patients received conscious sedation as part of their fracture reduction procedure and 99 did not. Univariate analysis showed that African-American and Caucasian children had different forearm fracture patterns (P = 0.0116) and different severities of angulation (P = 0.0094). Multivariate statistical analysis revealed that higher amounts of fracture translation (P < 0.0001) and angulation (P < 0.0027) and younger age of the patient (P = 0.0059) were significant predictors of conscious sedation use. Race was not found to be significantly associated with the use of conscious sedation (P = 0.0606 in univariate analysis, P = 0.1678 in multivariate analysis). The authors found that the decision to use conscious sedation for pediatric forearm fractures was not influenced by race, but was influenced by certain fracture characteristics and patient age. 2006 Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2006 Adolescent African Americans/statistics & numerical data Analgesia/methods Attitude to Health/ethnology Backlog Bone/ethnology/radiography/surgery Chi-Square Distribution Child Cohort Studies Comparative Study Conscious Sedation/methods Crawford AH Emergency Service European Continental Ancestry Group/statistics & numerical data Female Foad SL Follow-up Studies Forearm Injuries/ethnology/radiography/surgery Fracture Fixation/methods Fractures Hospital Humans Injury Severity Score Journal Article Journal of Pediatric Orthopaedics Logistic Models Male Mehlman CT Multivariate Analysis Non-U.S. Gov't Pain Measurement PedPal Lit Preschool Probability Research Support Retrospective Studies Risk Assessment VanderBeek BL Wall EJ Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=16449934" target="_blank" rel="noreferrer noopener">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=16449934</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource [Management of cancer pain in children] Publisher An entity responsible for making the resource available Annales pharmaceutiques françaises Date A point or period of time associated with an event in the lifecycle of the resource 2006 Subject The topic of the resource Child; Humans; Pain Measurement; PedPal Lit; Neoplasms/complications; Analgesics/therapeutic use; Antineoplastic Agents/adverse effects; Chemistry; Pharmaceutical; Iatrogenic Disease; English Abstract; Pain/drug therapy/etiology Creator An entity primarily responsible for making the resource Bourdon O; Brion F Description An account of the resource Pain and cancer cannot be dissociated. A particular feature observed in children is that the child exhibits a certain psychomotor atony with increasing pain. The child complains less and less, making it difficult to recognize the degree of suffering and provide adequate relief. The most painful events for the child are iatrogenic: local care, puncture, injection, infusion, sample taking. The healthcare team must limit such events to the strict minimum. 2006 Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article Identifier An unambiguous reference to the resource within a given context <a href="https://www.sciencedirect.com/science/article/abs/pii/S0003450906752890?via%3Dihub">10.1016/s0003-4509(06)75289-0</a> 2006 Analgesics/therapeutic use Annales pharmaceutiques françaises Antineoplastic Agents/adverse effects Backlog Bourdon O Brion F Chemistry Child English Abstract Humans Iatrogenic Disease Journal Article Neoplasms/complications Pain Measurement Pain/drug therapy/etiology PedPal Lit Pharmaceutical Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=16514332" target="_blank" rel="noreferrer">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=16514332</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Factors related to the quality of life in adolescents with chronic pain Publisher An entity responsible for making the resource available The Clinical Journal Of Pain Date A point or period of time associated with an event in the lifecycle of the resource 2006 Subject The topic of the resource Child; Cross-Sectional Studies; Female; Humans; Male; Prognosis; Questionnaires; Risk Factors; Psychology; adolescent; PedPal Lit; Chronic disease; quality of life; Netherlands/epidemiology; Pain Measurement; Pain/diagnosis/epidemiology/psychology; Risk Assessment/methods Creator An entity primarily responsible for making the resource Merlijn VP; Hunfeld JA; van der Wouden JC; Hazebroek-Kampschreur AA; Passchier J; Koes BW Description An account of the resource OBJECTIVE: This study examined the relationships between pain characteristics, psychosocial factors, and quality of life among adolescents with chronic pain that existed for at least 3 months, either recurrently (ie, pain with pain-free intervals) or continuously. METHODS: The authors conducted a cross-sectional study in 194 adolescents aged 12 to 18 years who completed questionnaires on pain, psychosocial factors (ie, vulnerability, reinforcement, modeling, and coping), and quality of life, and also kept a diary about their pain complaints for 3 weeks. RESULTS: Multiple hierarchical regression analysis revealed that psychosocial variables accounted for a significant variance in the adolescents' quality of life, even when controlling for pain characteristics. Analysis of the independent variables showed that pain intensity and vulnerability contributed significantly and uniquely to the variance of most quality-of-life domains. In addition, the authors found that emotion-focused avoidance coping strategies (ie, catastrophizing) strengthened the negative relation between pain intensity and psychological functioning. CONCLUSIONS: In addition to pain, psychosocial factors (vulnerability, reinforcement, modeling, and coping) are strongly associated with quality of life in adolescents with chronic pain. These results may contribute to psychological interventions focused on psychological adaptation in young pain patients to improve their quality of life. 2006 Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2006 Adolescent Backlog Child Chronic Disease Cross-sectional Studies Female Hazebroek-Kampschreur AA Humans Hunfeld JA Journal Article Koes BW Male Merlijn VP Netherlands/epidemiology Pain Measurement Pain/diagnosis/epidemiology/psychology Passchier J PedPal Lit Prognosis Psychology Quality Of Life Questionnaires Risk Assessment/methods Risk Factors The Clinical Journal Of Pain van der Wouden JC Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=16522488" target="_blank" rel="noreferrer">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=16522488</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Avoiding admission for afebrile pediatric sickle cell pain: pain management methods Publisher An entity responsible for making the resource available Journal Of Pediatric Health Care Date A point or period of time associated with an event in the lifecycle of the resource 2006 Subject The topic of the resource Child; Humans; infant; Pain Measurement; Adult; Anemia; adolescent; Preschool; PedPal Lit; infant; Newborn; United States/epidemiology; Analgesics/therapeutic use; Patient Education; Antisickling Agents/therapeutic use; Hydroxyurea/therapeutic use; Pain/epidemiology/nursing/psychology/therapy; Relaxation Techniques; Sickle Cell/mortality/nursing/psychology/therapy Creator An entity primarily responsible for making the resource Dumaplin CA Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article Description An account of the resource 2006 2006 Adolescent Adult Analgesics/therapeutic use Anemia Antisickling Agents/therapeutic use Backlog Child Dumaplin CA Humans Hydroxyurea/therapeutic use Infant Journal Article Journal Of Pediatric Health Care Newborn Pain Measurement Pain/epidemiology/nursing/psychology/therapy Patient Education PedPal Lit Preschool Relaxation Techniques Sickle Cell/mortality/nursing/psychology/therapy United States/epidemiology Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=16544799" target="_blank" rel="noreferrer">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=16544799</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Nurses' attitudes to pain management during routine venepuncture in young children Publisher An entity responsible for making the resource available Paediatric Nursing Date A point or period of time associated with an event in the lifecycle of the resource 2006 Subject The topic of the resource Child; Humans; Pain Measurement; Questionnaires; Age Factors; Severity of Illness Index; Nursing Assessment; Nursing Methodology Research; Child Advocacy; Nursing Staff; Patient Rights; Practice; Preschool; Attitudes; PedPal Lit; infant; Health Knowledge; Hospitalized/psychology; Child; Nurse's Role/psychology; Attitude of Health Personnel; administration/psychology; Hospital/education/organization &; Pain/diagnosis/etiology/prevention & control/psychology; Pediatric Nursing/education/organization & administration; Phlebotomy/adverse effects Creator An entity primarily responsible for making the resource Melhuish S; Payne H Description An account of the resource Venepuncture is one of the most commonly performed clinical procedures carried out on young children. Evidence indicates inconsistency in the use of pain management strategies during these procedures. A survey method was used to explore nurses' views on the experience of pain by infants and toddlers and the pain management techniques they use. All children's nurses on the general medical and surgical wards at one hospital site were invited to participate (n=55) 45 responses were receive (81 per cent). These children's nurses believe that infants and toddlers feel more pain and display more distress than older children. Respondents reported that pharmacological preparations were not generally used on infants prior to venous cannulation Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2006 administration/psychology Age Factors Attitude Of Health Personnel Attitudes Backlog Child Child Advocacy Health Knowledge Hospital/education/organization & Hospitalized/psychology Humans Infant Journal Article Melhuish S Nurse's Role/psychology Nursing Assessment Nursing Methodology Research Nursing Staff Paediatric Nursing Pain Measurement Pain/diagnosis/etiology/prevention & control/psychology Patient Rights Payne H Pediatric Nursing/education/organization & administration PedPal Lit Phlebotomy/adverse effects Practice Preschool Questionnaires Severity Of Illness Index Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=16553248" target="_blank" rel="noreferrer">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=16553248</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Pain in pediatric oncology: do the experiences of children and parents differ from those of nurses and physicians? Publisher An entity responsible for making the resource available Upsala Journal of Medical Sciences Date A point or period of time associated with an event in the lifecycle of the resource 2006 Subject The topic of the resource Child; Humans; Pain Measurement; Adult; Attitude to Health; Non-U.S. Gov't; Research Support; PedPal Lit; Comparative Study; Parents/psychology; Physicians/psychology; Nurses/psychology; Attitude of Health Personnel; Neoplasms/complications/psychology; Pain/etiology/prevention & control/psychology Creator An entity primarily responsible for making the resource Ljungman G; Kreuger A; Gordh T; Sorensen S Description An account of the resource Diagnosis and treatment of pain are central components in the care of children with cancer. The aim of the present study was to compare the viewpoints of children and parents with those of professionals, on different aspects of pain in children with cancer. Information was collected through questionnaires and interviews. In particular, we focused on the extent and causes of pain, strategies to reduce procedural pain, pain evaluation, and attitudes to pain treatment. We found that both families and professionals shared the opinion that pain was a common symptom during different phases of cancer treatment but, surprisingly, professionals regarded it as more frequent than families. The groups agreed that treatment related pain is the most critical problem, followed by procedure and cancer related pain. Concerning strategies to decrease procedural pain, there was a high concordance in views between groups. Nurses and physicians more often claimed that failing pain treatment was associated with psychological factors such as high levels of anxiety in parents and children, loneliness, and lack of preparation. The self-report, according to both parents and professionals, is a feasible procedure even in young children from 4 years of age. Both groups asserted that parents were better in ascertaining the extent of their child's pain. In conclusion, although the families and professionals in this study have many comparable views concerning pain in children with cancer, divergences also exist. To acquire a more accurate picture of the situation we must focus on the views of the children first, and then those of parents and professionals. A tendency to overestimate the problems was observed in professionals. Hopefully this reflects a keen awareness of the current situation. 2006 Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2006 Adult Attitude Of Health Personnel Attitude To Health Backlog Child Comparative Study Gordh T Humans Journal Article Kreuger A Ljungman G Neoplasms/complications/psychology Non-U.S. Gov't Nurses/psychology Pain Measurement Pain/etiology/prevention & control/psychology Parents/psychology PedPal Lit Physicians/psychology Research Support Sorensen S Upsala Journal of Medical Sciences Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=16579309" target="_blank" rel="noreferrer">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=16579309</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Chronic abdominal pain in children: an update Publisher An entity responsible for making the resource available Missouri Medicine Date A point or period of time associated with an event in the lifecycle of the resource 2006 Subject The topic of the resource Child; Female; Humans; Male; Pain Measurement; Prevalence; Prognosis; Socioeconomic Factors; Severity of Illness Index; Risk Assessment; Combined Modality Therapy; Psychology; Education; adolescent; Preschool; PedPal Lit; Chronic disease; continuing; Medical; Abdominal Pain/diagnosis/epidemiology/therapy; Gastrointestinal Diseases/diagnosis/epidemiology/therapy; Missouri/epidemiology Creator An entity primarily responsible for making the resource Schurman JV; Friesen CA Description An account of the resource Despite the fact that chronic abdominal pain is a common complaint in children and adolescents, the complexity of this condition only recently has begun to be understood. This article summarizes new advances in the diagnosis, conceptualization, and treatment of chronic abdominal pain. Implications for effective assessment and treatment within the pediatric primary care setting are discussed. 2006 Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2006 Abdominal Pain/diagnosis/epidemiology/therapy Adolescent Backlog Child Chronic Disease Combined Modality Therapy Continuing Education Female Friesen CA Gastrointestinal Diseases/diagnosis/epidemiology/therapy Humans Journal Article Male Medical Missouri Medicine Missouri/epidemiology Pain Measurement PedPal Lit Preschool Prevalence Prognosis Psychology Risk Assessment Schurman JV Severity Of Illness Index Socioeconomic Factors Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1001/archpedi.157.11.1071" target="_blank" rel="noreferrer">http://doi.org/10.1001/archpedi.157.11.1071</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Beta-endorphin concentration after administration of sucrose in preterm infants Publisher An entity responsible for making the resource available Archives Of Pediatrics & Adolescent Medicine Date A point or period of time associated with an event in the lifecycle of the resource 2003 Subject The topic of the resource Female; Humans; infant; Male; Pain Measurement; Prospective Studies; Intensive Care; Administration; beta-Endorphin/blood; Biomarkers of Pain; Newborn; Oral; Pain/drug therapy/etiology; Premature; Sucrose/administration & dosage Creator An entity primarily responsible for making the resource Taddio A; Shah V; Shah P; Katz J Description An account of the resource BACKGROUND: Sucrose is an effective analgesic for procedural pain in preterm infants. It has been hypothesized that its analgesic effects are mediated by the release of endogenous opioid neurotransmitters such as beta-endorphin. OBJECTIVE: To determine whether intraoral administration of sucrose was associated with an increase in serum beta-endorphin concentrations in preterm infants with a gestation period less than 29 weeks who were not exposed to a painful stimulus. METHODS: We performed a prospective open-label study in preterm infants admitted to 2 tertiary neonatal intensive care units. Each infant received a single dose of 30% sucrose intraorally during a 1- to 2-minute period. A blood sample was obtained using an indwelling arterial catheter to determine beta-endorphin concentration immediately before and 2 to 5 minutes after the commencement of sucrose administration. RESULTS: We enrolled 11 preterm infants with a mean +/- SD gestational age of 27.2 +/- 0.9 weeks and a mean +/- SD birth weight of 1018 +/- 238 g (1.02 +/- 0.24 kg) at a mean +/- SD postnatal age of 3.0 +/- 2.5 days. The mean +/- SD beta-endorphin concentration before and after sucrose administration was 60.4 +/- 30.5 pg/mL and 57.4 +/- 22.4 pg/mL, respectively (P =.45). No adverse events were observed during the study procedures. CONCLUSION: Intraoral administration of sucrose in preterm infants did not lead to an increase in serum beta-endorphin concentrations at a point in time when the analgesic effects of sucrose were presumed to be present. 2003 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1001/archpedi.157.11.1071" target="_blank" rel="noreferrer">10.1001/archpedi.157.11.1071</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2003 Administration Archives Of Pediatrics & Adolescent Medicine Backlog beta-Endorphin/blood Biomarkers of Pain Female Humans Infant Intensive Care Journal Article Katz J Male Newborn Oral Pain Measurement Pain/drug therapy/etiology Premature Prospective Studies Shah P Shah V Sucrose/administration & dosage Taddio A Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1001/jama.290.13.1757" target="_blank" rel="noreferrer">http://doi.org/10.1001/jama.290.13.1757</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain: a randomized controlled trial Publisher An entity responsible for making the resource available Jama Date A point or period of time associated with an event in the lifecycle of the resource 2003 Subject The topic of the resource Female; Humans; Male; Pain Measurement; Adult; Analgesics; Middle Aged; Double-Blind Method; Cross-Over Studies; Non-U.S. Gov't; Research Support; Chronic disease; Hyperalgesia/complications/drug therapy; Non-Narcotic/therapeutic use; Pain/complications/drug therapy; Tetrahydrocannabinol/analogs & derivatives/therapeutic use Creator An entity primarily responsible for making the resource Karst M; Salim K; Burstein S; Conrad I; Hoy L; Schneider U Description An account of the resource CONTEXT: 1',1'dimethylheptyl-Delta8-tetrahydrocannabinol-11-oic acid (CT-3), a potent analog of THC-11-oic acid, produces marked antiallodynic and analgesic effects in animals without evoking the typical effects described in models of cannabinoids. Therefore, CT-3 may be an effective analgesic for poorly controlled resistant neuropathic pain. OBJECTIVE: To examine the analgesic efficacy and safety of CT-3 in chronic neuropathic pain in humans. DESIGN AND SETTING: Randomized, placebo-controlled, double-blind crossover trial conducted in Germany from May-September 2002. PARTICIPANTS: Twenty-one patients (8 women and 13 men) aged 29 to 65 years (mean, 51 years) who had a clinical presentation and examination consistent with chronic neuropathic pain (for at least 6 months) with hyperalgesia (n = 21) and allodynia (n = 7). INTERVENTIONS: Patients were randomized to two 7-day treatment orders in a crossover design. Two daily doses of CT-3 (four 10-mg capsules per day) or identical placebo capsules were given during the first 4 days and 8 capsules per day were given in 2 daily doses in the following 3 days. After a washout and baseline period of 1 week each, patients crossed over to the second 7-day treatment period. MAIN OUTCOME MEASURES: Visual analog scale (VAS) and verbal rating scale scores for pain; vital sign, hematologic and blood chemistry, and electrocardiogram measurements; scores on the Trail-Making Test and the Addiction Research Center Inventory-Marijuana scale; and adverse effects. RESULTS: The mean differences over time for the VAS values in the CT-3-placebo sequence measured 3 hours after intake of study drug differed significantly from those in the placebo-CT-3 sequence (mean [SD], -11.54 [14.16] vs 9.86 [21.43]; P =.02). Eight hours after intake of the drug, the pain scale differences between groups were less marked. No dose response was observed. Adverse effects, mainly transient dry mouth and tiredness, were reported significantly more often during CT-3 treatment (mean [SD] difference, -0.67 [0.50] for CT-3-placebo sequence vs 0.10 [0.74] for placebo-CT-3 sequence; P =.02). There were no significant differences with respect to vital signs, blood tests, electrocardiogram, Trail-Making Test, and Addiction Research Center Inventory-Marijuana scale. No carryover or period effects were observed except on the Trail-Making Test. CONCLUSIONS: In this preliminary study, CT-3 was effective in reducing chronic neuropathic pain compared with placebo. No major adverse effects were observed. 2003 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1001/jama.290.13.1757" target="_blank" rel="noreferrer">10.1001/jama.290.13.1757</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2003 Adult Analgesics Backlog Burstein S Chronic Disease Conrad I Cross-Over Studies Double-Blind Method Female Hoy L Humans Hyperalgesia/complications/drug therapy JAMA Journal Article Karst M Male Middle Aged Non-Narcotic/therapeutic use Non-U.S. Gov't Pain Measurement Pain/complications/drug therapy Research Support Salim K Schneider U Tetrahydrocannabinol/analogs & derivatives/therapeutic use Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1016/j.pain.2004.08.029" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.pain.2004.08.029</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Control of inflammatory pain by chemokine-mediated recruitment of opioid-containing polymorphonuclear cells Publisher An entity responsible for making the resource available Pain Date A point or period of time associated with an event in the lifecycle of the resource 2004 Subject The topic of the resource Male; Pain Measurement; Analysis of Variance; Animals; Rats; Non-U.S. Gov't; Research Support; Comparative Study; Dose-Response Relationship; Drug; Receptors; Naloxone/pharmacology; Freund's Adjuvant; Wistar; Flow Cytometry/methods; Antibodies/pharmacology; Cell Count/methods; Cell Movement/physiology; Chemokines; Chemokines/immunology/physiology; Corticotropin-Releasing Hormone/therapeutic use; CXC/immunology/metabolism; Drug Administration Routes; Enzyme-Linked Immunosorbent Assay/methods; Gene Expression Regulation/physiology; Immunohistochemistry/methods; Intercellular Signaling Peptides and Proteins/immunology/metabolism; Interleukin-8B/metabolism; Narcotics/metabolism; Neurogenic Inflammation/chemically induced/complications/therapy; Neutrophils/metabolism; Pain Threshold/drug effects; Pain/etiology/therapy Creator An entity primarily responsible for making the resource Brack A; Rittner HL; Machelska H; Leder K; Mousa SA; Schafer M; Stein C Description An account of the resource Opioid-containing leukocytes can counteract inflammatory hyperalgesia. Under stress or after local injection of corticotropin releasing factor (CRF), opioid peptides are released from leukocytes, bind to opioid receptors on peripheral sensory neurons and mediate antinociception. Since polymorphonuclear cells (PMN) are the predominant opioid-containing leukocyte subpopulation in early inflammation, we hypothesized that PMN and their recruitment by chemokines are important for peripheral opioid-mediated antinociception at this stage. Rats were intraplantarly injected with complete Freund's adjuvant (CFA). Using flow cytometry, immunohistochemistry, and ELISA, leukocyte subpopulations, chemokine receptor (CXCR2) expression on opioid-containing leukocytes and the CXCR2 ligands keratinocyte-derived chemokine (KC), macrophage inflammatory protein-2 (MIP-2) and cytokine-induced neutrophil chemoattractant-2 (CINC-2) were quantified. Paw pressure threshold (PPT) was determined before and after intraplantar and subcutaneous injection of CRF with or without naloxone. PMN depletion was achieved by intravenous injection of an antiserum. Chemokines were blocked by intraplantar injection of anti-MIP-2 and/or anti-KC antiserum. We found that at 2 h post CFA (i) intraplantar but not subcutaneous injection of CRF produced dose-dependent and naloxone-reversible antinociception (P0.05, ANOVA). In summary, in early inflammation peripheral opioid-mediated antinociception is critically dependent on PMN and their recruitment by CXCR2 chemokines. 2004 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/j.pain.2004.08.029" target="_blank" rel="noreferrer">10.1016/j.pain.2004.08.029</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2004 Analysis of Variance Animals Antibodies/pharmacology Backlog Brack A Cell Count/methods Cell Movement/physiology Chemokines Chemokines/immunology/physiology Comparative Study Corticotropin-Releasing Hormone/therapeutic use CXC/immunology/metabolism Dose-Response Relationship Drug Drug Administration Routes Enzyme-Linked Immunosorbent Assay/methods Flow Cytometry/methods Freund's Adjuvant Gene Expression Regulation/physiology Immunohistochemistry/methods Intercellular Signaling Peptides and Proteins/immunology/metabolism Interleukin-8B/metabolism Journal Article Leder K Machelska H Male Mousa SA Naloxone/pharmacology Narcotics/metabolism Neurogenic Inflammation/chemically induced/complications/therapy Neutrophils/metabolism Non-U.S. Gov't Pain Pain Measurement Pain Threshold/drug effects Pain/etiology/therapy Rats Receptors Research Support Rittner HL Schafer M Stein C Wistar Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1016/j.pain.2004.09.019" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.pain.2004.09.019</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Opioids in chronic non-cancer pain: systematic review of efficacy and safety Publisher An entity responsible for making the resource available Pain Date A point or period of time associated with an event in the lifecycle of the resource 2004 Subject The topic of the resource Humans; Pain Measurement; Analgesics; Treatment Outcome; Methadone; Time Factors; Double-Blind Method; Non-U.S. Gov't; Research Support; Comparative Study; Chronic disease; Pain/drug therapy; Opioid/adverse effects/therapeutic use; Drug Evaluation; Drug Utilization Review; Randomized Controlled Trials/methods Creator An entity primarily responsible for making the resource Kalso E; Edwards JE; Moore RA; McQuay HJ Description An account of the resource Opioids are used increasingly for chronic non-cancer pain. Controversy exists about their effectiveness and safety with long-term use. We analysed available randomised, placebo-controlled trials of WHO step 3 opioids for efficacy and safety in chronic non-cancer pain. The Oxford Pain Relief Database (1950-1994) and Medline, EMBASE and the Cochrane Library were searched until September 2003. Inclusion criteria were randomised comparisons of WHO step 3 opioids with placebo in chronic non-cancer pain. Double-blind studies reporting on pain intensity outcomes using validated pain scales were included. Fifteen randomised placebo-controlled trials were included. Four investigations with 120 patients studied intravenous opioid testing. Eleven studies (1025 patients) compared oral opioids with placebo for four days to eight weeks. Six of the 15 included trials had an open label follow-up of 6-24 months. The mean decrease in pain intensity in most studies was at least 30% with opioids and was comparable in neuropathic and musculoskeletal pain. About 80% of patients experienced at least one adverse event, with constipation (41%), nausea (32%) and somnolence (29%) being most common. Only 44% of 388 patients on open label treatments were still on opioids after therapy for between 7 and 24 months. The short-term efficacy of opioids was good in both neuropathic and musculoskeletal pain conditions. However, only a minority of patients in these studies went on to long-term management with opioids. The small number of selected patients and the short follow-ups do not allow conclusions concerning problems such as tolerance and addiction. 2004 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/j.pain.2004.09.019" target="_blank" rel="noreferrer">10.1016/j.pain.2004.09.019</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2004 Analgesics Backlog Chronic Disease Comparative Study Double-Blind Method Drug Evaluation Drug Utilization Review Edwards JE Humans Journal Article Kalso E McQuay HJ Methadone Moore RA Non-U.S. Gov't Opioid/adverse effects/therapeutic use Pain Pain Measurement Pain/drug Therapy Randomized Controlled Trials/methods Research Support Time Factors Treatment Outcome