1
40
62
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/j.cmpb.2004.05.006" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.cmpb.2004.05.006</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Metadata-driven Delphi rating on the Internet
Publisher
An entity responsible for making the resource available
Computer Methods And Programs In Biomedicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
Subject
The topic of the resource
Delphi Technique; Internet; P.H.S.; Research Support; U.S. Gov't; Guidelines; Software
Creator
An entity primarily responsible for making the resource
Deshpande AM; Shiffman RN; Nadkarni PM
Description
An account of the resource
Paper-based data collection and analysis for consensus development is inefficient and error-prone. Computerized techniques that could improve efficiency, however, have been criticized as costly, inconvenient and difficult to use. We designed and implemented a metadata-driven Web-based Delphi rating and analysis tool, employing the flexible entity-attribute-value schema to create generic, reusable software. The software can be applied to various domains by altering the metadata; the programming code remains intact. This approach greatly reduces the marginal cost of re-using the software. We implemented our software to prepare for the Conference on Guidelines Standardization. Twenty-three invited experts completed the first round of the Delphi rating on the Web. For each participant, the software generated individualized reports that described the median rating and the disagreement index (calculated from the Interpercentile Range Adjusted for Symmetry) as defined by the RAND/UCLA Appropriateness Method. We evaluated the software with a satisfaction survey using a five-level Likert scale. The panelists felt that Web data entry was convenient (median 4, interquartile range [IQR] 4.0-5.0), acceptable (median 4.5, IQR 4.0-5.0) and easily accessible (median 5, IQR 4.0-5.0). We conclude that Web-based Delphi rating for consensus development is a convenient and acceptable alternative to the traditional paper-based method.
2005
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.cmpb.2004.05.006" target="_blank" rel="noreferrer">10.1016/j.cmpb.2004.05.006</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2005
Backlog
Computer Methods And Programs In Biomedicine
Delphi Technique
Deshpande AM
Guidelines
Internet
Journal Article
Nadkarni PM
P.H.S.
Research Support
Shiffman RN
Software
U.S. Gov't
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/j.jpeds.2004.11.031" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.jpeds.2004.11.031</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Gastric sensory and motor dysfunction in adolescents with functional dyspepsia
Publisher
An entity responsible for making the resource available
The Journal Of Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
Subject
The topic of the resource
Female; Humans; Male; adolescent; Non-U.S. Gov't; P.H.S.; Research Support; U.S. Gov't; Emission-Computed; Tomography; Receptors; Breath Tests; Dyspepsia/physiopathology; Gastric Emptying; Sensory/physiopathology; Single-Photon; Stomach/physiopathology
Creator
An entity primarily responsible for making the resource
Chitkara DK; Camilleri M; Zinsmeister AR; Burton D; El-Youssef M; Freese D; Walker L; Stephens D
Description
An account of the resource
OBJECTIVES: Validated, noninvasive studies were used to compare sensation and motor function of the upper gastrointestinal tract in adolescents with functional dyspepsia (FD) and in control subjects. STUDY DESIGN: Fifteen adolescents with FD and 15 healthy participants underwent standardized symptom assessment, a satiation nutrient drink test, and 13 C-Spirulina platensis breath test for gastric emptying of solids. Adolescents with FD also underwent measurements of fasting and postprandial gastric volume by means of single-photon emission computed tomography, and their results were compared with those from 15 healthy volunteers (age, 18 to 25 years). RESULTS: Compared with control subjects, adolescents with FD had significantly higher postprandial symptoms 30 minutes after reaching maximum satiation with the nutrient drink test and significant delay in the T 1/2 for gastric emptying of solids. Compared with healthy 18- to 25-year-old adults, adolescents had a diminished postprandial gastric volume response. By means of single-photon emission computed tomography, frequent baseline dyspeptic symptoms were associated with prolonged T 1/2 for gastric emptying and higher postprandial aggregate symptom score. A baseline increased severity of dyspepsia symptoms was associated with prolonged T 1/2 for gastric emptying. CONCLUSIONS: Adolescents with FD demonstrate increased postprandial symptoms after challenge, delayed gastric emptying, and a reduced gastric volume response to feeding.
2005
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jpeds.2004.11.031" target="_blank" rel="noreferrer">10.1016/j.jpeds.2004.11.031</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2005
Adolescent
Backlog
Breath Tests
Burton D
Camilleri M
Chitkara DK
Dyspepsia/physiopathology
El-Youssef M
Emission-Computed
Female
Freese D
Gastric Emptying
Humans
Journal Article
Male
Non-U.S. Gov't
P.H.S.
Receptors
Research Support
Sensory/physiopathology
Single-Photon
Stephens D
Stomach/physiopathology
The Journal Of Pediatrics
Tomography
U.S. Gov't
Walker L
Zinsmeister AR
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/j.tips.2005.01.009" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.tips.2005.01.009</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Individual responder analyses for pain: does one pain scale fit all?
Publisher
An entity responsible for making the resource available
Trends In Pharmacological Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
Subject
The topic of the resource
Humans; Reproducibility of Results; P.H.S.; Research Support; U.S. Gov't; Comparative Study; Pain/drug therapy/physiopathology; Clinical Trials/methods/trends; Pain Measurement/drug effects/methods/standards
Creator
An entity primarily responsible for making the resource
Dionne RA; Bartoshuk L; Mogil J; Witter J
Description
An account of the resource
The outcomes of clinical trials are based on the mean responses of large numbers of subjects but fail to address inter-individual differences. The molecular mechanisms that underlie pain vary among individuals over time and among different types of pain to produce wide inter-individual variations in pain perception and response. Gender, ethnicity, temperament and genetic factors also contribute to individual variation in pain sensitivity and responses to analgesics. Pain measurement scales can be used differently across individuals based on the past pain experiences of individuals. We propose that individual responder analyses could be used in clinical trials to better detect analgesic activity across patient groups and within sub-groups, and to identify molecular-genetic mechanisms that contribute to individual variation.
2005
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.tips.2005.01.009" target="_blank" rel="noreferrer">10.1016/j.tips.2005.01.009</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2005
Backlog
Bartoshuk L
Clinical Trials/methods/trends
Comparative Study
Dionne RA
Humans
Journal Article
Mogil J
P.H.S.
Pain Measurement/drug effects/methods/standards
Pain/drug therapy/physiopathology
Reproducibility of Results
Research Support
Trends In Pharmacological Sciences
U.S. Gov't
Witter J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1037/0022-3514.88.5.827" target="_blank" rel="noreferrer">http://doi.org/10.1037/0022-3514.88.5.827</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Resilience to loss in bereaved spouses, bereaved parents, and bereaved gay men
Publisher
An entity responsible for making the resource available
Journal Of Personality And Social Psychology
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
Subject
The topic of the resource
Humans; Male; Middle Aged; Affect; P.H.S.; Research Support; U.S. Gov't; Psychological; bereavement; Parents/psychology; N.I.H.; Social Behavior; Interview; Homosexuality; Male/psychology; Extramural; Spouses/psychology
Creator
An entity primarily responsible for making the resource
Bonanno GA; Moskowitz JT; Papa A; Folkman S
Description
An account of the resource
Recent research has indicated that many people faced with highly aversive events suffer only minor, transient disruptions in functioning and retain a capacity for positive affect and experiences. This article reports 2 studies that replicate and extend these findings among bereaved parents, spouses, and caregivers of a chronically ill life partner using a range of self-report and objective measures of adjustment. Resilience was evidenced in half of each bereaved sample when compared with matched, nonbereaved counterparts and 36% of the caregiver sample in a more conservative, repeated-measures ipsative comparison. Resilient individuals were not distinguished by the quality of their relationship with spouse/partner or caregiver burden but were rated more positively and as better adjusted by close friends.
2005
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1037/0022-3514.88.5.827" target="_blank" rel="noreferrer">10.1037/0022-3514.88.5.827</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2005
Affect
Backlog
Bereavement
Bonanno GA
Extramural
Folkman S
Homosexuality
Humans
Interview
Journal Article
Journal Of Personality And Social Psychology
Male
Male/psychology
Middle Aged
Moskowitz JT
N.I.H.
P.H.S.
Papa A
Parents/psychology
Psychological
Research Support
Social Behavior
Spouses/psychology
U.S. Gov't
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1056/NEJMra041867" target="_blank" rel="noreferrer">http://doi.org/10.1056/NEJMra041867</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The serotonin syndrome
Publisher
An entity responsible for making the resource available
The New England Journal Of Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
Subject
The topic of the resource
Humans; Drug Interactions; P.H.S.; Research Support; U.S. Gov't; algorithms; Antidepressive Agents/adverse effects; Diagnostic Errors; Monoamine Oxidase Inhibitors/adverse effects; Overdose/complications; Serotonin Syndrome/chemically induced/diagnosis/drug therapy/physiopathology; Serotonin Uptake Inhibitors/adverse effects
Creator
An entity primarily responsible for making the resource
Boyer EW; Shannon M
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1056/NEJMra041867" target="_blank" rel="noreferrer">10.1056/NEJMra041867</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
2005
2005
algorithms
Antidepressive Agents/adverse effects
Backlog
Boyer EW
Diagnostic Errors
Drug Interactions
Humans
Journal Article
Monoamine Oxidase Inhibitors/adverse effects
Overdose/complications
P.H.S.
Research Support
Serotonin Syndrome/chemically induced/diagnosis/drug therapy/physiopathology
Serotonin Uptake Inhibitors/adverse effects
Shannon M
The New England Journal Of Medicine
U.S. Gov't
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1089/jpm.2005.8.13" target="_blank" rel="noreferrer">http://doi.org/10.1089/jpm.2005.8.13</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Palliative care outcomes research: the next steps
Publisher
An entity responsible for making the resource available
Journal Of Palliative Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
Subject
The topic of the resource
Humans; United States; Aged; Research; P.H.S.; Research Support; U.S. Gov't; Palliative Care/trends; Hospital Mortality/trends; Hospitalization/statistics & numerical data/trends
Creator
An entity primarily responsible for making the resource
Morrison RS
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1089/jpm.2005.8.13" target="_blank" rel="noreferrer">10.1089/jpm.2005.8.13</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
2005
2005
Aged
Backlog
Hospital Mortality/trends
Hospitalization/statistics & numerical data/trends
Humans
Journal Article
Journal of Palliative Medicine
Morrison RS
P.H.S.
Palliative Care/trends
Research
Research Support
U.S. Gov't
United States
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1002/mpo.10057" target="_blank" rel="noreferrer">http://doi.org/10.1002/mpo.10057</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Osteopenia in children with acute lymphoblastic leukemia: a pilot study of amelioration with Pamidronate
Publisher
An entity responsible for making the resource available
Medical & Pediatric Oncology
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Child; Female; Humans; Male; Pilot Projects; Leukemia; Drug Administration Schedule; Bone Diseases; adolescent; Preschool; P.H.S.; Research Support; U.S. Gov't; Clodronate; Acute; Anti-Inflammatory Agents/administration & dosage/therapeutic use; Antineoplastic Agents/administration & dosage/therapeutic use; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Asparaginase/therapeutic use; Dexamethasone/therapeutic use; Diphosphonates/administration & dosage/therapeutic use; Doxorubicin/therapeutic use; L1/complications/drug therapy; Lymphocytic; Metabolic/drug therapy/etiology
Creator
An entity primarily responsible for making the resource
Barr RD; Guo CY; Wiernikowski J; Webber C; Wright M; Atkinson S
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/mpo.10057" target="_blank" rel="noreferrer">10.1002/mpo.10057</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
2002
2002
Acute
Adolescent
Anti-Inflammatory Agents/administration & dosage/therapeutic use
Antineoplastic Agents/administration & dosage/therapeutic use
Antineoplastic Combined Chemotherapy Protocols/therapeutic use
Asparaginase/therapeutic use
Atkinson S
Backlog
Barr RD
Bone Diseases
Child
Clodronate
Dexamethasone/therapeutic use
Diphosphonates/administration & dosage/therapeutic use
Doxorubicin/therapeutic use
Drug Administration Schedule
Female
Guo CY
Humans
Journal Article
L1/complications/drug therapy
Leukemia
Lymphocytic
Male
Medical & Pediatric Oncology
Metabolic/drug therapy/etiology
P.H.S.
Pilot Projects
Preschool
Research Support
U.S. Gov't
Webber C
Wiernikowski J
Wright M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1023/A:1022003126168" target="_blank" rel="noreferrer">http://doi.org/10.1023/A:1022003126168</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The prevalence of PTSD following the violent death of a child and predictors of change 5 years later
Publisher
An entity responsible for making the resource available
Journal Of Traumatic Stress
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Child; Female; Humans; Male; Adult; Prevalence; Parent-Child Relations; Aged; Middle Aged; Self Concept; Death; Sex Factors; Risk Factors; adolescent; Non-U.S. Gov't; P.H.S.; Research Support; U.S. Gov't; Adaptation; Psychological; bereavement; cause of death; social support; Stress Disorders; Post-Traumatic/epidemiology/etiology/psychology; Violence
Creator
An entity primarily responsible for making the resource
Murphy SA; Johnson LC; Chung IJ; Beaton RD
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1023/A:1022003126168" target="_blank" rel="noreferrer">10.1023/A:1022003126168</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
In this study, we examined the violent death bereavement trajectories of 173 parents by following them prospectively for 5 years after their children's deaths by accident, suicide, homicide, or undetermined causes. Using latent growth curve methodology, we examined how the initial level of PTSD and the rate of change over time were influenced by 9 predictors: the deceased children's causes of death, parents' gender, self-esteem, 3 coping strategies, perceived social support, concurrent levels of mental distress, and an intervention offered in early bereavement. Six of the nine factors predicted initial levels of PTSD; however, only parents' gender and perceived social support predicted change in PTSD over the 5-year time frame. Five years postdeath, 3 times as many study mothers (27.7%) met diagnostic criteria for PTSD and twice as many study fathers (12.5%) met diagnostic criteria for PTSD compared with the normative samples.
2003
Adaptation
Adolescent
Adult
Aged
Backlog
Beaton RD
Bereavement
Cause Of Death
Child
Chung IJ
Death
Female
Humans
Johnson LC
Journal Article
Journal Of Traumatic Stress
Male
Middle Aged
Murphy SA
Non-U.S. Gov't
P.H.S.
Parent-child Relations
Post-Traumatic/epidemiology/etiology/psychology
Prevalence
Psychological
Research Support
Risk Factors
Self Concept
Sex Factors
Social Support
Stress Disorders
U.S. Gov't
Violence
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1023/B:JOTS.0000038481.17167.0d" target="_blank" rel="noreferrer">http://doi.org/10.1023/B:JOTS.0000038481.17167.0d</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Changes in mothers' basic beliefs following a child's bone marrow transplantation: the role of prior trauma and negative life events
Publisher
An entity responsible for making the resource available
Journal Of Traumatic Stress
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Subject
The topic of the resource
Child; Female; Hospitalization; Humans; Male; Adult; Attitude to Health; Mother-Child Relations; Health Status; Longitudinal Studies; Mental Health; P.H.S.; Research Support; U.S. Gov't; Adaptation; Psychological; Psychological; Stress; Bone Marrow Transplantation/psychology; Wounds and Injuries/psychology
Creator
An entity primarily responsible for making the resource
Rini C; Manne S; DuHamel KN; Austin J; Ostroff J; Boulad F; Parsons SK; Martini R; Williams S; Mee L; Sexson S; Redd WH
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1023/B:JOTS.0000038481.17167.0d" target="_blank" rel="noreferrer">10.1023/B:JOTS.0000038481.17167.0d</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
This longitudinal study examined the relation between life stress and basic beliefs about self-worth and the benevolence and meaningfulness of the world among mothers of children undergoing bone marrow transplantation (BMT). One hundred mothers completed study measures during the child's hospitalization for BMT and 1 year later. Prior trauma and recent negative events were associated with basic beliefs during hospitalization and also with changes in basic beliefs in the subsequent year, with distress mediating some of these relations. Findings also demonstrated relations between basic beliefs and physical and mental functioning. However, each basic belief exhibited different relations with study variables, suggesting the need to investigate them separately.
2004
Adaptation
Adult
Attitude To Health
Austin J
Backlog
Bone Marrow Transplantation/psychology
Boulad F
Child
DuHamel KN
Female
Health Status
Hospitalization
Humans
Journal Article
Journal Of Traumatic Stress
Longitudinal Studies
Male
Manne S
Martini R
Mee L
Mental Health
Mother-child Relations
Ostroff J
P.H.S.
Parsons SK
Psychological
Redd WH
Research Support
Rini C
Sexson S
Stress
U.S. Gov't
Williams S
Wounds and Injuries/psychology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1056/NEJMoa013171" target="_blank" rel="noreferrer">http://doi.org/10.1056/NEJMoa013171</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Risperidone in children with autism and serious behavioral problems
Publisher
An entity responsible for making the resource available
The New England Journal Of Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Child; Female; Humans; Male; Treatment Outcome; Double-Blind Method; adolescent; Preschool; Non-U.S. Gov't; P.H.S.; Research Support; U.S. Gov't; Comparative Study; Antipsychotic Agents/administration & dosage/adverse effects/therapeutic use; Autistic Disorder/drug therapy/psychology; Child Behavior/drug effects; Risperidone/administration & dosage/adverse effects/therapeutic use
Creator
An entity primarily responsible for making the resource
McCracken JT; McGough J; Shah B; Cronin P; Hong D; Aman MG; Arnold LE; Lindsay R; Nash P; Hollway J; McDougle CJ; Posey D; Swiezy N; Kohn A; Scahill L; Martin A; Koenig K; Volkmar F; Carroll D; Lancor A; Tierney E; Ghuman J; Gonzalez NM; Grados M; Vitiello B; Ritz L; Davies M; Robinson J; McMahon D; Research Units on Pediatric Psychopharmacology (RUPP) Autism Network
Description
An account of the resource
BACKGROUND: Atypical antipsychotic agents, which block postsynaptic dopamine and serotonin receptors, have advantages over traditional antipsychotic medications in the treatment of adults with schizophrenia and may be beneficial in children with autistic disorder who have serious behavioral disturbances. However, data on the safety and efficacy of atypical antipsychotic agents in children are limited. METHODS: We conducted a multisite, randomized, double-blind trial of risperidone as compared with placebo for the treatment of autistic disorder accompanied by severe tantrums, aggression, or self-injurious behavior in children 5 to 17 years old. The primary outcome measures were the score on the Irritability subscale of the Aberrant Behavior Checklist and the rating on the Clinical Global Impressions - Improvement (CGI-I) scale at eight weeks. RESULTS: A total of 101 children (82 boys and 19 girls; mean [+/-SD] age, 8.8+/-2.7 years) were randomly assigned to receive risperidone (49 children) or placebo (52). Treatment with risperidone for eight weeks (dose range, 0.5 to 3.5 mg per day) resulted in a 56.9 percent reduction in the Irritability score, as compared with a 14.1 percent decrease in the placebo group (P<0.001). The rate of a positive response, defined as at least a 25 percent decrease in the Irritability score and a rating of much improved or very much improved on the CGI-I scale, was 69 percent in the risperidone group (34 of 49 children had a positive response) and 12 percent in the placebo group (6 of 52, P<0.001). Risperidone therapy was associated with an average weight gain of 2.7+/-2.9 kg, as compared with 0.8+/-2.2 kg with placebo (P<0.001). Increased appetite, fatigue, drowsiness, dizziness, and drooling were more common in the risperidone group than in the placebo group (P<0.05 for each comparison). In two thirds of the children with a positive response to risperidone at eight weeks (23 of 34), the benefit was maintained at six months. CONCLUSIONS: Risperidone was effective and well tolerated for the treatment of tantrums, aggression, or self-injurious behavior in children with autistic disorder. The short period of this trial limits inferences about adverse effects such as tardive dyskinesia.
2002
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1056/NEJMoa013171" target="_blank" rel="noreferrer">10.1056/NEJMoa013171</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2002
Adolescent
Aman MG
Antipsychotic Agents/administration & dosage/adverse effects/therapeutic use
Arnold LE
Autistic Disorder/drug therapy/psychology
Backlog
Carroll D
Child
Child Behavior/drug effects
Comparative Study
Cronin P
Davies M
Double-Blind Method
Female
Ghuman J
Gonzalez NM
Grados M
Hollway J
Hong D
Humans
Journal Article
Koenig K
Kohn A
Lancor A
Lindsay R
Male
Martin A
McCracken JT
McDougle CJ
McGough J
McMahon D
Nash P
Non-U.S. Gov't
P.H.S.
Posey D
Preschool
Research Support
Research Units on Pediatric Psychopharmacology (RUPP) Autism Network
Risperidone/administration & dosage/adverse effects/therapeutic use
Ritz L
Robinson J
Scahill L
Shah B
Swiezy N
The New England Journal Of Medicine
Tierney E
Treatment Outcome
U.S. Gov't
Vitiello B
Volkmar F
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1056/NEJMra012626" target="_blank" rel="noreferrer">http://doi.org/10.1056/NEJMra012626</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Analgesics for the treatment of pain in children
Publisher
An entity responsible for making the resource available
The New England Journal Of Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Child; Humans; infant; Analgesics; Analgesia; Anesthetics; Non-U.S. Gov't; P.H.S.; Research Support; U.S. Gov't; infant; Chronic disease; Newborn; Pain/drug therapy/etiology; Anesthesia; Anti-Inflammatory Agents; Neoplasms/complications; Patient-Controlled; Analgesics/administration & dosage/therapeutic use; General; Acetaminophen/therapeutic use; Aspirin/therapeutic use; Local; Non-Steroidal/therapeutic use; Opioid/pharmacokinetics/pharmacology/therapeutic use
Creator
An entity primarily responsible for making the resource
Berde CB; Sethna NF
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1056/NEJMra012626" target="_blank" rel="noreferrer">10.1056/NEJMra012626</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
2002
2002
Acetaminophen/therapeutic use
Analgesia
Analgesics
Analgesics/administration & dosage/therapeutic use
Anesthesia
Anesthetics
Anti-Inflammatory Agents
Aspirin/therapeutic use
Backlog
Berde CB
Child
Chronic Disease
General
Humans
Infant
Journal Article
Local
Neoplasms/complications
Newborn
Non-Steroidal/therapeutic use
Non-U.S. Gov't
Opioid/pharmacokinetics/pharmacology/therapeutic use
P.H.S.
Pain/drug therapy/etiology
Patient-Controlled
Research Support
Sethna NF
The New England Journal Of Medicine
U.S. Gov't
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1067/mpd.2002.124380" target="_blank" rel="noreferrer">http://doi.org/10.1067/mpd.2002.124380</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Physical therapy and cognitive-behavioral treatment for complex regional pain syndromes
Publisher
An entity responsible for making the resource available
The Journal Of Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Child; Female; Humans; Male; Prospective Studies; adolescent; P.H.S.; Research Support; U.S. Gov't; Nonparametric; Statistics; Cognitive Therapy; Complex Regional Pain Syndromes/psychology/rehabilitation; Physical Therapy Modalities
Creator
An entity primarily responsible for making the resource
Lee BH; Scharff L; Sethna NF; McCarthy CF; Scott-Sutherland J; Shea AM; Sullivan P; Meier P; Zurakowski D; Masek BJ; Berde CB
Description
An account of the resource
Complex regional pain syndromes (CRPS; type 1, reflex sympathetic dystrophy, and type 2, causalgia) involve persistent pain, allodynia, and vasomotor signs. We conducted a prospective, randomized, single-blind trial of physical therapy (PT) and cognitive-behavioral treatment for children and adolescents with CRPS. Children 8 to 17 years of age (n = 28) were randomly assigned to either group A (PT once per week for 6 weeks) or group B (PT 3 times per week for 6 weeks). Both groups received 6 sessions of cognitive-behavioral treatment. Assessments of pain and function were repeated at two follow-up time periods. Outcomes were compared at the three time points through the use of parametric or nonparametric analysis of variance and post hoc tests. All five measures of pain and function improved significantly in both groups after treatment, with sustained benefit evident in the majority of patients at long-term follow-up. Recurrent episodes were reported in 50% of patients, and 10 patients eventually received sympathetic blockade. Most children with CRPS showed reduced pain and improved function with a noninvasive rehabilitative treatment approach. Long-term functional outcomes were also very good.
2002
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1067/mpd.2002.124380" target="_blank" rel="noreferrer">10.1067/mpd.2002.124380</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2002
Adolescent
Backlog
Berde CB
Child
Cognitive Therapy
Complex Regional Pain Syndromes/psychology/rehabilitation
Female
Humans
Journal Article
Lee BH
Male
Masek BJ
McCarthy CF
Meier P
Nonparametric
P.H.S.
Physical Therapy Modalities
Prospective Studies
Research Support
Scharff L
Scott-Sutherland J
Sethna NF
Shea AM
Statistics
Sullivan P
The Journal Of Pediatrics
U.S. Gov't
Zurakowski D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1067/mpd.2002.129847" target="_blank" rel="noreferrer">http://doi.org/10.1067/mpd.2002.129847</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Induced sputum inflammatory measures correlate with lung function in children with cystic fibrosis
Publisher
An entity responsible for making the resource available
The Journal Of Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Child; Female; Humans; Male; adolescent; Non-U.S. Gov't; P.H.S.; Research Support; U.S. Gov't; Cell Count; Cystic Fibrosis/diagnosis/metabolism; Forced Expiratory Volume; Interleukin-8 - analysis; Leukocyte Elastase/metabolism; Lung/physiopathology; Spirometry; Sputum/chemistry/cytology
Creator
An entity primarily responsible for making the resource
Sagel SD; Sontag MK; Wagener JS; Kapsner RK; Osberg I; Accurso FJ
Description
An account of the resource
OBJECTIVE: To validate a sputum induction technique in cystic fibrosis (CF), we examined the relation between airway inflammation and pulmonary function in children with CF by correlating inflammatory indexes in induced sputum with FEV(1). STUDY DESIGN: We measured baseline spirometry and oxygen saturations and then performed sputum inductions with 3% hypertonic saline in 20 clinically stable children with CF (11 girls). We examined the relation of airway inflammation and lung function in the 19 individuals (95%) who expectorated an adequate sputum sample. Measures of airway inflammation in induced sputum included total cell counts, neutrophil (PMN) counts, interleukin-8 levels, and free neutrophil elastase activity. RESULTS: There were significant inverse relations between FEV(1) and total cell counts and PMN counts (r = -0.57, P <.01 for both), interleukin-8 (r = -0.72, P =.002), and elastase (r = -0.75, P =.001). Airway infection, as assessed by bacterial density in induced sputum, did not correlate with lung function or indexes of inflammation. CONCLUSIONS: We conclude that measures of inflammation in induced sputum correlate with FEV(1) in clinically stable children with CF with normal to mildly abnormal lung function and that they may be useful as surrogate outcome measures in clinical trials.
2002
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1067/mpd.2002.129847" target="_blank" rel="noreferrer">10.1067/mpd.2002.129847</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2002
Accurso FJ
Adolescent
Backlog
Cell Count
Child
Cystic Fibrosis/diagnosis/metabolism
Female
Forced Expiratory Volume
Humans
Interleukin-8 - analysis
Journal Article
Kapsner RK
Leukocyte Elastase/metabolism
Lung/physiopathology
Male
Non-U.S. Gov't
Osberg I
P.H.S.
Research Support
Sagel SD
Sontag MK
Spirometry
Sputum/chemistry/cytology
The Journal Of Pediatrics
U.S. Gov't
Wagener JS
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1073/pnas.0407162101" target="_blank" rel="noreferrer">http://doi.org/10.1073/pnas.0407162101</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Accelerated telomere shortening in response to life stress
Publisher
An entity responsible for making the resource available
Proceedings Of The National Academy Of Sciences Of The United States Of America
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Subject
The topic of the resource
Female; Humans; Adult; Middle Aged; Age Factors; Non-U.S. Gov't; P.H.S.; Research Support; U.S. Gov't; Psychological; Stress; Leukocytes; mothers; Telemeres; Cell Aging; Mononuclear/physiology; Oxidative Stress; Premenopause; Telomere/metabolism/ultrastructure
Creator
An entity primarily responsible for making the resource
Epel ES; Blackburn EH; Lin J; Dhabhar FS; Adler NE; Morrow JD; Cawthon RM
Description
An account of the resource
Numerous studies demonstrate links between chronic stress and indices of poor health, including risk factors for cardiovascular disease and poorer immune function. Nevertheless, the exact mechanisms of how stress gets "under the skin" remain elusive. We investigated the hypothesis that stress impacts health by modulating the rate of cellular aging. Here we provide evidence that psychological stress--both perceived stress and chronicity of stress--is significantly associated with higher oxidative stress, lower telomerase activity, and shorter telomere length, which are known determinants of cell senescence and longevity, in peripheral blood mononuclear cells from healthy premenopausal women. Women with the highest levels of perceived stress have telomeres shorter on average by the equivalent of at least one decade of additional aging compared to low stress women. These findings have implications for understanding how, at the cellular level, stress may promote earlier onset of age-related diseases.
2004
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1073/pnas.0407162101" target="_blank" rel="noreferrer">10.1073/pnas.0407162101</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2004
Adler NE
Adult
Age Factors
Backlog
Blackburn EH
Cawthon RM
Cell Aging
Dhabhar FS
Epel ES
Female
Humans
Journal Article
Leukocytes
Lin J
Middle Aged
Mononuclear/physiology
Morrow JD
Mothers
Non-U.S. Gov't
Oxidative Stress
P.H.S.
Premenopause
Proceedings Of The National Academy Of Sciences Of The United States Of America
Psychological
Research Support
Stress
Telemeres
Telomere/metabolism/ultrastructure
U.S. Gov't
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1086/378781" target="_blank" rel="noreferrer">http://doi.org/10.1086/378781</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Mutations in capillary morphogenesis gene-2 result in the allelic disorders juvenile hyaline fibromatosis and infantile systemic hyalinosis
Publisher
An entity responsible for making the resource available
American Journal Of Human Genetics
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Child; Female; Humans; Male; Mutation; P.H.S.; Research Support; U.S. Gov't; Syndrome; infant; Models; Pedigree; Membrane Proteins/genetics; Base Sequence; Amino Acid Sequence; Exons; Genes; Recessive; Missense; Molecular; Chromosome Mapping; Fibroma/genetics; Genetic Markers; Focal/genetics; Glomerulosclerosis; Protein Conformation; Protein Structure; Secondary
Creator
An entity primarily responsible for making the resource
Dowling O; Difeo A; Ramirez MC; Tukel T; Narla G; Bonafe L; Kayserili H; Yuksel-Apak M; Paller AS; Norton K; Teebi AS; Grum-Tokars V; Martin GS; Davis GE; Glucksman MJ; Martignetti JA
Description
An account of the resource
Juvenile hyaline fibromatosis (JHF) and infantile systemic hyalinosis (ISH) are autosomal recessive syndromes of unknown etiology characterized by multiple, recurring subcutaneous tumors, gingival hypertrophy, joint contractures, osteolysis, and osteoporosis. Both are believed to be allelic disorders; ISH is distinguished from JHF by its more severe phenotype, which includes hyaline deposits in multiple organs, recurrent infections, and death within the first 2 years of life. Using the previously reported chromosome 4q21 JHF disease locus as a guide for candidate-gene identification, we identified and characterized JHF and ISH disease-causing mutations in the capillary morphogenesis factor-2 gene (CMG2). Although CMG2 encodes a protein upregulated in endothelial cells during capillary formation and was recently shown to function as an anthrax-toxin receptor, its physiologic role is unclear. Two ISH family-specific truncating mutations, E220X and the 1-bp insertion P357insC that results in translation of an out-of-frame stop codon, were generated by site-directed mutagenesis and were shown to delete the CMG-2 transmembrane and/or cytosolic domains, respectively. An ISH compound mutation, I189T, is predicted to create a novel and destabilizing internal cavity within the protein. The JHF family-specific homoallelic missense mutation G105D destabilizes a von Willebrand factor A extracellular domain alpha-helix, whereas the other mutation, L329R, occurs within the transmembrane domain of the protein. Finally, and possibly providing insight into the pathophysiology of these diseases, analysis of fibroblasts derived from patients with JHF or ISH suggests that CMG2 mutations abrogate normal cell interactions with the extracellular matrix.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1086/378781" target="_blank" rel="noreferrer">10.1086/378781</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
American Journal Of Human Genetics
Amino Acid Sequence
Backlog
Base Sequence
Bonafe L
Child
Chromosome Mapping
Davis GE
Difeo A
Dowling O
Exons
Female
Fibroma/genetics
Focal/genetics
Genes
Genetic Markers
Glomerulosclerosis
Glucksman MJ
Grum-Tokars V
Humans
Infant
Journal Article
Kayserili H
Male
Martignetti JA
Martin GS
Membrane Proteins/genetics
Missense
Models
Molecular
Mutation
Narla G
Norton K
P.H.S.
Paller AS
Pedigree
Protein Conformation
Protein Structure
Ramirez MC
Recessive
Research Support
Secondary
Syndrome
Teebi AS
Tukel T
U.S. Gov't
Yuksel-Apak M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1093/jncimonographs/lgh007" target="_blank" rel="noreferrer">http://doi.org/10.1093/jncimonographs/lgh007</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Palliative care in children with cancer: which child and when?
Publisher
An entity responsible for making the resource available
Journal Of The National Cancer Institute. Monographs
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Subject
The topic of the resource
Child; Humans; Palliative Care; quality of life; Preschool; Non-U.S. Gov't; P.H.S.; Research Support; U.S. Gov't; Psychological; Stress; caregivers; Neoplasms/complications/therapy; Biomedical Research/trends; Medical Oncology/education/standards; Pediatrics/education/standards
Creator
An entity primarily responsible for making the resource
Harris MB
Description
An account of the resource
At a time of increasing interest in palliative care in pediatrics, pediatric oncology programs may be failing to deliver adequate palliation to children with cancer. In a recent study, parents of children who died on a pediatric oncology service reported that despite treatment at the end of life, their children's suffering was not adequately relieved and that parents were more likely than caregivers to recognize their children's suffering. Why do pediatric oncologists fail? First, death in children from cancer is a rare event. Second, few prospective trials in the field of pediatric palliative care describe and quantify symptoms during cure-directed care or at the end of life. This leads to a lack of evidence-based practice and forces the clinician to use personal experience and trial-by-error medical care. Third, pediatric oncologists and those charged with developing pediatric palliative care programs must deal with the different physiologic and developmental stages encountered while caring for infants, children, and adolescents. Fourth, education is needed for pediatric oncology caregivers in many areas of palliative care. Finally, reimbursement issues surround the palliative care field and are a major hindrance in developing effective integrated palliative care teams. These factors have also made it difficult to perform palliative care research in children. When discussing palliative care in children with cancer, where few die but many suffer, a paradigm shift must occur that does not equate palliative care with end-of-life care. A model on how we might make the transition from symptom control that we should offer to every patient to end-of-life care is discussed.
2004
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/jncimonographs/lgh007" target="_blank" rel="noreferrer">10.1093/jncimonographs/lgh007</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2004
Backlog
Biomedical Research/trends
Caregivers
Child
Harris MB
Humans
Journal Article
Journal Of The National Cancer Institute. Monographs
Medical Oncology/education/standards
Neoplasms/complications/therapy
Non-U.S. Gov't
P.H.S.
Palliative Care
Pediatrics/education/standards
Preschool
Psychological
Quality Of Life
Research Support
Stress
U.S. Gov't
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1097/01.ccm.0000129972.31533.37" target="_blank" rel="noreferrer">http://doi.org/10.1097/01.ccm.0000129972.31533.37</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Mechanical ventilation in Ontario, 1992-2000: incidence, survival, and hospital bed utilization of noncardiac surgery adult patients
Publisher
An entity responsible for making the resource available
Critical Care Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Subject
The topic of the resource
Female; Humans; Male; Intensive Care Units; Adult; Hospital Mortality; Aged; Middle Aged; Length of Stay; Respiration; Survival Analysis; Critical Care; Incidence; Non-U.S. Gov't; P.H.S.; Research Support; U.S. Gov't; retrospective studies; Hospitalization/statistics & numerical data; Databases; Factual; Ontario/epidemiology; Artificial/statistics & numerical data/utilization
Creator
An entity primarily responsible for making the resource
Needham DM; Bronskill SE; Sibbald WJ; Pronovost PJ; Laupacis A
Description
An account of the resource
OBJECTIVE: Mechanical ventilation is a common therapy used in caring for critically ill patients, but its epidemiology is poorly understood. We describe population-based, temporal trends in the incidence, survival, and hospital bed utilization of mechanically ventilated, noncardiac surgery adult patients. DESIGN: Retrospective, observational cohort study using linked administrative databases. SETTING: Province of Ontario, Canada. PATIENTS: Subjects were 150,755 unique patients who received mechanical ventilation between 1992 and 2000. INTERVENTIONS: None. MEASUREMENTS: Annual measures of mechanical ventilation incidence, 30-day patient mortality rate, and number of mechanical ventilation days and inpatient days for mechanically ventilated patients as a proportion of total adult inpatient bed days. MAIN RESULTS: From 1992 to 2000, the crude and age- and gender-adjusted incidence of mechanical ventilation increased 9% (p 80 yrs (2.3, 2.2-2.3), Charlson score 3+ (2.0, 2.0-2.1), and specific diagnosis. From 1992 to 2000, the number of mechanical ventilation days and inpatient days for mechanically ventilated patients, as a proportion of total adult inpatient bed days, increased 69% and 30% (both p <.001), respectively, to 1.8% and 6.2%. CONCLUSIONS: There was a small, but important, increase in mechanical ventilation incidence and a substantial increase in the proportion of inpatient bed days used by mechanically ventilated patients in Ontario during the 1990s. These trends are important in planning for expansion of health care resources to meet the needs of the aging population. The increase, over time, in risk-adjusted mortality rate of mechanically ventilated patients is concerning and requires further investigation.
2004
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/01.ccm.0000129972.31533.37" target="_blank" rel="noreferrer">10.1097/01.ccm.0000129972.31533.37</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2004
Adult
Aged
Artificial/statistics & numerical data/utilization
Backlog
Bronskill SE
Critical Care
Critical Care Medicine
Databases
Factual
Female
Hospital Mortality
Hospitalization/statistics & numerical data
Humans
Incidence
Intensive Care Units
Journal Article
Laupacis A
Length Of Stay
Male
Middle Aged
Needham DM
Non-U.S. Gov't
Ontario/epidemiology
P.H.S.
Pronovost PJ
Research Support
Respiration
Retrospective Studies
Sibbald WJ
Survival Analysis
U.S. Gov't
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1097/01.pec.0000081238.98249.40" target="_blank" rel="noreferrer">http://doi.org/10.1097/01.pec.0000081238.98249.40</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Validation of a decision rule identifying febrile young girls at high risk for urinary tract infection
Publisher
An entity responsible for making the resource available
Pediatric Emergency Care
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Child; Female; Humans; Decision Support Techniques; Risk Factors; European Continental Ancestry Group; Sensitivity and Specificity; Hospitals; Case-Control Studies; Emergency Service; Preschool; P.H.S.; Research Support; U.S. Gov't; infant; retrospective studies; Pediatric/statistics & numerical data; Pennsylvania/epidemiology; ROC Curve; Area Under Curve; Bacteriuria/diagnosis/microbiology; Colony Count; False Positive Reactions; Fever/etiology; Hospital/statistics & numerical data; Microbial; Urinary Tract Infections/diagnosis/epidemiology
Creator
An entity primarily responsible for making the resource
Gorelick MH; Hoberman A; Kearney D; Wald E; Shaw KN
Description
An account of the resource
OBJECTIVE: To validate a previously published clinical decision rule to predict risk of urinary tract infection in febrile young girls. METHODS: We performed a retrospective case-control study at a children's hospital emergency department in a different city than that in which the original derivation study took place. Girls younger than 2 years in whom urinalysis and urine culture were performed for evaluation of fever were eligible. Cases consisted of all patients with a positive urine culture result, defined as 50,000 or more colony-forming units per milliliter of a urinary tract pathogen (n = 98). A random sample of patients with a negative urine culture result (n = 114) was also selected as controls. The clinical prediction rule included five risk factors: age younger than 12 months, white race, temperature of 39.0 degrees C or higher, absence of any other potential source of fever, and fever for 2 days or more. The sensitivity and false-positive rate of this rule were calculated at different cutoff values. RESULTS: The overall discriminative ability of the rule, as indicated by the area under the receiver-operator characteristic curve (AUC), was similar in this validation sample (AUC = 0.72) to that in the original study (AUC = 0.76). However, in the validation sample, the presence of three or more risk factors (rather than two or more as in the original study) appeared to be the optimum cutoff to define a positive rule, which results in an indication for obtaining further diagnostic testing (sensitivity, 88% [95% CI, 79-94%]; false-positive rate, 70% [95% CI, 61-79%]). CONCLUSION: A simple clinical decision rule previously developed to predict urinary tract infection based on five risk factors performs similarly in a different patient population.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/01.pec.0000081238.98249.40" target="_blank" rel="noreferrer">10.1097/01.pec.0000081238.98249.40</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Area Under Curve
Backlog
Bacteriuria/diagnosis/microbiology
Case-Control Studies
Child
Colony Count
Decision Support Techniques
Emergency Service
European Continental Ancestry Group
False Positive Reactions
Female
Fever/etiology
Gorelick MH
Hoberman A
Hospital/statistics & numerical data
Hospitals
Humans
Infant
Journal Article
Kearney D
Microbial
P.H.S.
Pediatric Emergency Care
Pediatric/statistics & Numerical Data
Pennsylvania/epidemiology
Preschool
Research Support
Retrospective Studies
Risk Factors
ROC Curve
Sensitivity and Specificity
Shaw KN
U.S. Gov't
Urinary Tract Infections/diagnosis/epidemiology
Wald E
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1136/bmj.327.7425.1219" target="_blank" rel="noreferrer">http://doi.org/10.1136/bmj.327.7425.1219</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Continuity of care: a multidisciplinary review
Publisher
An entity responsible for making the resource available
Bmj
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Humans; Interprofessional Relations; Non-U.S. Gov't; P.H.S.; Research Support; U.S. Gov't; Miller 2009 BMC HSR Refs; Primary Health Care/organization & administration; Continuity of Patient Care/organization & administration; Disease Management; Patient Care Team/organization & administration; Mental Health Services/organization & administration; Nursing Care/organization & administration; Paintings
Creator
An entity primarily responsible for making the resource
Haggerty JL; Reid RJ; Freeman GK; Starfield B; Adair CE; McKendry R
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1136/bmj.327.7425.1219" target="_blank" rel="noreferrer">10.1136/bmj.327.7425.1219</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
2003
2003
Adair CE
Backlog
Bmj
Continuity Of Patient Care/organization & Administration
Disease Management
Freeman GK
Haggerty JL
Humans
Interprofessional Relations
Journal Article
McKendry R
Mental Health Services/organization & administration
Miller 2009 BMC HSR Refs
Non-U.S. Gov't
Nursing Care/organization & administration
P.H.S.
Paintings
Patient Care Team/organization & administration
Primary Health Care/organization & administration
Reid RJ
Research Support
Starfield B
U.S. Gov't
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1136/bmj.328.7440.607" target="_blank" rel="noreferrer">http://doi.org/10.1136/bmj.328.7440.607</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Use of hospitals, physician visits, and hospice care during last six months of life among cohorts loyal to highly respected hospitals in the United States
Publisher
An entity responsible for making the resource available
Bmj (clinical Research Ed.)
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Subject
The topic of the resource
Humans; United States; Cohort Studies; Aged; Outcome Assessment (Health Care); Hospitals; 80 and over; Non-U.S. Gov't; P.H.S.; Research Support; U.S. Gov't; retrospective studies; Patient Acceptance of Health Care/statistics & numerical data; Teaching/utilization; Hospitalization/statistics & numerical data; Terminally Ill/statistics & numerical data; Health Services Needs and Demand/statistics & numerical data; Hospice Care/utilization; General/utilization; Terminal Care/utilization
Creator
An entity primarily responsible for making the resource
Wennberg JE; Fisher ES; Stukel TA; Skinner JS; Sharp SM; Bronner KK
Description
An account of the resource
OBJECTIVE: To evaluate the use of healthcare resources during the last six months of life among patients of US hospitals with strong reputations for high quality care in managing chronic illness. DESIGN: Retrospective cohort study based on claims data from the US Medicare programme. PARTICIPANTS: Cohorts receiving most of their hospital care from 77 hospitals that appeared on the 2001 US News and World Report "best hospitals" list for heart and pulmonary disease, cancer, and geriatric services. MAIN OUTCOME MEASURES: Use of healthcare resources in the last six months of life: number of days spent in hospital and in intensive care units; number of physician visits; percentage of patients seeing 10 or more physicians; percentage enrolled in hospice. Terminal care: percentage of deaths occurring in hospital; percentage of deaths occurring in association with a stay in an intensive care unit. RESULTS: Extensive variation in each measure existed among the 77 hospital cohorts. Days in hospital per decedent ranged from 9.4 to 27.1 (interquartile range 11.6-16.1); days in intensive care units ranged from 1.6 to 9.5 (2.6-4.5); number of physician visits ranged from 17.6 to 76.2 (25.5-39.5); percentage of patients seeing 10 or more physicians ranged from 16.9% to 58.5% (29.4-43.4%); and hospice enrollment ranged from 10.8% to 43.8% (22.0-32.0%). The percentage of deaths occurring in hospital ranged from 15.9% to 55.6% (35.4-43.1%), and the percentage of deaths associated with a stay in intensive care ranged from 8.4% to 36.8% (20.2-27.1%). CONCLUSION: Striking variation exists in the utilisation of end of life care among US medical centres with strong national reputations for clinical care.
2004
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1136/bmj.328.7440.607" target="_blank" rel="noreferrer">10.1136/bmj.328.7440.607</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2004
80 And Over
Aged
Backlog
Bmj (clinical Research Ed.)
Bronner KK
Cohort Studies
Fisher ES
General/utilization
Health Services Needs and Demand/statistics & numerical data
Hospice Care/utilization
Hospitalization/statistics & numerical data
Hospitals
Humans
Journal Article
Non-U.S. Gov't
Outcome Assessment (health Care)
P.H.S.
Patient Acceptance Of Health Care/statistics & Numerical Data
Research Support
Retrospective Studies
Sharp SM
Skinner JS
Stukel TA
Teaching/utilization
Terminal Care/utilization
Terminally Ill/statistics & numerical data
U.S. Gov't
United States
Wennberg JE
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1186/1741-7015-1-3" target="_blank" rel="noreferrer">http://doi.org/10.1186/1741-7015-1-3</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Hospital care for children and young adults in the last year of life: a population-based study
Publisher
An entity responsible for making the resource available
Bmc Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Child; Female; Humans; infant; Male; Adult; Hospital Mortality; Age Factors; Length of Stay; adolescent; Preschool; P.H.S.; Research Support; U.S. Gov't; Palliative Care/organization & administration; infant; Newborn; ICU Decision Making; Hospitalization/statistics & numerical data; Terminally Ill/statistics & numerical data; Terminal Care/utilization; Chronic Disease/classification/mortality/therapy; Washington/epidemiology
Creator
An entity primarily responsible for making the resource
Feudtner C; DiGiuseppe DL; Neff JM
Description
An account of the resource
BACKGROUND: To help design population-based pediatric palliative care services, we sought to describe the hospital care received in the last year of life by children and young adults who died. We also determined the proportion with complex chronic conditions (CCCs) and tested whether the use of hospital services increased as the date of death drew nearer. METHODS: For all deaths occurring under 25 years of age from 1990 to 1996 in Washington State, USA, we linked death certificate information to hospital utilization records and analyzed the timing and duration of hospitalizations and the nature of hospital procedures during the year prior to death. RESULTS: Of the 8 893 deaths, 25 % had CCCs. Among infants with CCCs, 84 % were hospitalized at the time of death and 50 % had been mechanically ventilated during their terminal admission. Among the 458 CCC neonates dying under a week of age, 92% of all days of life were spent in the hospital; among the 172 CCC neonates dying during the second to fourth weeks of life, 85 % of all days of life were spent hospitalized; among the 286 CCC infants dying during the second to twelfth month of life, 41 % of all days of life were spent hospitalized. Among children and young adults with CCCs, 55 % were hospitalized at the time of death, and 19 % had been mechanically ventilated during their terminal admission. For these older patients, the median number of days spent in the hospital during the year preceding death was 18, yet less than a third of this group was hospitalized at any point in time until the last week of their lives. The rate of hospital use increased as death drew near. For subjects who had received hospital care, 44 % had governmental insurance as the source of primary payment. CONCLUSIONS: Infants who died spent a substantial proportion of their lives in hospitals, whereas children and adolescents who died from CCCs predominantly lived outside of the hospital during the last year of life. To serve these patients, pediatric palliative and end-of-life care will have to be provided in an integrated, coordinated manner both in hospitals and home communities.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1186/1741-7015-1-3" target="_blank" rel="noreferrer">10.1186/1741-7015-1-3</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Adolescent
Adult
Age Factors
Backlog
Bmc Medicine
Child
Chronic Disease/classification/mortality/therapy
DiGiuseppe DL
Female
Feudtner C
Hospital Mortality
Hospitalization/statistics & numerical data
Humans
ICU Decision Making
Infant
Journal Article
Length Of Stay
Male
Neff JM
Newborn
P.H.S.
Palliative Care/organization & Administration
Preschool
Research Support
Terminal Care/utilization
Terminally Ill/statistics & numerical data
U.S. Gov't
Washington/epidemiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1207/s15324796abm2802_9" target="_blank" rel="noreferrer">http://doi.org/10.1207/s15324796abm2802_9</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Mothers' perceptions of benefit following pediatric stem cell transplantation: a longitudinal investigation of the roles of optimism, medical risk, and sociodemographic resources
Publisher
An entity responsible for making the resource available
Annals Of Behavioral Medicine: A Publication Of The Society Of Behavioral Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Subject
The topic of the resource
Child; Female; Hospitalization; Humans; Male; Adult; Mother-Child Relations; Attitude; Longitudinal Studies; Risk Factors; Social Class; Regression Analysis; Perception; adolescent; Preschool; P.H.S.; Research Support; U.S. Gov't; Adaptation; Psychological; infant; Psychological; Stress; social support; Hematopoietic stem cell transplantation
Creator
An entity primarily responsible for making the resource
Rini C; Manne S; DuHamel KN; Austin J; Ostroff J; Boulad F; Parsons SK; Martini R; Williams SE; Mee L; Sexson S; Redd WH
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1207/s15324796abm2802_9" target="_blank" rel="noreferrer">10.1207/s15324796abm2802_9</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
BACKGROUND: This longitudinal study investigated the course and predictors of benefit finding among 144 mothers of children undergoing hematopoietic stem cell transplantation (HSCT), a severely stressful and life-threatening medical procedure. PURPOSE: Children's medical risk and mothers' dispositional optimism and sociodemographic resources were examined as predictors of benefit finding. The association between benefit finding and mothers' psychosocial adaptation was also investigated. METHODS: Assessments occurred during hospitalization for HSCT (Time 1 [T1]) and 6 months later (Time 2 [T2]). RESULTS: Hierarchial multiple regression analyses revealed that predictors of benefit finding differed systematically across assessments, with optimism and medical risk predicting benefit finding at both time points but sociodemographic resources predicting only T2 benefit findings. Benefit finding did not predict psychosocial adaptation until optimism was considered as a moderator of their relation: T1 benefit finding was positively associated with T2 adaptation only for mothers high in optimism. CONCLUSION: The need for longitudinal research on posttrauma adaptation and the utility of considering the natural history of the trauma are discussed.
2004
Adaptation
Adolescent
Adult
Annals Of Behavioral Medicine: A Publication Of The Society Of Behavioral Medicine
Attitude
Austin J
Backlog
Boulad F
Child
DuHamel KN
Female
Hematopoietic stem cell transplantation
Hospitalization
Humans
Infant
Journal Article
Longitudinal Studies
Male
Manne S
Martini R
Mee L
Mother-child Relations
Ostroff J
P.H.S.
Parsons SK
Perception
Preschool
Psychological
Redd WH
Regression Analysis
Research Support
Rini C
Risk Factors
Sexson S
Social Class
Social Support
Stress
U.S. Gov't
Williams SE
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1542/peds.109.4.656" target="_blank" rel="noreferrer">http://doi.org/10.1542/peds.109.4.656</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Where do children with complex chronic conditions die? Patterns in Washington State, 1980-1998
Publisher
An entity responsible for making the resource available
Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Child; Female; Humans; infant; Male; Survival Analysis; adolescent; Preschool; P.H.S.; Research Support; U.S. Gov't; infant; Newborn; retrospective studies; ICU Decision Making; cause of death; Chronic Disease/mortality; location of death; Washington/epidemiology
Creator
An entity primarily responsible for making the resource
Feudtner C; Silveira MJ; Christakis DA
Description
An account of the resource
OBJECTIVE: Little is known about factors that influence whether children with chronic conditions die at home. We sought to test whether deaths attributable to underlying complex chronic conditions (CCCs) were increasingly occurring at home and to determine what features were associated with home deaths. DESIGN: A retrospective case series was conducted of all deaths that occurred to children age 0 to 18 years in Washington state from 1980 to 1998 using death certificate data, augmented with 1990 US Census data regarding median household income by zip code in 1989, to determine the site of death. RESULTS: Of the 31 455 deaths identified in infants, children, and adults younger than 25 years, 52% occurred in the hospital, 17.2% occurred at home, 8.5% occurred in the emergency department or during transportation, 0.4% occurred in nursing homes, and 21.7% occurred at other sites. Among children who died as a result of some form of CCC (excluding injury, sudden infant death syndrome, and non-CCC medical conditions), the percentage of cases younger than 1 year who died at home rose slightly from 7.8% in 1980 to 11.6% in 1998, whereas the percentage of older children and young adults who had a CCC and died at home rose substantially from 21% in 1980 to 43% in 1998. Children who had lived in more affluent neighborhoods were more likely to have died at home. Using leukemia-related deaths as a benchmark, deaths as a result of congenital, genetic, neuromuscular, and metabolic conditions and other forms of cancer all were more likely to have occurred at home. Significant variation in the likelihood of home death, not explained by the individual attributes of the cases, also existed across the 39 counties in Washington state. CONCLUSIONS: Children who die with underlying CCCs increasingly do so at home. Age at death, specific condition, local area affluence, and the location of home all influence the likelihood of home death. These findings warrant additional study, as they have implications for how we envision pediatric palliative care, hospice, and other supportive services for the future.
2002
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1542/peds.109.4.656" target="_blank" rel="noreferrer">10.1542/peds.109.4.656</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2002
Adolescent
Backlog
Cause Of Death
Child
Christakis DA
Chronic Disease/mortality
Female
Feudtner C
Humans
ICU Decision Making
Infant
Journal Article
Location Of Death
Male
Newborn
P.H.S.
Pediatrics
Preschool
Research Support
Retrospective Studies
Silveira MJ
Survival Analysis
U.S. Gov't
Washington/epidemiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1542/peds.114.1.79" target="_blank" rel="noreferrer">http://doi.org/10.1542/peds.114.1.79</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Health services use and health care expenditures for children with disabilities
Publisher
An entity responsible for making the resource available
Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Subject
The topic of the resource
Child; Humans; United States; Prevalence; Health Care Surveys; Multivariate Analysis; Income; adolescent; Preschool; P.H.S.; Research Support; U.S. Gov't; infant; Health; Insurance; Health Services/utilization; Disabled Children/statistics & numerical data; Cost Sharing/statistics & numerical data; Financing; Health Expenditures/statistics & numerical data; Home Care Services/economics/utilization; Hospitalization/economics/statistics & numerical data; Office Visits/utilization; Personal/statistics & numerical data
Creator
An entity primarily responsible for making the resource
Newacheck P; Inkelas M; Kim SE
Description
An account of the resource
OBJECTIVE: To examine health care utilization and expenditure patterns for children with disabilities. METHODS: Secondary data analysis was conducted of the 1999 and 2000 editions of the Medical Expenditure Panel Survey (MEPS), a nationally representative survey conducted in 5 rounds by household interview. Two years of MEPS data were combined in this analysis to improve the precision of estimates. Disability was defined by the presence of a limitation in age-appropriate social role activities, such as school or play, or receipt of specialized services through the early intervention or special education programs. The survey sample included 13,792 children younger than 18 years. The overall response rate was 65.5%. RESULTS: Our findings demonstrate that the 7.3% of US children with disabilities used many more services than their counterparts without disabilities in 1999-2000. The largest differences in utilization were for hospital days (464 vs 55 days per 1000), nonphysician professional visits (3.0 vs 0.6), and home health provider days (3.8 vs 0.04). As a result of their greater use, children with disabilities also had much higher health care expenditures (2669 dollars vs 676 dollars) and higher out-of-pocket expenditures (297 dollars vs 189 dollars). We also found that the distributions of total and out-of-pocket expenses were highly skewed, with a small fraction of the disabled population accounting for a large proportion of expenditures: the upper decile accounted for 65% of total health care expenses and 85% of all out-of-pocket expenses for the population with disabilities. Health insurance was found to convey significant protection against financially burdensome expenses. However, even after controlling for insurance status, low-income families experienced greater financial burdens than higher income families. CONCLUSIONS: The skewed distribution of out-of-pocket expenses found in this and earlier studies indicates that the financial burden of childhood disability continues to be shared unevenly by families. Low-income families are especially vulnerable to burdensome out-of-pocket expenses. Additional efforts are needed to protect these high-risk families.
2004
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1542/peds.114.1.79" target="_blank" rel="noreferrer">10.1542/peds.114.1.79</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2004
Adolescent
Backlog
Child
Cost Sharing/statistics & numerical data
Disabled Children/statistics & numerical data
Financing
Health
Health Care Surveys
Health Expenditures/statistics & numerical data
Health Services/utilization
Home Care Services/economics/utilization
Hospitalization/economics/statistics & numerical data
Humans
Income
Infant
Inkelas M
Insurance
Journal Article
Kim SE
Multivariate Analysis
Newacheck P
Office Visits/utilization
P.H.S.
Pediatrics
Personal/statistics & numerical data
Preschool
Prevalence
Research Support
U.S. Gov't
United States
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.5014/ajot.58.5.551" target="_blank" rel="noreferrer">http://doi.org/10.5014/ajot.58.5.551</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Parenting a child with a chronic medical condition
Publisher
An entity responsible for making the resource available
American Journal Of Occupational Therapy
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Subject
The topic of the resource
P.H.S.; U.S. Gov't; PedPal Lit; Adult Disabled Children/psychology/rehabilitation Family/psychology Humans Infant Occupational Therapy Parenting/psychology Questionnaires Research Support; and journals were analyzed for themes that related to caregiving; and self-identity. RESULTS: Parents felt that they "always needed to be with their child; how they maintain their social lives; social activities; students' field notes
Creator
An entity primarily responsible for making the resource
Case-Smith J
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.5014/ajot.58.5.551" target="_blank" rel="noreferrer">10.5014/ajot.58.5.551</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
2004
2004
Adult Disabled Children/psychology/rehabilitation Family/psychology Humans Infant Occupational Therapy Parenting/psychology Questionnaires Research Support
American Journal Of Occupational Therapy
and journals were analyzed for themes that related to caregiving
and self-identity. RESULTS: Parents felt that they "always needed to be with their child
Backlog
Case-Smith J
how they maintain their social lives
Journal Article
P.H.S.
PedPal Lit
social activities
students' field notes
U.S. Gov't
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12133245" target="_blank" rel="noreferrer">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12133245</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Evolution in measuring the quality of dying
Publisher
An entity responsible for making the resource available
Journal Of Palliative Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Attitude to Death; Non-U.S. Gov't; P.H.S.; U.S. Gov't; Human; Support; Quality Assurance; Non-P.H.S.; Health Care/trends; Hospice Care/psychology/standards; Process Assessment (Health Care)/methods; Quality of Life/psychology; Terminal Care/psychology/standards
Creator
An entity primarily responsible for making the resource
Steinhauser KE; Clipp EC; Tulsky JA
Description
An account of the resource
PURPOSE: Despite multiple efforts to improve the experience for dying patients, researchers still struggle to identify appropriate outcome measures that assess patients' and families' experiences. If health care systems are to provide excellent, compassionate care to dying patients and their families, there must be a valid means of assessing the quality of those experiences and interventions to improve care. The purpose of this paper is to evaluate quality-of-life instruments currently used to assess the experiences of dying patients, and to offer a design for a next generation instrument to measure quality at the end of life. DESIGN: Sources were attained through a review of the quality of life, quality of dying, and end-of-life care literatures. The terms quality of life, quality of care, terminal care, hospice, assessment, and measurement were used singly and in combination in the MEDLINE database from 1966 to 2001. DISCUSSION: An appropriate clinical quality of dying instrument must be derived from the perspectives of end-of-life care participants and include the multiple domains of experience important to patients and families. Because dying patients are often too ill to communicate, nonresponse bias is a major problem in this population. Researchers must identify additional objective and subjective measures that clearly reflect, correspond well (or predictably) with, and serve as alternatives to patients' self-ratings. Additionally, an appropriate assessment tool must accommodate individual definitions of the quality of dying and demonstrate sensitivity to change over time.
2002
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2002
Attitude To Death
Backlog
Clipp EC
Health Care/trends
Hospice Care/psychology/standards
Human
Journal Article
Journal of Palliative Medicine
Non-P.H.S.
Non-U.S. Gov't
P.H.S.
Process Assessment (Health Care)/methods
Quality Assurance
Quality Of Life/psychology
Steinhauser KE
Support
Terminal Care/psychology/standards
Tulsky JA
U.S. Gov't
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12660386" target="_blank" rel="noreferrer">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12660386</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Oral opioid therapy for chronic peripheral and central neuropathic pain
Publisher
An entity responsible for making the resource available
New England Journal Of Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Female; Male; Adult; Analgesics; Aged; Outcome Assessment (Health Care); Double-Blind Method; 80 and over; Non-U.S. Gov't; P.H.S.; U.S. Gov't; Chronic disease; Dose-Response Relationship; Drug; Drug Tolerance; Human; Support; Middle Age; Opioid/administration & dosage/adverse effects/therapeutic; use; Central Nervous System Diseases/drug therapy; Levorphanol/administration & dosage/adverse effects/therapeutic use; Neuralgia/drug therapy; Peripheral Nervous System Diseases/drug therapy
Creator
An entity primarily responsible for making the resource
Rowbotham MC; Twilling L; Davies PS; Reisner L; Taylor K; Mohr D
Description
An account of the resource
BACKGROUND: Although opioids are commonly used to treat chronic neuropathic pain, there are limited data to guide their use. Few controlled trials have been performed, and many types of neuropathic pain remain unstudied. METHODS: Adults with neuropathic pain that was refractory to treatment were randomly assigned to receive either high-strength (0.75-mg) or low-strength (0.15-mg) capsules of the potent mu-opioid agonist levorphanol for eight weeks under double-blind conditions. Intake was titrated by the patient to a maximum of 21 capsules of either strength per day. Outcome measures included the intensity of pain as recorded in a diary, the degree of pain relief, quality of life, psychological and cognitive function, the number of capsules taken daily, and blood levorphanol levels. RESULTS: Among the 81 patients exposed to the study drug, high-strength levorphanol capsules reduced pain by 36 percent, as compared with a 21 percent reduction in pain in the low-strength group (P=0.02). On average, patients in the high-strength group took 11.9 capsules per day (8.9 mg per day) and patients in the low-strength group took close to the 21 allowed (18.3 capsules per day; 2.7 mg per day). Affective distress and interference with functioning were reduced, and sleep was improved, but there were no differences between the high-strength group and the low-strength group in terms of these variables. Noncompletion of the study was primarily due to side effects of the opioid. Patients with central pain after stroke were the least likely to report benefit. CONCLUSIONS: The reduction in the intensity of neuropathic pain was significantly greater during treatment with higher doses of opioids than with lower doses. Higher doses produced more side effects without significant additional benefit in terms of other outcome measures.
2003
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
80 And Over
Adult
Aged
Analgesics
Backlog
Central Nervous System Diseases/drug therapy
Chronic Disease
Davies PS
Dose-Response Relationship
Double-Blind Method
Drug
Drug Tolerance
Female
Human
Journal Article
Levorphanol/administration & dosage/adverse effects/therapeutic use
Male
Middle Age
Mohr D
Neuralgia/drug therapy
New England Journal Of Medicine
Non-U.S. Gov't
Opioid/administration & dosage/adverse effects/therapeutic
Outcome Assessment (health Care)
P.H.S.
Peripheral Nervous System Diseases/drug therapy
Reisner L
Rowbotham MC
Support
Taylor K
Twilling L
U.S. Gov't
use
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12837717" target="_blank" rel="noreferrer">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12837717</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Complexities in prognostication in advanced cancer: "to help them live their lives the way they want to"
Publisher
An entity responsible for making the resource available
Jama
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Female; Physician-Patient Relations; Prognosis; Aged; Patient Participation; Survival Analysis; Antineoplastic Agents; 80 and over; Non-U.S. Gov't; P.H.S.; U.S. Gov't; algorithms; Human; Truth Disclosure; Support; Adenocarcinoma/drug therapy/secondary; Hormonal/therapeutic use; Skin Neoplasms/drug therapy/secondary; Stomach Neoplasms/drug therapy/pathology; Tamoxifen/therapeutic use
Creator
An entity primarily responsible for making the resource
Lamont EB; Christakis NA
Description
An account of the resource
Predicting survival and disclosing the prediction to patients with advanced disease, particularly cancer, is among the most difficult tasks that physicians face. With the de-emphasis of prognosis in favor of diagnosis and therapeutics in the medical literature, physicians may have difficulty finding the survival information they need to make appropriate estimates of survival for patients who develop cancer. Quite separate from the challenge of estimating survival accurately, physicians may also find the process of disclosing the prognosis to their patients difficult. Using the vignette of a real patient with advanced cancer who far outlived her physician's prognostic estimate, we discuss clinical issues related to the science of prognosis in advanced cancer and the art of its disclosure.
2003
Rights
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
80 And Over
Adenocarcinoma/drug therapy/secondary
Aged
algorithms
Antineoplastic Agents
Backlog
Christakis NA
Female
Hormonal/therapeutic use
Human
JAMA
Journal Article
Lamont EB
Non-U.S. Gov't
P.H.S.
Patient Participation
Physician-patient Relations
Prognosis
Skin Neoplasms/drug therapy/secondary
Stomach Neoplasms/drug therapy/pathology
Support
Survival Analysis
Tamoxifen/therapeutic use
Truth Disclosure
U.S. Gov't
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0002-7138(09)61529-6" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0002-7138(09)61529-6</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Death of a child at home or in the hospital: subsequent psychological adjustment of the family
Publisher
An entity responsible for making the resource available
Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
1983
Subject
The topic of the resource
Child; Female; Hospitalization; Humans; Male; Grief; Family; Adult; Middle Aged; Death; Personality Inventory; Non-U.S. Gov't; P.H.S.; Research Support; U.S. Gov't; Adaptation; Psychological; Comparative Study; Neoplasms/therapy; location of death; Interview; home care services; MMPI; Terminal Care/methods
Creator
An entity primarily responsible for making the resource
Mulhern RK; Lauer ME; Hoffmann RG
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0002-7138(09)61529-6" target="_blank" rel="noreferrer">10.1016/s0002-7138(09)61529-6</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
Twenty-four families who had participated in a Home Care Program for children terminally ill with cancer and 13 families of similar children who had died in the hospital completed inventories on parent and sibling personality as well as family functioning three to 29 months after the child's death. Parents of patients who received terminal care in the hospital were more anxious, depressed, and defensive and had greater tendencies toward somatic and interpersonal problems than parents of patients in the Home Care Program. Siblings of patients who received terminal care in the hospital were more emotionally inhibited, withdrawn, and fearful than their counterparts in the Home Care Program. Although some group differences in parental personality may have antedated terminal care, these results confirm parental reports of more adequate family adjustment following participation in a structured Home Care Program.
1983
Adaptation
Adult
Backlog
Child
Comparative Study
Death
Family
Female
Grief
Hoffmann RG
home care services
Hospitalization
Humans
Interview
Journal Article
Lauer ME
Location Of Death
Male
Middle Aged
MMPI
Mulhern RK
Neoplasms/therapy
Non-U.S. Gov't
P.H.S.
Pediatrics
Personality Inventory
Psychological
Research Support
Terminal Care/methods
U.S. Gov't
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1038/clpt.1988.159" target="_blank" rel="noreferrer">http://doi.org/10.1038/clpt.1988.159</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sublingual absorption of selected opioid analgesics
Publisher
An entity responsible for making the resource available
Clinical Pharmacology And Therapeutics
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
Subject
The topic of the resource
Humans; Adult; Analgesics; Time Factors; Analysis of Variance; Non-U.S. Gov't; P.H.S.; Research Support; U.S. Gov't; Comparative Study; Administration; Biological Availability; Buprenorphine/pharmacokinetics; Fentanyl/pharmacokinetics; Heroin/pharmacokinetics; Hydromorphone/pharmacokinetics; Levorphanol/pharmacokinetics; Methadone/pharmacokinetics; Morphine/blood/pharmacokinetics; Mouth/metabolism; Naloxone/pharmacokinetics; Opioid/administration & dosage/pharmacokinetics; Oxycodone/pharmacokinetics; Sublingual
Creator
An entity primarily responsible for making the resource
Weinberg DS; Inturrisi CE; Reidenberg B; Moulin DE; Nip TJ; Wallenstein S; Houde RW; Foley KM
Description
An account of the resource
Ongoing interest in the improvement of pain management with opioid analgesics had led to the investigation of sublingual opioid absorption. The present report determined the percent absorption of selected opioid analgesics from the oral cavity of normal subjects under conditions of controlled pH and swallowing when a 1.0 ml aliquot of the test drug was placed under the tongue for a 10-minute period. Compared with morphine sulfate at pH 6.5 (18% absorption), buprenorphine (55%), fentanyl (51%), and methadone (34%) were absorbed to a significantly greater extent (p less than 0.05), whereas levorphanol, hydromorphone, oxycodone, heroin, and the opioid antagonist naloxone were not. Overall, lipophilic drugs were better absorbed than were hydrophilic drugs. Plasma morphine concentration-time profiles indicate that the apparent sublingual bioavailability of morphine is only 9.0% +/- 11.9% (SD) of that after intramuscular administration. In the same subjects the estimated sublingual absorption was 22.4% +/- 9.2% (SD), indicating that the sublingual absorption method may overestimate apparent bioavailability. When the oral cavity was buffered to pH 8.5, methadone absorption was increased to 75%. Thus, an alkaline pH microenvironment that favors the unionized fraction of opioids increased sublingual drug absorption. Although absorption was found to be independent of drug concentration, it was contact time dependent for methadone and fentanyl but not for buprenorphine. These results indicate that although the sublingual absorption and apparent sublingual bioavailability of morphine are poor, the sublingual absorption of methadone, fentanyl, and buprenorphine under controlled conditions is relatively high.
1988
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/clpt.1988.159" target="_blank" rel="noreferrer">10.1038/clpt.1988.159</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1988
Administration
Adult
Analgesics
Analysis of Variance
Backlog
Biological Availability
Buprenorphine/pharmacokinetics
Clinical Pharmacology And Therapeutics
Comparative Study
Fentanyl/pharmacokinetics
Foley KM
Heroin/pharmacokinetics
Houde RW
Humans
Hydromorphone/pharmacokinetics
Inturrisi CE
Journal Article
Levorphanol/pharmacokinetics
Methadone/pharmacokinetics
Morphine/blood/pharmacokinetics
Moulin DE
Mouth/metabolism
Naloxone/pharmacokinetics
Nip TJ
Non-U.S. Gov't
Opioid/administration & dosage/pharmacokinetics
Oxycodone/pharmacokinetics
P.H.S.
Reidenberg B
Research Support
Sublingual
Time Factors
U.S. Gov't
Wallenstein S
Weinberg DS
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1056/nejm198205273062103" target="_blank" rel="noreferrer">http://doi.org/10.1056/nejm198205273062103</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
On the elicitation of preferences for alternative therapies
Publisher
An entity responsible for making the resource available
The New England Journal Of Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1982
Subject
The topic of the resource
Humans; Male; Adult; Aged; Middle Aged; Choice Behavior; Patient Participation; Probability; Therapeutics; Outcome and Process Assessment (Health Care); Non-U.S. Gov't; P.H.S.; Research Support; U.S. Gov't; decision making; Life Expectancy; Lung Neoplasms/mortality/radiotherapy/surgery
Creator
An entity primarily responsible for making the resource
McNeil BJ; Pauker SG; Sox HC; Tversky A
Description
An account of the resource
We investigated how variations in the way information is presented to patients influence their choices between alternative therapies. Data were presented summarizing the results of surgery and radiation therapy for lung cancer to 238 ambulatory patients with different chronic medical conditions and to 491 graduate students and 424 physicians. We asked the subjects to imagine that they had lung cancer and to choose between the two therapies on the basis of both cumulative probabilities and life-expectancy data. Different groups of respondents received input data that differed only in whether or not the treatments were identified and whether the outcomes were framed in terms of the probability of living or the probability of dying. In all three populations, the attractiveness of surgery, relative to radiation therapy, was substantially greater when the treatments were identified rather than unidentified, when the information consisted of life expectancy rather than cumulative probability, and when the problem was framed in terms of the probability of living rather than in terms of the probability of dying. We suggest that an awareness of these effects among physicians and patients could help reduce bias and improve the quality of medical decision making.
1982
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1056/nejm198205273062103" target="_blank" rel="noreferrer">10.1056/nejm198205273062103</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1982
Adult
Aged
Backlog
Choice Behavior
Decision Making
Humans
Journal Article
Life Expectancy
Lung Neoplasms/mortality/radiotherapy/surgery
Male
McNeil BJ
Middle Aged
Non-U.S. Gov't
Outcome And Process Assessment (health Care)
P.H.S.
Patient Participation
Pauker SG
Probability
Research Support
Sox HC
The New England Journal Of Medicine
Therapeutics
Tversky A
U.S. Gov't
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1093/geronj/45.5.p181" target="_blank" rel="noreferrer">http://doi.org/10.1093/geronj/45.5.p181</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Psychiatric and physical morbidity effects of caregiving
Publisher
An entity responsible for making the resource available
Journal Of Gerontology
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
Subject
The topic of the resource
Female; Humans; Male; Attitude to Health; Middle Aged; Morbidity; Stress; P.H.S.; Research Support; U.S. Gov't; Psychological/complications; Immunity; Depression/diagnosis/etiology; Home Nursing/psychology; Meta-Analysis
Creator
An entity primarily responsible for making the resource
Schulz R; Visintainer P; Williamson GM
Description
An account of the resource
Existing empirical literature on the prolonged or cumulative consequences of exposure to the stresses of caregiving is reviewed. Specific goals are to identify psychiatric and physical morbidity effects, report the magnitude of those effects, evaluate research and analytic methods used to assess morbidity, and make recommendations for future research. Overall, the literature indicates increases in self-report psychiatric symptomatology and increases in psychiatric illness among most caregivers when compared to population norms or appropriate control groups. However, there is little information on the population prevalence or incidence of clinically significant psychiatric conditions attributable to caregiving. Studies of physical health effects as assessed by self-report, health care utilization, and immune function are less conclusive but, nevertheless, suggest increased vulnerability to physical illness among caregivers. We conclude with a discussion of why morbidity effects are difficult to obtain in caregiver studies and with recommendations for future research.
1990
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/geronj/45.5.p181" target="_blank" rel="noreferrer">10.1093/geronj/45.5.p181</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1990
Attitude To Health
Backlog
Depression/diagnosis/etiology
Female
Home Nursing/psychology
Humans
Immunity
Journal Article
Journal Of Gerontology
Male
Meta-Analysis
Middle Aged
Morbidity
P.H.S.
Psychological/complications
Research Support
Schulz R
Stress
U.S. Gov't
Visintainer P
Williamson GM
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1093/geront/20.6.649" target="_blank" rel="noreferrer">http://doi.org/10.1093/geront/20.6.649</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Relatives of the impaired elderly: correlates of feelings of burden
Publisher
An entity responsible for making the resource available
The Gerontologist
Date
A point or period of time associated with an event in the lifecycle of the resource
1980
Subject
The topic of the resource
Humans; Aged; Life Support Care; P.H.S.; Research Support; U.S. Gov't; Dementia/rehabilitation; Guilt
Creator
An entity primarily responsible for making the resource
Zarit SH; Reever KE; Bach-Peterson J
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/geront/20.6.649" target="_blank" rel="noreferrer">10.1093/geront/20.6.649</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
1980
1980
Aged
Bach-Peterson J
Backlog
Dementia/rehabilitation
Guilt
Humans
Journal Article
Life Support Care
P.H.S.
Reever KE
Research Support
The Gerontologist
U.S. Gov't
Zarit SH
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1093/geront/29.2.159" target="_blank" rel="noreferrer">http://doi.org/10.1093/geront/29.2.159</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Husbands and wives as caregivers: antecedents of depression and burden
Publisher
An entity responsible for making the resource available
The Gerontologist
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
Subject
The topic of the resource
Humans; Mental Health; Sex Factors; Depression; Regression Analysis; P.H.S.; Research Support; U.S. Gov't; Interviews; Alzheimer Disease/psychology; Marriage; Home Nursing/psychology
Creator
An entity primarily responsible for making the resource
Pruchno RA; Resch NL
Description
An account of the resource
Contrasting predictors of depression among 101 men and 214 women providing care to spouses suffering from Alzheimer's Disease indicated that the sole predictor for husbands was ill health, whereas for wives less emotional investment was also predictive. While there were no significant predictors for burden among husbands, for wives, burden was associated with poorer health, less emotional investment, greater spouse impairment, and provision of more assistance with tasks.
1989
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/geront/29.2.159" target="_blank" rel="noreferrer">10.1093/geront/29.2.159</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1989
Alzheimer Disease/psychology
Backlog
Depression
Home Nursing/psychology
Humans
Interviews
Journal Article
Marriage
Mental Health
P.H.S.
Pruchno RA
Regression Analysis
Resch NL
Research Support
Sex Factors
The Gerontologist
U.S. Gov't
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1111/j.1467-6494.1989.tb00485.x" target="_blank" rel="noreferrer">http://doi.org/10.1111/j.1467-6494.1989.tb00485.x</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Combat experience and emotional health: impairment and resilience in later life
Publisher
An entity responsible for making the resource available
Journal Of Personality
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
Subject
The topic of the resource
Humans; Male; Adult; Memory; Longitudinal Studies; Risk Factors; adolescent; P.H.S.; Research Support; U.S. Gov't; Adaptation; Psychological; Stress Disorders; War; Human Development; Non-P.H.S.; Veterans/psychology; Post-Traumatic/psychology; Assertiveness; Ego
Creator
An entity primarily responsible for making the resource
Elder GH; Clipp EC
Description
An account of the resource
War's influence on emotional health includes potential psychological gains as well as losses. In a sample of 149 veterans from longitudinal samples at the Institute of Human Development, University of California, Berkeley, this study explores two questions on the legacy of combat in World War II and the Korean conflict. The first concerns the subjective experience or meanings of combat that veterans hold in later life, with particular attention to how such accounts are linked to the severity of combat and postwar adaptations. The second question links these accounts to the psychosocial functioning of veterans before the war and in later life using reports from veterans and their spouses and Q-sort ratings in adolescence and at age 40. Findings center on veterans of heavy combat. Compared to the noncombatants and light combat veterans, these men were at greater risk of emotional and behavioral problems in the postwar years. In mid-life, they hold mixed memories of painful losses and life benefits associated with military experience. Clinical ratings show that heavy combat veterans became more resilient and less helpless over time when compared to other men. As in the case of life events generally, short- and long-term effects may impair and enhance personal growth.
1989
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/j.1467-6494.1989.tb00485.x" target="_blank" rel="noreferrer">10.1111/j.1467-6494.1989.tb00485.x</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1989
Adaptation
Adolescent
Adult
Assertiveness
Backlog
Clipp EC
Ego
Elder GH
Human Development
Humans
Journal Article
Journal Of Personality
Longitudinal Studies
Male
Memory
Non-P.H.S.
P.H.S.
Post-Traumatic/psychology
Psychological
Research Support
Risk Factors
Stress Disorders
U.S. Gov't
Veterans/psychology
War
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1111/j.1939-0025.1985.tb03422.x" target="_blank" rel="noreferrer">http://doi.org/10.1111/j.1939-0025.1985.tb03422.x</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effects of self-help and psychotherapy intervention on child loss: the limits of recovery
Publisher
An entity responsible for making the resource available
The American Journal Of Orthopsychiatry
Date
A point or period of time associated with an event in the lifecycle of the resource
1985
Subject
The topic of the resource
Child; Female; Humans; Male; Grief; Social Adjustment; Self-Help Groups; Combined Modality Therapy; Non-U.S. Gov't; P.H.S.; Research Support; U.S. Gov't; Adaptation; Psychological; Parents/psychology; Intervention; Interventions; Adjustment Disorders/therapy; Psychotherapy/methods
Creator
An entity primarily responsible for making the resource
Videka-Sherman L; Lieberman M
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/j.1939-0025.1985.tb03422.x" target="_blank" rel="noreferrer">10.1111/j.1939-0025.1985.tb03422.x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
Results of a longitudinal study of the effects of bereaved parents' participation in a self-help group and in psychotherapy are presented. Active self-help group participants evidenced unique changes in attitudes about bereavement. Reasons for lack of differences in mental health, marital, and parental roles are discussed.
1985
Adaptation
Adjustment Disorders/therapy
Backlog
Child
Combined Modality Therapy
Female
Grief
Humans
Intervention
Interventions
Journal Article
Lieberman M
Male
Non-U.S. Gov't
P.H.S.
Parents/psychology
Psychological
Psychotherapy/methods
Research Support
Self-Help Groups
Social Adjustment
The American Journal Of Orthopsychiatry
U.S. Gov't
Videka-Sherman L
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=6643644" target="_blank" rel="noreferrer">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=6643644</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
National hospice study analysis plan
Publisher
An entity responsible for making the resource available
Journal Of Chronic Diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
1983
Subject
The topic of the resource
United States; Family; Research Design; Non-U.S. Gov't; P.H.S.; U.S. Gov't; Models; Costs and Cost Analysis; Human; Theoretical; Support; Hospices/economics; Evaluation Studies/methods; Health Services Research/methods
Creator
An entity primarily responsible for making the resource
Greer DS; Mor V; Sherwood S; Morris JN; Birnbaum H
Description
An account of the resource
Since the founding of the first hospice in the United States in 1974, the number of health care organizations providing hospice services has grown rapidly. In 1978, the U.S. General Accounting Office identified 59 operational hospices [1]. A survey undertaken by the National Hospice Organization (NHO) in 1980 found 235 operational programs and many more actively planning to deliver services. By the summer of 1981, the Joint Commission on the Accreditation of Hospitals (JCAH), in studying the feasibility of a voluntary hospice accreditation program, had 650 responses to a national survey [2]. Finally, the 1981 NHO directory identifies 464 operational "provider programs" as well as 33 functioning state-level hospice organizations with an additional 353 programs in various stages of establishing hospice programs of care [3]. The growth of the movement and the public recognition it has received have catalyzed advocacy of Federal support for hospice services. In 1979, the Congress responded by mandating a study to delineate the implications of inclusion of hospice services in the Medicare program. The Health Care Financing Administration (HCFA) then selected 26 hospices (from an applicant pool of 233) to participate in a two-year experimental program. These demonstration sites receive reimbursement for services provided Medicare beneficiaries not otherwise available under current regulations. The special reimbursement provisions went into effect on October 1, 1980. (See Appendix A: Description of the Hospice Reimbursement Program.) In the spring of 1980, the Robert Wood Johnson Foundation and the John A. Hartford Foundation joined with the Health Care Financing Administration (HCFA) to solicit proposals for a national evaluation of hospice care as a basis for future Federal fiscal policy and legislation. Brown University was selected as the evaluation center by competitive process and the grant was awarded on September 30, 1980. The evaluation employs a quasi-experimental design in which the impact of hospice care (with and without reimbursement) on quality of life and costs are compared to non-hospice (conventional) terminal care. Eight hundred patients and families in 24 comparison sites located in three regional areas (Southern New England, Northern Midwest and Southern California) are expected to participate. Primary data collection began on August 1, 1981. Analyses of differential outcome are performed using standard linear multiple regression and logistic multiple regression with separate models for each comparison group. Effects are tested by separately estimating the specific response variable for the prototype (average) hospice patient for each model.
1983
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1983
Backlog
Birnbaum H
Costs And Cost Analysis
Evaluation Studies/methods
Family
Greer DS
Health Services Research/methods
Hospices/economics
Human
Journal Article
Journal Of Chronic Diseases
Models
Mor V
Morris JN
Non-U.S. Gov't
P.H.S.
Research Design
Sherwood S
Support
Theoretical
U.S. Gov't
United States
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1001/archinte.1995.00430060097012" target="_blank" rel="noreferrer">http://doi.org/10.1001/archinte.1995.00430060097012</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Decisions about life-sustaining treatment. Impact of physicians' behaviors on the family
Publisher
An entity responsible for making the resource available
Archives Of Internal Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
Subject
The topic of the resource
Humans; Consensus; Withholding Treatment; Communication; Life Support Care; Physician's Role; Nurse's Role; Professional-Patient Relations; Disclosure; Empirical Approach; P.H.S.; Professional Patient Relationship; Research Support; U.S. Gov't; Death and Euthanasia; Interviews; decision making; Family/psychology; Practice Guidelines
Creator
An entity primarily responsible for making the resource
Tilden VP; Tolle SW; Garland MJ; Nelson CA
Description
An account of the resource
BACKGROUND: Despite the growing availability of advance directives, most patients in the intensive care unit lack written directives, and, therefore, consultation with families about treatment decisions remains the rule. In the context of decision making about withdrawing life-sustaining treatments, we investigated which physician and nurse behaviors families find supportive and which behaviors increase the family's burden. METHODS: We conducted intensive 1- to 2-hour-long individual interviews using a semistructured interview protocol with 32 family members of patients without advance directives whose deaths followed a stay in the intensive care unit and withdrawal of treatment. We analyzed more than 700 pages of verbatim interview data using content analysis techniques and achieved more than 90% interrater agreement on data codes. RESULTS: Themes emerged as families identified selected physician and nursing behaviors as helpful: encouraging advanced planning, timely communication, clarification of families' roles, facilitating family consensus, and accommodating family's grief. Behaviors that made families feel excluded or increased their burden included postponing discussions about treatment withdrawal, delaying withdrawal once scheduled, placing the full burden of decision making on one person, withdrawing from the family, and defining death as a failure. CONCLUSIONS: Study findings provide an increased understanding of the unmet needs of families and serve to guide physicians and nurses in reducing actions that increase families' burdens as they participate in treatment withdrawal decisions.
1995
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1001/archinte.1995.00430060097012" target="_blank" rel="noreferrer">10.1001/archinte.1995.00430060097012</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1995
Archives Of Internal Medicine
Backlog
Communication
Consensus
Death and Euthanasia
Decision Making
Disclosure
Empirical Approach
Family/psychology
Garland MJ
Humans
Interviews
Journal Article
Life Support Care
Nelson CA
Nurse's Role
P.H.S.
Physician's Role
Practice Guidelines
Professional Patient Relationship
Professional-patient Relations
Research Support
Tilden VP
Tolle SW
U.S. Gov't
Withholding Treatment
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0277-9536(97)00040-3" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0277-9536(97)00040-3</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Positive psychological states and coping with severe stress
Publisher
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Social Science & Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
Subject
The topic of the resource
Humans; Male; Death; P.H.S.; Research Support; U.S. Gov't; Adaptation; Psychological; bereavement; Caregivers/psychology; Models; Psychological; Stress; Acquired Immunodeficiency Syndrome/psychology/therapy
Creator
An entity primarily responsible for making the resource
Folkman S
Description
An account of the resource
Providing care to a spouse or partner who is dying and then losing that person are among the most stressful of human experiences. A longitudinal study of the caregiving partners of men with AIDS showed that in addition to intense negative psychological states, these men also experienced positive psychological state states throughout caregiving and bereavement. The co-occurrence of positive and negative psychological states in the midst of enduring and profoundly stressful circumstances has important implications for our understanding of the coping process. Coping theory had traditionally focused on the management of distress. This article describes coping processes that are associated with positive psychological states in the context of intense distress and discusses the theoretical implications of positive psychological states in the coping process.
1997
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0277-9536(97)00040-3" target="_blank" rel="noreferrer">10.1016/s0277-9536(97)00040-3</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1997
Acquired Immunodeficiency Syndrome/psychology/therapy
Adaptation
Backlog
Bereavement
Caregivers/psychology
Death
Folkman S
Humans
Journal Article
Male
Models
P.H.S.
Psychological
Research Support
Social science & medicine
Stress
U.S. Gov't
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0304-3959(00)00229-3" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0304-3959(00)00229-3</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Systemic lidocaine for neuropathic pain relief
Publisher
An entity responsible for making the resource available
Pain
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
Subject
The topic of the resource
Humans; Animals; P.H.S.; Research Support; U.S. Gov't; Administration; Oral; Analgesics/administration & dosage/diagnostic use/therapeutic use; Lidocaine/administration & dosage/diagnostic use/therapeutic use; Mexiletine/therapeutic use; Neuralgia/drug therapy/metabolism; Sodium Channel Blockers
Creator
An entity primarily responsible for making the resource
Mao J; Chen LL
Description
An account of the resource
The effectiveness of systemic lidocaine in relieving acute and chronic pain has been recognized for over 35 years. In particular, systemic lidocaine has been utilized both as a diagnostic and therapeutic tool for intractable neuropathic pain during the last decade. The introduction of oral lidocaine congeners such as mexiletine has significantly extended the usage of lidocaine therapy in chronic pain settings. However, a number of clinical issues remain to be addressed including (1) an effective, meaningful dose range for the clinical lidocaine test, (2) the predictive value of the lidocaine test for an oral trial of lidocaine congeners, (3) identification of pain symptoms and signs relieved by systemic lidocaine, (4) comparisons of therapeutic effects between systemic lidocaine and its oral congeners, and (5) long-term outcomes of systemic lidocaine and its oral congeners. Mechanisms of neuropathic pain relief from lidocaine therapy are yet to be understood. Both central and peripheral mechanisms have been postulated. Systemic lidocaine is thought to have its suppressive effects on spontaneous ectopic discharges of the injured nerve without blocking normal nerve conduction. However, there remain inconsistencies in the scientific basis underlying the clinical application of lidocaine therapy. Recent demonstration of changes in tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels following nerve injury and their link to certain neuropathic pain symptoms may lead to the development of subtype-specific sodium channel blockers. The thoughtful use of lidocaine therapy and the potential application of subtype-specific sodium channel blockers could provide better management of distinctive neuropathic pain symptoms.
2000
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0304-3959(00)00229-3" target="_blank" rel="noreferrer">10.1016/s0304-3959(00)00229-3</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2000
Administration
Analgesics/administration & dosage/diagnostic use/therapeutic use
Animals
Backlog
Chen LL
Humans
Journal Article
Lidocaine/administration & dosage/diagnostic use/therapeutic use
Mao J
Mexiletine/therapeutic use
Neuralgia/drug therapy/metabolism
Oral
P.H.S.
Pain
Research Support
Sodium Channel Blockers
U.S. Gov't