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Text
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URL Address
<a href="http://doi.org/10.1016/j.jemermed.2004.12.015" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.jemermed.2004.12.015</a>
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Title
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Are one or two dangerous? Opioid exposure in toddlers
Publisher
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The Journal Of Emergency Medicine
Date
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2005
Subject
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Child; Humans; Analgesics; Preschool; infant; Dose-Response Relationship; Drug; Codeine/poisoning; Emergency Medicine/methods; Fentanyl/poisoning; Methadone/poisoning; Opioid/poisoning; Overdose; Pediatrics/methods; Poisoning/diagnosis/physiopathology/therapy; Tramadol/poisoning
Creator
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Sachdeva DK; Stadnyk JM
Description
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Ingestions of opioid analgesics by children may lead to significant toxicity as a result of depression of the respiratory and central nervous systems. A review of the medical literature was performed to determine whether low doses of opioids are dangerous in the pediatric population under 6 years old. Methadone was found to be the most toxic of the opioids; doses as low as a single tablet can lead to death. All children who have ingested any amount of methadone need to be observed in an Emergency Department (ED) for at least 6 h and considered for hospital admission. Most other opioids are better tolerated in ingestions as small as one or two tablets. Based on the limited data available for these opioids, we conclude that equianalgesic doses of 5 mg/kg of codeine or greater require 4 to 6 h of observation in the ED. Data for propoxyphene and all extended-release preparations are limited; their prolonged half-lives would suggest the need for longer observation periods. All opioid ingestions leading to respiratory depression or significant central nervous system depression require admission to an intensive care unit.
2005
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jemermed.2004.12.015" target="_blank" rel="noreferrer">10.1016/j.jemermed.2004.12.015</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2005
Analgesics
Backlog
Child
Codeine/poisoning
Dose-Response Relationship
Drug
Emergency Medicine/methods
Fentanyl/poisoning
Humans
Infant
Journal Article
Methadone/poisoning
Opioid/poisoning
Overdose
Pediatrics/methods
Poisoning/diagnosis/physiopathology/therapy
Preschool
Sachdeva DK
Stadnyk JM
The Journal Of Emergency Medicine
Tramadol/poisoning