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<a href="http://doi.org/10.1021/bi0300635" target="_blank" rel="noreferrer">http://doi.org/10.1021/bi0300635</a>
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Title
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Human neutrophils as a source of nociceptin: a novel link between pain and inflammation
Publisher
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Biochemistry
Date
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2003
Subject
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Humans; Molecular Sequence Data; Biomarkers of Pain; Receptors; Neutrophils/metabolism; Arthritis/metabolism; Cyclic AMP/metabolism; Inflammation/metabolism; Opioid Peptides/metabolism; Opioid/agonists/genetics/metabolism; Pain/metabolism; Phosphorylation; Protein-Tyrosine Kinases/metabolism; Proto-Oncogene Proteins c-hck; Proto-Oncogene Proteins/metabolism; Synovial Fluid/chemistry/immunology
Creator
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Fiset ME; Gilbert C; Poubelle PE; Pouliot M
Description
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Nociceptin is a neuropeptide sharing sequence homology with classical opioid peptides but with a distinct pharmacological profile. Through activation of its receptor, NociR, nociceptin has been linked with several physiological functions in the central nervous system including memory, locomotion, and processing of pain signals. Recently, peripheral blood neutrophils (PMNs) were demonstrated to express a functional NociR, a result suggesting that additional functions of the neuropeptide remain to be elucidated. The present study investigated the possibility that PMNs may be a source of nociceptin and whether the neuropeptide elicits PMN early responses. We observed the presence of nociceptin in the synovial fluids from arthritic patients, an inflammatory milieu typically containing high numbers of PMNs. In addition, freshly isolated PMNs were found to express and secrete nociceptin following degranulation, identifying these inflammatory cells as a novel source of the neuropeptide. Incubation of PMNs with nociceptin elicited a specific pattern of cellular protein phosphorylation on tyrosine residues in a rapid and transient fashion. Moreover, nociceptin prevented intracellular accumulation of cAMP in fMLP-stimulated PMNs, an effect mimicked by the specific NociR synthetic agonist, Ro 64-6198. Taken together, these results show that nociceptin/NociR is present and functional in human neutrophils, and the results identify a novel dialogue pathway between neural and immune tissues.
2003
Identifier
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<a href="http://doi.org/10.1021/bi0300635" target="_blank" rel="noreferrer">10.1021/bi0300635</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
2003
Arthritis/metabolism
Backlog
Biochemistry
Biomarkers of Pain
Cyclic AMP/metabolism
Fiset ME
Gilbert C
Humans
Inflammation/metabolism
Journal Article
Molecular Sequence Data
Neutrophils/metabolism
Opioid Peptides/metabolism
Opioid/agonists/genetics/metabolism
Pain/metabolism
Phosphorylation
Poubelle PE
Pouliot M
Protein-Tyrosine Kinases/metabolism
Proto-Oncogene Proteins c-hck
Proto-Oncogene Proteins/metabolism
Receptors
Synovial Fluid/chemistry/immunology