1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1007/978-3-540-33823-9_2" target="_blank" rel="noreferrer">http://doi.org/10.1007/978-3-540-33823-9_2</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Opioids Publisher An entity responsible for making the resource available Handbook Of Experimental Pharmacology Date A point or period of time associated with an event in the lifecycle of the resource 2007 Subject The topic of the resource Humans; Analgesics; Animals; Molecular Sequence Data; Chronic disease; Biomarkers of Pain; Drug Tolerance; Receptors; Amino Acid Sequence; Ligands; Opioid/adverse effects/pharmacology/therapeutic use; Opioid/drug effects Creator An entity primarily responsible for making the resource Zollner C; Stein C Description An account of the resource Opioids are the most effective and widely used drugs in the treatment of severe pain. They act through G protein-coupled receptors. Four families of endogenous ligands (opioid peptides) are known. The standard exogenous opioid analgesic is morphine. Opioid agonists can activate central and peripheral opioid receptors. Three classes of opioid receptors (mu, delta, kappa) have been identified. Multiple pathways ofopioid receptor signaling (e.g., G(i/o) coupling, cAMP inhibition, Ca++ channel inhibition) have been described. The differential regulation of effectors, preclinical pharmacology, clinical applications, and side effects will be reviewed in this chapter. 2007 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1007/978-3-540-33823-9_2" target="_blank" rel="noreferrer">10.1007/978-3-540-33823-9_2</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2007 Amino Acid Sequence Analgesics Animals Backlog Biomarkers of Pain Chronic Disease Drug Tolerance Handbook Of Experimental Pharmacology Humans Journal Article Ligands Molecular Sequence Data Opioid/adverse effects/pharmacology/therapeutic use Opioid/drug effects Receptors Stein C Zollner C