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Text
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Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1155/2005/286713" target="_blank" rel="noreferrer">http://doi.org/10.1155/2005/286713</a>
Dublin Core
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Title
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A review of the use of methadone for the treatment of chronic noncancer pain
Publisher
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Pain Research & Management : The Journal Of The Canadian Pain Society = Journal De La Societe Canadienne Pour Le Traitement De La Douleur
Date
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2005
Subject
The topic of the resource
Humans; Canada; Analgesics; Methadone; Non-U.S. Gov't; Research Support; Chronic disease; Pain/drug therapy; Drug; Legislation; Methadone/adverse effects/chemistry/pharmacokinetics/pharmacology/therapeutic use; Opioid/adverse effects/chemistry/pharmacokinetics/pharmacology/therapeutic use
Creator
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Lynch ME
Description
An account of the resource
Methadone, although having been available for approximately half a century, is now receiving increasing attention in the management of chronic pain. This is due to recent research showing that methadone exhibits at least three different mechanisms of action including potent opioid agonism, N-methyl-D-aspartate antagonism and monoaminergic effects. This, along with methadone's excellent oral and rectal absorption, high bioavailability, long duration of action and low cost, make it a very attractive option for the treatment of chronic pain. The disadvantages of significant interindividual variation in pharmacokinetics, graduated dose equivalency ratios based on prerotation opioid dose when switching from another opioid, and the requirement for special exemption for prescribing methadone make it more complicated to use. The present review is intended to educate physicians interested in adding methadone to their armamentarium for assisting patients with moderate to severe pain.
2005
Identifier
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<a href="http://doi.org/10.1155/2005/286713" target="_blank" rel="noreferrer">10.1155/2005/286713</a>
Rights
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2005
Analgesics
Backlog
Canada
Chronic Disease
Drug
Humans
Journal Article
Legislation
Lynch ME
Methadone
Methadone/adverse effects/chemistry/pharmacokinetics/pharmacology/therapeutic use
Non-U.S. Gov't
Opioid/adverse effects/chemistry/pharmacokinetics/pharmacology/therapeutic use
Pain Research & Management : The Journal Of The Canadian Pain Society = Journal De La Societe Canadienne Pour Le Traitement De La Douleur
Pain/drug Therapy
Research Support