1
40
8
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1503/cmaj.100187" target="_blank" rel="noreferrer">http://doi.org/10.1503/cmaj.100187</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Opioids for chronic noncancer pain: a new Canadian practice guideline
Publisher
An entity responsible for making the resource available
Canadian Medical Association Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
Subject
The topic of the resource
Humans; Canada; Practice Guidelines as Topic; Analgesics; Chronic disease; Pain/drug therapy; Opioid/administration & dosage/adverse effects/therapeutic use; Advisory Committees/organization & administration
Creator
An entity primarily responsible for making the resource
Furlan AD; Reardon R; Weppler C; National Opioid Use Guideline Group
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1503/cmaj.100187" target="_blank" rel="noreferrer">10.1503/cmaj.100187</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
2010
2010
Advisory Committees/organization & administration
Analgesics
Backlog
Canada
Canadian Medical Association Journal
Chronic Disease
Furlan AD
Humans
Journal Article
National Opioid Use Guideline Group
Opioid/administration & dosage/adverse effects/therapeutic use
Pain/drug Therapy
Practice Guidelines As Topic
Reardon R
Weppler C
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1007/bf03020377" target="_blank" rel="noreferrer">http://doi.org/10.1007/bf03020377</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Methadone is safe for treating hospitalized patients with severe pain
Publisher
An entity responsible for making the resource available
Canadian Journal Of Anaesthesia
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
Subject
The topic of the resource
Child; Female; Hospitalization; Humans; Male; Adult; Analgesics; Aged; Middle Aged; Analgesia; adolescent; Preschool; infant; Administration; Oral; retrospective studies; Pain/drug therapy; Pain Measurement/drug effects; Epidural; Methadone/administration & dosage/adverse effects/therapeutic use; Monitoring; Opioid/administration & dosage/adverse effects/therapeutic use; Physiologic
Creator
An entity primarily responsible for making the resource
Shir Y; Rosen G; Zeldin A; Davidson EM
Description
An account of the resource
PURPOSE: Methadone is still regarded as a second line opioid for patients suffering from severe pain, and is rarely used in hospitalized patients. The infrequent use of methadone is probably due to its long plasma half-life that could lead to accumulation and toxicity. In the present study we report that clinically effective analgesic doses of methadone, given either epidurally or orally, can be used safely for prolonged treatment in hospitalized patients. Clinical features: Over a five-year period we administered methadone at Hadassah Hospital in Jerusalem to 3,954 in-patients with severe pain, 12% of whom were younger than 17 yr. Satisfactory pain relief was recorded in more than 85% of the patients. None of the patients treated with oral methadone developed serious side effects. Three patients, treated with epidural methadone (0.09%), developed a clinically significant respiratory depression. In all three cases, epidural pump failure or pump misprogramming resulted in methadone overdose. None of the children or adults treated with methadone developed addiction during hospitalization. CONCLUSION: Based on its analgesic properties and marked safety profile, we suggest that methadone could be added to the analgesic armamentarium of in-hospital health-care providers. Moreover, methadone could serve as the opioid of first choice in some in-patient populations.
2001
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf03020377" target="_blank" rel="noreferrer">10.1007/bf03020377</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2001
Administration
Adolescent
Adult
Aged
Analgesia
Analgesics
Backlog
Canadian Journal Of Anaesthesia
Child
Davidson EM
Epidural
Female
Hospitalization
Humans
Infant
Journal Article
Male
Methadone/administration & dosage/adverse effects/therapeutic use
Middle Aged
Monitoring
Opioid/administration & dosage/adverse effects/therapeutic use
Oral
Pain Measurement/drug effects
Pain/drug Therapy
Physiologic
Preschool
Retrospective Studies
Rosen G
Shir Y
Zeldin A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0304-3959(96)03286-1" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0304-3959(96)03286-1</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
An update on the clinical use of methadone for cancer pain
Publisher
An entity responsible for making the resource available
Pain
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
Subject
The topic of the resource
Humans; Analgesics; Non-U.S. Gov't; Research Support; Evaluation Studies; Administration; Oral; Neoplasms/drug therapy; Methadone/administration & dosage/adverse effects/therapeutic use; Opioid/administration & dosage/adverse effects/therapeutic use; Rectal; Palliative Care/trends
Creator
An entity primarily responsible for making the resource
Ripamonti C; Zecca E; Bruera E
Description
An account of the resource
Methadone is a synthetic opioid agonist considered a second choice drug in the management of cancer pain. Methadone has a number of unique characteristics including excellent oral and rectal absorption, no known active metabolites, high potency, low cost, and longer administration intervals, as well as an incomplete cross-tolerance with respect to other mu-opioid receptor agonist drugs. For these reasons, methadone has the potential of playing a major role in the treatment of cancer pain. However, its use is limited by the remarkably long and unpredictable half-life, large inter-individual variations in pharmacokinetics, the potential for delayed toxicity, and above all by the limited knowledge of correct administration intervals and the equianalgesic ratio with other opioids when administered chronically. Recent findings suggest that standard equianalgesic tables are unreliable for methadone titration in patients tolerant to high doses of opioid agonists and that switchovers should take place slowly and should be personalized. Future research has to better define the variation in both bioavailability and elimination of methadone in different patient populations, the interaction between methadone and the most commonly used drugs in cancer patients, the type and activity of potential methadone metabolites, and the equianalgesic doses between methadone and the most commonly used opioids.
1997
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0304-3959(96)03286-1" target="_blank" rel="noreferrer">10.1016/s0304-3959(96)03286-1</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1997
Administration
Analgesics
Backlog
Bruera E
Evaluation Studies
Humans
Journal Article
Methadone/administration & dosage/adverse effects/therapeutic use
Neoplasms/drug therapy
Non-U.S. Gov't
Opioid/administration & dosage/adverse effects/therapeutic use
Oral
Pain
Palliative Care/trends
Rectal
Research Support
Ripamonti C
Zecca E
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0885-3924(99)00048-2" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0885-3924(99)00048-2</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Methadone response in advanced cancer patients with pain followed at home
Publisher
An entity responsible for making the resource available
Journal Of Pain And Symptom Management
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
Subject
The topic of the resource
Female; Humans; Male; Pain; Pain Measurement; Analgesics; Prospective Studies; Middle Aged; Sex Factors; Neoplasms/physiopathology; Methadone/administration & dosage/adverse effects/therapeutic use; Opioid/administration & dosage/adverse effects/therapeutic use; home care services; Intractable/drug therapy
Creator
An entity primarily responsible for making the resource
Mercadante S; Casuccio A; Agnello A; Barresi L
Description
An account of the resource
Concerns about the safety of therapy with methadone, which may arise because of its pharmacokinetic characteristics and inappropriate dosing, may deter clinicians from using this drug, especially in elderly patients. Experience is accumulating that the drug may be used safely and successfully if low doses are given initially and care is taken in the titration of the dose against the pain. A prospective study was carried out in a consecutive sample of 45 advanced cancer patients followed at home, who had never received other strong opioids for their pain. Patients were treated with an oral liquid preparation of methadone, which was administered 2-3 times daily, according to need. Doses were kept as low as possible and were titrated to achieve acceptable analgesia with minimal adverse effects. The methadone starting dose (MSD) at referral, the maximum dose of methadone (MMD), the days of methadone treatment, the use of other nonopioid analgesics, symptoms associated with methadone therapy, pain intensity, and pain mechanism were recorded. Methadone escalation index percentage (MEI%) and methadone escalation index in mg (MEI mg) were calculated from these parameters. No correlations between age and gender, and MSD, MMD, days on methadone, VAS and symptoms were found. No significant differences were found in pain mechanisms, age, and other parameters, including methadone-related symptoms. Treatment of pain with methadone provides important support to patients with cancer followed at home and the risks are low with individually titrated doses, even in older patients or in the presence of a neuropathic pain mechanism.
1999
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0885-3924(99)00048-2" target="_blank" rel="noreferrer">10.1016/s0885-3924(99)00048-2</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1999
Agnello A
Analgesics
Backlog
Barresi L
Casuccio A
Female
home care services
Humans
Intractable/drug therapy
Journal Article
Journal of Pain and Symptom Management
Male
Mercadante S
Methadone/administration & dosage/adverse effects/therapeutic use
Middle Aged
Neoplasms/physiopathology
Opioid/administration & dosage/adverse effects/therapeutic use
Pain
Pain Measurement
Prospective Studies
Sex Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1046/j.1460-9592.1999.00384.x" target="_blank" rel="noreferrer">http://doi.org/10.1046/j.1460-9592.1999.00384.x</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Efficacy and complications of morphine infusions in postoperative paediatric patients
Publisher
An entity responsible for making the resource available
Paediatric Anaesthesia
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
Subject
The topic of the resource
Child; Female; Humans; Male; Pain; Analgesics; Follow-Up Studies; Confidence Intervals; Incidence; Acute Disease; adolescent; Preschool; infant; retrospective studies; Infusions; Intravenous; Opioid/administration & dosage/adverse effects/therapeutic use; Morphine/administration & dosage/adverse effects/therapeutic use; Postoperative/prevention & control; Respiration/drug effects; Akathisia; Analgesia/nursing; Anesthesia Recovery Period; Anoxemia/chemically induced; Arousal/drug effects; Drug-Induced/etiology; Postoperative Nausea and Vomiting/chemically induced; Pruritus/chemically induced; Urinary Retention/chemically induced
Creator
An entity primarily responsible for making the resource
Esmail Z; Montgomery C; Courtrn C; Hamilton D; Kestle J
Description
An account of the resource
The aim of the study was to evaluate the efficacy and the incidence of clinically significant adverse drug reactions (ADRs) in paediatric patients receiving continuous intravenous morphine infusions for acute postoperative pain. Definitions were established for ADRs and data were collected in an immediately retrospective fashion for a maximum of 72 h in 110 patients >/=5 three months of age (0.3-16.7 years) receiving morphine infusions and admitted to a general ward over a three month convenience sampling period. Inadequate analgesia occurred in 65.5% of patients during the first 24 h of therapy and occurred most frequently in patients with infusion rates of 20 microg.kg-1.h-1 or less. Nausea/vomiting was the most commonly experienced ADR (42.5%). The incidence of respiratory depression was 0% (95% CI=0-3.3%). Other ADRs included: urinary retention (13.5%), pruritus (12.7%), dysphoria (7.3%), hypoxaemia (4.5%), discontinuation of morphine for treatment of an ADR (3.6%), and difficulty in arousal (0.9%). The most common ADRs associated with morphine infusions were inadequate analgesia (in the first 24 h) and nausea/vomiting. There were no cases of respiratory depression. Methods of avoiding initial inadequate analgesia and treating nausea and vomiting associated with morphine infusions are needed.
1999
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1046/j.1460-9592.1999.00384.x" target="_blank" rel="noreferrer">10.1046/j.1460-9592.1999.00384.x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1999
Acute Disease
Adolescent
Akathisia
Analgesia/nursing
Analgesics
Anesthesia Recovery Period
Anoxemia/chemically induced
Arousal/drug effects
Backlog
Child
Confidence Intervals
Courtrn C
Drug-Induced/etiology
Esmail Z
Female
Follow-up Studies
Hamilton D
Humans
Incidence
Infant
Infusions
Intravenous
Journal Article
Kestle J
Male
Montgomery C
Morphine/administration & dosage/adverse effects/therapeutic use
Opioid/administration & dosage/adverse effects/therapeutic use
Paediatric Anaesthesia
Pain
Postoperative Nausea and Vomiting/chemically induced
Postoperative/prevention & control
Preschool
Pruritus/chemically induced
Respiration/drug effects
Retrospective Studies
Urinary Retention/chemically induced
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1046/j.1460-9592.2001.00659.x" target="_blank" rel="noreferrer">http://doi.org/10.1046/j.1460-9592.2001.00659.x</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Postoperative epidural analgesia with bupivacaine and fentanyl: hourly pain assessment in 348 paediatric cases
Publisher
An entity responsible for making the resource available
Paediatric Anaesthesia
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
Subject
The topic of the resource
Child; Female; Humans; infant; Male; Pain; Analgesics; Prospective Studies; Analgesia; Anesthetics; adolescent; Preschool; infant; Newborn; Pain Measurement/drug effects; Opioid/administration & dosage/adverse effects/therapeutic use; Sleep/drug effects; Postoperative/drug therapy; Bupivacaine/administration & dosage/adverse effects/therapeutic use; Epidural/adverse effects; Fentanyl/administration & dosage/adverse effects/therapeutic use; Local/administration & dosage/adverse effects/therapeutic use
Creator
An entity primarily responsible for making the resource
Lejus C; Surbled M; Schwoerer D; Renaudin M; Guillaud C; Berard L; Pinaud M
Description
An account of the resource
BACKGROUND: The objective of this prospective study was the evaluation of the analgesia provided by an epidural infusion of bupivacaine and fentanyl after different types of surgery in children. METHODS: Data were collected from 348 epidural analgesia in 87 children below 2 years of age, in 80 children between 2 and 6 years and 181 above 6 years of age, for a median duration of 43 postoperative hours. Bupivacaine (mean concentration 0.185%) and fentanyl (5 microg.kg-1.day-1) were administered on the surgical ward. RESULTS: Pain control was considered excellent in 86% of the 11 072 pain hourly assessments. Analgesia was found to be better for children older than 2 years, and the overall quality of their night's sleep was better than that of older children. Higher pain scores were noted for Nissen fundoplication surgery and club foot repairs. Early discontinuation rarely occurred, and only because of technical problems with the epidural catheter (4%) or insufficient analgesia (6%). Complications were minor (nausea/vomiting 14%, pruritus 0.6%, urinary retention 17%) and easily reversed. CONCLUSIONS: This combination of bupivacaine-fentanyl provides safe analgesia after major surgery in children with frequent clinical monitoring. Regular pain assessments of intensity and duration are useful to improve the quality of postoperative analgesia.
2001
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1046/j.1460-9592.2001.00659.x" target="_blank" rel="noreferrer">10.1046/j.1460-9592.2001.00659.x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2001
Adolescent
Analgesia
Analgesics
Anesthetics
Backlog
Berard L
Bupivacaine/administration & dosage/adverse effects/therapeutic use
Child
Epidural/adverse effects
Female
Fentanyl/administration & dosage/adverse effects/therapeutic use
Guillaud C
Humans
Infant
Journal Article
Lejus C
Local/administration & dosage/adverse effects/therapeutic use
Male
Newborn
Opioid/administration & dosage/adverse effects/therapeutic use
Paediatric Anaesthesia
Pain
Pain Measurement/drug effects
Pinaud M
Postoperative/drug therapy
Preschool
Prospective Studies
Renaudin M
Schwoerer D
Sleep/drug effects
Surbled M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1054/bjoc.2001.1680" target="_blank" rel="noreferrer">http://doi.org/10.1054/bjoc.2001.1680</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Morphine and alternative opioids in cancer pain: the EAPC recommendations
Publisher
An entity responsible for making the resource available
British Journal Of Cancer
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
Subject
The topic of the resource
Humans; Analgesics; Drug Administration Schedule; Administration; Oral; Palliative Care/standards; Injections; Intravenous; Subcutaneous; Oxycodone/administration & Pain/drug therapy; Opioid/administration & dosage/adverse effects/therapeutic use; Spinal; Chemistry; Fentanyl/administration & dosage/therapeutic use; Hydromorphone/administration & Infusions; Methadone/pharmacokinetics/therapeutic use; Morphine/administration & Neoplasms/drug therapy; Pharmaceutical
Creator
An entity primarily responsible for making the resource
Hanks GW; Conno F; Cherny NI; Hanna M; Kalso E; McQuay HJ; Mercadante S; Meynadier J; Poulain P; Ripamonti C; Radbruch L; Casas JR; Sawe J; Twycross RG; Ventafridda V; Expert Working Group of the Research Network of the European Association for Palliative Care
Description
An account of the resource
An expert working group of the European Association for Palliative Care has revised and updated its guidelines on the use of morphine in the management of cancer pain. The revised recommendations presented here give guidance on the use of morphine and the alternative strong opioid analgesics which have been introduced in many parts of the world in recent years. Practical strategies for dealing with difficult situations are described presenting a consensus view where supporting evidence is lacking. The strength of the evidence on which each recommendation is based is indicated.
2001
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1054/bjoc.2001.1680" target="_blank" rel="noreferrer">10.1054/bjoc.2001.1680</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2001
Administration
Analgesics
Backlog
British Journal Of Cancer
Casas JR
Chemistry
Cherny NI
Conno F
Drug Administration Schedule
Expert Working Group of the Research Network of the European Association for Palliative Care
Fentanyl/administration & dosage/therapeutic use
Hanks GW
Hanna M
Humans
Hydromorphone/administration & Infusions
Injections
Intravenous
Journal Article
Kalso E
McQuay HJ
Mercadante S
Methadone/pharmacokinetics/therapeutic use
Meynadier J
Morphine/administration & Neoplasms/drug therapy
Opioid/administration & dosage/adverse effects/therapeutic use
Oral
Oxycodone/administration & Pain/drug therapy
Palliative Care/standards
Pharmaceutical
Poulain P
Radbruch L
Ripamonti C
Sawe J
Spinal
Subcutaneous
Twycross RG
Ventafridda V
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.2165/00003495-199651050-00002" target="_blank" rel="noreferrer">http://doi.org/10.2165/00003495-199651050-00002</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Opioid analgesics: comparative features and prescribing guidelines
Publisher
An entity responsible for making the resource available
Drugs
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
Subject
The topic of the resource
Humans; Analgesics; Prescriptions; Comparative Study; Pain/drug therapy; Drug; Opioid/administration & dosage/adverse effects/therapeutic use
Creator
An entity primarily responsible for making the resource
Cherny NI
Description
An account of the resource
The term 'opioid' is a generic term for naturally occurring, semisynthetic and synthetic drugs which combine with opioid receptors to produce physiological effects and which are stereospecifically antagonised by naloxone. For clinical purposes, opioids can be classified according to their receptor interactions (agonist, partial agonist, agonist-antagonist and antagonist), the pain intensity for which they are conventionally used (moderate or severe), and their half-life (short or long). Pure agonists conventionally used for moderate pain, short and long half-life pure agonists conventionally used for severe pain, mixed agonist-antagonists and partial agonist opioids are described in detail. The effective clinical use of opioid drugs requires familiarity with drug selection, routes of administration, dosage guidelines and potential adverse effects. Opioids are unequivocally indicated in the management of severe acute pain and moderate to severe pain associated with cancer. There is increasing acceptance of the role of opioids in the management of recurring acute pain, chronic nonmalignant pain of organic origin and severe neuropathic pain. The selection of opioids is influenced by pain intensity, pharmacokinetic and formulary considerations, previous adverse effects and the presence of coexisting disease. Some patients will require sequential trials of several different opioids before a drug which is effective and well tolerated is identified. Opioid agents should be administered by the most comfortable and convenient route that meets the specific needs of the patient. The regimen for opioid medications should generally provide around-the-clock analgesia with provision for rescue doses for the management of exacerbations of the pain not covered by the regular dosage. At all times, uncontrolled pain should be addressed by gradual increase in the opioid dose until either pain control is achieved or intolerable and unmanageable adverse effects supervene. The management of pain with opioid analgesics demands frequent patient assessment and a readiness to re-evaluate the therapeutic plan in the setting of either inadequate relief or adverse effects.
1996
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.2165/00003495-199651050-00002" target="_blank" rel="noreferrer">10.2165/00003495-199651050-00002</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1996
Analgesics
Backlog
Cherny NI
Comparative Study
Drug
Drugs
Humans
Journal Article
Opioid/administration & dosage/adverse effects/therapeutic use
Pain/drug Therapy
Prescriptions