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40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12453926" target="_blank" rel="noreferrer">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12453926</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Pharmacogenetics of codeine metabolism in an urban population of children and its implications for analgesic reliability
Publisher
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British Journal Of Anaesthesia
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Child; Female; Male; Analgesics; Double-Blind Method; Phenotype; Urban Population; Preschool; Non-U.S. Gov't; Anti-Inflammatory Agents; Human; Support; Vomiting/chemically induced; Genotype; Analgesia; Tonsillectomy; Non-Steroidal/administration & dosage; Morphine Derivatives/blood; Central Nervous System Stimulants/blood; Codeine/genetics/metabolism; Diclofenac/administration & dosage; Morphine/metabolism; Opioid/metabolism
Creator
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Williams DG; Patel A; Howard RF
Description
An account of the resource
BACKGROUND: Codeine analgesia is wholly or mostly due to its metabolism to morphine by the cytochrome P450 enzyme CYP2D6, which shows significant genetic variation in activity. The aims of this study were to investigate genotype, phenotype and morphine production from codeine in children undergoing adenotonsillectomy, and to compare analgesia from codeine or morphine combined with diclofenac. METHODS: Ninety-six children received either codeine 1.5 mg kg(-1) or morphine 0.15 mg kg(-1) in a randomized, double-blind design. Genetic analysis was performed and plasma morphine concentrations at 1 h were determined. Postoperative analgesia and side-effects were recorded. RESULTS: Forty-seven per cent of children had genotypes associated with reduced enzyme activity. Mean (SD) morphine concentrations were significantly lower (P<0.001) after codeine [4.5 (0.3) ng ml(-1)] than after morphine [24.7 (1.5) ng ml(-1)], and morphine and its metabolites were not detected in 36% of children given codeine. There was a significant relationship between phenotype and plasma morphine (P=0.02). More children required rescue analgesia after codeine at both 2 (P<0.05) and 4 h after administration (P<0.01). Fifty-six per cent of children vomited after morphine and 29% after codeine (P<0.01). Neither phenotype nor morphine concentration was correlated with either pain score or the need for rescue analgesia (r=-0.21, 95% confidence interval -0.4, -0.01). CONCLUSIONS: Reduced ability for codeine metabolism may be more common than previously reported. Plasma morphine concentration 1 h after codeine is very low, and related to phenotype. Codeine analgesia is less reliable than morphine, but was not well correlated with either phenotype or plasma morphine in this study.
2002
Rights
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2002
Analgesia
Analgesics
Anti-Inflammatory Agents
Backlog
British Journal Of Anaesthesia
Central Nervous System Stimulants/blood
Child
Codeine/genetics/metabolism
Diclofenac/administration & dosage
Double-Blind Method
Female
Genotype
Howard RF
Human
Journal Article
Male
Morphine Derivatives/blood
Morphine/metabolism
Non-Steroidal/administration & dosage
Non-U.S. Gov't
Opioid/metabolism
Patel A
Phenotype
Preschool
Support
Tonsillectomy
Urban Population
Vomiting/chemically induced
Williams DG
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1191/026921598672378032" target="_blank" rel="noreferrer">http://doi.org/10.1191/026921598672378032</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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The treatment of lateral epicondylitis by iontophoresis of sodium salicylate and sodium diclofenac
Publisher
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Clinical Rehabilitation
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
Subject
The topic of the resource
Humans; Male; Pain Measurement; Adult; Middle Aged; Comparative Study; Anti-Inflammatory Agents; Random Allocation; Diclofenac/administration & Female; Iontophoresis; Non-Steroidal/administration & dosage; Sodium Salicylate/administration & Tennis Elbow/drug therapy
Creator
An entity primarily responsible for making the resource
Demirtas RN; Oner C
Description
An account of the resource
OBJECTIVE: To investigate the effectiveness of sodium diclofenac and sodium salicylate applied by topical iontophoresis and to compare them in the treatment of lateral epicondylitis. SUBJECTS: Forty patients with lateral epicondylitis were randomized into two groups of 20 patients who were matched for age and sex. INTERVENTIONS: The patients in one group were treated by iontophoresis of sodium diclofenac and the other group were treated by iontophoresis of sodium salicylate. Then infrared treatment was applied to patients in both groups. MAIN OUTCOME MEASURES: Pain scores obtained before and after treatment were compared. RESULTS: Pain produced by pressure on the lateral epicondyle, on resisting wrist extension, during function and spontaneous pain at rest significantly decreased in both groups after treatment (p < 0.001). When pain scores obtained after treatment were compared, greater decrease was observed in the pain produced on resisting wrist extension (p < 0.01) and by pressure on the lateral epicondyle (p < 0.05) in the group treated with sodium diclofenac than in the group treated with sodium salicylate. CONCLUSIONS: The results suggest some benefits from the process of iontophoresis and the use of infrared in the treatment of lateral epicondylitis and indicate that iontophoresis of sodium diclofenac is more effective than that of sodium salicylate.
1998
Identifier
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<a href="http://doi.org/10.1191/026921598672378032" target="_blank" rel="noreferrer">10.1191/026921598672378032</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1998
Adult
Anti-Inflammatory Agents
Backlog
Clinical Rehabilitation
Comparative Study
Demirtas RN
Diclofenac/administration & Female
Humans
Iontophoresis
Journal Article
Male
Middle Aged
Non-Steroidal/administration & dosage
Oner C
Pain Measurement
Random Allocation
Sodium Salicylate/administration & Tennis Elbow/drug therapy