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Text
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URL Address
<a href="http://doi.org/10.1126/science.282.5391.1075" target="_blank" rel="noreferrer">http://doi.org/10.1126/science.282.5391.1075</a>
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Title
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Genetic classification of primary neurodegenerative disease
Publisher
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Science
Date
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1998
Subject
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Humans; Mutation; Brain; Neurodegenerative Diseases; Genes; Trinucleotide Repeats; Parkinson Disease; Alzheimer Disease; Dominant; Nerve Tissue Proteins; Peptides; Synucleins; tau Proteins
Creator
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Hardy J; Gwinn-Hardy K
Description
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Review During the past 10 years (the "decade of the brain"), some of the genetic causes of many of the primary neurodegenerative diseases, which include Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, prion disease, and many ataxic syndromes, have been found. These breakthroughs mean that for many of these diseases we now know the initiating trigger as well as the final outcome. These diseases have many pathological mechanisms in common, and there may be relatively few pathways to neuronal death seen in these disorders. Thus, treatment strategies developed for a particular disease may be found to have efficacy in more than one disorder.
1998-11
Identifier
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<a href="http://doi.org/10.1126/science.282.5391.1075" target="_blank" rel="noreferrer">10.1126/science.282.5391.1075</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
1998
Alzheimer Disease
Backlog
Brain
Dominant
Genes
Gwinn-Hardy K
Hardy J
Humans
Journal Article
Mutation
Nerve Tissue Proteins
Neurodegenerative Diseases
Parkinson Disease
Peptides
Science
Synucleins
tau Proteins
Trinucleotide Repeats