Browse Items · Pediatric Palliative Care Library

Analgesics for the treatment of pain in children

2002

Tags: 2002, Acetaminophen/therapeutic use, Analgesia, Analgesics, Analgesics/administration & dosage/therapeutic use, Anesthesia, Anesthetics, Anti-Inflammatory Agents, Aspirin/therapeutic use, Backlog, Berde CB, Child, Chronic Disease, General, Humans, Infant, Journal Article, Local, Neoplasms/complications, Newborn, Non-Steroidal/therapeutic use, Non-U.S. Gov't, Opioid/pharmacokinetics/pharmacology/therapeutic use, P.H.S., Pain/drug therapy/etiology, Patient-Controlled, Research Support, Sethna NF, The New England Journal Of Medicine, U.S. Gov't

A Phase I, open label, dose ranging trial of intravenous bolus zoledronic acid, a novel bisphosphonate, in cancer patients with metastatic bone disease

BACKGROUND: Bone metastases typically are associated with osteolytic bone destruction, resulting in bone pain, pathologic fractures, spinal cord compression, and hypercalcemia. Bisphosphonates are potent inhibitors of normal and pathologic bone…

Ketamine-fentanyl-midazolam infusion for the control of symptoms in terminal life care

In this report, we describe nine terminally ill patients with metastatic cancer who were treated with an intravenous infusion consisting of ketamine (2 mg/ml)/fentanyl (5 micrograms/ml)/midazolam (0.1 mg/ml) (K/F/M) to control pain after traditional…

[Management of cancer pain in children]

Pain and cancer cannot be dissociated. A particular feature observed in children is that the child exhibits a certain psychomotor atony with increasing pain. The child complains less and less, making it difficult to recognize the degree of suffering…

Tags: 2006, Analgesics/therapeutic use, Annales pharmaceutiques françaises, Antineoplastic Agents/adverse effects, Backlog, Bourdon O, Brion F, Chemistry, Child, English Abstract, Humans, Iatrogenic Disease, Journal Article, Neoplasms/complications, Pain Measurement, Pain/drug therapy/etiology, PedPal Lit, Pharmaceutical

Opioid rotation in patients with cancer pain. A retrospective comparison of dose ratios between methadone, hydromorphone, and morphine

BACKGROUND. When a change of opioid is considered, equianalgesic dose tables are used. These tables generally propose a dose ratio of 5:1 between morphine and hydromorphone. In the case of a change from subcutaneous hydromorphone to methadone, dose…

Methadone use in cancer patients with pain: a review

In recent years a better understanding of the pharmacologic and pharmacokinetic properties of methadone, including equianalgesic ratios has led to its increased use as a second line opioid for the treatment of pain in patients with cancer. Methadone…

Tags: 2002, Analgesics, Backlog, Bruera E, Drug Interactions, Humans, Journal Article, Journal of Palliative Medicine, Methadone/pharmacokinetics/therapeutic use, Neoplasms/complications, Opioid/pharmacokinetics/therapeutic use, Pain/drug therapy/etiology, Sweeney C

The pharmacological management of cancer pain

2001

Tags: 2001, Analgesics/adverse effects/therapeutic use, Backlog, Central Nervous System Diseases/chemically induced/therapy, Cherny NI, Conscious Sedation, Decision Making, Drug Administration Routes, Drug Administration Schedule, European Journal Of Cancer, Gastrointestinal Diseases/chemically induced/therapy, Humans, Journal Article, Neoplasms/complications, Pain/drug therapy/etiology, Respiration Disorders/chemically induced/therapy, Urinary Retention/chemically induced/therapy

Research methodology: cancer cachexia syndrome

Cachexia is a syndrome and therefore does not have a specific definition. Patients are characterized by the presence of anorexia, early satiety, weight loss, weakness, anaemia and oedema. These features occur to a variable extent in different…

Tags: 2004, Ambulatory Care, Backlog, Biomedical Research/methods, Body Composition, Cachexia/etiology, Dahele M, Exercise/physiology, Fearon KC, Humans, Journal Article, Neoplasms/complications, Nutritional Status, Palliative Medicine, Placebo Effect, Prognosis, Quality Of Life, Weight Gain

Clinical experience with oral methadone administration in the treatment of pain in 196 advanced cancer patients

PURPOSE: The aims of this study were to describe the analgesia, side effects, and dosage and the causes of suspension of treatment in a large sample of advanced cancer patients with pain after treatment with oral methadone from 7 to 90 days. PATIENTS…

Should we be reluctant to prescribe opioids for chronic non-malignant pain?

2007

Tags: 2007, Analgesics, Attitude Of Health Personnel, Backlog, Chronic Disease, Fields HL, Humans, Journal Article, Neoplasms/complications, Opioid-Related Disorders/etiology/prevention & control, Opioid/adverse effects/therapeutic use, Pain, Pain/drug therapy/etiology, Physician's Practice Patterns/trends

Pain management in children

Interest in the management and study of pain in children has increased in recent years. A range of techniques appropriate to children with different developmental levels is now available for the assessment of various aspects of childhood pain. A…

Tags: 1991, Anti-Inflammatory Agents, Backlog, British Medical Bulletin, Child, Goldman A, Humans, Infant, Journal Article, Lloyd-Thomas AR, Narcotics/therapeutic use, Neoplasms/complications, Newborn, Non-Steroidal/therapeutic use, Pain, Pain Measurement/methods, Pain/drug therapy/etiology, Postoperative/drug therapy, Preschool

Comparative clinical efficacy and safety of a novel controlled-release oxycodone formulation and controlled-release hydromorphone in the treatment of cancer pain

BACKGROUND: The use of oxycodone to treat chronic cancer pain has been hampered by its short elimination half-life, which necessitates administration every 4 hours. This study compared the clinical efficacy and safety of a novel oxycodone formulation…

Tags: 1997, Analgesics, Babul N, Backlog, Cancer, Comparative Study, Cross-Over Studies, Delayed-Action Preparations, Double-Blind Method, Drug Evaluation, Female, Hagen NA, Humans, Hydromorphone/administration & Male, Journal Article, Middle Aged, Neoplasms/complications, Opioid/administration & dosage, Oxycodone/administration & Pain/drug therapy

Comparative clinical efficacy and safety of immediate release and controlled release hydromorphone for chronic severe cancer pain

BACKGROUND. The short elimination half-life of hydromorphone necessitates 4-hourly dosing to maintain optimal levels of analgesia in patients with chronic cancer pain. The purpose of this study was to compare the clinical efficacy and safety of…

Opioid use in palliative care of children and young people with cancer

OBJECTIVE: Identify opioids prescribed, preferred routes, and doses among children with incurable cancer. STUDY DESIGN: Prospective survey with monthly questionnaires regarding patients 0 to 19 years old from oncology centers. Data were collected by…

Propofol use in pediatric patients with severe cancer pain at the end of life

This article describes the use and effectiveness of adjuvant propofol for pain control for pediatric oncology patients at the end of life. All patients experienced severe pain and agitation, not well controlled by continuous infusion opioids and…

Tags: 2007, Backlog, Bostrom B, Child, Grund E, Hooke MC, Humans, Journal Article, Journal Of Pediatric Oncology Nursing, McCormick P, Miller B, Neoplasms/complications, Pain/drug therapy/etiology, Palliative Care, Propofol/therapeutic use, Quammen H, Terminal Care

Population pharmacokinetics of oral morphine and its glucuronides in children receiving morphine as immediate-release liquid or sustained-release tablets for cancer pain

OBJECTIVES: (1) To determine the pharmacokinetics of morphine, morphine-6-glucuronide (M6G), and morphine-3-glucuronide (M3G) in children with cancer receiving morphine as immediate-release morphine liquid or sustained-release tablets. (2) To…

Human suffering: the need for relationship-based research in pediatric end-of-life care

Children living with and dying from advanced cancer and their families experience significant suffering. The cure of disease and the relief of suffering are dual moral obligations of our professions. To relieve suffering, health care providers must…

Reflections on pain

1998

Tags: 1998, Backlog, Forecasting, Guidelines, Humans, Journal Article, Journal Of Clinical Pharmacy And Therapeutics, Kilwein JH, Neoplasms/complications, Pain/drug therapy/prevention & control, Substance-Related Disorders

Intravenous morphine for emergency treatment of cancer pain

Despite the wide use of the World Health Organization (WHO) analgesic ladder for the relief of cancer pain, it is not uncommon to find patients presenting with severe pain to palliative care centres. This is more so in the developing world, where…

Treatment of pain in pediatric oncology: a Swedish nationwide survey

Pain treatment is a crucial aspect in the care of children with cancer and there are many studies demonstrating inefficient pain treatment. In this study, questionnaires dealing with pain treatment of children with malignant diseases were sent to all…

A Longitudinal, Randomized, Controlled Trial Of Advance Care Planning For Teens With Cancer: Anxiety, Depression, Quality Of Life, Advance Directives, Spirituality

To test the feasibility, acceptability and safety of a pediatric advance care planning intervention, Family-Centered Advance Care Planning for Teens With Cancer (FACE-TC).
METHODS:
Adolescent (age 14-20 years)/family dyads (N = 30) with a cancer…

Understanding and managing cancer cachexia

2003

Tags: 2003, Backlog, Baracos VE, Cachexia/etiology/pathology/prevention & control, Dunn GP, Easson AM, Humans, Journal Article, Journal Of The American College Of Surgeons, MacDonald N, Mazurak VC, Muscle, Neoplasms/complications, Nutritional Failure, Skeletal/pathology

Opioid switch to oral methadone in cancer pain

The occurrence of undesirable side effects due to opioids (delirium, confusion, myoclonus, nausea, emesis) is one of the major complications in the management of pain, especially in chronic cancer pain states. Methadone, as an alternative to…

Development of the World Health Organization Guidelines on Cancer Pain Relief and Palliative Care in Children

Assess pain regularly throughout the course of treatment. Follow the WHO Analgesic Ladder for selecting pain-relief drugs, that is, a stepwise approach to analgesic management, where a child's pain severity determines the level of analgesics. Use…

Tags: 1996, Backlog, Child, Human, Journal Article, Journal of Pain and Symptom Management, McGrath PA, Neoplasms/complications, Pain/etiology/therapy, Palliative Care/methods, Practice Guidelines, World Health Organization

Switching from morphine to methadone to improve analgesia and tolerability in cancer patients: a prospective study

PURPOSE: To evaluate the clinical benefits of switching from morphine to oral methadone in patients who experience poor analgesia or adverse effects from morphine. PATIENTS AND METHODS: Fifty-two consecutive cancer patients receiving oral morphine…

Patient-controlled analgesia with oral methadone in cancer pain: preliminary report

BACKGROUND: Methadone is a very useful drug in cancer pain because of its low cost, lack of active metabolites, high oral availability, and the rapid onset of its analgesic effect. It seems to be well tolerated in patients with difficult pain…

The Memorial Symptom Assessment Scale: an instrument for the evaluation of symptom prevalence, characteristics and distress

The Memorial Symptom Assessment Scale (MSAS) is a new patient-rated instrument that was developed to provide multidimensional information about a diverse group of common symptoms. This study evaluated the reliability and validity of the MSAS in the…

Tramadol: does it have a role in cancer pain management?

Tramadol (Ultram, Ortho-McNeil Pharmaceutical, Inc., Raritan, NJ) is considered a Step 2 analgesic under the World Health Organization's guidelines for the treatment of patients with cancer pain. It is a centrally acting analgesic that has affinity…

Tags: 2005, Analgesics, Backlog, Humans, Journal Article, Journal of opioid management, Methadone, Neoplasms/complications, Opioid/adverse effects/chemistry/pharmacokinetics/therapeutic use, Pain/drug therapy/etiology, Prommer EE, Tramadol/adverse effects/chemistry/pharmacokinetics/therapeutic use

High-dose oral morphine in cancer pain management: a report of twelve cases

We present 12 case reports from patients treated with more than 600 mg of morphine per day. We found no "opioid-nonresponsive pain" under treatment with a combination of morphine and nonopioids, supplemented with coanalgesics where appropriate. Side…

The use of methadone for cancer pain

Methadone is not a new analgesic drug [69]. Several studies have demonstrated that methadone is a valid alternative to morphine, hydromorphone, and fentanyl for the treatment of cancer-related pain, and extensive reviews on the subject have been…

Switching from morphine to oral methadone in treating cancer pain: what is the equianalgesic dose ratio?

PURPOSE: To define the dose ratio between morphine and methadone in relation to the previous morphine dose and the number of days needed to achieve the same level of analgesia in a group of patients with advanced cancer with pain who switched from…

Safety of subcutaneous clodronate and efficacy in hypercalcemia of malignancy: a novel route of administration

Bisphosphonates have become standard treatment in management of malignancy-induced hypercalcemia and malignant bone pain. One obstacle to the routine use of bisphosphonates in palliative patients is that oral bisphosphonates have low bioavailability…

Patient-controlled analgesia with intravenous L-methadone in a child with cancer pain refractory to high-dose morphine

Common gastrointestinal symptoms in pediatric palliative care: nausea, vomiting, constipation, anorexia, cachexia

Gastrointestinal symptoms are suffered commonly by children at the end of life. Diagnosis and management of these common symptoms include careful history and physical examination to assess for possible causes

Tags: 2007, Anorexia/etiology/therapy, Backlog, Cachexia/etiology/therapy, Child, Constipation/drug therapy/etiology, Humans, Journal Article, Mack JW, Medulla Oblongata/physiology, Nausea/etiology/therapy, Neoplasms/complications, Palliative Care, Pediatric Clinics of North America, Santucci G, Vomiting/etiology/prevention & control

Systematic review of bisphosphonates for hypercalcaemia of malignancy

BACKGROUND: Bisphosphonates are the treatment of choice for hypercalcaemia of malignancy (HCM) but there is no consensus regarding which drug or dose should be given. We designed a systematic review to investigate the efficacy of bisphosphonates in…

Tags: 2004, Backlog, Broadley KE, Diphosphonates/therapeutic use, Edmonds PM, Humans, Hypercalcemia/drug therapy, Journal Article, Neoplasms/complications, Non-U.S. Gov't, Palliative Medicine, Patel S, Randomized Controlled Trials, Research Support, Ross JR, Saunders Y, Steering Group, Treatment Outcome

Tags: 1999, Backlog, Dopamine Antagonists/adverse effects/therapeutic use, Hospital Medicine, Humans, Journal Article, Methotrimeprazine/adverse effects/therapeutic use, Nausea/drug therapy/etiology, Neoplasms/complications, Non-U.S. Gov't, Palliative Care, Research Support, Skinner A, Skinner J, Vomiting/drug therapy/etiology

Browse Items (45 total)