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<a href="http://doi.org/10.1503/cmaj.091278" target="_blank" rel="noreferrer">http://doi.org/10.1503/cmaj.091278</a>
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Title
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Handgrip strength and mortality in the oldest old population: the Leiden 85-plus study
Publisher
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Canadian Medical Association Journal
Date
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2010
Subject
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Female; Humans; Male; mortality; Follow-Up Studies; Prospective Studies; Aged; Comorbidity; Netherlands; Activities of Daily Living; Depression; Kaplan-Meier Estimate; Disability Evaluation; 80 and over; Study Design; Neuropsychological Tests; Hand Strength; Cardiovascular Diseases; Muscle Strength Dynamometer
Creator
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Ling CHY; Taekema D; de Craen Anton JM; Gussekloo J; Westendorp RG; Maier AB
Description
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BACKGROUND: Poor muscular strength has been shown to be associated with increased morbidity and mortality in diverse samples of middle-aged and elderly people. However, the oldest old population (i.e., over 85 years) is underrepresented in such studies. Our objective was to assess the association between muscular strength and mortality in the oldest old population. METHODS: We included 555 participants (65% women) from the Leiden 85-plus study, a prospective population-based study of all 85-year-old inhabitants of Leiden, Netherlands. We measured the handgrip strength of participants at baseline and again at age 89 years. We collected baseline data on comorbidities, functional status, levels of physical activity, and adjusted for potential confounders. During the follow-up period, we collected data on mortality. RESULTS: During a follow-up period of 9.5 years (range 8.5-10.5 years), 444 (80%) participants died. Risk for all-cause mortality was elevated among participants in the lowest tertile of handgrip strength at age 85 years (hazard ratio [HR] 1.35, 95% confidence interval [CI] 1.00-1.82, p = 0.047) and the lowest two tertiles of handgrip strength at age 89 years (HR 2.04, CI 1.24-3.35, p = 0.005 and HR 1.73, CI 1.11-2.70, p = 0.016). We also observed significantly increased mortality among participants in the tertile with the highest relative loss of handgrip strength over four years (HR 1.72, CI 1.07-2.77, p = 0.026). INTERPRETATION: Handgrip strength, a surrogate measurement of overall muscular strength, is a predictor of all-cause mortality in the oldest old population and may serve as a convenient tool for prognostication of mortality risk among elderly people.
2010-03
Identifier
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<a href="http://doi.org/10.1503/cmaj.091278" target="_blank" rel="noreferrer">10.1503/cmaj.091278</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
2010
80 And Over
Activities of Daily Living
Aged
Backlog
Canadian Medical Association Journal
Cardiovascular Diseases
Comorbidity
de Craen Anton JM
Depression
Disability Evaluation
Female
Follow-up Studies
Gussekloo J
Hand Strength
Humans
Journal Article
Kaplan-Meier Estimate
Ling CHY
Maier AB
Male
Mortality
Muscle Strength Dynamometer
Netherlands
Neuropsychological Tests
Prospective Studies
Study Design
Taekema D
Westendorp RG