1
40
1
-
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Treatment of Symptoms in Children with Q3 Conditions Scoping Review Results
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0067042" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0067042</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Disorders of Upper Limb Movements in Ataxia-Telangiectasia
Publisher
An entity responsible for making the resource available
PLoS ONE
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
Subject
The topic of the resource
Cross-Sectional Studies; Age Factors; Male; Severity of Illness Index; Young Adult; Child; Humans; Adult; Adolescent; Female; Child Preschool; Periodicity; Ataxia Telangiectasia/pp [Physiopathology]; Motor Activity; Movement; Upper Extremity; Accelerometry; Biomechanical Phenomena; Motor Activity/ph [Physiology]; Movement Disorders/pp [Physiopathology]; Movement/ph [Physiology]; Posture/ph [Physiology]; Tremor/pp [Physiopathology]; Upper Extremity/pp [Physiopathology]; tone and motor problems; ataxia telangiectasia; trajectory; characteristics; abnormal involuntary movements; kinetic tremor; postural tremor; resting tremor
Creator
An entity primarily responsible for making the resource
Shaikh A G; Zee D S; Mandir A S; Lederman H M; Crawford T O
Description
An account of the resource
Ataxia-telangiectasia is known for cerebellar degeneration, but clinical descriptions of abnormal tone, posture, and movements suggest involvement of the network between cerebellum and basal ganglia. We quantitatively assessed the nature of upper-limb movement disorders in ataxia-telangiectasia. We used a three-axis accelerometer to assess the natural history and severity of abnormal upper-limb movements in 80 ataxia-telangiectasia and 19 healthy subjects. Recordings were made during goal-directed movements of upper limb (kinetic task), while arms were outstretched (postural task), and at rest. Almost all ataxia-telangiectasia subjects (79/80) had abnormal involuntary movements, such as rhythmic oscillations (tremor), slow drifts (dystonia or athetosis), and isolated rapid movements (dystonic jerks or myoclonus). All patients with involuntary movements had both kinetic and postural tremor, while 48 (61%) also had resting tremor. The tremor was present in transient episodes lasting several seconds during two-minute recording sessions of all three conditions. Percent time during which episodic tremor was present was greater for postural and kinetic tasks compared to rest. Resting tremor had higher frequency but smaller amplitude than postural and kinetic tremor. Rapid non-rhythmic movements were minimal during rest, but were triggered during sustained arm postures and goal directed arm movements suggesting they are best considered a form of dystonic jerks or action myoclonus. Advancing age did not correlate with the severity of involuntary limb movements. Abnormal upper-limb movements in ataxia-telangiectasia feature classic cerebellar impairment, but also suggest involvement of the network between the cerebellum and basal ganglia.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0067042" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0067042</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
abnormal involuntary movements
accelerometry
Adolescent
Adult
Age Factors
ataxia telangiectasia
Ataxia Telangiectasia/pp [Physiopathology]
Biomechanical Phenomena
characteristics
Child
Child Preschool
Crawford T O
Cross-sectional Studies
Female
Humans
kinetic tremor
Lederman H M
Male
Mandir A S
Motor Activity
Motor Activity/ph [Physiology]
Movement
Movement Disorders/pp [Physiopathology]
Movement/ph [Physiology]
Periodicity
PLoS One
postural tremor
Posture/ph [Physiology]
resting tremor
Severity Of Illness Index
Shaikh A G
tone and motor problems
Trajectory
Tremor/pp [Physiopathology]
Upper Extremity
Upper Extremity/pp [Physiopathology]
Young Adult
Zee D S