Need for rigorous assessment of palliative care
Randomized Controlled Trials; Human; Palliative Care
1994
McQuay H; Moore A
British Medical Journal
1994
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
Anticonvulsant drugs for management of pain: a systematic review
Treatment Outcome; Non-U.S. Gov't; Human; Anticonvulsants/tu [Therapeutic Use]; Anticonvulsants/ae [Adverse Effects]; Support; Pain/dt [Drug Therapy]; Carbamazepine/ae [Adverse Effects]; Carbamazepine/tu [Therapeutic Use]; Clonazepam/ae [Adverse Effects]; Clonazepam/tu [Therapeutic Use]; Diabetic Neuropathies/dt [Drug Therapy]; Phenytoin/ae [Adverse Effects]; Phenytoin/tu [Therapeutic Use]; Trigeminal Neuralgia/dt [Drug Therapy]; Valproic Acid/ae [Adverse Effects]; Valproic Acid/tu [Therapeutic Use]
OBJECTIVE--To determine effectiveness and adverse effects of anticonvulsant drugs in management of pain. DESIGN--Systematic review of randomised controlled trials of anticonvulsants for acute, chronic, or cancer pain identified by using Medline, by hand searching, by searching reference lists, and by contacting investigators. SUBJECTS--Between 1966 and February 1994, 37 reports were found; 20 reports, of four anticonvulsants, were eligible. MAIN OUTCOME MEASURES--Numbers needed to treat were calculated for effectiveness, adverse effects, and drug related withdrawal from study. RESULTS--The only placebo controlled study in acute pain found no analgesic effect of sodium valproate. For treating trigeminal neuralgia, carbamazepine had a combined number needed to treat of 2.6 for effectiveness, 3.4 for adverse effects, and 24 for severe effects (withdrawal from study). For treating diabetic neuropathy, anticonvulsants had a combined number needed to treat of 2.5 for effectiveness, 3.1 for adverse effects, and 20 for severe effects. For migraine prophylaxis, anticonvulsants had a combined number needed to treat of 1.6 for effectiveness, 2.4 for adverse effects, and 39 for severe effects. Phenytoin had no effect on the irritable bowel syndrome, and carbamazepine had little effect on pain after stroke. Clonazepam was effective in one study for temporomandibular joint dysfunction. No study compared one anticonvulsant with another. CONCLUSIONS--Anticonvulsants were effective for trigeminal neuralgia and diabetic neuropathy and for migraine prophylaxis. Minor adverse effects occurred as often as benefit. [References: 53]
1995
McQuay H; Carroll D; Jadad AR; Wiffen P; Moore A
British Medical Journal
1995
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1136/bmj.311.7012.1047" target="_blank" rel="noreferrer">10.1136/bmj.311.7012.1047</a>
Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis
2015-02
Finnerup NB; Attal N; Haroutounian S; McNicol E; Baron R; Dworkin RH; Gilron I; Haanpää M; Hansson P; Jensen TS; Kamerman PR; Lund K; Moore A; Raja SN; Rice ASC; Rowbotham M; Sena E; Siddall P; Smith BH; Wallace M
The Lancet Neurology
2015
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1016/S1474-4422(14)70251-0" target="_blank" rel="noreferrer">10.1016/S1474-4422(14)70251-0</a>
Pediatric Chronic Critical Illness, Prolonged ICU Admissions, and Clinician Distress
Chronic critical illness; communication; health teams; interdisciplinary; palliative care; pediatric intensive care unit
To gain an in-depth understanding of the experience of pediatric intensive care unit (PICU) clinicians caring for children with chronic critical illness (CCI), we conducted, audiotaped, and transcribed in-person interviews with PICU clinicians. We used purposive sampling to identify five PICU patients who died following long admissions, whose care generated substantial staff distress. We recruited four to six interdisciplinary clinicians per patient who had frequent clinical interactions with the patient/family for interviews. Conventional content analysis was applied to the transcripts resulting in the emergence of five themes: nonbeneficial treatment; who is driving care? Elusive goals of care, compromised personhood, and suffering. Interventions directed at increasing consensus, clarifying goals of care, developing systems allowing children with CCI to be cared for outside of the ICU, and improving communication may help to ameliorate this distress. Copyright © 2021 Thieme India. All rights reserved.
Miles AH; Rushton CH; Wise BM; Moore A; Boss RD
Journal of Pediatric Intensive Care.
2021
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1055/s-0041-1724098" target="_blank" rel="noreferrer noopener">10.1055/s-0041-1724098</a>